Clinical trials: Diabetic Neuropathy
Diabetic Foot
Diabetic Foot School and Biomechanics
The primary aim of the study is to establish a diabetic foot school. The secondary aim is to compare the effects of the training given to diabetic foot patients within the scope of the diabetic foot school, on sensory, balance…
- Trial name
- NCT05431660
- Testing
- education and exercise protocol about diabetic foot, control group
- Volunteers
- 50 people
- Sponsor
- Ankara Yildirim Beyazıt University
Foot Ulcer, Varicose Ulcer
Skin Ulcers Treatment With an Handicraft Topical Device
The aim of this study was to evaluate the efficacy of a handicraft topical device of negative pressure versus traditional healing treatment for skin ulcers in lower limbs; in patients with diabetes mellitus, venous stasis and…
- Trial name
- NCT02512159
- Testing
- drenovac handcrafted, Healing
- Volunteers
- 144 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Painful Diabetic Peripheral Neuropathy (PDPN)
Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral Neuropathy
A phase 3, prospective, adaptive, randomized, multicenter, double-blind, triple-masked, parallel clinical trial to evaluate the efficacy and safety of N0750 in relieving pain associated with painful diabetic peripheral neuropathy…
- Trial name
- ENFORCE (NCT06715462)
- Testing
- N0750, Cymbalta®, Lyrica®
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Diabetes Mellitus, Foot Ulcer
REOXCARE Dressing to Improve Healing in Diabetic Foot Ulcers (DFU)
It has been shown that diabetic patients present a significant increase in markers related to oxidative stress, which increases even more in those with diabetic foot ulcers and gradually depending on the severity of the injury…
- Conditions
- Diabetes Mellitus, Foot Ulcer, Neuroischemic Foot Ulcer
- Trial name
- REOXDFU (NCT05413746)
- Testing
- Reoxcare antioxidant dressing
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Histocell, S.L.
Painful Diabetic Neuropathy
The Therapeutic Effect of Low-intensity Focused Ultrasound on Painful Diabetic Peripheral Neuropathy
Diabetic painful peripheral neuropathy (DPN) constitutes a serious threat to the outcomes of patients with diabetes. Yet, the treatments for targeting the underlying nerve damage and relieving pain are limited.
- Trial name
- NCT05624762
- Testing
- Low-Intensity Focused Ultrasound (LIFU)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chongqing Medical University
Diabetic Peripheral Neuropathy, Balance
Effects of Virtual Reality-Based Balance Training Compared to Conventional Balance Training to Reduce Risk of Fall in Patients With Diabetic Peripheral Neuropathy: A Randomized Control Trial
The objective of this study is to determine the effects of virtual reality based balance training compared to conventional balance training to reduce risk of fall in patients with diabetic peripheral neuropathy in terms of fall…
- Conditions
- Diabetic Peripheral Neuropathy, Balance, Fall Risk
- Trial name
- NCT06740227
- Testing
- Virtual Reality-Based Balance Training, Conventional Balance Training
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad
Diabetic Foot Ulcer
BB-101 for the Treatment of Diabetic Lower Leg and Foot Ulcers
This is a randomized, double-blinded, vehicle-controlled, parallel, phase II study to evaluate the efficacy and safety of topical BB-101 for the treatment of diabetic lower leg and foot ulcer.
- Trial name
- NCT06383013
- Testing
- BB-101
- Where
- 5 sites in Taiwan
- Volunteers
- 96 people
- Sponsor
- Blue Blood Biotech Corp.
Balance Impairment, Diabetic Neuropathy
Comparative Effects of Perturbation-Based Balance Training on Firm Surface and Rolling Board for Diabetic Neuropathy Patients
The present study is designed to compare the effectiveness of perturbation-based balance training performed on two different surfaces, stable (firm surface) and unstable (rolling board), for enhancing static, dynamic, and…
- Trial name
- NCT07598513
- Testing
- Group A (Perturbation Based Training on Firm Surface), Group B (Perturbation Based Training on Rolling Board)
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- University of Faisalabad
Diabetes Mellitus, Type 2, Neuropathy
Effects of Modified Otago Exercises in Individuals With Diabetic Neuropathy
The aim of the study is to investigate the effects of modified otago exercises on joint position sense, balance and physical fitness parameters in individuals with diabetic neuropathy.
- Trial name
- NCT05691738
- Testing
- Exercise Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Karamanoğlu Mehmetbey University
Diabetes Mellitus, Diabetic Autonomic Neuropathy
Inspiratory Muscle Training in Patients With Autonomic Neuropathic
This study describes a controlled randomized clinical trial to evaluate the effect of inspiratory muscle training in patients with diabetic autonomic neuropathy.
