Clinical trials: Diabetic Retinal Disease
Macular Edema
Investigation of the Change of Vision-related Quality of Life in Subjects Treated With Aflibercept According to EU Label for DME.
To evaluate the change in quality of life (NEI VFQ 25) in subjects with DME during the first year of treatment with aflibercept according to the EU Label.
- Trial name
- AQUA (NCT02581995)
- Testing
- Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
- Where
- 76 sites in Austria, Canada and 12 more
- Volunteers
- 560 people
- Sponsor
- Bayer
OctA .FFA Findings in DR
Optical Coherence Tomography Angiography and in Fluorescein Angiography in Diabetic Retinopathy
Diabetic retinopathy (DR) is the leading cause of decreased vision in working age people. Patients with DR can develop macular edema and proliferative retinopathy which are major causes of visual impairment [1].
- Trial name
- NCT05190965
- Testing
- OCTAngiography .FFangiography
- Volunteers
- 40 people
- Sponsor
- Assiut University
Age-related Macular Degeneration, Diabetic Vascular Diseases
Comfort and Antimicrobial Efficacy of Chlorhexidine vs Betadine for Intravitreal Injections
The purpose of this prospective interventional study is to compare patient experience, ocular surface irritation, and bacterial colony counts and microbial spectrum between povidine iodine and aqueous chlorhexidine as ocular…
- Conditions
- Age-related Macular Degeneration, Diabetic Vascular Diseases, Proliferative Retinopathy, Retina Vein Occlusion
- Trial name
- NCT03571100
- Testing
- Chlorhexidine, Povidine-Iodine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MidAtlantic Retina
Type 1 Diabetes, Diabetic Retinopathy
Incidence of Retinopathy and Associated Risk Factors in Children and Young Adults With Type 1 Diabetes in Denmark
The objective of this study is to clarify the current diabetic status, including development of complications, in a nationwide cohort of type 1 diabetics, who were last examined together in a large study in 1995.
- Trial name
- DCPD1987 (NCT01785667)
- Where
- Denmark
- Volunteers
- 132 people
- Sponsor
- Odense University Hospital
Proliferative Diabetic Retinopathy
Endolaserless Vitrectomy With Intravitreal IAI for PDR-Related VH
This is a phase I/II open label, randomized, interventional clinical trial. Study eyes will receive one preoperative intravitreal aflibercept injection (IAI) <21 days but >7 days prior to vitrectomy and one intraoperative IAI at…
- Trial name
- LASERLESS (NCT02976012)
- Testing
- Aflibercept, Endolaserless Vitrectomy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Southeast Retina Center, Georgia
Type 1 Diabetes, Neuropathy
Corneal Confocal Microscopy to Detect Diabetic Neuropathy in Children
The overall aim of this study is to confirm the utility of corneal confocal microscopy (CCM) as a new technique to rapidly and non-invasively assess diabetic neuropathy (DN) in children.
- Conditions
- Type 1 Diabetes, Neuropathy, Retinopathy
- Trial name
- CCM (NCT02321904)
- Testing
- Corneal Confocal Microscopy, Nerve Conduction Studies, Quantitative sensory testing
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Diabetic Retinopathy, Type2 Diabetes
Diabetic Retinopathy Screening in General Practice
Diabetic Retinopathy is a microvascular eye complication of diabetes, which can go unnoticed until permanent vision damage has occurred - in worst-case blindness.
- Trial name
- NCT05276778
- Testing
- Diabetic Retinopathy Screening
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Aalborg University
Proliferative Diabetic Retinopathy
Prompt Panretinal Photocoagulation Versus Ranibizumab+Deferred Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
The primary objective of the protocol is to determine if visual acuity outcomes at 2 years in eyes with proliferative diabetic retinopathy (PDR) that receive anti-vascular endothelial growth factor (anti-VEGF) therapy with…
- Trial name
- Protocol S (NCT01489189)
- Testing
- Prompt Panretinal Photocoagulation, 0.5-mg Ranibizumab, Deferred panretinal photocoagulation
- Where
- 48 sites in United States
- Volunteers
- 305 people
- Sponsor
- Jaeb Center for Health Research
Does Hyperbaric Chaber Treatment Improve Diabetic Retinopathy
The Effect of Hyperbaric Chamber Treatment on Patients With Diabetic Retinopathy
Diabetic retinopathy (DR) is a common complication of diabetes and is divided into non proliferative DR and proliferative DR. The damage is caused by either macular edema, macular ischemia that can be followed by vascular…
- Trial name
- NCT02235935
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Assaf-Harofeh Medical Center
Diabetes Complications
Effect of Intravitreal Bevacizumab on Focal Edema With Hard Exudates Secondary to Diabetic Retinopathy
Purpose: To evaluate the efficacy of intravitreal bevacizumab (IVB) on focal edema with hard exudates secondary to diabetic retinopathy. Design: Prospective interventional case series.
- Trial name
- NCT01422018
- Testing
- Avastin (bevacizumab)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul St. Mary's Hospital
Diabetic Macular Edema
Visual Outcomes and the Predictive Factors in Chinese Patients With Diabetic Macular Edema Treated With Ranibizumab
The aim of this study is to evaluate the one-year visual outcome and prognostic factors after intraocular injections of ranibizumab under pro re nata treatment regimen for the patients with diabetic macular edema (DME).
- Trial name
- IVRDME (NCT03973138)
- Testing
- Ranibizumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Vitreous Hemorrhage, Proliferative Diabetic Retinopathy
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
To evaluate the efficacy of intravitreal bevacizumab injections for treatment of proliferative diabetic retinopathy (PDR) with new dense vitreous hemorrhage (VH) after previous full panretinal photocoagulation (PRP).
- Trial name
- NCT01724385
- Testing
- intravitreal injection of bevacizumab
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Khon Kaen University
Diabetic Macular Edema, Diabetic Retinopathy
Early Anatomical, Physiological, and Clinical Changes in Diabetic Macular Edema After Intravitreal Aflibercept Injection
This is a one month pre post intervention study. Subjects with diabetic macular edema were given intravitreal anti VEGF (Aflibercept) injection.
- Conditions
- Diabetic Macular Edema, Diabetic Retinopathy, Clinically Significant Macular Edema
- Trial name
- NCT03453281
- Testing
- Aflibercept Injection [Eylea]
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Indonesia
Glaucoma, Diabetic Retinopathy
Glaucoma Algorithm Validation Study in African Population - the MAGIC Study
Artificial Intelligence (AI) algorithms require validation in a variety of populations to ensure widespread clinical applicability.
- Trial name
- MAGIC (NCT06552247)
- Testing
- Fundus Picture AI testing
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Universitário Lisboa Norte
Diabetic Macular Edema
Intraocular Anti-VEGF Compared With Intraocular Triamcinolone in Patients With Diabetic Macular Edema
The purpose of this study is to investigate the change in macular edema and the absolute change in visual acuity following intravitreal administered injections of Bevacizumab (Avastin®) or Ranibizumab (Lucentis®) compared with…
- Trial name
- TRIASTIN (NCT00682539)
- Testing
- Bevacizumab (Avastin), Triamcinolone, Lucentis
- Where
- Austria
- Volunteers
- 71 people
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy, Age Related Macular Degeneration
AI-Assisted Detection of Posterior Segment Diseases: DR, AMD, RVO, and Glaucoma
The purpose of this multi-center study is to evaluate the extent to which AI-assisted fundus image interpretation improves the diagnostic performance of ophthalmologists.
- Conditions
- Diabetic Retinopathy, Age Related Macular Degeneration, Retinal Vein Occlusion, Glaucoma
- Trial name
- NCT07318428
- Testing
- VUNO Med-Fundus AI
- Where
- 5 sites in South Korea
- Volunteers
- 10 people
- Sponsor
- Inje University
Central Retinal Vein Occlusion With Macular Edema
Use of Ziv Aflibercept in Different Retinal Diseases
A prospective interventional case series study was conducted on 20 eyes of 20 patients with active myopic choroidal neovascularisation (CNV) ,20 eyes with resistant diabetic macular edema and 15 eyes with non ischaemic central…
- Trial name
- NCT04290195
- Testing
- Ziv-Aflibercept 25 MG/ML [Zaltrap]
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Amin El Sayed Nawar
Age-related Macular Degeneration, Diabetic Macular Edema
Observational Study of Vision Improvement in Patients With Retinal Disorders
The purpose of this study is to assess the vision improvement achieved by patients with retinal disorders who received corneal treatments by a low vision aid device.
- Trial name
- NCT04693702
- Testing
- Corneal treatment by a low vision aid device
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Optimal Acuity Corporation
Macular Edema, Diabetic Macular Edema
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients
This was an open-label, multi-center, FIH study with a single ascending dose (SAD) design that assessed the safety, tolerability and pharmacokinetics (PK) of a single IVT dose of MHU650 in up to 24 participants with macular edema.
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusion
- Trial name
- NCT04635800
- Testing
- MHU650
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Insulin-Dependent Diabetes Mellitus 1
Prevalence of DRP and DME Among Type 1 Diabetics Treated With Long-term Intensified Insulin Therapy
This study is designed to evaluate the prevalence of different stages of diabetic retinopathy and diabetic macular edema among patients suffering from type 1 diabetes (DM1) for 5 to 25 years and have been treated with intensified…
- Trial name
- NCT03437551
- Testing
- cross-sectional observation
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Vista Klinik
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