Clinical trials: Diagnostic
Mucopolysaccharidoses, Progressive Pseudorheumatoid Dysplasia
Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Children Hospital
To identify the most common underlying causes of non-inflammatory arthropathy in children presenting to Assiut University Children Hospital for through clinical evaluation, laboratory testing, and imaging, in order to improve…
- Conditions
- Mucopolysaccharidoses, Progressive Pseudorheumatoid Dysplasia, Farber Disease, Osteogenesis Imperfecta
- Trial name
- NCT07173010
- Volunteers
- 35 people
- Sponsor
- Assiut University
Autism Spectrum Disorder
Combination of Predictive Biomarkers to Increase Diagnostics Efficiency of Autism Spectrum Disorder
Early identification and diagnosis of autism spectrum disorder (ASD) is necessary to promote access to early treatment. Despite the high incidence, in Italy it is estimated that 1 in 77 children (age 7-9 years) (Narzisi et al.…
- Trial name
- NCT05796310
- Testing
- Salivary collection, eye-tracking recorder, neuropsychological assessment
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Diabetes Mellitus
Integrated Clinical Evaluation of Traditional Chinese Medicine (TCM) and Conventional Medicine on Diabetic Patients
In traditional Chinese medicine (TCM), examination of the tongue plays an important role in diagnosis. The characteristics of the tongue(e.g., color of the tongue body, tongue fur, teeth-marked tongue) provides some clues and…
- Trial name
- NCT02564913
- Testing
- clinical evaluation
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Pancreatic Neoplasm
22G FNA Needle vs. 22G ProCore Needle
The aim of this research study is to identify the best needle for performing biopsy during EUS procedures. There are two types of needles for performing biopsy: A FNA needle that provides a small sample of tissue for analysis and…
- Trial name
- NCT01394159
- Testing
- 22G ProCore biopsy needle, 22G standard FNA needle
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- AdventHealth
Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor
Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy, such as ixabepilone, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor, Ovarian Cancer, Testicular Germ Cell Tumor
- Trial name
- NCT00070096
- Testing
- ixabepilone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Mild Cognitive Impairment
Management of Mild Cognitive Impairment Patients With Extra Virgin Olive Oil - MICOIL
There is accumulating evidence suggesting that olive oil may have a positive impact on conditions involving cognitive deficits, such as MCI and AD.
- Trial name
- MICOIL (NCT03362996)
- Testing
- Freshly-Pressed Extra Virgin Olive Oil, extra virgin olive oil, mediterranean diet
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Greek Alzheimer's Association and Related Disorders
Delirium, Depression
Incidence and Predictors of Delirium After Cardiac Surgery
The objective of the present research is to evaluate the incidence and independent predictors of delirium observed among patients after cardiac surgery.
- Conditions
- Delirium, Depression, Cognitive Impairment
- Trial name
- IPDACS (NCT00784576)
- Where
- Poland
- Volunteers
- 563 people
- Sponsor
- Medical University of Lodz
Mediastinal ( Chest) Masses, Gastrointestinal Subepithelial Tumors
Role of Endoscopic Ultrasound Elastography in Diagnosis of Gastrointestinal Subepithelial and Mediastinal Lesions
The aim of this study is to evaluate the role of endoscopic ultrasound (EUS) in the diagnosis of mediastinal and gastrointestinal subepithelial lesions.
- Trial name
- NCT07419191
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Assiut University
Preterm Birth
Evaluation of a Novel Diagnostic Kit for the Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth in Women Presenting With Signs and Symptoms of Preterm Labor
Currently, the American College of Obstetricians and Gynecologists (ACOG) indicate in their most recent Practice Bulletin on the Management of Preterm Labor that many tests to identify women at risk of preterm birth have been…
- Trial name
- PartoSure (NCT05742997)
- Testing
- PartoSure, Fetal Fibronectine
- Where
- Belgium
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Prostate Cancer, Elevated PSA
Upright MRI for Prostate Cancer Screening
This is an investigator initiated study to test the efficacy of an upright MRI (Magnetic Resonance Imaging) for the screening of prostate cancer.
- Conditions
- Prostate Cancer, Elevated PSA, Elevated Prostate Specific Antigen
- Trial name
- NCT03474913
- Testing
- Upright MRI, Standard MRI
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Depression, Fatigue
Individualized Exercise Programs for Patients Receiving Chemotherapy for Newly Diagnosed Acute or Relapsed Myeloid Leukemia or Lymphoblastic Leukemia
RATIONALE: An individualized exercise program may be effective in lessening fatigue and depression and improving quality of life in patients undergoing chemotherapy for leukemia.
- Conditions
- Depression, Fatigue, Leukemia, Musculoskeletal Complications
- Trial name
- NCT00499759
- Testing
- Resting vitals, Body Composition, Timed Get-up and Go test (TGUG).
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Glioma, IDH1/IDH2 Mutation
Non Invasive Detection of IDH1/2 Mutation in Gliomas
This trial develops a non invasive diagnostic approach of IDH1 mutated gliomas combining mutation detection from free plasmatic DNA, D-2HG dosage in urine samples, and D-2HG detection by Brain Spectro MRI.
- Trial name
- IDASPE (NCT02597335)
- Testing
- Spectro-MRI, Dosage of free circulating plasmatic DNA, Dosage of D-2HG in the urine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia, Pneumococcal, Hiv
Prevention of Missed Opportunities for HIV Diagnosis by Promoting HIV Testing of Patients With Pneumococcal Pneumonia at Nice University Hospital (PneumoVIH)
According to usual practices, HIV testing should be performed for each patient diagnosed for pneumococcal pneumonia. Unfortunately, in 2018, only 27% of patients were tested for HIV following pneumococcal pneumonia in Nice…
- Trial name
- PneumoVIH (NCT04909268)
- Testing
- HIV testing
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Knee Osteoarthritis
The McKenzie System With Arthritic Knees: Do Some Knees Respond to Specific Exercise More Than General or no Exercise
The purpose of the study is to explore if a subgroup of people with osteoarthritic knees can be identified using the McKenzie System of Mechanical Diagnosis and Therapy.
- Trial name
- NCT01641874
- Testing
- Exercise, Evidence based exercise
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Multiple Myeloma
A Trial Evaluating Efficacy & Safety of RVD +/- Panobinostat in Transplant Eligible, Newly Diagnosed Multiple Myeloma (NDMM)
This was a multicenter, open-label, randomized phase II study which were to enroll 112 newly diagnosed symptomatic multiple myeloma patients in a 1:1 fashion.
- Trial name
- PANORAMA4 (NCT02720510)
- Testing
- Revlimid, Velcade, dexamethasone
- Where
- 5 sites in United States
- Volunteers
- 6 people
- Sponsor
- Novartis Pharmaceuticals
Herpes Genitalis
A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies.
Genital herpes (GH) is a commonly occurring sexually transmitted disease caused by herpes simplex virus (HSV). There are two types of HSV, type 1 (HSV-1) and type 2 (HSV-2); both can cause GH, although the latter is much more…
- Trial name
- NCT00158860
- Testing
- Valaciclovir
- Where
- 72 sites in United States, Argentina and 3 more
- Volunteers
- 384 people
- Sponsor
- GlaxoSmithKline
Adenoid Hypertrophy, Middle Ear Effusion
It is Accepted That Adenoid Hypertrophy is Related to Otitis Media With Effusion Incidence. Better Understanding of the Correlation Between the Relative Size of AH and the Incidence of Persistent OME May Provide Evidence to Support a More Standardized Approach to the Diagnosis and Treatment of OME.
The aim of this study is to further investigate the correlation between Site and size of adenoid hypertrophy and middle ear effusion in order to provide evidence for designing a more standardized approach to the diagnosis and…
- Trial name
- NCT06674720
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Covid19
Sensitivity Evaluation of Serological Tests for Covid-19
The primary objective of this study is to test the diagnostic sensitivity of antibody tests for the diagnosis of SARS-CoV2 infection, available to clinical laboratories, within a national network of hospitals carrying out…
- Trial name
- COVIDIAGNOSTIX (NCT04678024)
- Where
- Italy
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Gastrointestinal Stromal Tumor (GIST)
Resistance Profiling Using Functional Imaging and Next Generation Sequencing in Refractory Gastrointestinal Stomal Tumors (GIST)
Gastrointestinal stromal tumors (GIST) are the most common malignant sarcomas of the gastrointestinal tract. Inhibitors of the mutated driver proteins KIT and PDGFRA can temporarily control disseminated GIST disease but cannot…
- Trial name
- PATHFINDERS (NCT07109024)
- Testing
- Generation of a comprehensive and single-lesion resistance profile
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Universität Duisburg-Essen
Diffuse Large B-Cell Lymphoma
Orelabrutinib With R-CHOP-like Regimen for Patients With Newly Diagnosed Untreated Non-GCB DLBCL
The purpose of this study is to evaluate the efficacy and safety of orelabrutinib combined with rituximab，followed by orelabrutinib combined with R-CHOP-like regimen for newly diagnosed untreated Non-GCB DLBCL Patients
- Trial name
- NCT05498259
- Testing
- Orelabrutinib, Rituximab, CHOP-like Regimen
- Where
- China
- Volunteers
- 46 people
- Sponsor
- The First Affiliated Hospital of Soochow University