- Trial name
- NCT00752440
- Testing
- Inspiratory muscle training (IMT)
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Diabetic Foot Infection
PHOTOFINISH: a Clinical Study To Evaluate The Efficacy And Safety Of the System VULNOFAST® Plus/VULNOLIGHT® In Addition To The Usual Care (UC) Vs UC Alone For The Treatment Of Infected Diabetic Foot Ulcers
The aim of this randomised, open-label, multicentre clinical trial is to evaluate the superiority of the treatment which foresees the addition of the system VULNOFAST® plus / VULNOLIGHT® to the Usual Care, versus the treatment…
- Trial name
- PHOTOFINISH (NCT05613985)
- Testing
- Usual Care alone, System VULNOFAST® plus / VULNOLIGHT® in addition to Usual Care
- Where
- 7 sites in Italy
- Volunteers
- 78 people
- Sponsor
- L.Molteni & C. dei F.lli Alitti-Soc. di Esercizio S.p.A.
Diabetic Foot Ulcers, Foot Wounds
Santyl vs. Sharp Debridement of Diabetic Foot Wounds
This study tests two different approaches to the removal of dead tissue from the surface of a wound.
- Trial name
- NCT01056198
- Testing
- Santyl, Control
- Where
- 9 sites in United States
- Volunteers
- 48 people
- Sponsor
- Healthpoint
Diabetic Foot Ulcers
Clinical Trials of Footwear in Patients With Diabetes-Study Arm 2,3
This is a randomized clinical trial to: (1) Determine the extent to which custom made study shoes will reduce the incidence of reulceration in diabetic individuals with prior history of foot ulcers, and (2) Estimate costs of…
- Trial name
- NCT00013299
- Testing
- Prevention of Diabetic Ulcers
- Where
- United States
- Volunteers
- 427 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Foot
Negative Pressure Wound Therapy in Diabetic Wounds
Topical Negative Pressure Wound Therapy (TNPW) is an established tool in the management of Diabetic foot ulcer in many countries. This treatment option is under utilized in the public sector of Mauritius.
- Trial name
- NCT05041244
- Testing
- Negative pressure wound therapy delivered through VAC, Standard of care
- Where
- Mauritius
- Volunteers
- 80 people
- Sponsor
- University of Mauritius
Diabetic Neuropathy, Painful
A Study in Participants With Diabetic Peripheral Neuropathic Pain in China
The purpose of this trial is to assess the efficacy of duloxetine 60 milligrams (mg) once daily (QD) compared with placebo, on the change in pain severity from baseline to 12 weeks as measured by the weekly mean of the daily pain…
- Trial name
- NCT01179672
- Testing
- Duloxetine
- Where
- 15 sites in China
- Volunteers
- 405 people
- Sponsor
- Eli Lilly and Company
Diabetic Peripheral Neuropathy
Treatment of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the safety, tolerability and effectiveness of DS-5565 compared to placebo (inactive substance) and pregabalin in diabetic subjects with DPN.
- Trial name
- NCT01496365
- Testing
- DS-5565 tablet, pregabalin capsule
- Where
- 78 sites in United States
- Volunteers
- 452 people
- Sponsor
- Daiichi Sankyo
Diabetic Peripheral Neuropathic Pain, Diabetic Peripheral Neuropathy
Efficacy and Safety of ETX-018810 for the Treatment of Diabetic Peripheral Neuropathic Pain
A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel-Group Study to Evaluate the Efficacy and Safety of ETX 018810 in Subjects with Diabetic Peripheral Neuropathic Pain.
- Trial name
- NCT04688671
- Testing
- ETX-018810
- Where
- 22 sites in United States
- Volunteers
- 167 people
- Sponsor
- Eliem Therapeutics (UK) Ltd.
Diabetic Neuropathy Peripheral
Evaluating a Nitric Oxide Generator, Nebivolol as a Disease Modifier in Patients With Diabetic Neuropathy.
The goal of this clinical trial is to test in patients with diabetic neuropathy, Can Nevibolol at a dose of 2.5 mg- 10 mg compared with standard pain modulating treatment conserve the mean nerve action potential amplitude (sural…
- Trial name
- EVANESCENT-DPN (NCT06201611)
- Testing
- Nebivolol+ Standard care arm, Epalrestat + Alpha Lipoic Acid +Standard care, Standard care alone
- Where
- 2 sites in India
- Volunteers
- 120 people
- Sponsor
- St. John's Research Institute
Diabetic Neuropathies, Plantar Callus
Short-term Effect of Podiatric Callus Debridement on Plantar Pressure in Diabetic Neuropathic Patients
Diabetes peripheral neuropathy (DPN) affects up to 50% of the diabetes population. In the diabetic neuropathic foot, it commonly manifests as loss of protective sensation, foot deformity and skin dryness.
- Trial name
- NCT06357884
- Testing
- Callus debridement
- Where
- Hong Kong
- Volunteers
- 16 people
- Sponsor
- Chinese University of Hong Kong
Diabetic Foot Ulcers
A Comparative Efficacy Study of DermaPure™ to Treat Diabetic Foot Ulcers
This study has been designed to help determine how safe and effective DermaPure™ may be in treating hard-to-heal diabetic foot ulcers compared to the current standard of care.
- Trial name
- NCT02081352
- Testing
- DermaPure™, Standard care
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- TRx Wound Care Limited