Clinical trials: Diaphragmatic Dysfunction
Chronic Neck Pain
Effects of Manual Therapy and Exercise Training of Diaphragm in Patients With Chronic Neck Pain
Chronic neck pain is a commonly reported problem and often associated with functional disability. Studies showed that patients with chronic neck pain compensated with changes in breathing pattern.
- Trial name
- NCT04664842
- Testing
- Diaphragmatic Stretch Technique, Breathing Exercise Training
- Where
- Taiwan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- National Cheng Kung University
Respiratory Insufficiency, Pneumonia
Diaphragm Dysfunction and Ultrasound Perioperatively
This study aims at determining whether diaphragm ultrasound examining diaphragm thickening fraction, excursion and density before and after surgery can predict respiratory complications in the postoperative period.
- Conditions
- Respiratory Insufficiency, Pneumonia, Desaturation of Blood, Tachypnea
- Trial name
- DiaphPeriop (NCT05906030)
- Testing
- Diaphragm ultrasound
- Where
- 2 sites in Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Diaphragm Issues, Mechanical Ventilation Complication
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.
- Conditions
- Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
- Trial name
- DAM (NCT05211661)
- Testing
- Respiratory Muscle Testing
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University
Diaphragm Dysfunction, Mechanical Ventilation
A Biobank for Diaphragm Muscular Fiber
This non-interventional study focuses on mechanical ventilation used in intensive care unit to supplement ventilatory function in patients.
- Trial name
- BOTAN (NCT02900300)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Cardiac Surgery
Cardiac Surgery and Diaphragm Function
Diaphragm dysfunction is common after cardiac surgery and may delay weaning from mechanical ventilation and cause respiratory distress.
- Trial name
- NCT02208479
- Testing
- Non invasive ultrasound measurement of the diaphragm thickness during breathing
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Critical Illness, Mechanical Ventilation
Transcutaneous Diaphragm Electrical Stimulation in Critically Ill Patients
This study evaluates the effect of a transcutaneous electrical stimulation in critically ill patients compared to a sham electrical stimulation to decrease the incidence of diaphragm dysfunction before mechanical ventilation…
- Conditions
- Critical Illness, Mechanical Ventilation, Intensive Care Unit
- Trial name
- TESLA (NCT04171024)
- Testing
- Transcutaneous diaphragm electrical stimulation
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Groupe Hospitalier du Havre
Respiratory Distress Syndrome, Adult
Prevalence and Kinetics of Diaphragmatic Dysfunction in Elderly Patients With Acute Respiratory Distress
Acute respiratory distress (ARD) is one of the most frequent reasons for consultation and hospitalization in emergency medicine.
- Trial name
- OLDIA (NCT04520815)
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Diaphragmatic Paralysis
Effects of Inspiratory Muscle Training on Exertional Breathlessness in Patients With Unilateral Diaphragm Paralysis
Treatment options for unilateral diaphragm paralysis are limited. Diaphragmatic plication via mini thoracotomy is sometimes considered in the University Hospital Leuven if severe symptoms persist for longer than 12 months after…
- Trial name
- NCT04563468
- Testing
- Strength inspiratory muscle training, Endurance inspiratory muscle training
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Neuromodulation, Phrenic Nerve Stimulation
Randomized Study of the pdSTIM™ System in Failure to Wean Mechanically Ventilated Patients
This prospective, multi-center, randomized, controlled clinical trial is being conducted to evaluate the safety and efficacy of the pdSTIM System to facilitate weaning from mechanical ventilation through phrenic nerve…
- Conditions
- Neuromodulation, Phrenic Nerve Stimulation, Ventilator Induced Diaphragm Dysfunction, Mechanical Ventilation Weaning
- Trial name
- ReInvigorate (NCT05998018)
- Testing
- pdSTIM System Therapy, Conventional Medical Management
- Where
- 16 sites in United States
- Volunteers
- 32 people
- Sponsor
- Stimdia Medical Inc.
Diaphragm Dysfunction, COPD Exacerbation
Influence of Respiratory Mechanics on Diaphragmatic Dysfunction in COPD Patients Who Have Failed NIV (RHYDIAN)
Although non-invasive mechanical ventilation (NIV) is the gold standard treatment for patients with acute exacerbation of COPD (AECOPD) who develop respiratory acidosis, failure rate are still high ranging from 5% to 40%.
- Conditions
- Diaphragm Dysfunction, COPD Exacerbation, Mechanical Ventilation
- Trial name
- RHYDIAN (NCT03852394)
- Testing
- Respiratory mechanics assessment
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Modena and Reggio Emilia
Anesthesia
Diaphragmatic Dysfunction After Ultrasound-guided Supraclavicular Block With Single or Double Injection Technique
The investigators plan to determine the incidence of hemi-diaphragmatic paresis (HDP) with two commonly used techniques of supraclavicular nerve block, the single and double injection techniques.
- Trial name
- NCT02795598
- Testing
- Single injection supraclavicular nerve block, Double injection supraclavicular nerve block
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Diaphragmatic Dysfunction, Muscle Weakness
Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
The effect of neuromuscular blocking agents (NMBA, e.g. rocuronium) on respiratory muscle activity is well known. However, since the availability of sugammadex, to our knowledge, no study has been conducted to evaluate the effect…
- Conditions
- Diaphragmatic Dysfunction, Muscle Weakness, Muscle Fatigue
- Trial name
- SUDIA (NCT01962298)
- Testing
- sugammadex 2mg/kg, neostigmine, sugammadex 4mg/kg
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- University Hospital, Antwerp
Ventilator Induced Diaphragm Dysfunction
A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation
This clinical investigation is an open-label, multi-center RCT to demonstrate the safety and effective performance of the Lungpacer DPTS (plus standard of care) as compared to Control (standard of care only) in patients aged 18…
- Trial name
- RESCUE 3 (NCT03783884)
- Testing
- Lungpacer Diaphragm Pacing Therapy
- Where
- 33 sites in United States, France and 1 more
- Volunteers
- 223 people
- Sponsor
- Lungpacer Medical Inc.
Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation
Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients
Rationale: Patients with invasive mechanical ventilation (IMV) frequently develop diaphragm dysfunction and experience difficult weaning.
- Conditions
- Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation, Respiratory Failure, ICU
- Trial name
- DISSECT (NCT07819864)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- Radboud University Medical Center
COVID-19, Diaphragm Injury
Respiratory Muscles After Inspiratory Muscle Training After COVID-19
It is the aim of the current (follow-up) project for the first time in post-COVID-19 patients who continue to complain of shortness of breath and for whom there is no other explanation than possibly proven diaphragmatic weakness…
- Trial name
- NCT05582642
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- RWTH Aachen University
Weaning Failure
Can High Intensity Inspiratory Muscle Training Improve Inspiratory Muscle Strength and Accelerate Weaning in Medical Patients With Difficulty on Weaning?
Introduction: It has been described that invasive mechanical ventilation leads to diaphragm weakness. The inspiratory muscle weakness is related with a difficult and prolonged weaning as well as longer duration of mechanical…
- Trial name
- NCT04347317
- Testing
- Low Intensity IMT, High Intensity IMT
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Musculoskeletal Manipulations
Specific Effect of Foot Reflexology on Diaphragm Function
Diaphragm dysfunction, are refractory to drug therapy. This encourage investigators to explore new non-drug therapeutic paths, such as plantar reflexology (RP).
- Trial name
- FOOT (NCT04661774)
- Testing
- reflexology massage
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Ventilator Induced Diaphragmatic Dysfunction (VIDD)
PEPNS System Feasibility Study
The purpose of this feasibility study is to evaluate the safety and performance of the PEPNS System in patients that need to be mechanically ventilated for at least 48 hours and up to 7 days in the Intensive Care Unit (ICU).
- Trial name
- NCT03559933
- Testing
- PEPNS System
- Where
- 2 sites in Czechia, Ireland
- Volunteers
- 12 people
- Sponsor
- Stimdia Medical Inc.
Early Mobilization, Critically Ill
Effect of Early Extracorporeal Diaphragm Pacing Combined With Tilt Table in Ventilated Patients.
The aim of this study is to test the effect of 1week of extracorporeal diaphragm pacing (EDP) combined either with or without tilt table verticalization (TTV) on diaphragm function in patients with mechanical ventilation compared…
- Conditions
- Early Mobilization, Critically Ill, Mechanical Ventilation, Diaphragm Dysfunction
- Trial name
- NCT05953649
- Testing
- Extracorporeal Diaphragm Pacing, Tilt Table Verticalization, Conventional Physiotherapy
- Volunteers
- 90 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Diaphragmatic Dysfunction
3D Evaluation to Quantify Regional Volume Change Between FRC and TLC
The aim of this study is first to validate an IC measurement using analysis of two 3D acquisitions, and to appreciate the inter-observer variability of this IC measurement between a trained technician of respiratory function…
- Trial name
- MATH3D (NCT05339698)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris