Clinical trials: Diabetic Neuropathy, Painful
Painful Diabetic Neuropathy
Study Evaluating Long-term Safety and Efficacy of Lacosamide in Subjects With Painful Distal Diabetic Neuropathy.
SP746 (NCT00546351) is a multi-center, open-label, follow-on trial. The purpose of this trial is to assess safety and tolerability of long-term exposure of lacosamide (previously referred to as SPM 927) in subjects with painful…
- Trial name
- NCT00546351
- Testing
- Lacosamide
- Where
- 101 sites in Austria, Belgium and 13 more
- Volunteers
- 621 people
- Sponsor
- UCB Pharma
Healthy
Bioequivalence Study of Two Formulations of Pregabalin CR (Controlled-release) Table 150 mg
The purpose of this clinical trial is to (1) evaluate the bioequivalence(BE) of GLA5PR GLARS-NF3 tablet 150mg administered regular diet relative to GLA5PR GLARS-NF1 tablet 150mg administered regular diet and (2) determine the…
- Trial name
- NCT02955472
- Testing
- GLA5PR GLARS-NF3 tablet 150mg, GLA5PR GLARS-NF1 tablet 150mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Diabetes Mellitus, Diabetic Neuropathies
Use of taVNS for Painful Diabetic Neuropathy: 12-Week Randomized, Sham-Controlled Trial
This 12-week, randomized, double-blind, sham-controlled, parallel-group trial will evaluate the analgesic and mechanistic effects of home-based transcutaneous auricular vagus nerve stimulation (taVNS) in adults with painful…
- Conditions
- Diabetes Mellitus, Diabetic Neuropathies, Type2diabetes, Neuropathic Pain
- Trial name
- PAK-VAGUS (NCT06292962)
- Testing
- non-invasive transcutaneous vagal nerve stimulation (tVNS)
- Where
- Pakistan
- Volunteers
- 185 people
- Sponsor
- Saima Abass Tahammal
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to learn if topical lidocaine gel can effectively reduce pain intensity compared to oral duloxetine in adult patients (aged 30-70 years) with type 2 diabetes suffering from painful diabetic…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies, Type 2 Diabetes
- Trial name
- NCT07800468
- Testing
- Topical Lidocaine 2% Gel, Duloxetine (60 MG)
- Volunteers
- 80 people
- Sponsor
- Wah Medical college , POF hospital
Diabetic Polyneuropathy, Sleep Hygiene
The Effect of Sleep Hygiene Education on Sleep Quality and Quality of Life in Patients With Painful Diabetic Polyneuropathy
This randomized controlled study was designed to the effect of sleep hygiene education on sleep quality and quality of life in patients with painful diabetic polyneuropathy The study was conducted between January 2025 and January…
- Conditions
- Diabetic Polyneuropathy, Sleep Hygiene, Pain
- Trial name
- NCT07646743
- Testing
- sleep hygiene education, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Trakya University
Diabetic Neuropathy Peripheral, Neuropathic Pain
Peripheral Analgesia in Painful Diabetic Neuropathy
Chronic obliterative arteriopathy of the inferior limbs is a frequent condition observed in diabetics. The later stages induce pain at rest and trophic disorders (ulcer, gangrene) that lead to chronic limb ischemia.
- Conditions
- Diabetic Neuropathy Peripheral, Neuropathic Pain, Diabetic Foot Infection
- Trial name
- DIALOXY (NCT03354806)
- Testing
- Continuous peripheral nerve blocks, Analgesic treatment
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Diabetic Neuropathies
A Study Comparing the Effectiveness and Safety of Tramadol HCl/Acetaminophen Versus Placebo for the Treatment of Painful Neuropathy in Diabetic Patients
The purpose of this study is to explore the pain-reieiving effects and safety of tramadol HCl/acetaminophen as compared to placebo in patients experiencing painful diabetic neuropathy.
- Trial name
- NCT00210847
- Testing
- tramadol, acetaminophen
- Volunteers
- 313 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Painful Diabetic Neuropathy
The Therapeutic Effect of Low-intensity Focused Ultrasound on Painful Diabetic Peripheral Neuropathy
Diabetic painful peripheral neuropathy (DPN) constitutes a serious threat to the outcomes of patients with diabetes. Yet, the treatments for targeting the underlying nerve damage and relieving pain are limited.
- Trial name
- NCT05624762
- Testing
- Low-Intensity Focused Ultrasound (LIFU)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chongqing Medical University
Diabetic Neuropathies, Pain
The Effects of the Magnetic Molecular Energizer (MME) on Diabetic Peripheral Neuropathy
This study is intended to demonstrate that exposure to a high intensity, DC electromagnetic field, as supplied by the investigational device known as the Molecular Magnetic Energizer (MME), will create a clinically meaningful…
- Conditions
- Diabetic Neuropathies, Pain, Neuralgia
- Trial name
- NCT00134524
- Testing
- MME procedure
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Advanced Magnetic Research Institute International
Diabetic Neuropathy, Neuropathic Pain
Pain In Neuropathy Study
In the context of peripheral neuropathy, we will aim to elucidate correlates between sensory symptoms and: Sensory nerve dysfunction. Cutaneous small nerve fibre innervation density. Psychological co-morbidity.
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Chronic Pain, Carpal Tunnel Syndrome
- Trial name
- PINS (NCT02672059)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- King's College London
Diabetic Neuropathy
A Follow-On Trial to Assess the Long Term Safety and Efficacy of SPM 927 in Painful Distal Diabetic Neuropathy
Phase 2/3 open-label trial to assess the safety and tolerability of long-term treatment with lacosamide (SPM 927) in subjects with painful diabetic neuropathy.
- Trial name
- NCT00235443
- Testing
- lacosamide
- Where
- 84 sites in United States
- Volunteers
- 451 people
- Sponsor
- UCB Pharma
Painful Diabetic Neuropathy, Neuropathic Pain
Peripheral Nerve Block in Patients With Painful Diabetic Polyneuropathy
The purpose of the present study is to evaluate the role of peripheral afferent input for spontaneous pain in painful diabetic polyneuropathy
- Conditions
- Painful Diabetic Neuropathy, Neuropathic Pain, Neuropathy;Peripheral
- Trial name
- NCT04699734
- Testing
- Xylocaine 1%, NaCl 9mg/ml
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University of Aarhus
Healthy
Bioequivalence Study of Two Formulations of Pregabalin CR(Controlled-release) Table 300 mg
The purpose of this clinical trial is to (1) evaluate the bioequivalence(BE) of GLA5PR GLARS-NF3 tablet 300mg administered regular diet relative to GLA5PR GLARS-NF1 tablet 300mg administered regular diet and (2) determine the…
- Trial name
- NCT02952937
- Testing
- GLA5PR GLARS-NF3 tablet 300mg, GLA5PR GLARS-NF1 tablet 300mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Painful Diabetic Neuropathy
The Benefits of Vitamin B Combination as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient
Large population-based study has shown that the prevalence of painful diabetic neuropathy (PDN) is around 21%, and painful symptoms are more prevalent in patients with type 2 diabetes, females, and Asians.
- Trial name
- NCT04689971
- Testing
- Standard therapy, Vitamin B combination
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Duta Wacana Christian University
Painful Diabetic Neuropathies
Safety and Efficacy Study for the Treatment of Painful Diabetic Neuropathy
The purpose of this study is to determine if Engensis (VM202) is safe and effective in treating painful diabetic neuropathy.
- Trial name
- NCT01475786
- Testing
- Low Dose: 16 mg Engensis (VM202), High Dose: 32 mg Engensis (VM202)
- Where
- 17 sites in United States, South Korea
- Volunteers
- 104 people
- Sponsor
- Helixmith Co., Ltd.
Diabetic Peripheral Neuropathy
Exercise Effects on Pain, Sleep and Depression in Diabetic Peripheral Neuropathy
It is known that the pain experienced by individuals with diabetic neuropathy negatively impacts sleep and quality of life, leading to numerous psychosocial problems such as anxiety and depression.
- Trial name
- NCT07291596
- Testing
- Ankle-Foot Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Amasya University
Diabetes Mellitus, Diabetic Neuropathy
Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients
This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management
- Trial name
- ANKLE-DM (NCT07404124)
- Testing
- Ultrasound-Guided Ankle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Neuropathic Pain
Donepezil Compared to Placebo in Patients With Chronic Neuropathic Pain
Based on laboratory studies, donepezil will improve pain relief more than placebo in patients with chronic neuropathic pain who are currently taking gabapentin or pregabalin.
- Trial name
- NCT01743976
- Testing
- Donepezil
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University
Painful Diabetic Neuropathy, Diabetic Neuropathy, Painful
Phase 3 Gene Therapy for Painful Diabetic Neuropathy
The purpose of this study is to determine the safety and efficacy of bilateral intramuscular injections of VM202 versus placebo in the treatment of painful diabetic peripheral neuropathy.
- Trial name
- NCT02427464
- Testing
- Engensis (VM202)
- Where
- 25 sites in United States
- Volunteers
- 507 people
- Sponsor
- Helixmith Co., Ltd.
Neuropathic Pain, Quality of Life
Neuropathic Pain and Type II Diabetic Patients
Diabetes Mellitus (DM) is a common metabolic disease characterized by hyperglycemia resulting from insufficiency, deficiency or absence of the insulin hormone.
- Conditions
- Neuropathic Pain, Quality of Life, Diabetic Neuropathies
- Trial name
- NCT06798181
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Bilecik Seyh Edebali Universitesi