Clinical trials: Diaphragms
GERD
Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients
Researchers are trying to determine if abdominal breathing exercises can reduce symptoms associated with GERD (Gastroesophageal reflux disease).
- Trial name
- NCT04120025
- Testing
- Diaphragm Training
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Mayo Clinic
Covid19
Respiratory Muscle Function, Dyspnea, Exercise Capacity and Quality of Life in Severe COVID19 Patients
Further knowledge regarding sequelae in severe COVID-19 patients who have required ICU admission for invasive mechanical ventilation is still needed.
- Trial name
- NCT04853940
- Testing
- Data collection and clinical testing of subjects
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University
Pompe Disease
Safety Study of Recombinant Adeno-Associated Virus Acid Alpha-Glucosidase to Treat Pompe Disease
Pompe disease is an inherited condition of acid alpha-glucosidase (GAA) deficiency resulting in lysosomal accumulation of glycogen in all tissues. Glycogen accumulation leads to muscle dysfunction and profound muscle weakness.
- Trial name
- NCT00976352
- Testing
- rAAV1-CMV-GAA (study agent) Administration, RMST
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Amyotrophic Lateral Sclerosis
Contribution of Diaphragmatic Ultrasound for Monitoring Diaphragmatic Function in Patients With Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease that occurs in adults. It is characterized by a progressive degeneration of the first and second motor neurons leading to muscle failure.
- Trial name
- ALSUS (NCT05352958)
- Testing
- Diaphragmatic ultrasound, Electro-physiological exploration of the diaphragm
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Chronic Obstructive Pulmonary Disease
Evaluation of Diaphragm in Chronic Obstructive Pulmonary Disease Patients by Ultrasound in Relation to Severity
The study of the diaphragm is an important point in the assessment of COPD patients. Ultrasonographic evaluation of the diaphragm is considered a simple, non-invasive, available bedside technique.
- Trial name
- NCT05035875
- Testing
- ultrasonography
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Enas Sayed Farhat
Contraception
A Safety Study Of The Caya® Diaphragm Used With ContraGel®
The purpose of this study is to evaluate the safety of ContraGel versus the hydroxyethylcellulose (HEC) Universal Placebo gel when used with the Caya diaphragm during two 7-day periods of daily use, the first without intercourse…
- Trial name
- NCT02462954
- Testing
- ContraGel
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- CONRAD
Congenital Diaphragmatic Hernia
North American Fetal Therapy Network for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia
The purpose of this study is to evaluate successful placement and removal of Fetoscopic Endoluminal Tracheal Occlusion (FETO) device in cases of intrathoracic liver herniation with isolated left congenital diaphragmatic hernia…
- Trial name
- NCT06739356
- Testing
- Fetal Treatment arm (FETO Group)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Respiration, Artificial
Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm
The aim of this study is to study the combined impact of mechanical ventilation and sepsis on the human diaphragm in order to establish the neutral, protective or destructive character of mechanical ventilation by studying the…
- Trial name
- SEPTIC (NCT03371602)
- Testing
- surgery, multi-organ sampling
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Hospices Civils de Lyon
Low Skeletal Muscle Mas
High- and Moderate-Intensity Inspiratory Muscle Training on Diaphragm Ultrasound Parameters, Cognition, and Mental Health
Low skeletal muscle mass during young adulthood may impair diaphragm function, cognition, sleep, and psychological well-being. Inspiratory muscle training (IMT) has been shown to improve respiratory muscle performance; however…
- Trial name
- NCT07757139
- Testing
- High-Intensity IMT, Moderate-Intensity IMT
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Neonatal Oxygen Desaturation, Premature
Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants
This research study is being done to investigate the effect of changing an infant's body position on how hard the baby works to breathe, the baby's oxygen level, the baby's carbon dioxide level, the baby's lung volume, the baby's…
- Conditions
- Neonatal Oxygen Desaturation, Premature, Ventilator Lung; Newborn, Apnea of Prematurity
- Trial name
- NCT05968586
- Testing
- Body positioning
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Milton S. Hershey Medical Center
Competitive Atheletes of Brazilian Jiu Jitsu
20 Competitive Athletes of Brazilian Jiu Jitsu Where Randomly Assigned in a Myofascial Diaphragm Release Technique or a Sham Technique in Order to Investigate the Immediate Effects of Thoracic Mobility and Chest Expansion
Thoracic injuries, in high level competitive Brazilian jiu jitsu (BJJ) athletes occupied a significant percentage of all musculoskeletal injuries in this population.
- Trial name
- Myofascial Rx (NCT07150039)
- Testing
- Manual therapy intervention (Chaitow's myofascial diaphragm release)
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Evdokia Billis
Prolonged Mechanical Ventilation
Serial Diaphragm Ultrasound Evaluation During Inspiratory Muscle Training in Prolonged Mechanical Ventilation
Diaphragm dysfunction contributes to prolonged mechanical ventilation (PMV) and difficult weaning. Inspiratory muscle training (IMT) may improve respiratory muscle performance, while serial diaphragm ultrasound offers a bedside…
- Trial name
- NCT07709793
- Testing
- High intensity IMT, Low intensity IMT
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Congenital Diaphragmatic Hernia, Omphalocele
Functional Evaluation of the Fetal Lung by Functional Magnetic Resonance Imaging - Blood Oxygenation Level Dependent (MRI-BOLD), in Congenital Diaphragmatic and Parietal Malformations
The objective is to evaluate the quality of the response to the Blood Oxygen Level Dependent effect in fetuses with diaphragmatic hernias and abdominal wall malformations and to correlate with postnatal respiratory outcome.
- Conditions
- Congenital Diaphragmatic Hernia, Omphalocele, Gastroschisis
- Trial name
- BOLD FETUS (NCT04186039)
- Testing
- Functional magnetic resonance imaging - Blood Oxygenation Level Dependent
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Failure (ARF), Dyspnea
Cervical Erector Spinae Plane Block for Dyspnea in Acute Respiratory Failure: A Prospective Cohort
Dyspnea is common and distressing in patients with acute respiratory failure. In our intensive care unit, some patients receive a cervical erector spinae plane (ESP) block to help relieve dyspnea.
- Trial name
- NCT07182695
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Hiatal Hernia
Reducing Postoperative Opioids in Patients Undergoing Laparoscopic Hiatal Hernia
This is a prospective randomized, double-blinded, controlled trial that will target enrollment of 46 subjects undergoing laparoscopic hiatal hernia repair surgery.
- Trial name
- NCT05953428
- Testing
- Opioid Sparing Anesthesia Protocol (OSA), Opioid Based Anesthesia Protocol (OBA)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Mechanical Ventilation, Weaning
Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients
the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.
- Trial name
- NCT05629819
- Testing
- Non-invasive phrenic nerve stimulation
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Bing Sun
Accuracy of DE and DTF in Prediction of Extubation Success
Diaphragm Ultrasound to Predict Weaning Outcomes in Mechanically Ventilated Patients
This trial enrolled all the adult patients who were mechanically ventilated for more than 48 hours and met all creteria for extubation.
- Trial name
- NCT03480828
- Testing
- comparaison between DE and DTF in prediction of extubation success
- Where
- Tunisia
- Volunteers
- 36 people
- Sponsor
- Mongi Slim Hospital
Low Back Pain, Diaphragm
The Effect of Diaphragm Muscle Training on Chronic Low Back Pain
Brief Summary: Low back pain is very common problem in all the developed countries and affects children to elderly. Based on the etiology the low back pain is divided into two type: nonspecific and specific low back pain.
- Trial name
- LBP_DT (NCT03600207)
- Testing
- Complex training, Diaphragm training
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Szeged University
GERD, Hiatal Hernia
Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair
This single-blind randomized control study will follow 142 subjects across 7 sites randomized on a 1:1 ratio to compare treatment efficacy and safety between TIF and LNF in GERD patients with hiatal hernia undergoing hernia…
- Trial name
- CTIF (NCT04795934)
- Testing
- LAPAROSCOPIC PARAESOPHAGEAL HIATAL HERNIA REPAIR COMBINED WITH TRANSORAL INCISIONLESS FUNDOPLICATION
- Where
- 7 sites in United States
- Volunteers
- 142 people
- Sponsor
- Mayo Clinic
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