Clinical trials: Diabetic Peripheral Neuropathy
Painful Diabetic Neuropathy, Diabetes
A Safety Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Painful Diabetic Neuropathy
Study CLO-311 is a multicenter, open-label, single-arm study to assess the long-term use of Clonidine Gel in the treatment of pain associated with PDN.
- Trial name
- NCT02355158
- Testing
- clonidine hydrochloride topical gel, 0.1%
- Where
- 20 sites in United States
- Volunteers
- 197 people
- Sponsor
- BioDelivery Sciences International
Painful Diabetic Peripheral Neuropathy
The Effects of Ceylon Cinnamon (Cinnamomum Verum) Supplementation on Blood Glucose, Lipid Profile Levels, Body Mass Index, and Pain Intensity Among Adult Individuals With Painful Diabetic Peripheral Neuropathy
Background: Painful diabetic peripheral neuropathy (PDPN) is a severe, disabling complication of type 2 diabetes mellitus (T2DM), closely associated with insulin resistance, chronic neuroinflammation, and oxidative stress.
- Trial name
- PDPN- CC-RCT (NCT07743073)
- Testing
- Ceylon Cinnamon Supplement
- Where
- Jordan
- Volunteers
- 164 people
- Sponsor
- JAWAD AHMAD ABU-SHENNAR
Neuropathic Pain, Diabetes Mellitus, Type 2
A Randomized, Active-controlled, Parallel, Open-label, Multicenter, Phase 4 Study to Compare the Efficacy and Safety of Pregabalin Sustained Release Tablet and Pregabalin Immediate Release Capsule in Type II Diabetic Patients With Peripheral Neuropathic Pain
This study is to compare the efficacy and safety of pregabalin sustained release tablet and pregabalin immediate release capsule in type II diabetic patients with peripheral neuropathic pain.
- Trial name
- NCT05624853
- Testing
- pregabalin sustained release tablet, pregabalin immediate release capsule
- Where
- 8 sites in South Korea
- Volunteers
- 130 people
- Sponsor
- Yuhan Corporation
Diabetic Peripheral Neuropathy, Fibromyalgia
Pharmacokinetics of Two Formulation of Pregabalin
A Randomized, Single-Dose, Parallel-Group Study to Evaluate the Pharmacokinetic Profiles of Two Formulations of Pregabalin after Oral Administration in Healthy Volunteers under Fasting Conditions
- Conditions
- Diabetic Peripheral Neuropathy, Fibromyalgia, Partial Seizure Disorder
- Trial name
- NCT03712475
- Testing
- Pregabalin
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yung Shin Pharm. Ind. Co., Ltd.
Neuropathology
Assessment of the Prevalence of Small Fiber Peripheral Neuropathy Among Non-diabetic Obese Patients
Background / rational: Obesity is associated with significant comorbidities including type 2 diabetes (insulin resistance), heart disease, stroke, hypertension, sleep apnea syndrome, dyslipidemia, cancer, hepatobiliary diseases…
- Trial name
- NEUROBISITE (NCT02767583)
- Testing
- Exams
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Neuropathic Pain
BMS-741672 for Diabetic Neuropathic Pain
The purpose of the study is to determine whether BMS-741672 improves neuropathic pain in diabetic patients.
- Trial name
- NCT00683423
- Testing
- BMS-741672
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Bristol-Myers Squibb
Diabetic Peripheral Neuropathy, Diabetes
Diabetes, Falls, and Fractures
Comparing severity of diabetic peripheral neuropathy (small and large fibers including autonomic neuroapthy) to postural control and vestibular measurements
- Conditions
- Diabetic Peripheral Neuropathy, Diabetes, Balance; Distorted, Vestibular Neuropathy
- Trial name
- DIAFALL (NCT05389566)
- Testing
- Quantative Sensory Testing, NCStat-DPN-Check, Composite Autonomic Symptom Score 31
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Diabetic Peripheral Neuropathy (DPN)
Plantar Intrinsic Muscles Exercises and Three-dimensional Ankle Foot Exercises Comparative Effect in DPN
The aim of this study is to determine the comparative effects of plantar intrinsic muscles exercises and three-dimensional ankle foot exercises on balance, gait and fall risk in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07576179
- Testing
- Plantar intrinsic foot exercises, Three-Dimensional ankle foot exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Diabetic Foot Ulcer
Low Level Laser Therapy and Expression of VEGF, NO, VEGFR-2, HIF-1α in Diabetic Foot Ulcers
The purpose of this study is to examine the changes of factors including Vascular Endothelial Growth Factor(VEGF), VEGFReceptor-2, Nitric Oxide and hypoxia-inducible factor-1α (HIF-1α), measurements of oxygen saturation in…
- Trial name
- NCT02452086
- Testing
- Low Level Laser(Ga-As)
- Where
- Iran
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Tarbiat Modarres University
Diabetic Neuropathies
Effects of Aerobic Training and Neurodynamics to Prevent Fall and Improve Balance in Patients With Diabetic Neuropathy
Diabetes is a group of metabolic diseases, characterized by hyperglycemia resulting from defects in insulin secretion, actionor both.
