Clinical trials: Dialysis
Chronic Renal Failure
Study of Clinical Non-inferiority of Actparin® (Laboratorio Bergamo) Compared to Heparin Sodium (APP Pharmaceuticals), in Patients With Chronic Renal Failure
The purpose of this study is to investigate clinical non-inferiority, pharmacodynamic effect and safety of Actparin® (heparin sodium - Laboratório Químico Farmacêutico Bergamo Ltd.) compared to Heparin Sodium (APP…
- Trial name
- NCT01346215
- Testing
- heparin sodium
- Where
- Brazil
- Volunteers
- 132 people
- Sponsor
- Laboratório Químico Farmacêutico Bergamo Ltda.
Anemia, End Stage Renal Disease
Epodure Therapy of Anemia in End Stage Renal Disease on Dialysis With Epodure Skin Implant
In this End Stage Renal Disease (ESRD) patients who need Erythropoietin (epo) hormone will get it by a small implant of skin using their own skin, the implant will be treated in the laboratory and programmed to secrete Epo.
- Trial name
- NCT01555515
- Testing
- implantation of autologous skin graft after ex-vivo treatment, Subcutan implantation of autologus skin graft after ex-vivo treatment
- Volunteers
- 4 people
- Sponsor
- Medgenics Medical Israel Ltd.
End Stage Renal Disease, Hemodialysis
Sevelamer Hydrochloride and Femoral and Carotid Intima Media Thickness Progression in End Stage Renal Disease
Aims of the multi-center, randomized, treatment-controlled clinical trial are to compare the efficacy of sevelamer hydrochloride to calcium-containing phosphorus binders in reducing the rate of progression of femoral and carotid…
- Conditions
- End Stage Renal Disease, Hemodialysis, Intimal Media Thickness
- Trial name
- SUMMER (NCT01049815)
- Testing
- sevelamer hydrochloride, Calcium Carbonate
- Where
- 2 sites in Israel
- Volunteers
- 175 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Secondary Hyperparathyroidism, End Stage Renal Disease
A Study of an Investigational Medication for the Treatment of Secondary Hyperparathyroidism in Dialysis Patients
This 6 month long study will assess an investigational medication for patients on dialysis with secondary hyperparathyroidism. The study will look at the effects on parathyroid hormone, calcium and phosphorus levels.
- Trial name
- NCT00037635
- Testing
- AMG 073
- Volunteers
- 400 people
- Sponsor
- Amgen
Fluid Status, Peritoneal Dialysis
Bioimpedance as a Tool for Fluid Management in Peritoneal Dialysis (PD) Patients
Hypothesis: The investigators hypothesize that regular monitoring of BIA adds value to the management of fluid status in PD patients Objectives of the study: The objective is to show that in patients where the additional…
- Trial name
- NCT00801112
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University Hospital of North Staffordshire
Hemodialysis Complication, Hypotension During Dialysis
Evaluation of Total Blood Volume Measurement During Dialysis on the Incidence of Intradialytic Hypotension
Establishing the euvolemic state in hemodialysis patients -the so called "dry weight"- is an important clinical conundrum in every nephrologist's daily practice.
- Conditions
- Hemodialysis Complication, Hypotension During Dialysis, Diagnostic Tests
- Trial name
- NCT05872984
- Testing
- adjustment of dry weight based on absolute blood volume measurement
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- HagaZiekenhuis
Uremic Pruritus
CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
This is a multicenter, open-label study to evaluate the safety and effectiveness of intravenous (IV) CR845 at a dose of 0.5 mcg/kg administered after each dialysis session. The study includes an up to 12-week Treatment Period.
- Trial name
- NCT03998163
- Testing
- CR845 0.5 mcg/kg
- Where
- 47 sites in United States, Czechia and 2 more
- Volunteers
- 222 people
- Sponsor
- Cara Therapeutics, Inc.
End-Stage Renal Disease
Vitamin D3 Supplementation in Dialysis Patients
Vitamin D deficiency is highly prevalent among dialysis patients, and has been associated with cardiovascular risk factors such as increased aortic pulse wave velocity, blood pressure, inflammation, and brain natriuretic peptide.
- Trial name
- NCT01312714
- Testing
- Cholecalciferol
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Regional Hospital Holstebro
Calciphylaxis, Renal Insufficiency, Chronic
The Early Administration of Sodium Thiosulfate Should Help to Reduce the Mortality of Dialysis Patients With Calciphylaxis, From a National Cohort
The national drug safety agency authorizes nominatively the use of sodium thiosulfate in dialysis patients with calciphylaxis. To date, it is the largest global cohort (more 600 patients from 2012 to 2016).
- Trial name
- NCT03146793
- Testing
- Sodium Thiosulfate
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier St Esprit
END STAGE RENAL DISEASE
A Pilot Study to Evaluate ZADAXIN's® (Thymalfasin) Ability to Enhance Immune Response to the H1N1sw Influenza Vaccine
The purpose of this explorative trial is to collect preliminary data on efficacy and safety of thymosin alpha 1 given at different doses as an adjuvant to egg-derived H1N1sw monovalent influenza vaccine in hemodialysis patients.
- Trial name
- NCT01031966
- Testing
- MF59 adjuvanted H1N1 influenza monovalent vaccine, Thymosin alpha 1
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Chronic Kidney Disease stage4, Kidney Diseases
Medico-economic Impacts of NeLLY Service for Not on Dialysis Severe Chronic Kidney Disease
This medico-economic research project (PRME) aim to analyse NeLLY service efficiency for not on dialysis severe chronic kidney disease (DFG < 30ml/mn) patients care.
- Trial name
- NCT03348839
- Testing
- NeLLY service
- Where
- 10 sites in France
- Volunteers
- 600 people
- Sponsor
- Calydial
End Stage Renal Disease
Impact of Hemodialysis on Exhaled Volatile Organic Compounds in End Stage Renal Disease
End stage renal disease (ESRD) is a severe clinical state of irreversible loss of endogenous kidney function, shortening life expectancy, if left untreated.
- Trial name
- NCT01684228
- Where
- Israel
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Anemia
A Study of Subcutaneous Mircera for the Maintenance Treatment of Anemia in Participants With Chronic Kidney Disease Not on Dialysis
This single arm study will assess the efficacy and safety of monthly administration of subcutaneous methoxy polyethylene glycol-epoetin beta (Mircera) when administered for the maintenance of hemoglobin levels in participants…
- Trial name
- NCT00642967
- Testing
- Methoxy Polyethylene Glycol-epoetin Beta
- Where
- 69 sites in France
- Volunteers
- 127 people
- Sponsor
- Hoffmann-La Roche
Peritoneal Dialysis Patients
The Effects of Isoflavones on Cardiovascular and Bone Metabolism Markers in Peritoneal Dialysis Patients
The aim of this double-blind randomized clinical trial is to determine the effects of isoflavones on cardiovascular disease risk factors, bone metabolism markers, serum concentrations of fructoseamine and advanced glycated end…
- Trial name
- NCT03773029
- Testing
- soy isoflavone
- Where
- Iran
- Volunteers
- 47 people
- Sponsor
- National Nutrition and Food Technology Institute
Hemodialysis, Diabete Mellitus
Continuous Glucose Monitoring in Dialysis Patients to Overcome Dysglycemia Trial
This randomized controlled trial will investigate whether use of continuous glucose monitoring (CGM) vs. usual care with self-monitored blood glucose 1) enhances glycemic control, 2) reduces hypoglycemia risk, and 3) improves…
- Conditions
- Hemodialysis, Diabete Mellitus, Continuous Glucose Monitoring
- Trial name
- CONDOR (NCT05509881)
- Testing
- Continuous glucose monitoring (CGM), Usual care (Self-monitored blood glucose)
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, Irvine
End Stage Renal Disease, Decision Aid
A Guide to Conservative Care
This is a randomized pilot study to test the feasibility and acceptability of a patient decision aid on conservative care among older patients with advanced CKD and their close persons.
- Conditions
- End Stage Renal Disease, Decision Aid, Patient Engagement, Dialysis
- Trial name
- NCT04919941
- Testing
- A Guide to Conservative Care
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Washington
Functional Iron Deficiency
Out Come Study To Define Laboratory Parameters That Are Best Suited to Diagnose Functional Iron Deficiency
The purpose of the study is to define laboratory parameters which are best suited to diagnose functional iron deficiency. Functional iron deficiency is a condition where - due to the lack of iron bioavailability - the patient…
- Trial name
- SFIDS (NCT00495781)
- Testing
- %-hypo (laboratory parameter, functional iron deficiency), CHr (laboratory parameter, functional iron deficiency), RET-HE (laboratory parameter, functional iron deficiency)
- Where
- Switzerland
- Volunteers
- 77 people
- Sponsor
- Spital Zollikerberg
End Stage Renal Disease on Dialysis
RandomizEd ClinicAL triaL on the Efficacy and saFety of Incremental Hemodialysis (REAL-LIFE)
Background: The thrice-weekly hemodialysis (HD) regimen is widely accepted as a standard prescription. The concept of incremental dialysis has been established as a possible alternative for patients with preserved diuresis and…
- Trial name
- NCT04360694
- Testing
- Incremental hemodialysis, Conventional hemodialysis
- Where
- Italy
- Volunteers
- 190 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
End Stage Renal Failure on Dialysis
Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis
Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients…
- Trial name
- NCT01892839
- Testing
- low dialysate flow, smaller dialyzer, high dialysate flow, larger dialyzer
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Palo Alto Veterans Institute for Research
Anemia, Kidney Diseases
Alternate Dosing - Initiation of Every 2 Week Epoetin Alfa (PROCRIT) in the Treatment of Anemia.
The purpose of this study is to evaluate the hemoglobin response rate in subjects with anemia, associated with chronic kidney failure, after receiving epoetin alfa (PROCRIT®) every 2 weeks
- Trial name
- NCT00210743
- Testing
- epoetin alfa
- Volunteers
- 67 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.