Clinical trials: Diagnostic Screening Programs
SARS-CoV-2 Infection, COVID-19
Evaluation of a Screening Program for SARS-CoV-2 Infection in the General Population Based on the Use of New Detection Approaches or for Diagnostic Orientation on Saliva
The investigators hypothesize that detection of SARS-CoV2 on saliva samples will increase the performance of the screening program compared to the reference strategy (RT-PCR on a nasopharyngeal swab).
- Trial name
- SALICOV (NCT04578509)
- Testing
- Nasopharyngeal swab, Saliva sample, axillary sweat sample
- Where
- France
- Volunteers
- 5,197 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Fibrillation
RedStroke - Reducing Europe's Stroke Incidence
In the RedStroke study, the effect of a smartphone application in detecting Atrial Fibrillation (AF) will be assessed in a double-blind randomised controlled multicenter trial.
- Trial name
- RedStroke (NCT04108884)
- Testing
- App measurement, 14 day Holter ECG
- Where
- 7 sites in Germany, Greece and 4 more
- Volunteers
- 1,019 people
- Sponsor
- University Hospital, Basel, Switzerland
Colorectal Cancer, Colorectal Neoplasms
Evaluation of a Model for the Early Diagnosis of Colorectal Cancer by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA to the Community Colorectal Cancer Screening Program
The incidence rate and mortality of colorectal cancer are increasing year by year. Most colorectal cancer develops from colorectal adenoma and is a disease that can be prevented and controlled.
- Trial name
- METHOD-3 (NCT05638243)
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
HIV/AIDS, Cancer
IMPACt of an Enhanced Screening Program on the Detection of Non-AIDS NEOplasms in HIV Patients
Introduction: The incidence of malignancies is higher in the HIV-infected population than in the general population, and it is already one of the leading causes of death in people living with the virus.
- Trial name
- IMPACNEO (NCT04735445)
- Testing
- Digital rectal exam and / or anal cytology (day 1 and after 36 months), Semestral digital rectal exam and / or anal cytology if abnormal → ANOSCOPY with biopsy, Cervical cytology and cervical sample for HPV detection (day 1 and after 36 months)
- Where
- Spain
- Volunteers
- 4,638 people
- Sponsor
- Felix Gutierrez
SARS-CoV-2 Infection Covid19
Differential Leucocyte Count and Covid-19 Diagnosis
To date, the diagnosis of SARS-CoV-2 infection is made by identifying the viral RNA in samples collected through a nasopharyngeal swab or other respiratory samples but this technique, has several limitations for its application…
- Trial name
- NCT04643860
- Testing
- Differential Leucocyte Count (CLDC) device and algorithm
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Glaucoma
Barcelona Esquerra Glaucoma Artificial Intelligence-based Screening Program (BEGAS)
Two primary care-based screening systems will be tested to identify subjects with referrable glaucoma to hospital care. Subjects between 45 to 64 years old living in the metropolitan area of Barcelona will be invited to…
- Trial name
- BEGAS (NCT06353542)
- Testing
- Software analysis, Ophthalmologist examination
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Ovarian Diseases, Ovarian Neoplasms
Cancer Screening Program for Women at High Risk for Developing Ovarian Cancer
The main purpose of this program is to see whether periodically measuring CA-125 (tumor marker) levels in the blood and undergoing transvaginal ultrasounds over time will be effective in the early detection of ovarian cancer.
- Trial name
- OCEDP (NCT01292733)
- Testing
- Laboratory Tumor Marker Analysis, Transvaginal Ultrasound, Health Status Questionnaire
- Where
- United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Artificial Intelligence, Diagnostic Imaging
Real-time Artificial Intelligence System for Detecting Multiple Ocular Fundus Lesions by Ultra-widefield Fundus Imaging
This prospective multicenter study will evaluate the efficacy of a real-time artificial intelligence system for detecting multiple ocular fundus lesions by ultra-widefield fundus imaging in real-world settings.
- Conditions
- Artificial Intelligence, Diagnostic Imaging, Abnormality of the Fundus, Diagnostic Screening Programs
- Trial name
- NCT04859634
- Testing
- Taking an ultra-widefield fundus image
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Congenital Heart Disease in Pregnancy, Prenatal Diagnosis
The National Program for the Improvement of Management of Fetal Congenital Heart Disease in China
To investigate and evaluate the capacity of prenatal screening, diagnosis and counseling of congenital heart disease in medical institutions in China, in order to understand the current status and existing problems of prenatal…
- Conditions
- Congenital Heart Disease in Pregnancy, Prenatal Diagnosis, Fetal Echocardiography
- Trial name
- NCT05940363
- Testing
- Improvement on Prenatal Screening and Treatment Capabilities for Congenital Heart Disease with a Comprehensive Diagnosis and Treatment Program Incorporating New Technologies
- Volunteers
- 9,000 people
- Sponsor
- Beijing Anzhen Hospital
HIV Infections
Evaluation of Opt-Out Rapid HIV Testing in the Emergency Department
The purpose of this study is to evaluate the clinical effectiveness of performing opt-out rapid HIV screening in an urban, inner-city emergency department, as well as to evaluate its clinical efficiency, cost effectiveness, and…
- Trial name
- NCT00742898
- Testing
- Non-targeted opt-out rapid HIV screening
- Where
- United States
- Volunteers
- 120,000 people
- Sponsor
- Denver Health and Hospital Authority
Fabry Disease
Fabry Disease in Cerebrovascular Disease
Fabry disease is an X-linked disorder of glycosphingolipid catabolism caused by a deficiency of the enzyme α-galactosidase A (α-Gal A), which leads to a progressive accumulation of globotriaosylceramide (Gb-3) in plasma and…
- Trial name
- NCT02859363
- Testing
- 26 common Fabry mutation types in Taiwan
- Where
- Taiwan
- Volunteers
- 700 people
- Sponsor
- Chang Gung Memorial Hospital
HIV Infections
A Systems Analysis and Improvement Approach for Optimizing HIV Service Delivery in Syringe Services Programs
The goal of this clinical trial is to assess the effectiveness of an evidence-based, organizational-level implementation strategy, the Systems Analysis and Improvement Approach, in improving HIV service delivery (SAIA-SSP-HIV) in…
- Trial name
- SAIA-SSP-HIV (NCT06025435)
- Testing
- SAIA-HIV-SSP
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Toxoplasmosis, Congenital
Lyon Cohort of Maternal and Congenital Toxoplasma Infections
Several decades ago, France has made the choice to implement a national prevention program for congenital toxoplasmosis. The identification in their first trimester of pregnancy of all pregnant women who are susceptible to…
- Trial name
- NCT02936921
- Where
- France
- Volunteers
- 4,030 people
- Sponsor
- Hospices Civils de Lyon