Clinical trials: Diaphragms
Cerebral Palsy
Transcutaneous Diaphragmatic Electrical Stimulation and Pulmonary Function in Non-Ambulatory Cerebral Palsy
Does transcutaneous diaphragmatic electrical stimulation (TDES), added to a 6-week structured multimodal rehabilitation program, improve diaphragm function, head-neck control, and sitting balance in children with cerebral palsy…
- Trial name
- NCT07622875
- Testing
- Multimodal Rehabilitation, Transcutaneous diaphragmatic electrical stimulation (TDES)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Etlik City Hospital
Mechanical Ventilation Weaning
Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation
Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest…
- Trial name
- NCT06203353
- Testing
- diaphragm ultrasound monitoring
- Where
- Tunisia
- Volunteers
- 50 people
- Sponsor
- Mongi Slim Hospital
Congenital Diaphragmatic Hernia, Fetal Surgery
Fetal Surgery for Moderate Left Sided Congenital Diaphragmatic Hernia.
Isolated Congenital Diaphragmatic Hernia (CDH) can be diagnosed in the prenatal period, and remains associated with a 30 % chance of perinatal death and morbidity mainly because of pulmonary hypoplasia and pulmonary hypertension.
- Conditions
- Congenital Diaphragmatic Hernia, Fetal Surgery, Pulmonary Hypoplasia
- Trial name
- TOTAL moderate (NCT00763737)
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion
- Where
- 13 sites in United States, Australia and 8 more
- Volunteers
- 196 people
- Sponsor
- University Hospital, Gasthuisberg
Pes Planus, Diaphragm Issues
The Relationship Between Pes Planus, Diaphragm, Postural Control, and Plantar Pressure
Our primary aim is to compare diaphragm function (resting thickness, activity/resting thickness ratio indicating contractility), postural control, and plantar pressure between individuals with pes planus and healthy controls…
- Conditions
- Pes Planus, Diaphragm Issues, Plantar Pressure, Postural Control
- Trial name
- NCT06491212
- Testing
- Determination of Foot Deformity Level, Foot Function Index, UFAA-International Physical Activity Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Critical Illness, Muscle Weakness
Correlation Between Muscle Strength and Thickness in Critically Ill Patients
Mechanical ventilation (MV) is associated with adverse outcomes in ventilated patients, and impact of MV-induced diaphragm changes are still unclear.
- Trial name
- NCT06289244
- Testing
- Ultrasound, Muscle strength measurement
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ultrasonography, Low Back Pain
Ultrasonography Biofeedback for Diaphragm Training in Athletes With Lumbo-pelvic Pain
Objective: To determine the effectiveness of diaphragm biofeedback reeducation by ultrasonography in conjunction with high-intensity inspiratory muscle training versus isolated high-intensity inspiratory muscle training in…
- Trial name
- NCT04097392
- Testing
- Experimental, Active comparator
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Universidad de León
Gastroesophageal Reflux Disease, Hiatal Hernia
Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital
To study the long term outcome of Laparoscopic Hiatal Hernia Repair with human acellular dermal matrix Alloderm (LifeCell, Branchburg, NJ) mesh.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Paraesophageal Hernia
- Trial name
- NCT01776827
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Nebraska
ARDS (Moderate or Severe), Acute Hypoxemic Respiratory Failure
PEEP-induced Effects on Respiratory dRivE and EFfort
Rationale: In patients with acute hypoxemic respiratory failure (AHRF), preserving spontaneous breathing during mechanical ventilation offers physiological benefits, but also carries risks.
- Trial name
- REEF (NCT07203781)
- Testing
- PEEP level changes
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
PEEP by Lung Ultrasound, PEEP With Dynamic Compliance
Postoperative Diaphragm Function in Pediatric Laparoscopic Abdominal Surgery Using Compliance and PEEP Guided by Lung Ultrasound
Protective ventilation strategies and alveolar recruitment maneuvers (ARM) are employed in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) to improve oxygenation, prevent alveolar collapse…
- Trial name
- NCT07126067
- Testing
- Lung Ultrasound and PEEP Application, Application of PEEP with Dynamic Compliance
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Konya City Hospital
Paraesophageal Hernia
Effect of Hernia Sac Excision on Crural Tension in Paraesophageal Hernia Repair
Paraesophageal hernia can cause significant clinical symptoms, including reflux, chest pain, nausea, regurgitation, and even life threatening conditions such as bowel obstruction, and gastric volvulus.
- Trial name
- NCT07197619
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Corewell Health West
Diaphragm Ultrasound
Effects of Neostigmine-dose on Diaphragmatic Dynamics
The goal of this Randomized Clinical Trial is to compare the postoperative diaphragmatic excursion between patients receiving half-dose neostigmine (0.04 mg/kg) and those receiving full-dose neostigmine (0.08 mg/kg) for…
- Trial name
- DTF/DE/AChE (NCT06787638)
- Testing
- full dose of Neostigmine, half dose of Neostigmine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Laparoscopic Toupet Fundoplication, Radiological Negative
Laparoscopic Toupet's Fundoplication: Is it Proper Solution of Radiological Negative, Endoscopically Positive Hiatal Hernia Patients
This study aims to assess the feasibility and effectiveness of laparoscopic toupet fundoplication (LTF) for treating gastroesophageal reflux disease (GERD) symptoms and disease-specific Quality of Life (QoL).
- Conditions
- Laparoscopic Toupet Fundoplication, Radiological Negative, Endoscope, Hiatal Hernia
- Trial name
- NCT06884800
- Testing
- Laparoscopic toupet fundoplication
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Minia University
Heart Failure, Heart Failure and Reduced Ejection Fraction
Comparative Effects of Different Inspiratory Muscle Training Modalities in Patients With Heart Failure.
The purpose of this study is to compare the effects of three different modalities of inspiratory muscle training (IMT) in patients diagnosed with chronic heart failure who exhibit reduced or mid-range left ventricular ejection…
- Conditions
- Heart Failure, Heart Failure and Reduced Ejection Fraction, Heart Failure and Mildly Reduced Ejection Fraction, Muscle Weakness
- Trial name
- IMT-HF-COMPARE (NCT07688863)
- Testing
- Mechanical Pressure-Threshold IMT Device, PowerBreathe KH2 Electronic IMT Device
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Universidad Nacional Andres Bello
Fear of Flying
Diaphragmatic Breathing During Virtual Reality Exposure Therapy for Aviophobia
The study investigated the effect of diaphragmatic breathing as an additional coping strategy during Virtual Reality Exposure Therapy in patients with aviophobia.
- Trial name
- NCT02990208
- Testing
- Diaphragmatic breathing, Virtual Reality Exposure Therapy
- Volunteers
- 30 people
- Sponsor
- University of Regensburg
Diaphragm Injury, Postoperative Complications
High Flow Nasal Cannula and Diaphragmatic Function
Prospective randomized study investigating the effect of postoperative oxygen delivery on diaphragmatic function. Two different modalities of oxygen delivery will be compared: high flow nasal cannula versus standard oxygen…
- Trial name
- NCT05532033
- Testing
- High flow nasal cannula, Facial mask
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- Università degli Studi di Ferrara
Respiratory Muscle Weakness, Mechanical Ventilation Weaning
Progressive Pressure Support Reduction as Inspiratory Muscle Endurance Training in Mechanically Ventilated Patients
Mechanical ventilation causes rapid diaphragm muscle atrophy, detectable within 18 hours of ventilator support, which is a major contributor to weaning failure and prolonged ICU stay.
- Conditions
- Respiratory Muscle Weakness, Mechanical Ventilation Weaning, Physiotherapy, Endurance Training
- Trial name
- inspira-rct (NCT07689110)
- Testing
- Progressive Pressure Support Reduction (IRT-PS), Standard ICU Care
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Umbilical Cord Clamping, Congenital Diaphragmatic Hernia
Physiological Umbilical Cord Clamping in Patients With Congenital Diaphragmatic Hernia. Clinical Trial
Congenital diaphragmatic hernia (CDH) is a malformation that affects 1 in every 3000 newborns. The diaphragm does not complete its closure during embryogenesis, which allows the abdominal organs to herniate into the thoracic…
- Conditions
- Umbilical Cord Clamping, Congenital Diaphragmatic Hernia, Delayed Umbilical Cord Separation
- Trial name
- NCT06408376
- Testing
- Physiological cord clamping
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Hospital JP Garrahan
Sleep Deprivation, Healthy Volunteers
Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.
The purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.
- Conditions
- Sleep Deprivation, Healthy Volunteers, Diaphragm
- Trial name
- NoSleepDiaph (NCT02725190)
- Testing
- Sleepless night, Normal sleep night
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Diaphragmatic Dysfunction
Incidence of Diaphragmatic Dysfunction After Non-Intubated Video-Assisted Thoracoscopic Surgery
The objective of this this single-center prospective longitudinal study is to evaluate the incidence of diaphragmatic dysfunction after non-intubated video-assisted thoracoscopic surgery (NIVATS).
- Trial name
- DYNASTY (NCT06486168)
- Testing
- NIVATS
- Where
- France
- Volunteers
- 120 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Pulmonary Disease, Chronic Obstructive
EVALUATION OF RESPIRATORY MECHANICS AND FUNCTIONALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
To associate a lean mass, peripheral muscle strength, kinematic thoracic-abdominal, respiratory metabolic response, mobility and diaphragmatic thickness, verifying its relation with the obstruction level of COPD
- Trial name
- NCT03086590
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
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