Clinical trials: Diabetic Oculopathy
Corneal Epithelial Defects After Ocular Surgeries
Topical Autologous Insulin Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Topical insulin application has been proved recently to increase corneal reepithelization rate over diabetic animals. However, its effectiveness on corneal epithelial wound healing in patients who received pars planar vitrectomy…
- Trial name
- NCT01031888
- Testing
- Topical insulin eye drops, Conventional postoperative eye drops
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Taiwan University Hospital
Diabetic Retinopathy
Ozurdex in Reducing PVR After Vitreotomy in PDR
Diabetic retinopathy is a significant source of visual morbidity in the adult population. Complications of diabetic retinopathy include ischemic maculopathy, macular edema, and sequelae of fibrovascular proliferation, such as…
- Trial name
- NCT05415826
- Testing
- slow-release dexamethasone implant
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Retinal Vein Occlusion, Diabetic Macular Edema
Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO
This interventional study will evaluate the retinal vascular dynamics associated with Intravitreal Aflibercept Injection (IAI) therapy in eyes with diabetic macular edema (DME) or macular edema secondary to retinal vein occlusion…
- Conditions
- Retinal Vein Occlusion, Diabetic Macular Edema, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion
- Trial name
- PERMEATE (NCT02503540)
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Justis Ehlers
Type 2 Diabetes, Microvascular Function
The Effect of Pyridoxamine Supplementation on Microvascular Function in Type 2 Diabetes
Patients with type 2 diabetes have an increased risk of developing vascular complications. Microvascular dysfunction might be caused by the increased production of methylglyoxal under hyperglycaemic conditions.
- Conditions
- Type 2 Diabetes, Microvascular Function, Retinopathy, Diabetic, Nephropathy, Diabetic
- Trial name
- PYRAMID (NCT06376240)
- Testing
- Pyridoxamine 300mg per day
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Macular Edema
Clinical Trial on Alpha Lipoic Acid in Diabetic Macular Edema
To evaluate the effect of alpha lipoic acid (ALA) on the occurrence of diabetic macular edema.
- Trial name
- RETIPON (NCT01208948)
- Testing
- 1,2 dithiolane 3 valeric acid
- Where
- Germany
- Volunteers
- 520 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Diabetic Retinopathy
Automated AI-based System for Early Diagnosis of Diabetic Retinopathy
In this pivotal trial, we aim to perform a prospective study to find the efficacy of iPredict, an artificial intelligence (AI) based software tool on early diagnosis of Diabetic Retinopathy (DR)in the primary care, optometrist…
- Trial name
- NCT05324189
- Testing
- Referable versus Non Referable Diabetic Retinopathy diagnostic test
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The New York Eye & Ear Infirmary
Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy
Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment
Vitreoretinal surgery for epiretinal proliferation tractional retinal detachment associated with proliferative diabetic retinopathy (PDR) is often complicated by hemorrhage from fibrovascular tissue.
- Conditions
- Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy, Tractional Retinal Detachment, Diabetic Retinopathy
- Trial name
- NCT00548197
- Testing
- Bevacizumab
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Iran University of Medical Sciences
Diabetic Macular Edema
Safety, Efficacy and Cost-efficacy of Ranibizumab (Monotherapy or Combination With Laser) in the Treatment of Diabetic Macular Edema (DME)
To evaluate, specifically within the Canadian medical environment, the efficacy, safety and cost-efficacy of ranibizumab administered either as combination therapy (ranibizumab plus laser photocoagulation), or as monotherapy in…
- Trial name
- RESPOND (NCT01135914)
- Testing
- ranibizumab, Laser
- Where
- 20 sites in Canada
- Volunteers
- 241 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Macular Edema
Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema
The purpose of this study is to determine the efficacy of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) on the best corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS)…
- Trial name
- VISTA DME (NCT01363440)
- Testing
- Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321), Macular Laser Photocoagulation
- Where
- 51 sites in United States
- Volunteers
- 466 people
- Sponsor
- Regeneron Pharmaceuticals
Diabetes Mellitus
Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics
Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication.
- Trial name
- NCT00698698
- Where
- Pakistan
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Glaucoma, Diabetic Retinopathy
Glaucoma Algorithm Validation Study in African Population - the MAGIC Study
Artificial Intelligence (AI) algorithms require validation in a variety of populations to ensure widespread clinical applicability.
