Clinical trials: Diarrheal Disease
Healthy Volunteers
Effects of Lactobacillus Casei on Respiratory and Gastrointestinal Diseases in Adults
This project aims to study the benefits of probiotics namely Lactobacillus casei Zhang (LCZ) in prevention of upper respiratory and gastrointestinal illnesses, which are found common among adults in Malaysia aged from 18 to 81…
- Trial name
- NCT02541539
- Testing
- Lactobacillus casei Zhang
- Where
- Malaysia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Diarrhea
Evaluation of a mHealth Platform for Diarrheal Disease Decision-support
The study hypothesis is that clinical decision-support on a smartphone for the management of diarrheal disease will improve the assessment of dehydration, reduce IV fluid usage, and increase guideline adherence for the use of…
- Trial name
- NCT03154229
- Testing
- Smartphone-based decision-support, Paper-based decision-support, Pre-Assessment of practices
- Where
- Bangladesh
- Volunteers
- 4,975 people
- Sponsor
- University of Florida
Diarrhea Infectious, Cholera
Testing a Scalable Model of the Cholera Hospital-Based Intervention for 7 Days (CHoBI7)
The findings from previous recent randomized controlled trials of The Cholera Hospital Based Intervention for 7 Days (CHoBI7) demonstrated that this intervention was effective in significantly reducing symptomatic cholera…
- Trial name
- CHoBI7 (NCT06498817)
- Testing
- Standard Recommendation, CHoBI7 Scale-Up Program
- Where
- Bangladesh
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Total Urinary Arsenic, Total Arsenic in Water
Assessing the Effectiveness of a Water Filter Technology as an Arsenic Mitigation Strategy in West Bengal
The purpose of this study is to determine whether the use of a point-of-use water filtration technology can reduce the Arsenic content in drinking water and reduce the Arsenic body burden.
- Conditions
- Total Urinary Arsenic, Total Arsenic in Water, Diarrhoeal Disease
- Trial name
- NCT02372851
- Testing
- Pureit As+ Filter
- Where
- India
- Volunteers
- 362 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Diarrhea
Impact of the Nutritional Product PTM202 on Acute and Long-Term Recovery From Childhood Diarrheal Disease
This trial will assess the impact of the nutritional product PTM202 on childhood diarrhea in Guatemalan children. The product is based on cow-milk colostrum and egg.
- Trial name
- NCT02385773
- Testing
- PTM202, Enfamil Puramino
- Where
- 2 sites in Guatemala
- Volunteers
- 321 people
- Sponsor
- University of Colorado, Denver
Irritable Bowel Syndrome, Diarrhea
Fecal Microbiota Transplantation for IBS
The purpose of this study is to learn the efficacy and safety of fecal microbiota transplantation (FMT) using stool from a donor with low proteolytic activity and containing the bacteria Alistipes putredinis in patients with…
- Trial name
- NCT05776914
- Testing
- Donor Fecal Microbiota Transplantation, Autologous Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Madhusudan (Madhu) Grover, MBBS
Diarrhoea
Introduction of Hypo-osmolar ORS for Routine Use
The World Health Organization has very recently recommended the routine use of a hypo-osmolar ORS in the management of diarrhoeal diseases.
- Trial name
- NCT00244777
- Testing
- Hypo-osmolar ORS
- Where
- Bangladesh
- Volunteers
- 75,000 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Diarrhoea, Clostridium Difficile
Proof-of-Concept, Calcium Aluminosilicate Anti-Diarrheal (CASAD) for Treatment of Clostridium Difficile Infection
Clostridium difficile (C. difficile) can cause symptoms ranging from mild diarrhea to life-threatening colitis. Illness from C. difficile most commonly affects patients in hospitals and long-term care facilities and typically…
- Trial name
- NCT01570634
- Testing
- Calcium Aluminosilicate Anti-Diarrheal (CASAD)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Salient Pharmaceuticals Incorporated
Diarrheal Disorder
Long-term Impact and Intervention for Diarrhea in Brazil
The primary objectives of this study are to determine the effect of 1 year supplementation of Vitamin A, Zinc, and Vitamin A plus Zinc compared to placebo on the Height for Age Z Score (HAZ) and the number of episodes of diarrhea…
- Trial name
- NCT00133406
- Testing
- Glutamine, Vitamin A, glycine
- Where
- Brazil
- Volunteers
- 321 people
- Sponsor
- University of Virginia
Diarrhea
Registry and Clinical Observation of Children With Diarrhoeal Disease
This Study based on the actual clinical diagnosis and treatment of data, evaluate the clinical characteristics of children with diarrhea Therapeutic effect and security, and establish the platform to childhood diarrhea…
- Trial name
- NCT05052489
- Testing
- registy
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Zhejiang University
Intestinal Helminthiasis, Diarrhea
The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
Cheap and effective drugs called 'anthelmintics' are routinely administered to children in developing countries to eliminate infections by parasitic helminths.
- Trial name
- NCT02597556
- Testing
- Albendazole
- Where
- Vietnam
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Non-erosive Reflux Disease/Diarrheal Irritable Bowel Syndrome
Study on the Rule and Mechanism of Treating Functional Gastrointestinal Diseases From the Perspective of Liver and Spleen
To clarify the changes of intestinal flora - gut - brain axis in FGIDs patients represented by NERD disharmony of liver and stomach and IBS-D disharmony of liver and spleen, and confirm that the imbalance between intestinal flora…
- Trial name
- NCT04454996
- Testing
- tong-jiang granules, Chang 'an II Recipe
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
HIV Infections
Botswana Diarrheal Diseases Study
The goals of this study are to: 1. determine the diarrheal rates, morbidity, mortality, and pathogens present among breast-fed infants born to HIV-infected mothers.
- Trial name
- NCT00197652
- Where
- Botswana
- Volunteers
- 1,350 people
- Sponsor
- Harvard School of Public Health (HSPH)
Cholera, Diarrhea
Impact Evaluation of Urban Water Supply Improvements on Cholera and Other Diarrhoeal Diseases in Uvira, Democratic Republic of Congo
The aim of the study is to evaluate the impact of a large-scale urban water supply improvement intervention on cholera and other diarrhoeal diseases.
- Trial name
- NCT02928341
- Testing
- Improved water supply
- Where
- Democratic Republic of the Congo
- Volunteers
- 4,556 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Chemotherapeutic Agent Toxicity, Colorectal Cancer
Calcium Aluminosilicate Anti-Diarrheal in Treating and Preventing Diarrhea in Patients With Metastatic Colorectal Cancer Receiving Irinotecan
RATIONALE: Calcium aluminosilicate anti-diarrheal (CASAD) may help treat and prevent diarrhea caused by irinotecan. It is not yet known whether CASAD is more effective than a placebo in treating and preventing diarrhea in…
- Conditions
- Chemotherapeutic Agent Toxicity, Colorectal Cancer, Diarrhea
- Trial name
- NCT00748215
- Testing
- calcium aluminosilicate anti-diarrheal
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Diarrhoea
Double-blinded Trial of Household-based Chlorination in India
The proposed study is a 12-month double-blinded, randomized, placebo-controlled trial to determine if the impact of treating water with chlorine at the household level is effective in preventing diarrhea among young children.
- Trial name
- NCT01202383
- Testing
- Household-based water treatment with NADCC tablets
- Where
- India
- Volunteers
- 2,163 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Diarrhea
Safety of Lactobacillus LB Postbiotic in Immunocompromised Paediatric Patients With Diarrhoeal Disease
This prospective, interventional, single-center, open-label, phase 1 clinical trial to assess the safety of the Postbiotic Lactobacillus LB in immunocompromised paediatric patients with diarrhoeal disease will be performed at…
- Trial name
- NCT07758933
- Testing
- Lactobacillus LB
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Diarrhea
Epidemiology of Diarrheal Diseases in Pediatric Oncology Patients
Diarrhea is a common problem in the pediatric population. Children with cancer are especially at increased risk for gastrointestinal infection-related morbidity and mortality due to their ongoing immunosuppression.
- Trial name
- NCT02464098
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- St. Jude Children's Research Hospital
Diarrhea Infectious, Algorithms
The Acceptability and Impact of Diarrheal Etiology Prediction (DEP) Algorithm
This is a randomized crossover study, where clinicians will be randomized to periods where they will use a rehydration calculator application with or without the Diarrheal Etiology Prediction (DEP) algorithm.
- Conditions
- Diarrhea Infectious, Algorithms, Decision Support Systems, Clinical, Clinical Decision-Making
- Trial name
- NCT04602676
- Testing
- Rehydration calculator application with DEP algorithm, Rehydration calculator application
- Where
- 2 sites in Bangladesh, Mali
- Volunteers
- 30 people
- Sponsor
- University of Utah
Gastroenteritis
Impact of Emergency Department Probiotic Treatment of Diarrheal Illness on Daycare Attendance
The objective of this study is to determine for previously healthy children, who present to an ED with acute gastroenteritis, if the probability of daycare absenteeism is significantly different in those who receive a probiotic…
- Trial name
- NCT00760773
- Testing
- Lacidophil (experimental high dose), Lacidophil (experimental standard dose)
- Where
- 3 sites in Canada
- Volunteers
- 132 people
- Sponsor
- The Hospital for Sick Children