Clinical trials: Diarrheal Diseases
Diarrhoeal Disease
Evaluation of a Multiple Behaviour Programme for Diarrhoea Management
Control of diarrhoeal disease requires a comprehensive package of preventive and curative interventions. in Zambia, the Programme for Awareness and Elimination of Diarrhoea (PAED) aims to reduce child deaths by combating…
- Trial name
- NCT02081521
- Testing
- Community behaviour change campaign
- Where
- Zambia
- Volunteers
- 640 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Acute Respiratory Infection, Diarrheal Disease
Efficacy and Tolerance of a Follow-On Formula Fed to Children From 12-48 Months of Age in Salvador, Bahia, Brazil
The purpose is to determine if the consumption of study product has an effect on acute respiratory infections and/or diarrheal disease.
- Trial name
- NCT01431469
- Testing
- Cow's milk, Follow-On Formula
- Where
- Brazil
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Dietary Rice Bran Supplementation
Pilot Feasibility of Rice Bran Supplementation in Nicaraguan Children
The purpose is to assess feasibility of rice bran consumption in weaning children and collect pilot data on gut microbiome and metabolome modulation with rice bran intake for diarrheal prevention.
- Trial name
- NCT02615886
- Testing
- Observational Control, Rice bran
- Where
- 2 sites in United States, Nicaragua
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Antibiotic-Associated Diarrhea, Clostridium Difficile
Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy
To determine whether symptomatic treatment of the diarrhea in CDAD reduces morbidity and mortality of this serious nosocomial infection in patients who have antibiotic-associated diarrhea. Both C.
- Trial name
- loperamide (NCT00591357)
- Testing
- loperamide
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Diarrhea Infectious, Cholera
Testing a Scalable Model of the Cholera Hospital-Based Intervention for 7 Days (CHoBI7)
The findings from previous recent randomized controlled trials of The Cholera Hospital Based Intervention for 7 Days (CHoBI7) demonstrated that this intervention was effective in significantly reducing symptomatic cholera…
- Trial name
- CHoBI7 (NCT06498817)
- Testing
- Standard Recommendation, CHoBI7 Scale-Up Program
- Where
- Bangladesh
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diarrheal Illnesses, Respiratory Illness
A Trial of Zinc and Micronutrients in Tanzanian Children
A randomized clinical trial of multiple micronutrients, zinc, zinc + micronutrients, or placebo among 2400 children born to HIV-negative Tanzanian mothers.
- Conditions
- Diarrheal Illnesses, Respiratory Illness, Growth Faltering
- Trial name
- NCT00421668
- Testing
- Zinc, Multivitamins
- Where
- Tanzania
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Total Urinary Arsenic, Total Arsenic in Water
Assessing the Effectiveness of a Water Filter Technology as an Arsenic Mitigation Strategy in West Bengal
The purpose of this study is to determine whether the use of a point-of-use water filtration technology can reduce the Arsenic content in drinking water and reduce the Arsenic body burden.
- Conditions
- Total Urinary Arsenic, Total Arsenic in Water, Diarrhoeal Disease
- Trial name
- NCT02372851
- Testing
- Pureit As+ Filter
- Where
- India
- Volunteers
- 362 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Healthy Volunteer
CampETEC Hyperimmune Bovine Colostrum (HBC)
Gastrointestinal infections cause significant morbidity in the form of acute diarrheal illness in the United States (US) and among travelers to low- and middle-income countries (LMICs).
- Trial name
- NCT06122870
- Testing
- CampETEC HBC product, ProMilk 85, C. jejuni CG8421 Challenge strain
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diarrhea
Meatsafe Food Storage and Diarrhea Prevention Trial in Urban Bangladesh
The goal of this clinical trial was to evaluate whether a simple household food storage cabinet called a "meatsafe" could reduce bacterial contamination of complementary foods and decrease diarrhea among children aged 6 to 24…
- Trial name
- NCT07332078
- Testing
- Meatsafe Food Storage Cabinet
- Where
- Bangladesh
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Rotavirus Infections
Surveillance of Hospitalizations Due to Rotavirus Infections Among Children From Israel
Objectives 1. To determine the burden and characteristics of rotavirus-associated hospitalizations among children under five years of age of northern Israel 2.
- Trial name
- NCT00484952
- Where
- 2 sites in Israel
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Diarrhoea
Double-blinded Trial of Household-based Chlorination in India
The proposed study is a 12-month double-blinded, randomized, placebo-controlled trial to determine if the impact of treating water with chlorine at the household level is effective in preventing diarrhea among young children.