- Trial name
- NCT06240910
- Testing
- Neurodynamics, Aerobic training
- Where
- 2 sites in Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Diabetic Peripheral Neuropathy
Feldenkrais vs. Task Oriented Gait Training on Diabetic Peripheral Neuropathy
Diabetic Peripheral Neuropathy (DPN) causes balance problems, falls, and sensory loss in the feet. This study compares two non-drug exercise programs to see which works better.
- Trial name
- FEToG-DPN (NCT07616661)
- Testing
- Feldenkrais Exercises, Task Oriented Gait Training, baseline warm up and cool down Exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Faisalabad
Diabetic Neuropathy
Understanding Risk Factors and Determinants for Neuropathic Pain
Understanding risk factors and determinants for neuropathic pain.
- Trial name
- Neuropathic (NCT02402361)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Diabetic Peripheral Neuropathy
Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy
The purpose of this study is to see if an investigational drug known as the lidocaine 5% patch is safe and effective in reducing the symptoms of diabetic neuropathy, to examine how topical lidocaine affects the nerve endings, and…
- Trial name
- NCT01086150
- Testing
- Skin biopsy, Lidocaine 5% patches
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Diabetic Peripheral Neuropathy
Comparison of Otago and Beat it Program on Balance, Gait and QOL in Diabetic Neuropathy
this study aims to compare the effects of Otago exercise program and BEAT IT program on balance, gait and quality of life in patients with diabetic peripheral neuropathy.
- Trial name
- NCT07575113
- Testing
- Otago Program, BEAT it Program
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Type 2 Diabetes (Adult Onset), Diabetic Neuropathies
Clinical Study Evaluating the Safety and Efficacy of Roflumilast in Type 2 Diabetic Patients With Diabetic Neuropathy
Evaluation of the side effects and efficacy of roflumilast on glycemic parameters, insulin resistance, oxidative and inflammatory markers in Type 2 diabetic patients with diabetic neuropathy.
- Trial name
- NCT05369793
- Testing
- Alpha lipoic acid, Roflumilast
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Neuropathy
Effect of the Erchonia® EVRL OTC™ for the Relief of Diabetic Peripheral Neuropathy Foot Pain
This study is to see if applying red and violet low-level laser light can help to reduce foot pain associated with diabetic peripheral neuropathy,
- Trial name
- NCT05091047
- Testing
- Erchonia EVRL
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Erchonia Corporation
Electroacupuncture, Acupuncture
Effect of Electroacupuncture on Sensitive Symptoms of Distal Diabetic Peripheral Neuropathy
This is a controlled clinical trial with the aim to study the effects of electroacupuncture on neuropathic pain reduction, quality of life and changes in sensory and motor nerve conduction velocity in patients with type 2…
- Conditions
- Electroacupuncture, Acupuncture, Diabetic Polyneuropathy, Diabetic Peripheral Neuropathy
- Trial name
- EA&DPN (NCT05521737)
- Testing
- Electroacupuncture
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Instituto Mexicano del Seguro Social
Diabetes Mellitus, Claudication, Intermittent
Additional Hyperbaric Oxygen After Lower Extremity Amputation
This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or…
- Conditions
- Diabetes Mellitus, Claudication, Intermittent, Critical Limb Ischemia, Osteomyelitis
- Trial name
- AHOLEA (NCT03594344)
- Testing
- Hyperbaric oxygen therapy
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Diabetes Mellitus Type I, Diabetic Peripheral Neuropathy
Prevalence of Peripheral Neuropathy in Children and Adolescents With Type I Diabetes Mellitus: a Prospective Study
Diabetes mellitus type I is an increasing burden for more and younger children. Therapy should avoid long-term complications as macrovascular diseases and diabetic nephropathy, retinopathy and diabetic neuropathy (DN).
- Conditions
- Diabetes Mellitus Type I, Diabetic Peripheral Neuropathy, Nerve Conduction Study Not Performed
- Trial name
- NCT01512030
- Where
- Austria
- Volunteers
- 35 people
- Sponsor
- Landeskrankenhaus Feldkirch
Painful Diabetic Peripheral Neuropathy (PDPN)
Cryoneurolysis for Painful Diabetic Neuropathy of the Foot
The study is a single-center, randomized, participant- and observer-masked, human-subjects, post-market clinical pilot study to investigate the use of ultrasound-guided percutaneous cryoneurolysis to treat diabetic neuropathy of…
- Trial name
- NCT06646731
- Testing
- cryoneurolysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego