Clinical trials: Diabetic Neuropathy Peripheral
Diabetic Foot Ulcer, Diabetic Foot
Effect of Self-foot Exercise on the Incidence of Plantar Foot Diabetic Ulcer Recurrence
The incidence of diabetic foot ulcer recurrence in one year can reach 35%. Plantar foot diabetic foot ulcer is the most frequently diabetic foot ulcer recurrence.
- Trial name
- NCT04624516
- Testing
- self-structured foot exercise
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Maria Suryani
Neuropathy, Diabetic, Neuropathy, Painful
Methods of Early Detection and Grading Of Diabetic Peripheral Neuropathy (MEDON)
MEDON aims to examine new methods for early detection and grading of diabetic peripheral neuropathy focusing on both small- and large nerve fibers.
- Trial name
- MEDON (NCT04078516)
- Testing
- Perception Threshold Tracking (PTT), Axon-flair mediated respons, Heart rate variability
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Transcutaneous Vagal Nerve Stimulation (tVNS), Diabetic Polyneuropathy
Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outcomes in Diabetic Peripheral Neuropathy Patients
To evaluate the efficacy of vagus nerve stimulation in reducing neuropathic pain, symptom severity, electrophysiological studies and functional outcomes in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07405021
- Testing
- Conventional physical therapy program, Transcutaneous auricular vagus nerve stimulation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Painful Diabetic Neuropathy
Feasibility of Self-treatment of Painful Diabetic Neuropathy Using Electrical Vasomotor Nerve Stimulation
Electrical stimulation with EVNS (Electrical Vasomotor Neuro Stimulation), a methodology used by a specific group of neurostimulators known under various names, has proven its benefit in Painful Diabetic Neuropathy (PDN).
- Trial name
- HOME-EVNS (NCT06524284)
- Testing
- Releaf
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Neurecon BV
Diabetes Mellitus, Diabetic Autonomic Neuropathy
Inspiratory Muscle Training in Patients With Autonomic Neuropathic
This study describes a controlled randomized clinical trial to evaluate the effect of inspiratory muscle training in patients with diabetic autonomic neuropathy.
- Trial name
- NCT00752440
- Testing
- Inspiratory muscle training (IMT)
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Neuropathic Pain, Diabetes Mellitus, Type 2
A Randomized, Active-controlled, Parallel, Open-label, Multicenter, Phase 4 Study to Compare the Efficacy and Safety of Pregabalin Sustained Release Tablet and Pregabalin Immediate Release Capsule in Type II Diabetic Patients With Peripheral Neuropathic Pain
This study is to compare the efficacy and safety of pregabalin sustained release tablet and pregabalin immediate release capsule in type II diabetic patients with peripheral neuropathic pain.
- Trial name
- NCT05624853
- Testing
- pregabalin sustained release tablet, pregabalin immediate release capsule
- Where
- 8 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- Yuhan Corporation
Diabetes, Diabetic Polyneuropathy
Investigation of Ultrasonographic Measurements of Lower Extremity Nerves in Type 2 Diabetes Patients With Peripheral Polyneuropathy
The aim of this study is to quantitatively evaluate ultrasonographic measurements of the lower extremity nerves in patients diagnosed with diabetic polyneuropathy and to investigate the relationship with gait, static and dynamic…
- Trial name
- NCT06778005
- Testing
- Ultrasonography, Biodex Balance System, Douleur Neuropathique 4 (DN4) Pain Scale
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Diabetic Neuropathy
ACUpuncture in Diabetic Peripheral Neuropathy
Multicentric,randomized, two-armed confirmatory trial on the effectiveness of acupuncture in patients with symptomatic peripheral diabetic neuropathy compared to routine care.
- Trial name
- ACUDPN (NCT03755960)
- Testing
- acupuncture, routine care
- Where
- 2 sites in Germany
- Volunteers
- 62 people
- Sponsor
- Benno Brinkhaus
Diabetic Neuropathy, Neuropathic Pain
Pain In Neuropathy Study
In the context of peripheral neuropathy, we will aim to elucidate correlates between sensory symptoms and: Sensory nerve dysfunction. Cutaneous small nerve fibre innervation density. Psychological co-morbidity.
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Chronic Pain, Carpal Tunnel Syndrome
- Trial name
- PINS (NCT02672059)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- King's College London
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
The purpose of the study is to evaluate the clinical effects of the investigational drug, SB-509, in subjects with diabetic neuropathy.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Polyneuropathy
- Trial name
- NCT01079325
- Testing
- SB-509, Saline
- Where
- 31 sites in United States
- Volunteers
- 170 people
- Sponsor
- Sangamo Therapeutics
Diabetes, Diabetes Mellitus, Type 1
Comparison of Histamine and Local Heating for Evoking the Axon-reflex Flare Response in Diabetes
Diabetic peripheral neuropathy is the most common complication to diabetes mellitus affecting as much as 50% of the population with diabetes.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetic Neuropathy Peripheral, Small Fiber Neuropathy
- Trial name
- HistaHeat (NCT05921097)
- Testing
- Histamin-induced axon-reflex flare response, Local heating-induced axon-reflex flare response, 2-point discrimination tasks
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aalborg University Hospital
Diabetic Peripheral Neuropathy
Effect of High Tone External Muscle Stimulation on Peripheral Arterial Disease
to investigate the effect of high tone external muscle stimulation (HTEMS) on endothelial dysfunction and walking parameters in peripheral vascular disease.
- Trial name
- NCT04555876
- Testing
- high tone external muscle stimulation- stationary bicycle
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Kidney Disease Stage 3 and 4, Diabetes
Prediction of Peripheral Neuropathy With Functional Testing
Diabetes and chronic kidney disease (CKD) are two distinct pathologies. The former is defined as an impairment in insulin production and/or utilization, while the latter refers to structural or functional abnormalities of the…
- Trial name
- PredictNP (NCT06933108)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Université catholique de l'Ouest
Type 2 Diabetes, Bone Disease
Deep Phenotyping of Bone Disease in Type 2 Diabetes and Relations to Diabetic Neuropathy
Objectives: The goal of this cross sectional clinical trial is to examine the phenotype of bone disease in type 2 diabetes.The main aims are to: 1.
- Conditions
- Type 2 Diabetes, Bone Disease, Osteoporosis, Diabetic Neuropathy Peripheral
- Trial name
- NCT05642143
- Testing
- Dual Energy X-ray Absorbtiometry scan, High-resolution peripheral quantitative computed tomography, Microindentation
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Aalborg University Hospital
Diabetic Peripheral Neuropathy
Effects of Multisystem Exercise on Balance, Postural Stability, Mobility and Pain in Patients With DPN.
Upto the best knowledge of researcher, multisystem exercise program has been utilized in various populations, encompassing both healthy individuals and patients with diverse medical conditions.
- Trial name
- DPN (NCT06130917)
- Testing
- Multisystem Exercise, Conventional Treatment
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Diabetic Neuropathy
Efficacy of γ-linolenic Acid and Thioctic Acid in Patients With Diabetic Neuropathy
This study was a 12-week, multi-center, randomized, double-blind, double dummy, parallel clinical trial to compare the efficacy of γ-linolenic acid and Thioctic acid in patients with diabetic neuropathy.
- Trial name
- NCT03914404
- Where
- 11 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Chonbuk National University Hospital
Diabete Mellitus, Peripheral (Sensorimotor) Diabetic Polyneuropathy
Neurophysiological, Autonomic, and Sonographic Assessment of Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy causes pain, sensory loss, and foot risk; multimodal assessment enables earlier diagnosis and improved patient management.
- Trial name
- NCT07306884
- Testing
- Nerve conduction study, Nerve ultrasound, Autonomic assessment
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Neuropathy
The Balance Control Mechanism of DPN Patients
This study will evaluate the balance ability of DPN (diabetic peripheral neuropathy)patients, which will help us to understand the relationship between peripheral and central nervous system, in order to early diagnosis and…
- Trial name
- NCT02606747
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Geheng Yuan
Type 2 Diabetes Mellitus, Diabetic Neuropathy
GlucoBites Cookies (Gynura Procumbens) for Glycemic Control and Prevention of Diabetic Foot Ulcer Risk in Type 2 Diabetes
The goal of this randomized controlled trial is to learn if GlucoBites functional cookies containing Gynura procumbens can help improve blood sugar control and lower the risk of diabetic foot ulcers in adults with type 2…
- Trial name
- GlucoBites (NCT07151833)
- Testing
- GlucoBites (with Gynura procumbens), Control Cookies (without Gynura procumbens)
- Where
- Indonesia
- Volunteers
- 126 people
- Sponsor
- Andina Setyawati
Diabetic Peripheral Neuropathy
Study of Low Level Laser Therapy to Treat Diabetic Peripheral Neuropathy Foot Pain
The purpose of this study is to determine whether low level laser therapy is effective in the reduction of foot pain associated with diabetic peripheral neuropathy.
- Trial name
- NCT02461225
- Testing
- Erchonia® FX-635™
- Where
- 2 sites in United States, Ireland
- Volunteers
- 30 people
- Sponsor
- Erchonia Corporation