Clinical trials: Diaphragm Injury
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Neonatal Oxygen Desaturation, Premature
Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants
This research study is being done to investigate the effect of changing an infant's body position on how hard the baby works to breathe, the baby's oxygen level, the baby's carbon dioxide level, the baby's lung volume, the baby's…
- Conditions
- Neonatal Oxygen Desaturation, Premature, Ventilator Lung; Newborn, Apnea of Prematurity
- Trial name
- NCT05968586
- Testing
- Body positioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Spinal Cord Injury Cervical, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI
This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure.
- Trial name
- NCT07722130
- Testing
- Epidural spinal cord stimulation
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhongda Hospital
Noninvasive Ventlation, COVID-19 Respiratory Infection
Effects of Body Position on Diaphragmatic Activity in Patients Requiring Noninvasive Ventilation for Acute Respiratory Failure COVID-19 Related
The present investigation aims to assess the diaphragmatic thickening fraction, reflecting the diaphragmatic activity, during supine (baseline) and at 1 hour following prone position in patients assisted through non invasive…
- Conditions
- Noninvasive Ventlation, COVID-19 Respiratory Infection, Diaphragm Injury
- Trial name
- DiaCOVIDProne (NCT04904731)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Azienda Ospedaliera di Perugia
Cervical Spinal Cord Injury
Diaphragm Pacing in Individuals With Spinal Cord Injuries
This project will evaluate the effects of intramuscular diaphragm stimulation (pacing) and test the hypothesis that diaphragm pacing enhances neuromuscular diaphragm activation and respiratory function in adults with cervical…
- Trial name
- NCT04179799
- Testing
- Diaphragm Pacing
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Emergencies, Trauma Injury
Pre-Hospital Zone 1 Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Injured Patients With Exsanguinating Sub-diaphragmatic Haemorrhage
It is unknown whether this evolved strategy (Pre-Hospital Zone I P-REBOA) is feasible and with an acceptable safety profile. This study will address this question, therefore informing the design of a prospective multicentre…
- Conditions
- Emergencies, Trauma Injury, Trauma, Multiple
- Trial name
- P-PRO (NCT04145271)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 4 sites in United Kingdom
- Volunteers
- 10 people
- Sponsor
- Barts & The London NHS Trust
Diaphragmatic Paralysis, Postoperative Pain
Hemidiaphragmatic Paralysis With Diluted Continuous Interscalene Plexus Infusions
Interscalene brachial plexus block (ISB) constitutes the analgesic criterion standard for shoulder surgery. However, it is associated with a high incidence of hemidiaphragmatic paralysis (HDP) that may not be tolerated by…
- Conditions
- Diaphragmatic Paralysis, Postoperative Pain, Acute Pain, Shoulder Pain
- Trial name
- NCT03592056
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Clinica las Condes, Chile
Respiratory Failure, Long-term Non-invasive Ventilation
Ventilator-associated Injury (VAI) in Chronic Home Mechanical Ventilation
Rationale: The pathophysiological changes in respiratory muscle morphology and functioning in patients with end-stage pulmonary disease are not very well known.
- Trial name
- NCT04521426
- Testing
- No other than standard care
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Athletic Injuries
Effects of Inspiratory Muscle Training on Diaphragm Thickness, Respiratory Muscle Strength and Balance in Dancers.
Dance is a performing art form consisting of sports and art intertwined and complex dynamic choreographic figures were handled aesthetically and physically of narrative.
- Trial name
- NCT04845802
- Testing
- Inspiratory muscle training(high-IMT group), Inspiratory muscle training(low-IMT group)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Phrenic Paralysis, Shoulder Joint Surgery
The Effect of Brachial Plexus Block on Diaphragm Movement
The purpose of this study is to quickly evaluate the degree of phrenic nerve block by observing the changes of diaphragm movement through ultrasound, and to find the best scheme for clinical application by controlling the…
- Conditions
- Phrenic Paralysis, Shoulder Joint Surgery, Rotator Cuff Injury
- Trial name
- NCT06640621
- Testing
- Different concentration of ropivacaine for single brachial plexus block
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Respiratory Paralysis, Diaphragmatic Paralysis
Diaphragmatic Pacemaker in Tetraplegic Patients With Spinal Cord Injuries
Permanent dependency of breathing apparatus due to spinal cord injury is traditionally treated with different types of mechanical ventilation.
- Conditions
- Respiratory Paralysis, Diaphragmatic Paralysis, Spinal Cord Injury
- Trial name
- NCT01385384
- Testing
- NeuRx RA/4 diaphragmatic pacemaker
- Where
- 2 sites in Brazil
- Volunteers
- 5 people
- Sponsor
- University of Sao Paulo
Acute Respiratory Distress Syndrome, Diaphragm Injury
Re-Evaluation of Systemic Early Neuromuscular Blockade and Transthoracic Ultrasound Assessment of the Diaphragm
ROSETTA is a multi-centre study evaluating the time course of diaphragm thickness and function following exposure to neuromuscular blockade or control in patients with acute respiratory distress.
- Conditions
- Acute Respiratory Distress Syndrome, Diaphragm Injury, Neuromuscular Blockade
- Trial name
- ROSETTA (NCT03132896)
- Where
- 6 sites in United States
- Sponsor
- University Health Network, Toronto
Rib Fractures, Acute Pain
Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures
Traumatic rib fractures cause severe chest wall pain that can impair normal breathing, coughing, and lung function. While systemic opioids are commonly used to treat traumatic pain, their side effects, such as sedation and…
- Conditions
- Rib Fractures, Acute Pain, Thoracic Trauma
- Trial name
- NCT07827157
- Testing
- Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB
- Volunteers
- 100 people
- Sponsor
- Assiut University
Stroke, Diaphragm Injury
Effect of Body Tilting on Diaphragm Excursion and Thickness in the Stroke Patients With Tracheotomy by Ultrasonography
The purpose of this study was to examine whether if the effect of standing with assistance of the tilt table on diaphragm excursion and thickness in the stroke patients with tracheotomy.
- Conditions
- Stroke, Diaphragm Injury, Tracheostomy
- Trial name
- NCT05041894
- Testing
- tilt table
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Shenzhen Second People's Hospital
Diaphragm Injury, Mechanical Ventilation Complication
Evaluation of the Regeneration Capacity of Satellite Cells From the Quadriceps Compared to That of the Diaphragm
Actually no treatment exists to prevent the loss of diaphragmatic function induced by mechanical ventilation during an intensive care unit stay.
- Trial name
- ECARS (NCT05194631)
- Testing
- Quadriceps microbiopsy using a Tru-Cut biopsy needle
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Brain Injuries, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Brain Injury
Patients with severe brain injury may develop impaired respiratory drive, diaphragm dysfunction, prolonged mechanical ventilation, and difficulty recovering spontaneous breathing.
- Trial name
- BREATH (NCT07766681)
- Testing
- Epidural Electrode Implantation
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- Zhongda Hospital
Bronchopulmonary Dysplasia
Early Predictors of Bronchopulmonary Dysplasia in Extremely Preterm Infants
Bronchopulmonary dysplasia (BPD) remains one of the most common complications in extremely preterm infants despite advances in neonatal intensive care.
- Trial name
- EPIRESP (NCT07771387)
- Where
- Austria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diaphragmatic Function, Metacarpal Fracture
Evaluation of Diaphragmatic Function After Interscalene Block With Liposomal Bupivacaine
The study aims to evaluation the effects of Liposomal Bupivacaine on diaphragmatic function in patients undergoing upper limb surgery who receive Interscalene Brachial Plexus Block.
- Conditions
- Diaphragmatic Function, Metacarpal Fracture, Radius Fracture, Peripheral Nerve Neurolysis
- Trial name
- NCT07263295
- Testing
- 0.5% Hydrochloride Bupivacaine 20ml, 0.5% Hydrochloride Bupivacaine 10ml, Liposomal Bupivacaine 10mL
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhejiang University
COVID-19, Diaphragm Injury
Respiratory Muscles After Inspiratory Muscle Training After COVID-19
It is the aim of the current (follow-up) project for the first time in post-COVID-19 patients who continue to complain of shortness of breath and for whom there is no other explanation than possibly proven diaphragmatic weakness…
- Trial name
- NCT05582642
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- RWTH Aachen University