Clinical trials: Diaphragmatic Dysfunction
Diaphragmatic Paralysis
Effects of Inspiratory Muscle Training on Exertional Breathlessness in Patients With Unilateral Diaphragm Paralysis
Treatment options for unilateral diaphragm paralysis are limited. Diaphragmatic plication via mini thoracotomy is sometimes considered in the University Hospital Leuven if severe symptoms persist for longer than 12 months after…
- Trial name
- NCT04563468
- Testing
- Strength inspiratory muscle training, Endurance inspiratory muscle training
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Mechanical Ventilation, Weaning Failure
Comparison of Weaning Parameters and Diaphragm Thickness Changes
Determining the appropriate timing for mechanical ventilator weaning in intensive care unit patients is critical to avoid complications related to early or late weaning, including weaning failure.
- Conditions
- Mechanical Ventilation, Weaning Failure, Intensive Care Unit (ICU) Patients, Diaphragm Dysfunction
- Trial name
- Weaning (NCT06967623)
- Testing
- diaphragm ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Tarık Durna
Ventilator-Induced Diaphragmatic Dysfunction
Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients
The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on…
- Trial name
- NCT06515600
- Testing
- Practice flow trigger sensitivity adjustment on mechanical ventilation for 1 week twice daily in addition to their plan of treatment.
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- South Valley University
Critical Illness, ICU Acquired Weakness
Muscle Evaluation Using Ultrasound in the Critically Ill
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay.
- Trial name
- ULTRAMUSCLE (NCT03550222)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Diaphragmatic Dysfunction
Comparative Ultrasonic Study of Post Operative Diaphragmatic Dysfunction in Abdominal and Head and Neck Surgery
Diaphragmatic dysfunction (DD) is one of the main risk factors for post operative respiratory distress syndrome. Ultrasonography is a diagnosis tool for DD but few studies have been published.
- Trial name
- Under the Dome (NCT01737775)
- Testing
- Diaphragmatic amplitude measurement
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Atrial Fibrillation (AF), Phrenic Nerve-related Diaphragmatic Impairment
Diaphragmatic Evaluation by Fluoroscopy to Identify Phrenic Nerve Dysfunction Related to Electroporation
This study aims to better understand the potential side effects of a heart treatment called PFA (Pulsed Field Ablation), used to treat an arrhythmia known as atrial fibrillation.
- Trial name
- Define-PFA (NCT07127900)
- Sponsor
- Laurent Macle
Perioperative Respiratory Function, Diaphragmatic Dysfunction
LTV (Low Tidal Volüme) Ventilation and Diaphragmatic Motion in CABG (Coronary Artery Bypass Grafting)
The goal of this clinical trial is to evaluate whether low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) surgery helps preserve diaphragmatic excursion in adult patients undergoing coronary artery bypass…
- Conditions
- Perioperative Respiratory Function, Diaphragmatic Dysfunction, Low Tidal Volume Ventilation
- Trial name
- NCT07067684
- Testing
- Low Tidal Volume Ventilation During CPB
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Respiratory Distress Syndrome,Adult
Prevalence, Impact and Reversibility of Acute Diaprhagmatic Dysfunction in Acute Respiratory Detresse
The diaphragm is a fine striated muscle with both extra respiratory and respiratory functions. It does most of the breathing work in interaction with the accessory respiratory muscles, the rib cage and the abdomen.
- Trial name
- PIRD-DRA (NCT04106128)
- Testing
- ultrasound examination
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Diaphragm, Diaphragm Disease
Diaphragmatic Ultrasound and Weaning After Lung Transplant.
The prevalence and adverse effect of diaphragm dysfunction (DD) after bilateral-lung transplant (LT) are still unclear, despite a well-known negative impact on weaning and outcome in other cohorts of critically ill and surgical…
- Conditions
- Diaphragm, Diaphragm Disease, Diaphragm Issues, Weakness, Muscle
- Trial name
- NCT05670327
- Testing
- Diaphragmatic ultrasound assessment
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Padova
Coronary Artery Disease, Postoperative Pulmonary Complications
Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function
Pulmonary atelectasis and loss of lung aeration are common complications following cardiac surgery with cardiopulmonary bypass (CPB) and are associated with impaired oxygenation and prolonged mechanical ventilation.
- Conditions
- Coronary Artery Disease, Postoperative Pulmonary Complications, Pulmonary Atelectasis, Postoperative, Diaphragm Dysfunction
- Trial name
- FCV-PCV-DTI-LU (NCT07800741)
- Testing
- Flow-Controlled Ventilation, Pressure-Controlled Ventilation (PCV)
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Weaning Failure, Sepsis
Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome
This study aims to assess whether the degree of diaphragm excursion and diaphragm thickening measured by ultrasound during a weaning trial may be used to predict successful weaning from mechanical ventilation in patients with…
- Trial name
- NCT04825509
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease (COPD), Diaphragm Dysfunction
Effect of Inspiratory Muscle Training on Diaphragm Function in COPD Patients
This study investigates the effect of threshold inspiratory muscle training on diaphragm thickness and diaphragm excursion, measured using ultrasonography, in patients with stable chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07539974
- Testing
- Threshold Inspiratory Muscle Training, Philips Respironics Threshold IMT device
- Volunteers
- 15 people
- Sponsor
- Universitas Padjadjaran
Mechanical Ventilation Complication
Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.
- Trial name
- NCT03901924
- Testing
- Volume Support Mode Mechanical Ventilation, Assist Control Mode Mechanical Ventilation
- Where
- 2 sites in United States
- Volunteers
- 468 people
- Sponsor
- University of Chicago
Diaphragm Disease
Diaphragmatic Dysfunction and Cardiac Surgery; Perioperative Assessment and Effect on Outcome
This study evaluates incidence of diaphragmatic dysfunction after cardiac surgery and its effect on outcome of surgery.
- Trial name
- NCT03126838
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- National Heart Institute, Egypt
Diaphragm Issues, Neurosurgery
Post-neurosurgical Respiratory Muscle Dysfunction
Respiratory muscle dysfunction may contribute to the development of postoperative pulmonary complications. However, it prevalence in patients receiving neurosurgery is largely unknown.
- Conditions
- Diaphragm Issues, Neurosurgery, Pulmonary Complication
- Trial name
- NCT05951114
- Testing
- Maximum inspiratory/Expiratory manoeuvre for patients can follow the order
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Sanbo Brain Hospital
Ventilator Weaning
Interaction Diaphragm and Cardiac Function During Ventilator Weaning
Weaning failure is associated with prolonged duration of mechanical ventilation that itself can worsen patient's prognosis. Therefore, identification of the causes and mechanisms leading to weaning failure is important in daily…
- Trial name
- I-DISCO (NCT03486249)
- Testing
- Repetition of medical examinations performed as part of the care
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diaphragm Injury, Lung Transplant; Complications, Mechanical
Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation
The study is designed to characterize the changes in diaphragm function after lung transplantation.
- Conditions
- Diaphragm Injury, Lung Transplant; Complications, Mechanical, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- RADAR (NCT04103996)
- Testing
- Ultrasound, Respiratory function measurements
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Neuromuscular Diseases, Congenital Diaphragmatic Hernia
Respiratory Muscles and Work of Breathing in Children
Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology…
- Conditions
- Neuromuscular Diseases, Congenital Diaphragmatic Hernia, Lung Diseases, Cardiac Diseases
- Trial name
- WOB&MR_Ped (NCT05051254)
- Testing
- Esogastric pressure measurement
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diaphragmatic Paralysis, Healthy Volunteers
Assesment of New Devices for the Diagnostic Evaluation of Diaphragmatic Dysfunction
this study aim to evaluate wether new, non-invasive and non-contact devices such as Structured Light Plethysmography (SLP) and Sonar would be able to accurately detect and quantify diaphragm dysfunction (mono-or-bilateral) by…
- Trial name
- DYSDIA (NCT03463798)
- Testing
- Sonar, Structured light plethysmography (SLP)
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Malignant Pleural Effusion, Lung Neoplasms
Quantitative Diaphragmatic Ultrasound Evaluation in Pleural Effusions : A Feasability Study
Malignant pleural effusions cause breathlessness and impairs quality of life. Thoracocentesis is frequently used to relieve breathlessness. The severity of breathlessness correlates poorly with the size of the effusion.
- Trial name
- ADD-Echo (NCT04264325)
- Testing
- diaphragmatic ultrasound measure
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France