Clinical trials: Diaphragmatic Disorder
Diaphragm Disease
Ultrasound as Diagnostic Tool in Diaphragm Dysfunction
The diaphragm is the main muscle for inspiration and vital for ventilation. Multiple diagnostic modalities can be performed in the work-up of suspected diaphragm dysfunction.
- Trial name
- ULTRASONIC (NCT05682027)
- Testing
- ultrasound of the diaphragm
- Where
- 2 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- Isala
Chronic Obstructive Pulmonary Disease
Respiratory Muscle Stretching in Chronic Obstructive Pulmonary Disease (COPD)
Objective: The investigators studied the effects of respiratory muscle stretching in an 8-week pulmonary rehabilitation program. Methods: This was a simple-blind parallel controlled trial, conducted an out-patient clinic.
- Trial name
- NCT00935181
- Testing
- respiratory muscle stretching
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Faculdade Evangelica do Parana
Respiratory Insufficiency in Children, Newborn Rds
Diaphragmatic Work During HFNC and CPAP Support
The goal of this randomised controlled, cross-over clinical trial is to compare High Flow Nasal Cannulas (HFNC) and Continuous Positive Airways Pressure (CPAP) in neonates over 34 weeks' amenorrhoea (SA) up to children weighing…
- Conditions
- Respiratory Insufficiency in Children, Newborn Rds, Nasal Cannula, CPAP Ventilation
- Trial name
- DiaWorkHFNC (NCT06249009)
- Testing
- Non invasive ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Diaphragmatic Paralysis, Brachial Plexus Block
Diaphragmatic Paralysis Comparison Between Local Anesthetic Volumen Doses After Interscalene Block
Arthroscopic shoulder surgery involves dynamic and severe postoperative pain. Interscalene brachial plexus block (IBPB) provides adequate analgesia but the spread of local anaesthetics administered causes a phrenic nerve block…
- Trial name
- REDOLEV-2019 (NCT04385966)
- Testing
- Interscalene brachial plexus block, Levobupivacaine Hydrochloride 2.5 MG/ML
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Hiatal Hernia, Paraesophageal, Hiatal Hernia Large
Laparoscopic Nissen Versus Toupet Fundoplication for Hiatal Hernia.
This randomized controlled trial compares laparoscopic Nissen fundoplication and laparoscopic Toupet fundoplication in patients undergoing surgical treatment for hiatal hernia associated with gastroesophageal reflux disease.
- Conditions
- Hiatal Hernia, Paraesophageal, Hiatal Hernia Large, Hiatal Hernia With Gastroesophageal Reflux Disease
- Trial name
- NCT07718828
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic Toupet Fundoplication
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Sofia Med Hospital
COPD, COPD Exacerbation
Ultrasonographic Evaluation of Diaphragm and Quadriceps in Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is to evaluate the prognostic role of echographic diaphragmatic assessment and vastus lateralis muscle ultrasound (US) in two independent populations of patients hospitalized for exacerbated Chronic…
- Trial name
- EDIFEB (NCT04509128)
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele Roma
Rare Diseases, Congenital Diaphragmatic Hernia
Intact Cord Resuscitation in CDH
Isolated CDH is a rare disease (1/3500) and displays a wide range of severity and outcome. Despite attempts to standardize the management of this disease at birth and during the first months of life, the mortality varies from 20…
- Trial name
- CHIC (NCT04429750)
- Testing
- Immediate umbilical cord clamping, intact cord resuscitation
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Critical Illness, Respiratory Disease
UltraSound for Accurate Decisions in Chest PhysioTherapy
Introduction: Physiotherapist usually uses a clinical examination, including auscultation, an analysis of blood gasses and chest imaging to determine the indication for chest physiotherapy, to choose the treatment protocol and…
- Trial name
- US-ADEPT (NCT02881814)
- Testing
- Lung and diaphragm ultrasound, Lung and diaphragm ultrasound in MV patients
- Where
- 4 sites in Australia, France
- Volunteers
- 153 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Respiratory Failure
Effects of PBMT-sMF in Mechanically Ventilated Patients
The goal of this clinical trial is to evaluate the effectiveness of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) in adult patients who require mechanical ventilation.
- Trial name
- NCT06454006
- Testing
- Active PBMT-sMF
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- University of Nove de Julho
Sarcopenic Obesity, COPD
Prevalence of Sarcopenic Obesity in COPD
The goal of this observational study is to the purpose is to apply of ESPEN/EASO criteria for the diagnosis of sarcopenic obesity and calculation of OS prevalence in a sample of COPD patients.
- Trial name
- OS-BPCO (NCT06822504)
- Where
- Italy
- Volunteers
- 236 people
- Sponsor
- IRCCS San Raffaele Roma
Preterm Infants, Respiratory Distress Syndrome
Diaphragm Electrical Activity of Preterm Infants on nCPAP With Binasal Prongs Versus RAM Cannula
Preterm babies have immature lungs and frequent pauses in their breathing which often necessitates breathing support. Nasal Continuous Positive Airway Pressure (nCPAP) is one of the most commonly used tools, but the standard…
- Conditions
- Preterm Infants, Respiratory Distress Syndrome, CPAP, RAM Cannula
- Trial name
- NCT03121781
- Testing
- respiratory support- interface
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Asthma
Effects of MDRT vs CEE on Pulmonary Functions, Chest Expansion and Asthma Control in Asthma Patients
To determine the effects of manual diaphragmatic release technique (MDRT) versus chest wall expansion exercises on pulmonary function, chest wall expansion and asthma control in patients with asthma.
- Trial name
- NCT06460857
- Testing
- Manual Diaphragmatic Release Technique, Chest Wall Expansion Exercises
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Chronic Cor Pulmonale
The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale
This study evaluates the effect of external diaphragmatic pacemaker on the patients with chronic cor pulmonale. Half of participants will receive external diaphragmatic pacemaker, while the other half will receive routine therapy.
- Trial name
- NCT02976324
- Testing
- external diaphragmatic pacemaker group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhang Xiangyu
Hiatal Hernia With Gastroesophageal Reflux Disease
Comparison of Laparoscopic Nissen Fundoplication and Hill-Snow Repair for Hiatus Hernia With Endoscopic Evaluation
The goal of this clinical trial is to compare the clinical efficacy and safety of laparoscopic Nissen fundoplication (LNF) versus laparoscopic Hill-Snow repair (LHS) in the management of patients with congenital hiatus hernia, to…
- Trial name
- NCT07387042
- Testing
- Laparoscopic Hill-Snow repair, Laparoscopic Nissen Fundoplication
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Virtual Reality, Congenital Diaphragmatic Hernia
Virtual Reality and Congenital Diaphragmatic Hernia
The study has been designed to investigate the effect of 12 weeks of using virtual reality based exercises on pulmonary functions, exercise capacity, functional performance, and quality of life in children with…
- Conditions
- Virtual Reality, Congenital Diaphragmatic Hernia, Children
- Trial name
- NCT05612503
- Testing
- Traditional physical therapy program, Virtual reality-based exercises
- Where
- Saudi Arabia
- Volunteers
- 52 people
- Sponsor
- Qassim University
Congenital Diaphragmatic Hernia
Umbilical Cord Blood Mononuclear Cells for Hypoxic Neurologic Injury in Infants With Congenital Diaphragmatic Hernia (CDH)
The purpose of this study is to investigate the use of autologous umbilical cord blood (UCB) mononuclear cells to mitigate hypoxic neurologic injury among infants with high-risk congenital diaphragmatic hernia (CDH).
- Trial name
- NCT03526588
- Testing
- Autologous umbilical cord blood
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center, Houston
Congenital Diaphragmatic Hernia
Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax.
- Trial name
- NCT03980717
- Testing
- Goldbal Detachable Balloon and delivery microcatheter
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Michael A Belfort
Congenital Diaphragmatic Hernia
North American Fetal Therapy Network Prospective Registry for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia
The purpose of this research is to determine if babies who undergo a Fetoscopic Endoluminal Tracheal Occlusion (FETO) procedure survive more often and have less long-term complications than babies who have similarly severe…
- Trial name
- NCT07564297
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion, Standard of Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Abdominoplasty, Diaphragm
Gastroesophageal Reflux and Respiratory Function in Patients Undergoing Abdominoplasty
The objective of this observational study is to compare parameters of diaphragmatic mechanics, respiratory muscle function, and thoracoabdominal kinematics among women with gastroesophageal reflux disease (GERD) and a history of…
- Conditions
- Abdominoplasty, Diaphragm, Respiratory Mechanics, Gastroesophageal Reflux Disease
- Trial name
- NCT07868562
- Testing
- Assessment of anthropometric and sociodemographic data and clinical history, Assessment of Symptoms, Quality of Life, and Physical Activity, Spirometric assessment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco