Clinical trials: Diabetic Vascular Diseases
Subfoveal Choroidal Thickness, Intravitreal
Subfoveal Choroidal Thickness and Visual Acuity After Intravitreal Injection of Ranibizumab in Diabetic Retinopathy
The aim of this study is to compare subfoveal choroidal thickness (SFCT) and the visual status before and after intravitreal injection of ranibizumab in diabetic macular edema (DME) with the use of 3D-OCT by enhanced depth…
- Conditions
- Subfoveal Choroidal Thickness, Intravitreal, Ranibizumab, Visual Acuity
- Trial name
- NCT06173245
- Testing
- Intravitreal injection of ranibizumab
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Egyptian Biomedical Research Network
Type 1 Diabetes, Diabetic Kidney Disease
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range.
- Conditions
- Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- MANATEE-T1D (NCT05065372)
- Testing
- Metformin Hcl 1000Mg Tab, Aminohippurate Sodium 20 % Injection, Iohexol 300 Mg/mL Injectable Solution
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kalie Tommerdahl
Age Related Macular Degeneration, Diabetic Retinopathy
Strategies for Improving Linkage-to-Care After Eye Disease Screening
The goal of this randomized, parallel-group, controlled trial is to compare methods of improving linkage-to-care for participants in the Village Integrated Eye Worker II (VIEW II) trial who are referred to the eye hospital…
- Conditions
- Age Related Macular Degeneration, Diabetic Retinopathy, Glaucoma
- Trial name
- NCT06943599
- Testing
- Text Message Reminder, Health Worker Visit
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of California, San Francisco
Peripheral Arterial Disease
Stimulation TcPO2 Test in the PAD Diagnosis in Diabetic Foot
All diagnostic procedures of peripheral arterial disease (PAD) in the diabetic foot (DF) are limited due to diabetes mellitus and its late complications.
- Trial name
- stimTcPO2 (NCT04404699)
- Testing
- Stimulation TcPO2 test
- Where
- Czechia
- Volunteers
- 79 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Diabetic Foot, Regional Anesthesia
Efficacy of Continuous Sciatic Nerve Block in Diabetic Foot Patients
Patients who underwent surgery for diabetic foot were divided into three groups: sciatic nerve block (Group B), continuous nerve catheter (Group C) .
- Conditions
- Diabetic Foot, Regional Anesthesia, Catheter Blockage, Wound Heal
- Trial name
- NCT04212325
- Testing
- Group C (Continuous sciatic nerve block), Group S (sciatic nerve block)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gulhane School of Medicine
Diabetic Macular Edema (DME), Neovascular Age-related Macular Degeneration (NVAMD)
A 2-part Study Consisting of a Multiple Ascending Dose Safety Study in Participants With Macular Edema Following Branch Retinal Vein Occlusion and a Dose-finding Safety and Preliminary Efficacy Study in Participants With Either Diabetic Macular Edema or Neovascular Age-related Macular Degeneration
EYE-TIE-201 is a 2-part study to investigate the safety and effectiveness of a new drug being developed called EYE201. All participants in the study will receive a total of 3 injections of EYE201 into the study eye, spaced at 4…
- Conditions
- Diabetic Macular Edema (DME), Neovascular Age-related Macular Degeneration (NVAMD), BRVO - Branch Retinal Vein Occlusion
- Trial name
- NCT06664502
- Testing
- EYE201
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 38 people
- Sponsor
- EyeBiotech Ltd.
Diabetic Retinopathy, Age Related Macular Degeneration
AI-Assisted Detection of Posterior Segment Diseases: DR, AMD, RVO, and Glaucoma
The purpose of this multi-center study is to evaluate the extent to which AI-assisted fundus image interpretation improves the diagnostic performance of ophthalmologists.
- Conditions
- Diabetic Retinopathy, Age Related Macular Degeneration, Retinal Vein Occlusion, Glaucoma
- Trial name
- NCT07318428
- Testing
- VUNO Med-Fundus AI
- Where
- 5 sites in South Korea
- Volunteers
- 10 people
- Sponsor
- Inje University
Type I Diabetes Mellitus With Ulcer, Type II Diabetes Mellitus With Ulcer
Safety Study of Stem Cells Treatment in Diabetic Foot Ulcers
Diabetes Mellitus (DM) can be regarded as one of the "epidemics" of the western world. DM contributes to severe morbidity and mortality due to damage in the target organs (neuropathy, vasculopathy, nephropathy, retinopathy).
- Trial name
- NCT01686139
- Testing
- ABMD-MSC
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Sheba Medical Center
Diabetic Macular Edema
Laser vs Bevacizumab Injection Alone in Treatment of Diabetic Macular Edema
Currently, diabetic macular edema is treated is through injection of a medications such as off-label bevacizumab, which decreases the swelling in the retina.
- Trial name
- NCT02229175
- Testing
- bevacizumab, PASCAL Endpoint Management (EpM) laser treatment
- Where
- United States
- Sponsor
- University of California, San Francisco
Diabetic Foot Ulcers
Randomized, Controlled Multicenter Trial of Vacuum Assisted Closure Therapy™ in Diabetic Foot Ulcers
To determine if topical negative pressure therapy delivered by the V.A.C.® device is clinically efficacious and cost effective in the treatment of diabetic foot ulcers.
- Trial name
- NCT00432965
- Testing
- Moist Wound Therapy, VAC Therapy
- Where
- 25 sites in United States, Canada
- Volunteers
- 335 people
- Sponsor
- KCI USA, Inc
Diabetic Neuropathies
Effect of Customized Software for Foot-related Exercises (SOPeD) for Prevention and Treatment in People With Diabetic Neuropathy
The main objective of this trial is to investigate the effect of a customized foot-related exercises software (SOPeD) in diabetic neuropathy status, functional outcomes and gait biomechanics in people with diabetic neuropathy.
- Trial name
- FOCA-I (NCT04011267)
- Testing
- Physical therapy by foot-ankle segmental and functional exercises
- Where
- Brazil
- Volunteers
- 62 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetic Foot
Autologous Endothelial Progenitor Cells Treatment of Diabetic Foot
The vascular pathologic basis of diabetic foot include arterial obstruction and micro-circulation defects.The latest technology of arterial reconstruction can only rebuild blood flow of anterior,posterior tibial artery and…
- Trial name
- NCT02474381
- Testing
- EPCs plus PTA, Single PTA
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Peripheral Arterial Disease
Debulking Atherectomy Versus Stent Angioplasty for Limb Ischaemia of Diabetic Lower Limb Atherosclerosis-occlusive Disease.
In order to assessment the safety and efficacy of debulking atherectomy versus stent angioplasty for limb ischaemia of diabetic lower limb atherosclerosis-occlusive disease, we intend to conduct a prospective, multicenter…
- Trial name
- NCT05670171
- Testing
- Debulking Atherectomy, Stent Angioplasty
- Where
- 10 sites in China
- Volunteers
- 244 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypertension
Study of CS-3150 in Hypertensive Patients With Type 2 Diabetes and Albuminuria
To examine antihypertensive effect and safety of administration of CS-3150 in combination with ARB or ACE inhibitor in hypertensive patients with type 2 diabetes and albuminuria.
- Trial name
- NCT02807974
- Testing
- CS-3150
- Where
- Japan
- Volunteers
- 51 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy
Remote Ischemic Conditioning for Non-Proliferative Diabetic Retinopathy
The goal of this clinical trial is to evaluate whether remote ischemic conditioning (RIC) is a safe and effective treatment for non-proliferative diabetic retinopathy (NPDR) in adults aged 40-80 years with type 2 diabetes.
- Conditions
- Diabetic Retinopathy, Non-Proliferative Diabetic Retinopathy, Remote Ischemic Conditioning, Diabetes Mellitus, Type 2
- Trial name
- RIC-NPDR (NCT06713720)
- Testing
- Remote Ischemic Conditioning Device
- Where
- 2 sites in China
- Volunteers
- 68 people
- Sponsor
- Xuxiang Zhang, MD
Diabetic Foot Ulcer, Diabetes
Inforatio Technique to Promote Wound Healing of Diabetic Foot Ulcers
This randomized clinical trial will examine the effect of inforatio technique on healing of diabetic foot ulcers (DFUs). Inforatio technique is a novel procedure developed by the research group.
- Conditions
- Diabetic Foot Ulcer, Diabetes, Foot Ulcer, Diabetic Foot
- Trial name
- NCT05189470
- Testing
- Inforatio technique, Usual care of the respective outpatient clinics
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Diabetic Foot Ulcer (DFU), Offloading
Comparison of Posterior Slab Cast With Total Contact Cast in the Management of Diabetic Foot Ulcers
The goal of this clinical trial is to compare wound healing and foot related outcomes in people with plantar diabetic foot ulcer using Total contact cast (TCC) or Posterior slab cast (PSC).
- Trial name
- NCT07111741
- Testing
- Total contact cast, Posterior slab cast
- Where
- India
- Volunteers
- 99 people
- Sponsor
- ILS Hospital, Salt Lake
Diabetic Foot Ulcer
Laser Therapy for At-Home Treatment of Diabetic Foot Ulcers - Canada
The global prevalence of diabetes is on the rise and with it increase in prevalence of diabetic foot ulcers (DFU). These recalcitrant wounds are difficult to manage and pose a heavy economic burden.
- Trial name
- LLL&DIAB-02 (NCT03687580)
- Testing
- B-Cure Laser Pro
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Scarborough Rouge Hospital
Diffuse Diabetic Macular Edema
Vitrectomy and Bevacizumab for Diffuse Diabetic Macular Edema
To Evaluate combined effect of vitrectomy and bevacizumab to stabilize retinal thickness and visual acuity in patients with diffuse diabetic macular edema and their relation to renal disease.
- Trial name
- NCT00571142
- Testing
- Bevacizumab + Pars plana vitrectomy
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Wounds
Positive Predictive Value of the MolecuLight i:X Imaging Device to Predict the Presence of Bacteria in Chronic Wounds
This is a non-randomized evaluation for which 50 patients will be imaged at the Southwest Regional Wound Care Center, Lubbock, Texas, who present with a chronic wound and are receiving standard treatment.
- Trial name
- NCT02682069
- Testing
- MolecuLight i:X Imaging Device
- Volunteers
- 30 people
- Sponsor
- MolecuLight Inc.
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