Clinical trials: Diaphragms
Congenital Diaphragmatic Hernia
Neurally Adjusted Ventilatory Assist for Neonates With Congenital Diaphragmatic Hernias
Congenital Diaphragmatic Hernias (CDH) are typically repaired surgically in the first few days of a neonate's life. Following surgical repair, infants usually require ventilatory support to ensure adequate oxygenation.
- Trial name
- NAN-C (NCT05839340)
- Testing
- Neurally Adjusted Ventilatory Assist, Assist Control Ventilation
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- King's College Hospital NHS Trust
Acute Dyspnea, Acute Respiratory Failure
Diaphragm Response in Elderly for Acute Monitoring
Acute dyspnea is a common cause of emergency department admissions among elderly patients. Acute respiratory failure is often multifactorial and requires rapid and reliable evaluation.
- Conditions
- Acute Dyspnea, Acute Respiratory Failure, Diaphragmatic Ultrasound
- Trial name
- DREAM (NCT07132268)
- Where
- 9 sites in France
- Volunteers
- 145 people
- Sponsor
- Centre Hospitalier de Bethune
Muscle Weakness, Critical Illness
Electromagnetic Stimulation of the Phrenic Nerve in Critically Ill Mechanically Ventilated Patients (STIMIT-II)
Ventilator-induced diaphragmatic dysfunction is a common issue in critically ill patients. Muscle stimulation has shown to have beneficial effects in muscle groups on the extremities.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication
- Trial name
- STIMIT-II (NCT05238753)
- Testing
- Non-invasive electromagnetic stimulation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
Hernia, Paraesophageal Hernia
Randomized, Prospective Controlled Trial of Paraesophageal Hernia Repair With Small Intestinal Submucosa (SIS)
The purpose of this randomized study is to determine whether a type of mesh derived from a layer of pig small intestine (SIS) is of benefit in treating paraesophageal hernias versus standard surgical suture repair.
- Trial name
- NCT00272922
- Testing
- hernia repair
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Cook Group Incorporated
Aging
Diaphragmatic Breathing Program In Older People
In the present study a program of respiratory physical therapy based on diaphragmatic breathing is applied in institutionalized old people, evaluating lung function parameters (FVC, FEV1, FEV1/FVC) and oxygen saturation.
- Trial name
- BP-OP (NCT03782779)
- Testing
- Breathing program and regular exercise, Regular Exercise
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Breathing Exercises
The Effect of Diaphragmatic Breathing Exercise on Pain, Anxiety, and Depression
Background: After total knee replacement (TKR) surgery, patients often experience intense levels of pain, stress, and anxiety that can adversely affect postoperative recovery.
- Trial name
- NCT04225169
- Testing
- Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Brachial Plexus Blockade
Single-shot Versus Slow Infusion Interscalene Block and Its Impact on Diaphragmatic Function in Patients Undergoing Shoulder Surgery.
Interscalene brachial plexus block is a commonly chosen anesthetic technique for shoulder and proximal arm surgery yet it carry several risks including phrenic nerve block.
- Trial name
- NCT06820853
- Testing
- Diaphragmatic excursion evaluation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
GERD, Hiatal Hernia
Can EndoFLIP Improve Quality of Life Before and After Fundoplication?
Patients with reflux disease (heart burn), or a hiatal hernia, who do not get better with medication, may have surgery to help with their symptoms. Unfortunately, there is no agreed upon way to perform the surgery.
- Trial name
- NCT06159972
- Testing
- EndoFLIP
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Wiley Chung
Heart Failure
Diaphragmatic Functional Electrical Stimulation in Heart Failure
Heart failure is an incapacity to provide adequate blood flow to the others organs, such as brain, liver and kidney. The patients presents weakness and fatigue of inspiratory muscles, mainly diaphragm muscle, that contributes to…
- Trial name
- NCT02931708
- Testing
- Diaphragm functional electrical stimulation
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Septic Shock
Muscle Ultrasound Study in Shock Patients
Intensive Care Unit (ICU) patients are known to lose muscle mass and function for many reasons, ranging from prolonged immobilization, to the effects of ICU treatments such as mechanical ventilation (MV), to the critical illness…
- Trial name
- MUSiShock (NCT04550143)
- Testing
- Diaphragm ultrasound (DUS), Peripheral Muscle Ultrasound (PMUS), Airway occlusion pressure (P0.1)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Hiatus Hernia, Gastreoesophageal Reflux Disease
Phrenoesophageal Ligament Reconstruction With Mesh
Introduction: The phrenoesophageal ligament (PEL) is a crucial structure that attaches the esophagus to the diaphragm, allowing for independent movement during respiration and swallowing.
- Trial name
- NCT07251010
- Testing
- Phrenoesophageal Ligament Reconstruction with Mesh: A New Approach to Hiatal Hernia Repair (Alinasser's Technique), Classic approach
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Clinical Trial Aseer
Hiatal Hernia With Gastroesophageal Reflux Disease
Comparison of Laparoscopic Nissen Fundoplication and Hill-Snow Repair for Hiatus Hernia With Endoscopic Evaluation
The goal of this clinical trial is to compare the clinical efficacy and safety of laparoscopic Nissen fundoplication (LNF) versus laparoscopic Hill-Snow repair (LHS) in the management of patients with congenital hiatus hernia, to…
- Trial name
- NCT07387042
- Testing
- Laparoscopic Hill-Snow repair, Laparoscopic Nissen Fundoplication
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Postoperative Pain, Shoulder Arthroscopic Surgeries
Interscalene Block Versus Infraspinatus-Teres Minor Interfascial Plane Block for Shoulder Arthroscopy
This prospective randomized controlled study aims to compare the effects of interscalene block, infraspinatus-teres minor interfascial plane block, and a control group on postoperative analgesia and diaphragmatic function in…
- Conditions
- Postoperative Pain, Shoulder Arthroscopic Surgeries, Diaphragmatic Dysfunction
- Trial name
- NCT07670780
- Testing
- Ultrasound-Guided Interscalene Block, Ultrasound-Guided Infraspinatus-Teres Minor Interfascial Plane Block
- Volunteers
- 120 people
- Sponsor
- TC Erciyes University
Perioperative Respiratory Function, Diaphragmatic Dysfunction
LTV (Low Tidal Volüme) Ventilation and Diaphragmatic Motion in CABG (Coronary Artery Bypass Grafting)
The goal of this clinical trial is to evaluate whether low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) surgery helps preserve diaphragmatic excursion in adult patients undergoing coronary artery bypass…
- Conditions
- Perioperative Respiratory Function, Diaphragmatic Dysfunction, Low Tidal Volume Ventilation
- Trial name
- NCT07067684
- Testing
- Low Tidal Volume Ventilation During CPB
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Esophageal Cancer, Postoperative Complications
Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches
Worldwide, esophageal cancer is the 6th most common cause of cancer-related death. Currently curative resection remains the cornerstone of the therapy.
- Conditions
- Esophageal Cancer, Postoperative Complications, Diaphragm, Pulmonary Function
- Trial name
- NCT01053182
- Testing
- Ivor-Lewis Esophagectomy, Sweet Esophagectomy
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Sichuan University
Ventilator Induced Diaphragm Dysfunction
Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing (RESCUE1)
An early feasibility study to investigate the safety and feasibility of the Lungpacer Diaphragm Pacing Therapy System (DPTS) as a therapy to recondition and strengthen the diaphragm of patients who have been intubated and…
- Trial name
- RESCUE1 (NCT03107949)
- Testing
- Lungpacer DPTS (Diaphragm Pacing Therapy System)
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Lungpacer Medical Inc.
Mechanical Ventilation
TEDS in Prolonged Mechanical Ventilation
Muscle atrophy and diaphragm dysfunction are common with prolonged mechanical ventilation (PMV). Electrical stimulation has been shown to be beneficial in severe chronic heart failure and chronic obstructive pulmonary disease.
- Trial name
- TEDS (NCT04741724)
- Testing
- TEDS
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- Chang Gung University
Hernia, Diaphragmatic, Hypertension, Pulmonary
Chronic Sildenafil for Severe Diaphragmatic Hernia
The purpose of this study is to test if sildenafil is effective in the treatment of infants with severe congenital diaphragmatic hernia (determined by the presence of prolonged pulmonary hypertension or prolonged oxygen…
- Conditions
- Hernia, Diaphragmatic, Hypertension, Pulmonary, Hypoplasia, Pulmonary
- Trial name
- NCT00133679
- Testing
- sildenafil
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Acute Respiratory Distress Syndrome, Diaphragm Injury
Re-Evaluation of Systemic Early Neuromuscular Blockade and Transthoracic Ultrasound Assessment of the Diaphragm
ROSETTA is a multi-centre study evaluating the time course of diaphragm thickness and function following exposure to neuromuscular blockade or control in patients with acute respiratory distress.
- Conditions
- Acute Respiratory Distress Syndrome, Diaphragm Injury, Neuromuscular Blockade
- Trial name
- ROSETTA (NCT03132896)
- Where
- 6 sites in United States
- Sponsor
- University Health Network, Toronto
Breathing Exercises
Comparative Effects of ACBT and Diaphragmatic Breathing on Pulmonary Function and Sputum Diary After CABG
To compare the effects of active cycle of breathing technique and diaphragmatic breathing on pulmonary functions and sputum diary after coronary artery bypass graf
- Trial name
- NCT05936788
- Testing
- Active cycle of breathing technique, diaphragmatic breathing
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
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