- Trial name
- MAGIC (NCT06552247)
- Testing
- Fundus Picture AI testing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Diabetic Retinopathy
I-TRUST: Implementation of Teleophthalmology in Rural Health Systems Study
This pragmatic clinical trial is being conducted to test the effectiveness of I-SITE (Implementation for Sustained Impact in Teleophthalmology), an implementation program to sustain increased diabetic eye screening rates using…
- Trial name
- NCT05254535
- Testing
- I-SITE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Wisconsin, Madison
Diabetic Retinopathy (DR)
Diabetic Retinopathy Prevalence And Risk Factors
The goal of this retrospective observational study is to evaluate the prevalence and severity of diabetic retinopathy (DR) and to identify associated risk factors among patients with diabetes mellitus at Gia Dinh Family Hospital…
- Trial name
- DR-CENTRAL (NCT07468058)
- Testing
- fundus examination and optical coherence tomography (OCT)
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- Da Nang Family General Hospital
Macular Edema
Diabetic Macular Edema (DME) Treatment With Ranibizumab and Dexamethasone or Ranibizumab Only.
The aim of this study is to evaluate the visual outcome and prognostic factors after intraocular injections of Ranibizumab or combination of Ranibizumab And Dexamethasone under pro re nata treatment regimen for Diabetic Macular…
- Trial name
- NCT04601675
- Testing
- Ranibizumab Ophthalmic and Intravitreal Dexamethasone, Ranibizumab Ophthalmic only
- Where
- China
- Volunteers
- 100 people
- Sponsor
- He Eye Hospital
Diabetes Mellitus, Diabetic Retinopathy
A Study to Evaluate THR-687 Treatment for Diabetic Macular Oedema.
This study is conducted to select the THR-687 dose level (Part A of the study) and to assess the efficacy and safety of the selected dose level compared to aflibercept (Part B of the study).
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- INTEGRAL (NCT05063734)
- Testing
- THR-687 dose level 1, THR-687 dose level 2, THR-687 selected dose level
- Where
- 25 sites in United States, Estonia and 3 more
- Volunteers
- 16 people
- Sponsor
- Oxurion
Retinopathy, Diabetic
Assessment of Color Vision in Diabetic Patients
Assessment of color vision in diabetic patients before and after the use of anti-vegf in the treatment of diabetic macular edema
- Trial name
- NCT03345667
- Testing
- lucentis
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto de Olhos de Goiania
Vein Occlusion, Macular Degeneration Choroidal Neovascularization
Comparing Post-intravitreal Injection Pain Scores Using Loteprednol, Bromfenac Sodium, and Artificial Tears Over a 24-hour Period
The goal of this clinical trial is to learn how various topical drops (bromfenac, loteprednol, and artificial tears) fare in alleviating post-intravitreal injection pain.
- Conditions
- Vein Occlusion, Macular Degeneration Choroidal Neovascularization, Macular Edema, Diabetic Retinopathy
- Trial name
- NCT07090044
- Testing
- Bromfenac Sodium 0.07%, Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly, Propylene Glycol Preservative-free Artificial Tears
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Retina Research Institute, LLC
Microalbuminuria, Endothelial Dysfunction
Microalbuminuria as a Cardiovascular Risk Factor (PRECISED Substudy)
Microalbuminuria (MA) is an independent cardiovascular risk factor in diabetic and non-diabetic subjects. However, in the setting of type 2 diabetes, microalbuminuria could be a marker of either early diabetic nephropathy or…
- Conditions
- Microalbuminuria, Endothelial Dysfunction, Diabetic Nephropathy, Diabetic Retinopathy
- Trial name
- NCT02409511
- Testing
- non intervention
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Longitudinal Observational Study of Diabetic Retinopathy Progression in Type 2 Diabetes Patients
The purpose of this clinical study is to explore structural and functional imaging and systemic biomarkers of diabetic retinopathy (DR) progression, in eyes from Type 2 Diabetes (T2D) patients with moderate to severe…
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Diabetic Complication, Retinal Disease
- Trial name
- IMPORTANT (NCT07458516)
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Retinopathy
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy
This study will assess the safety, tolerability, and pharmacokinetics (PK) of intravitreal (IVT) injections of RO7663498 in participants with diabetic retinopathy (DR).
- Trial name
- CENOTE (NCT07588100)
- Testing
- RO7663498
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Hoffmann-La Roche