Clinical trials: Diaphragmatic Dysfunction, open to volunteers
Mechanical Ventilation Complication, Ventilator-induced Diaphragm Dysfunction
How Early Mobilization Impacts on Diaphragm Thickness in Critically Ill Children
The objective is to compare the impact of early mobilization and routine care on diaphragm thickness in critically ill children
- Trial name
- NCT04534296
- Testing
- early mobilization, routine care
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Children's Hospital of Fudan University
Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation
Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients
Rationale: Patients with invasive mechanical ventilation (IMV) frequently develop diaphragm dysfunction and experience difficult weaning.
- Conditions
- Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation, Respiratory Failure, ICU
- Trial name
- DISSECT (NCT07819864)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- Radboud University Medical Center
Pain and Diaphragmatic Dysfunction After Shoulder Arthroscopy
Effect of Optimal Biological Volume Bupivacaine Liposome Interscalene Brachial Plexus Block on Postoperative Analgesia After Shoulder Arthroscopy
This study aims to evaluate whether 15ml/75mg low-dose bupivacaine liposome is non-inferior to 15ml/133mg standard-dose bupivacaine liposome for postoperative analgesia in interscalene brachial plexus block during arthroscopic…
- Trial name
- NCT07792044
- Testing
- OBV bupivacaine liposome group, Standard dose bupivacaine liposome group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Chronic Obstructive Pulmonary Disease (COPD), Diaphragm Dysfunction
Effect of Inspiratory Muscle Training on Diaphragm Function in COPD Patients
This study investigates the effect of threshold inspiratory muscle training on diaphragm thickness and diaphragm excursion, measured using ultrasonography, in patients with stable chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT07539974
- Testing
- Threshold Inspiratory Muscle Training, Philips Respironics Threshold IMT device
- Volunteers
- 15 people
- Sponsor
- Universitas Padjadjaran
Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation
Rehab and Mechanical Ventilation
The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness.
- Conditions
- Inspiratory Strength Training (IST), Transcutaneous Spinal Stimulation, Sham Spinal Stimulation
- Trial name
- REHAB-MV (NCT07427121)
- Testing
- Spinal cord stimulation, Inspiratory Strength Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Florida
Atrial Fibrillation
Diaphragmatic Evaluation by Fluoroscopy to Identify Phrenic Nerve Dysfunction Related to Electroporation
Pulsed Field Ablation (PFA) represents a recent advance in the treatment of atrial fibrillation (AF), with a safety profile potentially superior to traditional thermal techniques, such as radiofrequency or cryoablation.
- Trial name
- DEFINE-PFA (NCT07462910)
- Testing
- Dynamic fluoroscopy
- Where
- 9 sites in Canada, France and 1 more
- Volunteers
- 250 people
- Sponsor
- French Cardiology Society
Bariatric Surgery, Bariatric Surgery Candidate
Effect of Transcutaneous Electrical Nerve Stimulation on PODD in Bariatric Surgery Patients
Researchers aim to evaluate impact of transcutaneous electric nerve stimulator on the incidence of postoperative diaphragmatic dysfunction in patients living with obesity undergoing bariatric surgery
- Trial name
- NCT07569705
- Testing
- Transcutaneous nerve stimulator
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Neuromuscular Diseases, Congenital Diaphragmatic Hernia
Respiratory Muscles and Work of Breathing in Children
Respiratory muscle testing allows a quantitative assessment of inspiratory and expiratory muscles in children of any age with primary or secondary respiratory muscle impairment, in order to better understand the pathophysiology…
- Conditions
- Neuromuscular Diseases, Congenital Diaphragmatic Hernia, Lung Diseases, Cardiac Diseases
- Trial name
- WOB&MR_Ped (NCT05051254)
- Testing
- Esogastric pressure measurement
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Induced Diaphragm Dysfunction
A Post-Approval Multicenter Study to Assess the Continued Safety and Effectiveness of the AeroPace® System
A single-arm, prospective, multicenter cohort study to assess the 30-day continued safety and effectiveness of the AeroPace System in patients on mechanical ventilation (MV) at least 96 hours and who have not weaned.
- Trial name
- AERO-PAS (NCT07477054)
- Testing
- Lungpacer Diaphragm Pacing Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Lungpacer Medical Inc.
Diaphragm Dysfunction
Incidence and Impact of ICU-acquired Diaphragm Weakness
ICU survivors are at an increased risk of hospital and ICU readmission. Among the complications of ICU stay, diaphragmatic dysfunction is common, with a prevalence of 60 to 80%, and is associated with increased mortality and…
- Trial name
- PRODIGY (NCT06420999)
- Testing
- Diaphragmatic ultrasound and data collection
- Where
- France
- Volunteers
- 194 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator-induced Diaphragm Dysfunction, VIDD
Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients.
Up to 76% of ICU patients on mechanical ventilation develop significant respiratory muscle atrophy within the first 24 hours, contributing to prolonged ventilation, increased morbidity, and higher healthcare costs.
- Conditions
- Ventilator-induced Diaphragm Dysfunction, VIDD, Weaning Failure
- Trial name
- NCT07363902
- Testing
- Heecap
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Tesai Care SL
Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence
Shenfu Injection for the Prevention and Treatment of Ventilator Dependence in Mechanically Ventilated Patients
This multicenter randomized controlled trial aims to evaluate the efficacy of Shenfu Injection in preventing and treating ventilator dependence and ventilator-induced diaphragm dysfunction (VIDD) in critically ill adult patients…
- Conditions
- Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence, Ventilator Weaning
- Trial name
- NCT07880977
- Testing
- Shenfu Injection, 5% glucose injection
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine