Clinical trials: Diaphragm
Muscle Weakness, Critical Illness
Electromagnetic Stimulation of the Phrenic Nerve in Critically Ill Mechanically Ventilated Patients (STIMIT-II)
Ventilator-induced diaphragmatic dysfunction is a common issue in critically ill patients. Muscle stimulation has shown to have beneficial effects in muscle groups on the extremities.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication
- Trial name
- STIMIT-II (NCT05238753)
- Testing
- Non-invasive electromagnetic stimulation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
COPD
Combined Effects of Transcutaneous Electrical Diaphragmatic Stimulation With ACBT'S in Copd
The combined effects of transcutaneous electrical diaphragmatic stimulation (TEDS) and active cycle of breathing techniques (ACBTs) in patients with chronic obstructive pulmonary disease (COPD) conducted as a randomized…
- Trial name
- NCT07079553
- Testing
- Transcutaneous Electrical Diaphragmatic Stimulation (TEDS), Active Cycle of Breathing Techniques (ACBT)
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Ventilator Induced Lung Injury
Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing, a First in Human Trial
Study conducted to confirm phrenic nerve stimulation using the Lungpacer LIVE Catheter, confirm capture of the diaphragm and confirm that the diaphragm can be paced in synchrony with mechanical ventilator breaths.
- Trial name
- NCT02670460
- Testing
- LIVE Catheter
- Where
- Paraguay
- Volunteers
- 24 people
- Sponsor
- Lungpacer Medical Inc.
Hernia, Diaphragmatic
Postoperative Outcomes of Trans-abdominal Open Surgical Repair of Traumatic Diaphragmatic Hernias in Adults.
Objective: Evaluation of our management of acute or chronic traumatic diaphragmatic hernia repair with sutures or mesh. Between January 2014 and January 2019, a retrospective study on 185 patients with acute and chronic traumatic…
- Trial name
- NCT05591482
- Testing
- mesh repair
- Volunteers
- 185 people
- Sponsor
- Zagazig University
Sleep Disturbance, Sleep Disorders
Effect of Progressive Muscle Relaxation and Diaphragmatic Breathing on Sleep Disturbances in Chemotherapy Patients
This randomized controlled trial aims to investigate the effect of combined Progressive Muscle Relaxation (PMR) and Diaphragmatic Breathing (DB) techniques on sleep disturbances among patients receiving chemotherapy.
- Conditions
- Sleep Disturbance, Sleep Disorders, Cancer
- Trial name
- PMR & DB (NCT07639710)
- Testing
- Progressive Muscle Relaxation and Diaphragmatic Breathing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Diaphragm Disease
Surgical Anatomy of the Distal Portion of the Phrenic Nerve
Prolonged mechanical ventilation has been shown to induce diaphragm dysfunction. Temporary diaphragm pacing is an interesting lead to halt or slow diaphragm dysfunction.
- Trial name
- DANP (NCT04716504)
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
GERD
Understanding the Pathophysiology and Effects of Diaphragmatic Breathing in Upright Gastroesophageal Reflux
This study aims to understand why patients have predominantly upright gastroesophageal reflux disease by comparing such patients to healthy persons AND whether a behavioral intervention (diaphragmatic breathing) will impact this…
- Trial name
- NCT02972047
- Testing
- Diaphragmatic Breathing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Oxygen Saturation, Heart Rate
Effects of Alternate Nostril Breathing Versus Diaphragmatic Breathing on Oxygen Saturation and Heart-rate Variability in Post Percutaneous Coronary Intervention Patients
This study is a two-arm randomized parallel group trial designed to compare the effects of alternate nostril breathing vs diaphragmatic breathing on oxygen saturation and Heart-rate variability in hemodynamically stable post-PCI…
- Trial name
- NCT07867457
- Testing
- Alternate Nostril Breathing, Diaphragmatic breathing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Foundation University Islamabad
Respiratory Insufficiency, Diaphragm Injury
Diaphragm Injury and Dysfunction During Mechanical Ventilation
This study is designed to evaluate the relationship between diaphragm activity during mechanical ventilation and the development of ventilator-induced diaphragm dysfunction (VIDD).
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Mechanical Ventilation Complication
- Trial name
- MYOTRAUMA (NCT03108118)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Incentive Spirometer, Diaphragmatic Breathing
Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease
The goal of this clinical trial is to evaluate whether two types of breathing training can improve symptoms of gastroesophageal reflux disease (GERD) in adults.
- Conditions
- Incentive Spirometer, Diaphragmatic Breathing, Gastroesophageal Reflux Disease (GERD), Breath Exercise
- Trial name
- NCT07179250
- Testing
- Volume-Oriented Incentive Spirometer, Diaphragmatic Breathing Exercise (DBE), Usual Care and Education
- Volunteers
- 51 people
- Sponsor
- Changhua Christian Hospital
Thyroid Diseases, Respiratory Failure
Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome
Although it is now recognized that a variety of respiratory abnormalities, such as diaphragmatic dysfunction, can be present in primary hypothyroidism and reverse with adequate hormone treatment, the role of thyroid hormone…
- Trial name
- NCT03157466
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
ARDS
Mechanical Ventilation and Respiratory Muscle Work of Breathing in Acute Respiratory Distress Syndrome (ARDS) Patients
The purpose of this study is to demonstrate that mechanical ventilation guided by the diaphragm EMG signal (also know as neurally adjusted ventilatory assist [NAVA]) is superior compared to pressure support and pressure control…
- Trial name
- NCT01289600
- Testing
- Mechanical ventilation
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Nijmegen
Fibromyalgia, Fibromyalgia Syndrome
Slow Breathing and Resistance Exercise in Fibromyalgia
This randomized controlled trial investigates whether slow breathing techniques influence heart rate variability, exercise self-efficacy, and resistance exercise performance in women with fibromyalgia.
- Trial name
- Breath-fibro (NCT07404384)
- Testing
- Slow Breathing with Visual Pacer, Slow Breathing without Visual Pacer, Spontaneous Breathing (Active Control)
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- University of Malaga
Unilateral Diaphragmatic Paralysis
Phrenic Nerve Conduction Study to Diagnose Unilateral Diaphragmatic Paralysis
The study aims as the principal objective to compare two approaches to diagnosis unilateral diaphragmatic paralysis: transdiaphragmatic pressure (Pdi) measurement versus phrenic nerve conduction (NPC) study.
- Trial name
- ENMG-DIAPH (NCT04142684)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hemidiaphragmatic Paralysis, Postoperative Pain
Comparative Evaluation of Diaphragmatic Function Following Interscalene, Anterior Suprascapular, and Costoclavicular Nerve Blocks in Shoulder Surgery
Shoulder surgery causes significant postoperative pain, and ultrasound-guided regional anesthesia is central to its management. The interscalene block (ISB) is the gold standard but frequently causes phrenic nerve paralysis and…
- Conditions
- Hemidiaphragmatic Paralysis, Postoperative Pain, Shoulder Surgery, Brachial Plexus Block
- Trial name
- NCT07671352
- Testing
- Ultrasound-guided interscalene brachial plexus block, Ultrasound-guided suprascapular nerve block, Ultrasound-guided costoclavicular brachial plexus block
- Volunteers
- 75 people
- Sponsor
- Menoufia University
Liver Tumours, Ultrasound
Standing Position Ultrasonography: Imaging Efficacy in Detecting Liver Diaphragmatic Dome Blind Area Lesions
Objective: To compare the detection efficacy of standing, supine, and left lateral decubitus ultrasonographic scanning for space-occupying lesions ≤3cm in the liver dome "blind area" and assess the feasibility of standing…
- Conditions
- Liver Tumours, Ultrasound, Position
- Trial name
- NCT07579533
- Where
- China
- Volunteers
- 95 people
- Sponsor
- The First Hospital of Jilin University
Tracheal Intubation, Extracorporeal Membrane Oxygenation
Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance
The goal of this clinical trial is to explore the effect of NO treatment on diaphragm function after mechanical ventilation with ECMO assistance.
- Conditions
- Tracheal Intubation, Extracorporeal Membrane Oxygenation, Nitric Oxide, Ventilator-induced Diaphragmatic Dysfunction
- Trial name
- NCT06660784
- Testing
- Nitric Oxide
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhongnan Hospital
Bronchopulmonary Dysplasia
Ultrasound Assessment of Diaphragmatic Function in Infants With BPD
Preterm infants have high and prolonged exposure to positive pressure ventilation, which contributes to acute lung injury and the development of bronchopulmonary dysplasia (BPD).
- Trial name
- NCT04941963
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assistance to spontaneous breathing based on the detection of the electrical activity of the diaphragm.
- Trial name
- NCT01280383
- Testing
- non-invasive neurally adjusted ventilatory assist
- Sponsor
- Insel Gruppe AG, University Hospital Bern