Clinical trials: Diabetic Vascular Diseases
Diabetic Foot Ulcer
Effect of Silver Nanoparticles Phonophoresis on Diabetic Foot Ulcer Heeling
This study was conducted to evaluate the effect of silver nanoparticle phonophoresis on accelerating chronic diabetic foot ulcer healing.
- Trial name
- NCT07821996
- Testing
- Active silver nanoparticle phonophoresis, Isolated low-intensity pulsed ultrasound therapy, Standard wound care
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Diabetic Macular Edema, Diabetic Retinopathy
Imaging Parameters and DME Treatment Response
Diabetic macular edema (DME) is the most common cause of vision loss in diabetic patients. While anti-VEGF treatments and to a lesser extent corticosteroid and macular photocoagulation have improved outcomes in patients with DME…
- Trial name
- NCT02637245
- Testing
- No intervention
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Diabete Type 2, Diabetic Foot Ulcer
Effects and Feasibility of Photobiomodulation at 830nm Nanometers in the Treatment of Diabetic Ulcers
Diabetic foot ulcers (DFU) are among the late complications of DFU, defined as skin lesions that involve the dermis to deeper structures, such as muscles and bones.
- Conditions
- Diabete Type 2, Diabetic Foot Ulcer, Photobiomodulation, Low Level Laser Therapy
- Trial name
- NCT07043868
- Testing
- Low Level Laser Therapy
- Volunteers
- 136 people
- Sponsor
- Federal University of Piaui
Diabetic Foot Ulcers
Wound Dressing Patch with Kelulut Honey-Infused Alginate (Tri-Gnate Alginate) for Effective Wound Care Management
The main aim of this study to effectiveness of dressing patch with Kelulut honey (Tri-Gnate Alginate) in promoting wound healing compared to conventional treatments (standard wound dressing + bactigras) and other types of…
- Trial name
- NCT06873646
- Testing
- Tri-Gnate Alginate Dressing, Dressing product from Manuka honey, Bactigras + Dermacyn
- Where
- Malaysia
- Volunteers
- 110 people
- Sponsor
- Mohd Khairul Zul Hasymi Firdaus
Diabetic Foot, Varicose Ulcer
Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb Ulcers
The purpose of this study is to compare the VERSAJET™ device with conventional surgical procedures (performed with a scalpel) in the debridement (removal of unhealthy tissue) of lower limb ulcers.
- Conditions
- Diabetic Foot, Varicose Ulcer, Pressure Ulcer
- Trial name
- NCT00521027
- Testing
- Versajet Hydrosurgery System, Conventional surgical debridement techniques
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Smith & Nephew, Inc.
Diabetic Foot, Cardiopulmonary
Feasibility and Acceptability of Non Weight-bearing Physical Activity for People With Diabetic Foot Ulceration
Intervention in the form of a PA (physical activity) program combining aerobic, resistance, and flexibility exercises adapted for wearing a lower limb offloading device and limiting weight-bearing on the feet, with a duration of…
- Conditions
- Diabetic Foot, Cardiopulmonary, Physical Inactivity
- Trial name
- DB-ACTIV (NCT06092827)
- Testing
- Non weight-bearing physical activity program
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Université du Québec à Trois-Rivières
Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD)
An Observational Study to Investigate the Use of Aflibercept 8 mg to Treat Adult Patients With Neovascular Age-Related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) in a Real-World Setting
The purpose of this research study is to observe the patient's clinical care and how EYLEA® HD is used as a treatment in real-world settings.
- Conditions
- Neovascular Age-related Macular Degeneration (nAMD), Wet Age-related Macular Degeneration (AMD), Diabetic Macular Edema (DME), Visual Impairment
- Trial name
- SPECTRUM-US (NCT06398080)
- Testing
- aflibercept 8 mg
- Sponsor
- Regeneron Pharmaceuticals
Diabetic Retinopathy
Study of Efficacy of Ranibizumab in Different Regimens in Patients With Diabetic Macula Edema
The purpose of this study was to demonstrate that the change of best corrected visual acuity (BCVA) was comparable in patients treated with ranibizumab at the discretion of the investigator vs.
- Trial name
- DIVERSE (NCT02366468)
- Testing
- ranibizumab 0.5 mg
- Where
- 30 sites in Germany
- Volunteers
- 135 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy
Integrating DR Into Mainstream Health System in Bangladesh
Diabetes mellitus is a leading cause of death and disability. Diabetic Retinopathy (DR) is an eye disease that affects the eyesight of about 21.3% persons with diabetes in Bangladesh in a way that is irreversible because of the…
- Trial name
- NCT03658980
- Testing
- Health Education Intervention
- Where
- Bangladesh
- Volunteers
- 299 people
- Sponsor
- Hiroshima University
Wound Heal, Diabetic Foot Ulcer
Effect of New High Ankle Block on Wound Healing After the Operation of Debridement of Diabetes Foot
The goal of this clinical trial is to compare high ankle block and general anesthesia on wound recovery and ankle blood flow perfusion after diabetes foot surgery in diabetics.
- Trial name
- NCT06395961
- Testing
- high ankle block, general anesthesia
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xuzhou Central Hospital
Diabetic Macular Edema
3 Month Outcome of Ziv-aflibercept for DME
The purpose is to show the 3-month efficacy and safety in diabetic macular edema treated with intravitreal ziv-aflibercept.
- Trial name
- NCT02772497
- Testing
- Ziv aflibercept
- Volunteers
- 10 people
- Sponsor
- Marashi Eye Clinic
Macular Degeneration, Retinal Vein Occlusion
Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders
This study will evaluate the safety and effectiveness of a new formulation of triamcinolone acetonide for the treatment of retinal blood vessel disorders.
- Trial name
- NCT00071227
- Testing
- Triamcinolone Acetonide (TAC-PF)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Eye Institute (NEI)
High Blood Pressure
Self-monitoring of Blood Pressure in Primary Care
This study is an open randomized controlled trial of 12-month duration, which compares the use of a home blood pressure (BP) tele-management system to the usual approach of home BP monitoring in older diabetic patients with…
- Trial name
- NCT00717665
- Testing
- Home blood pressure tele-management system., Usual care.
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Diabetes Mellitus, Type 2, Dyslipidemias
Curcumin's Effect on Diabetic Patients With Atherosclerotic Cardiovascular Risk
The aim of the study is to assess the safety and efficacy of Curcumin supplementation in combination to the conventional therapy in improving the clinical outcomes, oxidative stress and inflammation in diabetic patients with risk…
- Conditions
- Diabetes Mellitus, Type 2, Dyslipidemias, Hypertension
- Trial name
- NCT05753436
- Testing
- Puritans Pride Turmeric curcumin® 500 mg
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Diabetic Foot Ulcer, Cutaneous Ulcer
Safety, Tolerability and Efficacy of CYP-006TK in Adults with Diabetic Foot Ulcers
Design: A randomised, controlled, prospective trial. Participants will be patients with non-healing diabetic foot ulcers. The study will aim to recruit 15 participants per study group (30 participants in total).
- Trial name
- NCT05165628
- Testing
- CYP-006TK
- Where
- 4 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Cynata Therapeutics Limited
Diabetic Foot, Neuropathy
Effectiveness of Insoles Provided to Patients With Diabetes. A Longitudinal Randomized Controlled Study in Gothenburg
Introduction: Insoles and shoes are frequently prescribed to prevent foot ulcers in patients at risk of diabetes. A combination of neuropathy and foot deformities raises the risk from 1% to between 4-7% according to the Swedish…
- Conditions
- Diabetic Foot, Neuropathy, Quality of Life
- Trial name
- NCT01663519
- Testing
- Custom made insoles 35 shore, Prefabricated insoles, 55 shore Custom made insole
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Sahlgrenska University Hospital
Hypertension, Type 2 Diabetes
Aliskiren Versus Ramipril on Antiproteinuric Effect in Hypertensive, Type 2 Diabetic Patients With Microalbuminuria
The main objective of this study is to assess the extent and trend in time of antiproteinuric effect as well as that antihypertensive effect of aliskiren 300 mg / d versus ramipril 10 mg daily in hypertensive patients with type 2…
- Trial name
- NCT01038895
- Testing
- Ramipril, Experimental
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Pavia
Diabetic Retinopathy, Macular Edema
PPV With Internal Limiting Membrane Peeling for Treatment-Naïve DME
Treatment-naïve subjects with center-involved diabetic macular edema undergoing pars plana vitrectomy with internal limiting membrane peeling will have similar visual outcomes but better anatomical outcomes compared to subjects…
- Trial name
- NCT03660345
- Testing
- PPV/MP, Intravitreal injection
- Where
- Mexico
- Volunteers
- 11 people
- Sponsor
- Rush Eye Associates
Coronary Arteriosclerosis
Risk Stratification for Coronary Artery Disease With Type 2 Diabetic Patients
Diabetic type 2 patients (DB2) has a higher prevalence of coronary artery disease (CAD) than non-diabetic persons. Presence of CAD results in murmurs arising from the filling of the arteries and can be detected by the CADScor…
- Trial name
- CAD-risk (NCT02494557)
- Where
- Denmark
- Volunteers
- 108 people
- Sponsor
- Acarix
Diabetic Retinopathy (DR)
Preliminary Assessment of an Automated Tool for Diabetic Retinopathy Screening
This study is being done to evaluate the performance of a software that uses artificial intelligence to analyze photographs of the retina to help detect diabetic retinopathy.
- Trial name
- NCT07404657
- Testing
- automatic analysis of fundus images performed by the software tool based on artificial intelligence
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Centervue SpA
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