Clinical trials: Diabetic Polyneuropathies
Diabetes Mellitus, Type 2, Diabetic Polyneuropathy
Use of GDF15 as a Biomarker for Early Diagnosis of DM and Monitoring of Progress of Complications in Asians
Significant differences in the expression of individual Growth Differentiation Factor 15 (GDF-15) proteins among Taiwanese harboring different mitochondrial genotypes are noted, and their blood serum levels also exhibited…
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Polyneuropathy, Diabetic Nephropathies
- Trial name
- NCT04119167
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Diabetes Mellitus Type 2 Without Complication, Polyneuropathies, Diabetic
Polyneuropathy in Diabetes Mellitus Type 2
This is a population-based study of type 2 diabetes patients with and without neuropathy recruited from the Danish National Type 2 Diabetes cohort (DD2).
- Conditions
- Diabetes Mellitus Type 2 Without Complication, Polyneuropathies, Diabetic, Diabetes Complications, Diabetic Peripheral Neuropathy
- Trial name
- NCT02947828
- Where
- 2 sites in Denmark
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Danish Pain Research Center
Diabetic Polyneuropathy
Peripheral Nerve Stimulation in Diabetic Patients
The prevalence of diabetes mellitus (DM) in industrialized countries is estimated to be about 7.3% and its incidence has been growing in recent years.
- Trial name
- NCT01488474
- Testing
- peripheral nerve stimulation
- Where
- Austria
- Volunteers
- 124 people
- Sponsor
- Medical University of Graz
Complex Regional Pain Syndrome, Postherpetic Neuralgia
Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block
This study compares the efficacy of the ultrasound with fluoroscope in guidance of lumbar sympathetic block (LSB). The goals of the study are; 1) To show that US-guided LSB results in shorter performance time compared to…
- Conditions
- Complex Regional Pain Syndrome, Postherpetic Neuralgia, Diabetic Polyneuropathy, Peripheral Neuropathy
- Trial name
- NCT02737527
- Testing
- 24G intravenous route for Lumbar Sympathetic Block (LSB):, 15-cm Chiba needle for Lumbar Sympathetic Block (LSB), Ultrasound for Lumbar Sympathetic Block (LSB)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University
Diabetic Polyneuropathy, Diabetes Mellitus, Type 2
Driving with Neuropathy
This study is a proof-of-concept randomised controlled trial (RCT). The goal of the study is to investigate the effectiveness of a feedback intervention to improve use of the accelerator pedal in patients driving with diabetes…
- Trial name
- NCT06739135
- Testing
- Visual feedback training
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- Manchester Metropolitan University
Diabetic Neuropathies
Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy
One of the most common complications of diabetes mellitus is diabetic polyneuropathy, which leads to disability and reduces quality of life.
- Trial name
- CYLINDER (NCT04649203)
- Testing
- Cytoflavin (Inosine + Nicotinamide + Riboflavin + Succinic Acid)
- Where
- 16 sites in Russia
- Volunteers
- 216 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Healthy Volunteers, Diabetic Neuropathies
Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Polyneuropathy
Part A: Primary objective is to determine the effects of BIIB095 on nerve excitability in healthy participants. Secondary and exploratory objectives include determining the effects of BIIB095 on nerve excitability in diabetic…
- Trial name
- NCT04106050
- Testing
- BIIB095, BIIB074, Lidocaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biogen
Diabetic Neuropathic Pain
A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain
People with diabetes can, over time develop nerve damage throughout the body with symptoms such as pain, tingling, or numbness (loss of feeling) in the hands, arms, feet and legs.
- Trial name
- NCT01345045
- Testing
- ABT-639, pregabalin
- Where
- 35 sites in United States, Czechia and 3 more
- Volunteers
- 193 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Diabetes Mellitus, Type 1, Diabetic Polyneuropathy
Effect of C-Peptide on Diabetic Peripheral Neuropathy
The aim of the study is to investigate the effect of C-peptide administration on nerve function in patients with type 1 diabetes and peripheral sensory neuropathy.
- Trial name
- NCT00278980
- Testing
- C-peptide
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Creative Peptides Sweden Inc.
Diabetic Neuropathies
Effect of Neurodynamic Mobilization Techniques in Patients With Diabetic Neuropathy
Neurodynamic mobilization Techniques and Selected Physical program used as a treatment for diabetic neuropathy patients and assessed by nerve condition study and function outcome.
- Trial name
- NCT05628168
- Testing
- Neurodynamic Mobilization Techniques, Selected Physical Therapy Program
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- October 6 University
Diabetic Polyneuropathy, Foot Injuries
Spatio-Temporal Gait Parameters and Gait Symmetry In Diabetic Lower Extremity Burn Injury.
This study evaluated the spatio-temporal gait parameters and gait symmetry in individuals with lower extremity burn injury due to diabetic polyneuropathy.
- Trial name
- NCT03687840
- Testing
- gait analysis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Diabetes
Isokinetic Strength and Balance Assessment in Diabetic Patients
Diabetic polyneuropathy (DPN) is a type of nerve damage that can occur in diabetics. It can cause weakness and a loss of sensation, particularly in the legs and feet.
- Trial name
- NCT05770154
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Diabetic Polyneuropathy, Healthy Individuals (Controls)
PULP SENSIBILITY AND MASSETER INHIBITORY REFLEX IN DIABETIC POLYNEUROPATHY
Accurate evaluation of dental pulp health is essential to avoid unnecessary endodontic treatments. In routine dental practice, pulp sensibility is commonly assessed using electric pulp testing and thermal (cold) testing.
- Trial name
- NCT07369297
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Diabetes Mellitus, Polyneuropathies
Cost-effectiveness of In-shoe Pressure Measurement for Therapeutic Shoes
The purpose of this study is determine whether the use of plantar pressure measurements in the production of customized therapeutic footwear for patients with diabetes and a history of foot ulceration results in lower production…
- Trial name
- NCT02061059
- Testing
- block 1, block 2, standard
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University
Moderate to Severe Pain Due to Diabetic Polyneuropathy
A Study to Demonstrate the Analgesic Efficacy of Oxycodone/Naloxone Prolonged Release Tablets in Addition to Pregabalin Compared to Pregabalin Alone in Opioid-naïve Subjects Treated With Pregabalin Suffering From Moderate to Severe Pain Due to Diabetic Polyneuropathy
To show superior analgesic efficacy of OXN PR in addition to a patient's current dose of pregabalin compared to pregabalin alone.
- Trial name
- NCT00944697
- Testing
- Oxycodone Naloxone
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Diabetic Peripheral Neuropathy (DPN)
Effects of Insole Vibration With Proprioceptive Training in Patients With Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes, profoundly affecting quality of life with sensory disturbances and associated complications.
- Trial name
- NCT07128836
- Testing
- proprioceptive training exercise and receive insole vibrator, proprioceptive training exercise along with simple insoles without vibration
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Diabetic Polyneuropathy, Diabetic Foot Ulcer
TempTouch IR Thermometry & Diabetic Patient Self-Care
Foot ulcers develop in diabetics with neuropathy because of cumulative injury over the course of several days. These patients do not feel pain, and do not recognize their foot is being injured until a wound develops.
- Conditions
- Diabetic Polyneuropathy, Diabetic Foot Ulcer, Diabetes, Foot Infection
- Trial name
- NCT00289497
- Testing
- TempTouch®
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Diabetica Solutions Inc.
Diabetic Neuropathies
Effects of Benfotiamine on Intraepidermal Nerve Fiber Density (IENFD)
The aim of the present study is to assess before, as well as 6 and 12 months following a therapy with benfotiamine the influence of therapy on intraepidermal nerve fiber density (skin biopsy) and neuropathic symptoms and deficits…
- Trial name
- NCT01868191
- Testing
- Benfotiamine
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Diabetes Schwerpunktpraxis
Diabetes Mellitus, Type 2, Diabetic Nephropathies
Nutritional Outcomes of Lotus Seed (Nelumbo Nucifera) on Diabetic Sensorimotor Polyneuropathy
The study focuses on Diabetic Sensorimotor Polyneuropathy (DSPN), a common complication of type 1 and type 2 diabetes caused by hyperglycemia-induced nerve damage, leading to pain, numbness, and motor dysfunction in the limbs.
- Trial name
- NCT06778018
- Testing
- Lotus Seed
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Diabetic Peripheral Neuropathy
Safety Study of Intranasal Insulin in Type 1 Diabetes and Diabetic Peripheral Neuropathy
The aim of this study is to evaluate the safety and tolerability of intranasal insulin in people with type 1 diabetes and diabetic peripheral neuropathy and to determine whether intranasal insulin is effective in slowing the…
- Trial name
- IIDPN (NCT01469559)
- Testing
- Novolin Toronto insulin, Normal saline
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary