Clinical trials: Diaphragms
Cirrhosis of the Liver, Ascites
Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings
The goal of this observational study is to learn how liver cirrhosis affects the diaphragm, the main muscle used for breathing, in adults.
- Conditions
- Cirrhosis of the Liver, Ascites, Pleural Effusion Disorder, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07667608
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Respiratory Muscles, Electromyography
Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade
It was recently shown that neostigmine reversal was associated with increased atelectasis and that high-dose neostigmine was associated with longer postoperative length of stay and with an increased incidence of pulmonary edema…
- Trial name
- REDNESII (NCT02403063)
- Testing
- Sugammadex, Neostigmine, Neostigmine-sugammadex
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Onze Lieve Vrouw Hospital
Congenital Diaphragmatic Hernia
Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia
The purpose of this study is to evaluate the safety and efficacy of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in cases of severe Congenital Diaphragmatic Hernia (CDH).
- Trial name
- NCT06946576
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion (FETO) Procedure
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Respiratory Distress Syndrome, Newborn, Infant, Premature
Neural Control of Non-invasive Ventilation in the Preterm
The present study will use a new type of respirator in premature babies who need help with their breathing. This new respirator uses signals from the baby's diaphragm - the most important breathing muscle - to control the timing…
- Trial name
- NCT00368485
- Testing
- Neurally Controlled Mechanical Ventilation
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Diaphragmatic Plication, Diaphragmatic Paralysis
Short- and Long-term Effects of Robot-assisted Plication in Diaphragmatic Paralysis
Diaphragmatic paralysis may lead to severe symptoms such as breathlessness and reduced physical capacity. Diaphragmatic plication using Robotic-Assisted Thoracic Surgery (RATS) is a minimally invasive surgical technique developed…
- Conditions
- Diaphragmatic Plication, Diaphragmatic Paralysis, Diaphragmatic Eventration
- Trial name
- RAPIDLY (NCT06919185)
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala County Council, Sweden
DIAPHRAGM -Ultrasound -Weaning -Mechanical Ventilation
Diaphragm Training Ultrasound
Common neurological indications of intubation and initiation of mechanical ventilation (MV) include ischemic and hemorrhagic stroke, neurotrauma, and intracranial hemorrhage.
- Trial name
- DiaphUS (NCT04186325)
- Testing
- DIAPHRAGMATIC exercising
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Diaphragm Paralysis
The Effect of Interscalene Peripheral Nerve Block With 0.25% Bupivacaine vs 0.125% Bupivacaine on Lung Function
Peripheral nerve blocks are used to provide post-operative pain relief. Nerve blocks in the neck, in the interscalene area, provide pain relief after shoulder surgery but can cause temporary weakness or paralysis of the…
- Trial name
- NCT01429584
- Testing
- interscalene nerve block with 0.25% bupivacaine, interscalene block with 0.125% bupivacaine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction
Multimodal Assessment of NMES Effects on Respiratory and Peripheral Muscles in COPD
The goal of this clinical trial is to learn if targeted neuromuscular electrical stimulation (NMES) can treat respiratory and peripheral muscle weakness in patients with chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction, Muscle Weakness
- Trial name
- NMES in COPD (NCT07910006)
- Testing
- Neuromuscular Electric Stimulation, Exercise
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Padjadjaran
Diaphragm
Effects of Transcutaneous Electrical Phrenic Nerve Stimulation and Transcutaneous Electrical Diaphragmatic Stimulation
Transcutaneous electrical phrenic nerve stimulation (TEPNS) and transcutaneous electrical diaphragm stimulation (TEDS) are modalities that use surface electrodes placed on the patients' skin to generate action potentials and…
- Trial name
- NCT06339632
- Testing
- Transcutaneous electrical phrenic nerve stimulation (TEPNS), Transcutaneous electrical diaphragm stimulation (TEDS)
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Test Anxiety, Diaphragmatic Breathing
Diaphragmatic Breathing Exercises on Stress and Exam Anxiety in High School Seniors: A Randomized Study
This study aims to evaluate the effect of diaphragmatic breathing exercises on stress and exam anxiety in final-year high school students during the exam period.
- Conditions
- Test Anxiety, Diaphragmatic Breathing, Stress Measurement, Psychological
- Trial name
- NCT06949202
- Testing
- breating exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Igdir University
Congenital Diaphragmatic Hernia
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) occurs when the diaphragm, the muscle that separates the chest cavity from the abdominal cavity, does not form properly.
- Trial name
- NCT01098929
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hepatocellular Carcinoma (HCC)
Efficacy Evaluation of Microwave Ablation Assisted by Diaphragm Hydrodissection for Hepatocellular Carcinoma and Comparative Analysis With Surgical
The goal of this observational study is to evaluate the local efficacy and safety of hydrodissection-assisted microwave ablation for patients with hepatocellular carcinoma, and to compare its therapeutic outcomes with surgical…
- Trial name
- NCT07815054
- Testing
- Microwave Ablation Assisted by Diaphragm Hydrodissection, Surgical Resection
- Volunteers
- 200 people
- Sponsor
- The First Hospital of Jilin University
Congenital Diaphragmatic Hernia, Fetal Surgery
Fetal Surgery for Moderate Left Sided Congenital Diaphragmatic Hernia.
Isolated Congenital Diaphragmatic Hernia (CDH) can be diagnosed in the prenatal period, and remains associated with a 30 % chance of perinatal death and morbidity mainly because of pulmonary hypoplasia and pulmonary hypertension.
- Conditions
- Congenital Diaphragmatic Hernia, Fetal Surgery, Pulmonary Hypoplasia
- Trial name
- TOTAL moderate (NCT00763737)
- Testing
- Fetoscopic Endoluminal Tracheal Occlusion
- Where
- 13 sites in United States, Australia and 8 more
- Volunteers
- 196 people
- Sponsor
- University Hospital, Gasthuisberg
Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence
Shenfu Injection for the Prevention and Treatment of Ventilator Dependence in Mechanically Ventilated Patients
This multicenter randomized controlled trial aims to evaluate the efficacy of Shenfu Injection in preventing and treating ventilator dependence and ventilator-induced diaphragm dysfunction (VIDD) in critically ill adult patients…
- Conditions
- Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence, Ventilator Weaning
- Trial name
- NCT07880977
- Testing
- Shenfu Injection, 5% glucose injection
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Congenital Central Hypoventilation Syndrome
International Congenital Central Hypoventilation Syndrome (CCHS) Registry and CCHS SHARE
The Center for Autonomic Medicine in Pediatrics (CAMP), in collaboration with leading CCHS clinicians, scientists, and patient advocacy groups around the world has built the first International CCHS (Congenital Central…
- Trial name
- NCT03088020
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Ilya Khaytin
Congenital Diaphragmatic Hernia
Neurally Adjusted Ventilatory Assist for Neonates With Congenital Diaphragmatic Hernias
Congenital Diaphragmatic Hernias (CDH) are typically repaired surgically in the first few days of a neonate's life. Following surgical repair, infants usually require ventilatory support to ensure adequate oxygenation.
- Trial name
- NAN-C (NCT05839340)
- Testing
- Neurally Adjusted Ventilatory Assist, Assist Control Ventilation
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- King's College Hospital NHS Trust
Diaphragm; Relaxation
Effect of Transversus Abdominis Plane Block on Diaphragm Thickness
Hypothesis: Postoperative pain, by preventing effective diaphragmatic contraction, hinders deep inspiration and expiration. Inspiratory and expiratory levels can be assessed by measuring diaphragm thickness using…
- Trial name
- NCT06230289
- Testing
- Transabdominal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Konya City Hospital
Respiratory Insufficiency Requiring Mechanical Ventilation
Effects of Neuromuscular Electrical Stimulation on Critically Ill Patients With Mechanical Ventilation
Up to 25% of patients who require mechanical ventilation (MV) more than seven days in the intensive care unit (ICU) develop muscle weakness, which comprises deep muscle weakness , including the respiratory muscles.Early active…
- Trial name
- NCT05217511
- Testing
- Neuromuscular Electrical Stimulation
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Diaphragm Issues
Reliability of Diaphragm Ultrasound: Intra- and Interrater Analysis
It is often difficult for anesthesiologists to select an ultrasound method that will give consistent results and also be a reliable way to examine the diaphragm, especially on the left side of the chest.
- Trial name
- ReDU analysis (NCT07747532)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- University Health Network, Toronto
Post COVID-19 Condition
Effect of Kinesio Tape Versus Diaphragmatic Breathing Exercise In Post COVID-19
According to WHO, current evidence suggests some people experience a variety of long-term effects after they recover from their initial illness. These effects are collectively known as post COVID-19 condition or "long COVID.
- Trial name
- NCT05770193
- Testing
- Pursed lip breathing, Cognitive Behavior Therapy, Diaphragmatic breathing exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
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