Clinical trials: Diabetic Vascular Diseases
Diabetes Mellitus, Type 2, Coronary Artery Disease
Assessment of Dapagliflozin Effect on Diabetic Endothelial Dysfunction of Brachial Artery
Background Endothelial dysfunction is one of the early events in atherosclerotic plaque development. It is characterized by an increased ratio of substances with vasoconstrictive, pro-thrombotic, and proliferative properties over…
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Carotid Artery Diseases
- Trial name
- ADDENDA (NCT02919345)
- Testing
- Dapagliflozin 10 mg, Glibenclamide 5 mg
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Campinas, Brazil
Diabetic Retinopathy, Diabetic Macular Edema
Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema
The purpose of the study is to find out which is a better treatment for diabetic macular edema (DME): laser alone, laser combined with an intravitreal injection of triamcinolone, laser combined with an intravitreal injection of…
- Trial name
- LRT for DME (NCT00444600)
- Testing
- Triamcinolone Acetonide + laser, Ranibizumab + laser, Ranibizumab + deferred laser
- Where
- 50 sites in United States
- Volunteers
- 691 people
- Sponsor
- Jaeb Center for Health Research
Diabetic Foot Ulcer
Bioburden Reduction of Diabetic Foot Ulcer
Study to see if a laser can get rid of bacateria called MRSA in your diabetic ulcer
- Trial name
- NCT00776854
- Testing
- Noveon laser
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nomir Medical Technologies
Diabetic Foot Ulcer
A Clinical Investigation Evaluating Wound Closure With OptiPulse™ Versus SOC in the Treatment of Non-Healing DFU's
The purpose of this clinical investigation is to assess the safety and performance of Compedica's OptiPulse™ and to collect subject outcome data on the treatment of diabetic foot ulcers (DFU's) versus the standard of care (SOC).
- Trial name
- NCT05193929
- Testing
- OptiPulse™, Standard of Care offloading device
- Where
- 19 sites in United States, Canada
- Volunteers
- 162 people
- Sponsor
- Compedica Inc
Age-Related Macular Degeneration, Retinal Vein Occlusion
Extension Study to Gather Data on Effect of Macugen on the Corneal Endothelium
This study was conducted because the FDA requested clinical information on potential effects of intravitreal injections of Macugen (pegaptanib sodium injection) on the corneal endothelium from a 1-year (minimum) post-approval…
- Conditions
- Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema
- Trial name
- NCT01573572
- Testing
- pegaptanib sodium injection
- Where
- 4 sites in United States
- Volunteers
- 131 people
- Sponsor
- Bausch & Lomb Incorporated
Diabetic Foot Ulcer, Infection
Topical PluroGel PN for the Treatment of Mildly Infected Diabetic Foot Ulcers
This is an open label study of subjects who have failed Protocol PGN-1300. Adult subjects (greater than 18 years old) who present with a mildly infected diabetic foot ulcer (IDSA criteria) having full thickness (i.e., through the…
- Trial name
- NCT02119754
- Testing
- Plurogel PN
- Where
- 15 sites in United States
- Volunteers
- 15 people
- Sponsor
- PluroGen Therapeutics, Inc
Essential Hypertension, Diabetes Mellitus
Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular
The anthypertensive treatment with Losartan may have benefits beyond blood pressure reduction on myocardial structure and function in hypertensive diabetic patients.
- Trial name
- NCT00659451
- Testing
- Losartan, Amlodipine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Pavia
Diabetic Foot
The Effect of Thermal Evaluation in Prevention of Diabetic Foot Ulcer
The study was planned as a prospective randomized controlled clinical trial to determine the effect of thermal evaluation in preventing diabetic foot ulcers in patients with Type II Diabetes Mellitus (DM).
- Trial name
- NCT04480801
- Testing
- Thermal Evaluation and Foot Care, Foot Care
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Fatma Özkal
Diabetic Foot Ulcer
Clinical and Mechanistic Study of Transverse Tibial Transport in Complex Foot Ulcers
TTT is a novel surgical technique that may potentially solve the long-standing deficit of seeking effective treatment for diabetic foot ulcers, decreasing the need for amputations and softening the socio-economic impact it…
- Trial name
- NCT05704075
- Testing
- Transverse Tibial Transport (TTT), Conventional
- Volunteers
- 54 people
- Sponsor
- Chinese University of Hong Kong
Neuropathic Diabetic Ulcer - Foot
Safety Trial of the RedDress Wound Care System (RD1) in Management of Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
The purpose of this study is to assess the safety of the RedDress Wound Care System (RD1) in patients Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
- Trial name
- NCT01396837
- Testing
- RedDress Wound Care System (RD1)
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- RedDress Ltd.
Diabetic Foot
The Effect of Foot Care Training Given to Diabetic Hemodialysis Patients on Foot Care Behavior
Diabetic foot causes hospitalization, amputation and serious health problems in individuals. This situation also leads to loss of productivity of the individual, negatively.
- Trial name
- NCT06526936
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- University of Beykent
Diabetic Foot Ulcer, Venous Leg Ulcer
Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center
Prospective, single-blinded, single-center, parallel group, randomized controlled trial (RCT) to assess rate and frequency of wound healing and associated financial savings, when using Medaxis debritom+ versus standard of care as…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Surgical Wound Dehiscence, Traumatic Wounds
- Trial name
- EVIDENT (NCT04920253)
- Testing
- Study Device Debridement, SOC Debridement
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Medaxis, LLC
Non-healing Wound
Treatment of Wounds Using Oasis® ECM
The purpose of this clinical study is to gather post-market clinical evidence on the use of Oasis ECM as a treatment for donor site wounds in the community setting in the United Kingdom.
- Trial name
- NCT03632031
- Testing
- Oasis Extracellular Matrix, Standard Care (in control arm)
- Where
- 2 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cook Biotech Incorporated
Diabetic Retinopathy
Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy
This 24 month randomized research study will evaluate whether doxycycline can slow the deterioration or improve retinal function among patients with mild to moderate non-proliferative diabetic retinopathy.
- Trial name
- POC2 (NCT00917553)
- Testing
- doxycycline monohydrate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Thomas Gardner
Proliferative Diabetic Retinopathy
Trial of Yellow 577 nm Laser Versus Green 532 nm Laser for Proliferative Diabetic Retinopathy
The purpose of this study is to measure effectiveness of yellow 577 nm laser compared to conventional green laser 532 nm for diabetic retinopathy in terms of number of treatment sessions required and visual acuity outcome.
- Trial name
- UMPDR (NCT01044875)
- Testing
- Pan retinal photocoagulation laser treatment
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- University of Malaya
Coronary Artery Disease, Diabetes Mellitus, Type 2
Platelet Inhibition of Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients After Elective Percutaneous Coronary Intervention
This will be a single-center, randomized, open-label, active-controlled, parallel-group study to investigate the platelet inhibition of Ticagrelor versus Clopidogrel with acetylsalicylic acid (ASA) as background therapy in…
- Trial name
- PLATIDE-PCI (NCT02748330)
- Testing
- Ticagrelor, Clopidogrel, Aspirin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Leg Ulcer, Varicose Ulcer
Remote Ischemic Conditioning for Treatment of Chronic Wounds
The goals of this series of studies is to test the effect of RIC on chronic leg ulcers (Diabetic ulcers and venous ulcers) - and to improve the understanding of its biological mechanism.
- Trial name
- NCT02873728
- Testing
- Remote Ischemic Conditioning, Control
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Soroka University Medical Center
Diabetes (DM), Diabetes Complication
Feasibility of Home Monitoring of Visual Function in DR
Diabetes is a serious condition where patients can develop complications in their body including their eyes which can lead to sight loss.
- Conditions
- Diabetes (DM), Diabetes Complication, Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetic Retinopathy (DR)
- Trial name
- NCT07386613
- Testing
- Okko Health App
- Where
- 3 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Queen's University, Belfast
Hypertension, Obesity
A Randomized, Double-Blind, Active Control Trial Comparing Effects of Telmisartan, Candesartan and Amlodipine, Alone or Plus Metformin, on Non-Diabetic, Obese Hypertensive Patients
The epidemic of obesity is associated with a considerable rise in the incidence of the metabolic syndrome, type 2 diabetes mellitus, and hypertension.
- Trial name
- HOT-ACME (NCT00538486)
- Testing
- Telmisartan plus Metformin, Telmisartan, Candesartan
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Third Military Medical University
Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Wet Age Related Macular Degeneration
Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting
This study will describe the long-term safety and effectiveness, treatment patterns,and patient reported quality of life associated with ranibizumab treatment in routine clinical practice for all approved indication included in…
- Conditions
- Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- LUMINOUS (NCT01318941)
- Testing
- Ranibizumab
- Where
- 463 sites in Argentina, Australia and 41 more
- Volunteers
- 30,490 people
- Sponsor
- Novartis Pharmaceuticals
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