Clinical trials: Diarrhoea
Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction
Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
RATIONALE: Probiotic therapy may reduce or prevent gastrointestinal complications in patients undergoing chemotherapy and pelvic radiation therapy.
- Conditions
- Cognitive/Functional Effects, Constipation, Impaction, and Bowel Obstruction, Diarrhea, Fatigue
- Trial name
- NCT01473290
- Testing
- live freeze-dried lactic acid bacteria probiotic
- Sponsor
- Alliance for Clinical Trials in Oncology
Cryptosporidiosis
A Study to Characterize the Clinical Presentation and Course of Cryptosporidium in Pediatric Participants
This study aims to characterize the pediatric cryptosporidiosis disease profile with respect to clinical presentation.
- Trial name
- NCT07716410
- Where
- 4 sites in Kenya, Malaysia and 1 more
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Diarrhea, Infantile, Enteropathy
Whole Genome Sequencing Versus Whole Exome Sequencing for Congenital Diarrhea and Enteropahty
This study will seek to determine if whole genome sequencing (WGS) improves diagnostic rates, and outcomes for congenital diarrhea and enteropathy (CODE) patients.
- Trial name
- NCT04528303
- Testing
- Whole genome sequencing, Whole exome sequencing
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Children's Hospital of Fudan University
Irritable Bowel Syndrome (IBS)
Abdominal Symptom Phenotype Study in Children
Children and adults commonly suffer from recurrent abdominal (stomach) pain. One type is called irritable bowel syndrome (IBS). IBS in adults and children is one of the most common and costly health care problems in the US.
- Trial name
- ASPPNB (NCT01204515)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Diarrhea
Shigella WRSS1 Vaccine Trial in Bangladesh
This is a research study of an experimental (investigational) live attenuated Shigella sonnei vaccine (WRSS1) to find a dose of the vaccine that is safe, tolerable, and develops an immune response.
- Trial name
- NCT02934178
- Testing
- Shigella sonnei Strain WRSS1 Vaccine
- Where
- Bangladesh
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PATH
Irritable Bowel Syndrome
Association Between High Faecal Calprotectin, Increased Intestinal Permeability and Visceral Hypersensitivity in IBS-D Patients
Visceral hypersensitivity, low grade inflammation and increased intestinal permeability are three main pathophysiological mechanisms involved in irritable bowel syndrome. The connexion between these abnormalities is not known.
- Trial name
- SIIMPA (NCT02550704)
- Testing
- Colonoscopy with eleven biopsies in the left colon to assess intestinal permeability
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Rouen
Non-small Cell Lung Cancer, Advanced Solid Malignancies
A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline
This study is to determine the use of theophylline in patients with NSCLC and advanced solid malignancies and whether treatment with theophylline will help lower or diminish the side effect of diarrhea in patients taking…
- Trial name
- NCT02080078
- Testing
- Theophylline, Erlotinib
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- AHS Cancer Control Alberta
Cholera, Vibrio Infections
Safety and Immunogenicity of Single Dose Choleragarde® in HIV-Seropositive Adults
The purpose of this study is to assess the safety and immunogenicity of Peru-15 (CholeraGarde®) vaccine in HIV seropositive adult population of Bangkok Thailand
- Conditions
- Cholera, Vibrio Infections, Diarrhea
- Trial name
- NCT00741637
- Testing
- CholeraGarde®
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- International Vaccine Institute
Diarrhea, Cholera
PK Study of iOWH032 in Adult Male/Female Healthy Volunteers & Adult Males With Cholera
This study will assess if the pharmacokinetics, safety and tolerability of iOWH032 are grossly different in 1) Bangladeshi healthy population and 2) Bangladeshi cholera patients. This is not a hypothesis-driven research study.
- Trial name
- PISCES (NCT01823939)
- Testing
- iOWH032
- Where
- Bangladesh
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- PATH
Diarrhea
Prevention of Diarrheal Disease Due to Infection With Enterotoxigenic E. Coli (ETEC)
This is a Phase II b, double-blind, randomized, placebo-controlled study in healthy adults (age 18-65 years) to evaluate the safety, immunogenicity, different diagnostic tools and efficacy of ETVAX.
