Clinical trials: Diabetic Oculopathy
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Longitudinal Observational Study of Diabetic Retinopathy Progression in Type 2 Diabetes Patients
The purpose of this clinical study is to explore structural and functional imaging and systemic biomarkers of diabetic retinopathy (DR) progression, in eyes from Type 2 Diabetes (T2D) patients with moderate to severe…
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Diabetic Complication, Retinal Disease
- Trial name
- IMPORTANT (NCT07458516)
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Macular Edema
A Randomized, Placebo-Controlled Clinical Trial of Intravitreal Triamcinolone for Refractory Diabetic Macular Edema
To determine the efficacy and safety of intravitreal triamcinolone acetonide for refractory diabetic macular edema.
- Trial name
- NCT00369863
- Testing
- Triamcinolone acetonide
- Where
- Iran
- Volunteers
- 76 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Vision Disorders
Usability of the Software MacuFix for the Categorization of Metamorphopsia
The usability of a novel test to categorize a distorted visual impression (metamorphopsia) is examined with the questionnaire "SUS"
- Trial name
- MacuFix (NCT04347564)
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Augenheilkunde Lindenthal
Cataract, Glaucoma
Village-Integrated Eye Worker Trial II - Pilot
The vast majority of blindness is avoidable. The World Health Organization (WHO) estimates that 80% of cases of visual impairment could be prevented or reversed with early diagnosis and treatment.
- Conditions
- Cataract, Glaucoma, Age Related Macular Degeneration, Diabetic Retinopathy
- Trial name
- VIEW II Pilot (NCT03278587)
- Testing
- Community-based screening program, Cataract camp program, Community health worker program
- Where
- Nepal
- Volunteers
- 87,992 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetic Retinopathy
Octreotide Acetate in Microspheres in Patients With Diabetic Retinopathy
The most common ocular disease in patients with diabetes, diabetic retinopathy, is present in approximately 40% of diabetic patients; about 8% of diabetic patients have vision threatening diabetic retinopathy.
- Trial name
- NCT00131144
- Testing
- Octreotide Acetate in Microspheres 20 mg, Octreotide Acetate in Microspheres
- Where
- United States
- Volunteers
- 583 people
- Sponsor
- Novartis
Diabetic Retinopathy
Correlation of Biochemical Indexes and Retinal Hemodynamic in Patients With Different Degrees of Diabetic Retinopathy
All OCTA data and biochemical indexes of diabetic patients were acquired. A prediction model of diabetic retinopathy was built, and the random forest method was used to identify sensitive indicators.
- Trial name
- NCT05902650
- Testing
- imaging
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Mingzhe Cao
Diabetic Macular Edema, Retina Vein Occlusion
A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Diabetic Macular Edema and Retinal Vein Occlusion
Phase 2a multicenter, open-label, parallel-arm design study to evaluate the safety, tolerability and pharmacodynamics of a single intravitreal injection comparing 2 dose levels of GB-102 on subjects with Diabetic Macular Edema…
- Trial name
- NCT04085341
- Testing
- GB-102
- Where
- 6 sites in United States
- Volunteers
- 21 people
- Sponsor
- Graybug Vision
Diabetic Retinopathy
A Single-center, Retrospective Study to Evaluate the Clinical Performance of Artificial Intelligence Medical Assisted Diagnostic Software (VeriSee DR) for Screening of Diabetic Retinopathy in Patients With Diabetes Mellitus
This study is to evaluate the clinical performance of VeriSee DR for DR screening from color fundus photography images in patients with diabetes mellitus.
- Trial name
- NCT04160988
- Where
- Taiwan
- Volunteers
- 703 people
- Sponsor
- Acer Being Health Inc.
Diabetic Retinopathy
Diabetic Retinopathy Sulodexide Study
The aim of this phase 2 controlled placebo study is to assess the effectiveness of Sulodexide in the treatment of non proliferative (background) retinopathy in patients with Type 1 and Type 2 Diabetes Mellitus.
- Trial name
- DRESS (NCT01295775)
- Testing
- sulodexide
- Where
- South Korea
- Volunteers
- 127 people
- Sponsor
- Ajou University School of Medicine
Diabetic Retinopathy
Long-Term Follow-Up of Patients Enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS)
Patients enrolled in the original Early Treatment Diabetic Retinopathy Study at the Clinical Center at Johns Hopkins Wilmer Eye Institute will be invited for a follow-up visit at the National Eye Institute.
- Trial name
- NCT00001612
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy, Retinal Neovascularisation
Ranibizumab in Diabetic Vitrectomy. A Prospective, Randomised Controlled Trial of Ranibizumab Pre-treatment in Diabetic Vitrectomy - a Pilot Study
This study will evaluate the effect of ranibizumab on patients undergoing vitrectomy surgery for the complications of diabetic retinopathy.
- Trial name
- RaDiVit (NCT01306981)
- Testing
- Ranibizumab, Saline
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Diabetic Retinopathy, Diabetic Retinal Disease
Nursing Intervention Based on Stress Adaptation Theory for Patients Undergoing Diabetic Retinal Laser Surgery
This randomized controlled study evaluated whether a nursing intervention based on stress adaptation theory could improve pain trajectory and procedural tolerance in patients undergoing ambulatory retinal laser photocoagulation…
- Trial name
- NCT07544381
- Testing
- Nursing Intervention Based on Stress Adaptation Theory, Routine Peri-Procedural Care
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
Type 1 Diabetes, Diabetic Retinopathy
The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes
The purpose of this study is to compare the effect of two antihypertensive drugs on retinal vessel diameter in young type 1 diabetics.
- Conditions
- Type 1 Diabetes, Diabetic Retinopathy, Eye Diseases, Diabetes Complications
- Trial name
- NCT00337298
- Testing
- Amlodipine, Lisinopril
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- University of Aarhus
Diabetic Retinopathy
Intravitreal Triamcinolone Acetonide for Treatment of Refractory Diffuse Diabetic Macular Edema
Phase I/II study with intravitreal triamcinolone acetonide microspheres(RETAAC)for treatment of diffuse diabetic macular edema unresponsive to laser photocoagulation.
- Trial name
- NCT00407849
- Testing
- triamcinolone acetonide
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Diabetic Retinopathy
Investigating the Retardation Effect of OCTA-Guided Targeted Photocoagulation on the Progression of Non-Perfusion Areas in Diabetic Retinopathy Patients
This study aims to evaluate the impact of widefield OCTA-guided selective photocoagulation on the progression of diabetic retinopathy (DR) by comparing the control of non-perfusion (NP) areas, DR grading, and management of other…
- Trial name
- NCT06821633
- Testing
- Targeted laser photocoagulation guided by OCTA (Optical Coherence Tomography Angiography)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sichuan Provincial People's Hospital
Diabetic Retinopathy, Diabetic Macular Edema
Anti-VEGF Treatment for Prevention of PDR/DME
Multiple studies have implicated vascular endothelial growth factor VEGF as a major causative factor in human eye diseases characterized by neovascularization including proliferative diabetic retinopathy (PDR) and vascular…
- Trial name
- NCT02634333
- Testing
- Prompt aflibercept, Deferred laser, Deferred aflibercept
- Where
- 85 sites in United States, Canada
- Volunteers
- 399 people
- Sponsor
- Jaeb Center for Health Research
Diabetic Retinopathy
Camera Qualification Study
A multi-center study to evaluate the performance of an automated device for the detection of diabetic retinopathy with the use of an additional fundus camera with IDx-DR.
- Trial name
- NCT05808699
- Testing
- handheld fundus camera
- Where
- 9 sites in United States
- Volunteers
- 626 people
- Sponsor
- Digital Diagnostics, Inc.
Age-Related Macular Degeneration (AMD), Diabetic Retinopathy (DR)
Effectiveness and Cost-Effectiveness Evaluations of AI-Assisted Diagnostic Software (VeriSee) for Ophthalmic Disease Screening
This study aims to evaluate the effectiveness of an artificial intelligence (AI)-assisted screening system in ophthalmic diagnosis.
- Trial name
- NCT06843499
- Testing
- The VeriSee AI-assisted diagnostic system, Data collection from the patient's clinical history
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Diabetic Retinopathy (DR)
Multimodal Biomarkers in Prediction of Diabetic Retinopathy
The goal of this observational study is to enroll diabetic patients with diabetic retinopathy and those without diabetic retinopathy, follow up and observe the long-term changes in ocular structure and function of the subjects by…
- Trial name
- ZOCDR (NCT07098832)
- Where
- China
- Volunteers
- 1,538 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD)
An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting
The purpose of this research study is to observe the patient's clinical care and how EYLEA® HD is used as a treatment in real-world settings.
- Conditions
- Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD), Diabetic Macular Edema (DME), Visual Impairment
- Trial name
- SPECTRUM-US (NCT06398080)
- Testing
- aflibercept 8 mg
- Sponsor
- Regeneron Pharmaceuticals