- Trial name
- NCT01202383
- Testing
- Household-based water treatment with NADCC tablets
- Where
- India
- Volunteers
- 2,163 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Diarrhea
Randomized Controlled Field Trial of a Probiotics to Assess Its Role in Preventig Diarrhoea
A therapeutic as well as preventive role of probiotics has been suggested from results of different studies using different probiotics that have been tested, usually lactic acid producing bacteria such as lactobacillus…
- Trial name
- Yakult (NCT00534170)
- Testing
- Probiotic (Yakult)
- Where
- India
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Indian Council of Medical Research
Diarrhea
Impact of Hand Washing and WASH Educational Intervention on Under-five Diarrheal Diseases
The investigators evaluated the impact of water, sanitation and hygiene educational Intervention and hand washing with soap on the incidence of diarrhea among under-five children.
- Trial name
- WASH (NCT02779010)
- Testing
- Hand washing with soap and Health education
- Volunteers
- 1,190 people, healthy volunteers welcome
- Sponsor
- Ethiopian Institute of Water Resources
Diarrhoeal Disease, Respiratory Infection
Water Filters and Improved Cookstoves in Western Rwanda
DelAgua Health Rwanda (Implementation) Ltd. together with Rwanda Ministry of Health (MoH) are delivering an intervention, consisting on the free distribution of one advance water filter and one improved cookstove to all household…
- Conditions
- Diarrhoeal Disease, Respiratory Infection, Pneumonia
- Trial name
- NCT02239250
- Testing
- Water filter and cookstove
- Where
- Rwanda
- Volunteers
- 1,582 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Diarrhea
Impact of the Nutritional Product PTM202 on Acute and Long-Term Recovery From Childhood Diarrheal Disease
This trial will assess the impact of the nutritional product PTM202 on childhood diarrhea in Guatemalan children. The product is based on cow-milk colostrum and egg.
- Trial name
- NCT02385773
- Testing
- PTM202, Enfamil Puramino
- Where
- 2 sites in Guatemala
- Volunteers
- 321 people
- Sponsor
- University of Colorado, Denver
Respiratory Infection, Diarrheal Disease
Improved Respiratory Infection by Consuming Lactoferrin Fortified a2 Growing up Formula in Children of 2 to 3 Year Old
The goal of this observational study is to compare the incidence of ARI and/or diarrheal disease associated with feeding different formulas with and without lactoferrin supplement in children of 2-3 years old.
- Trial name
- NCT05670678
- Testing
- a2 growing up stage 3 formula puls lactoferrin supplement, Enfinitas growing up stage 3 formula
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Diarrhoea, Clostridium Difficile
Proof-of-Concept, Calcium Aluminosilicate Anti-Diarrheal (CASAD) for Treatment of Clostridium Difficile Infection
Clostridium difficile (C. difficile) can cause symptoms ranging from mild diarrhea to life-threatening colitis. Illness from C. difficile most commonly affects patients in hospitals and long-term care facilities and typically…
- Trial name
- NCT01570634
- Testing
- Calcium Aluminosilicate Anti-Diarrheal (CASAD)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Salient Pharmaceuticals Incorporated
Diarrhoea;Acute, Diarrhea, Infantile
Efficiency and Safety of Zinc Sulphate to Reduce the Duration of Acute Diarrheal Disease Between 6 and 59 Months of Age
This study evaluates the effect of zinc over the duration, severity and relapse of acute diarrheic disease, in children between 6 and 59 months of age.
- Trial name
- ESZnDiarrhea (NCT04061538)
- Testing
- zinc sulfate
- Where
- 9 sites in Mexico
- Volunteers
- 529 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Diarrheal Diseases
Effects of Multiple Interventions on Under-Five Diarrhea
Diarrhea is the leading cause of death, especially in developed nations. Though there are effective interventions, diarrhea remains the leading cause of death among children in Ethiopia
- Trial name
- NCT07158632
- Testing
- handwashing education, water chlorination, combined intervention
- Where
- Ethiopia
- Volunteers
- 835 people
- Sponsor
- Jimma University
HIV Infections
Botswana Diarrheal Diseases Study
The goals of this study are to: 1. determine the diarrheal rates, morbidity, mortality, and pathogens present among breast-fed infants born to HIV-infected mothers.
- Trial name
- NCT00197652
- Where
- Botswana
- Volunteers
- 1,350 people
- Sponsor
- Harvard School of Public Health (HSPH)