- Trial name
- NCT03729219
- Testing
- E. coli ETVAX
- Where
- Finland
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Scandinavian Biopharma AB
Hand-washing Behavior, Diarrhea
The Hope Soap Study: a Hand-washing Intervention Among Children in South Africa
The Hope Soap Study is a randomised-control pilot study of a hand-washing intervention in which children in treatment households received a bi-monthly delivery of HOPE SOAP©, a colourful, translucent bar of soap with a toy…
- Trial name
- NCT03280771
- Testing
- Hope Soap, Control group soap
- Volunteers
- 288 people
- Sponsor
- University of Cape Town
Diarrhoea;Acute
Efficacy of the Administration of Colloidal Silicon Dioxide in Tablet Dosage Form in Patients With Acute Diarrhea
The purpose of the study is to demonstrate the antidiarrheal efficacy of colloidal silicon dioxide in tablet dosage form (Carbowhite) in patients with acute diarrhea.
- Trial name
- NCT03633344
- Testing
- Carbowhite
- Volunteers
- 145 people
- Sponsor
- Omnifarma Kiev LLC
Colon Adenocarcinoma, Diarrhea
The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon
Many patients suffer from chronic diarrhoea after surgical treatment for cancer in the right side of the colon. The investigators' main hypothesis is that colon cancer patients with chronic diarrhoea have a higher risk of bile…
- Trial name
- NCT04003181
- Testing
- Antibiotics, Bile Acid Binder
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Traveler's Diarrhoea
Etiological Diagnosis of Traveler's Diarrhoea
Traveler's diarrhoea or turista is the most common disease in travelers. It has been reported based on studies in 20 to 60% of travelers, depending among other conditions and travel destinations.
- Trial name
- DIAVOY (NCT02866201)
- Testing
- Rectal swab
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Amebiasis
Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents
The purpose of this study is to determine the effect of nitazoxanide tablets in treating diarrhea caused by Entamoeba histolytica in adults and adolescents.
- Trial name
- NCT00366236
- Testing
- Nitazoxanide
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Romark Laboratories L.C.
Malaria, Respiratory Tract Infection Acute
Star Homes Project 2
Malaria, pneumonia and diarrhoea causes a lot of illness in children in Tanzania and the study want to find better ways of protecting people against these diseases and want to find out if the type of house design can affect the…
- Conditions
- Malaria, Respiratory Tract Infection Acute, Diarrhoea;Acute
- Trial name
- SHP2 (NCT04529434)
- Testing
- Star Homes, Traditional African houses
- Where
- Tanzania
- Volunteers
- 1,183 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Travel-Related Illness, Malaria
Infection Tracking in Travellers. The Project Aims to Identify Profiles of Travel-associated Illness and to Follow up on Long-term Sequelae of Arboviral Infections and Malaria
The investigators hypothesize that sex, age, area of exposure and purpose of travel are associated with different travel-related infections. The investigators also hypothesize that certain infections will have long-term sequelae.
- Conditions
- Travel-Related Illness, Malaria, Dengue, Chikungunya
- Trial name
- ITIT (NCT04672577)
- Testing
- Observational study
- Where
- Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Patricia Schlagenhauf
Irritable Bowel Syndrome, Diarrhea
Does Welchol (Colesevelam Hydrochloride) Improve Colonic Transit in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS)?
Our hypothesis is that the medication approved for treatment of high blood cholesterol levels, Colesevelam HCl (WELCHOL), decreases colonic transit and permeability in patients with diarrhea due to irritable bowel syndrome.
- Trial name
- welchol (NCT00911612)
- Testing
- Colesevelam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
COVID-19
Efficiency of the Imaging Strategy for the Management of Suspected Covid-19
Emergency departments have been placed at the heart of the patient triage strategy during the COVID-19 epidemic. In the absence of scientific knowledge on the most efficient strategy to put in place in emergency structures, the…
- Trial name
- EFFI-COVID-19 (NCT05077228)
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- University Hospital, Strasbourg, France
Irritable Bowel Syndrome
Fructose and Fructans in Irritabla Bowel Syndrome
The purpose of the study is to investigate if patients with Irritable Bowel Syndrome (IBS) who also report bloating are more likely to report clinically important gastrointestinal symptoms after consuming fructose or fructans…
- Trial name
- FABS (NCT01776853)
- Testing
- Glucose, Fructose, Fructans
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Nottingham