Clinical trials: Diarrhoea, open to volunteers
Renal Transplantation
Effect of Probiotics on Immunosuppressive-drug-associated Diarrhea Among Renal Transplant Recipients
The goal of this pilot project is to 1) examine whether oral administration of probiotics are helpful in reducing immunosuppressive drugs-associated diarrhea and adhering to the required dose of immunosuppressive drugs and 2)…
- Trial name
- NCT06150287
- Testing
- Florajen Digestion
- Volunteers
- 70 people
- Sponsor
- State University of New York - Upstate Medical University
Antibiotic Associated Diarrhea, Upper Respiratory Tract Infection
Effectiveness of Saccharomyces Boulardii in Prevention of Antibiotic Associated Diarrhea
Antibiotic-associated diarrhea (AAD) is a common adverse effect in pediatric patients receiving broad-spectrum antibiotics such as co-amoxiclav for upper respiratory tract infections (URTI).
- Trial name
- NCT07785206
- Testing
- Co-amoxiclav, Saccharomyces boulardii
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Infantile Colics, Constipation
Randomized, Blinded, Placebo-Controlled Evaluation of BioAmicus Complete
This is a randomized, single-blind, placebo-controlled study to evaluate the efficacy of the dietary supplement BioAmicus Complete (oral drops; a mixture of 10 strains of lacto- and bifidobacteria) in managing functional…
- Conditions
- Infantile Colics, Constipation, Infantile Diarrhea, