Clinical trials: Diaphragm Disease, open to volunteers
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Volleyball Players
Diaphragmatic Facilitation and Upper Extremity Performance in Volleyball Players
The diaphragm contributes to both respiration and trunk stabilization. Effective diaphragmatic function may support postural control, force transfer, and upper extremity performance during dynamic activities.
- Trial name
- NCT07784517
- Testing
- Diaphragmatic Facilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istinye University
Bronchopulmonary Dysplasia
Early Predictors of Bronchopulmonary Dysplasia in Extremely Preterm Infants
Bronchopulmonary dysplasia (BPD) remains one of the most common complications in extremely preterm infants despite advances in neonatal intensive care.
- Trial name
- EPIRESP (NCT07771387)
- Where
- Austria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Feto-Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia
Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses.
- Conditions
- Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary; Hypertension
- Trial name
- FETO (NCT02986087)
- Testing
- Fetal Tracheal Occlusion
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Diaphragmatic Hernia
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science
The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. The identification of such genes, and examination of their structure and function, will enable a delineation of…
- Trial name
- DHREAMS (NCT00950118)
- Where
- 14 sites in United States, Egypt
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Respiratory Failure
Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study
Study Objective This prospective observational study aims to investigate the role of the Diaphragmatic Physiology Similarity Index (DPSI) derived from speckle tracking ultrasound in titrating high-flow nasal cannula (HFNC) flow…
- Trial name
- NCT06996665
- Testing
- High-flow adjustment sequence
- Where
- 2 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Core Stability, Respiratory Function
Effects of Diaphragmatic Breathing During Equipment-Based Pilates in Women
This randomized controlled study aims to investigate the effects of diaphragmatic breathing exercises on core stabilization muscle strength, peak expiratory flow (PEF), and chest expansion in women performing equipment-based…
- Conditions
- Core Stability, Respiratory Function, Diaphragmatic Breathing
- Trial name
- NCT07652229
- Testing
- Diaphragmatic Breathing Exercise, Equipment-Based Pilates Training
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Paraesophageal Hernia
Fundoplication in Laparoscopic PEH Repair Based on FLIP
Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.
- Trial name
- PEHFLIP (NCT05807763)
- Testing
- Laparoscopic paraesophageal hernia repair without fundoplication
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The Foundation for Surgical Innovation and Education
Respiratory Insufficiency, Pneumonia
Diaphragm Dysfunction and Ultrasound Perioperatively
This study aims at determining whether diaphragm ultrasound examining diaphragm thickening fraction, excursion and density before and after surgery can predict respiratory complications in the postoperative period.
- Conditions
- Respiratory Insufficiency, Pneumonia, Desaturation of Blood, Tachypnea
- Trial name
- DiaphPeriop (NCT05906030)
- Testing
- Diaphragm ultrasound
- Where
- 2 sites in Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Breath Exercise, State Anxiety
The Effect of Diaphragmatic Breathing Exercises Before Gastroscopy on Anxiety, Fear, and Vital Signs
Gastroscopy, performed as an invasive procedure for the diagnosis and treatment of upper gastrointestinal tract diseases, is often perceived by patients as an unpleasant and frightening experience, leading to anxiety (Hua et al.…
- Conditions
- Breath Exercise, State Anxiety, Adult Patients, Vital Signs Monitoring
- Trial name
- NCT07781943
- Testing
- Diaphragmatic Breathing Exercises
- Where
- Cyprus
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Postoperative Pain, Shoulder Pain
Bupivacaine With Epinephrine Over Diaphragm in Laparoscopy
Postoperative shoulder pain is often reported to be particularly bothersome after laparoscopy. The benefits of local anesthetic, such as bupivacaine, applied to subcutaneous tissue for general postoperative pain management after…
- Trial name
- NCT07400146
- Testing
- Instillation of Bupivacaine with epinephrine over the diaphragm
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Young
The Effect of Diaphragmatic Breathing Exercises on Pain, Dyspnea, Posture, Body Awareness, Anxiety, and Depression in Young Adults
Prolonged sedentary behavior and sustained static postures in modern lifestyles induce musculoskeletal stress, restrict thoracic mobility, and impair diaphragmatic excursion, which can alter postural control, increase dyspnea…
- Trial name
- NCT07872163
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Alper Kemal Gürbüz
Abdominoplasty, Diaphragm
Gastroesophageal Reflux and Respiratory Function in Patients Undergoing Abdominoplasty
The objective of this observational study is to compare parameters of diaphragmatic mechanics, respiratory muscle function, and thoracoabdominal kinematics among women with gastroesophageal reflux disease (GERD) and a history of…
- Conditions
- Abdominoplasty, Diaphragm, Respiratory Mechanics, Gastroesophageal Reflux Disease
- Trial name
- NCT07868562
- Testing
- Assessment of anthropometric and sociodemographic data and clinical history, Assessment of Symptoms, Quality of Life, and Physical Activity, Spirometric assessment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Obstructive Sleep Apnea
Diaphragmatic Function and Respiratory Drive in OSA and COPD
This cross-sectional observational study aims to assess the diaphragmatic morphofunction and respiratory drive characteristics among patients with obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT07003399
- Testing
- Diaphragmatic Ultrasound and EMG Assessment
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Stroke
Ultrasonographic Evaluation of Morphological and Functional Characteristics of Intercostal Muscles in Stroke Patients and Their Relationship With Clinical Parameters
The aim of this study is to evaluate the morphological and functional characteristics of parasternal intercostal muscles in patients with stroke using ultrasonography.
- Trial name
- NCT07670585
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cirrhosis of the Liver, Ascites
Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings
The goal of this observational study is to learn how liver cirrhosis affects the diaphragm, the main muscle used for breathing, in adults.
- Conditions
- Cirrhosis of the Liver, Ascites, Pleural Effusion Disorder, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07667608
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Safety and Efficacy of FETO in CDH Phase III
Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses and standard of care control group
- Conditions
- Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia, Pulmonary Hypertension
- Trial name
- CDH FETO (NCT07187206)
- Testing
- FETO, Fetal Endoluminal Tracheal Occlusion
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Diaphragmatic Hernia
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
Despite advances in prenatal diagnosis and postnatal therapies, including ECMO (Extracorporeal Membrane Oxygenation), inhaled nitric oxide therapy, and ventilator strategies that minimize ventilator-induced lung injury, morbidity…
- Trial name
- NCT04583644
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion Surgery
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hanmin Lee
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Diaphragm Thickness, Dyspnoea
Abdominal Air-Pressure Resistance Versus Abdominal Weight Training for Improving Diaphragm Function in Healthy Young Adults
This study aims to compare the effects of abdominal air pressure resistance training, abdominal weight training, and breathing exercises on diaphragmatic strength, endurance, and physiological responses in young healthy adults.
- Trial name
- NCT07795905
- Testing
- Abdominal Air Pressure Resistance Training, Abdominal Weight Training (AWT), Breathing Exercise Control (BE)
- Where
- United Arab Emirates
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Sharjah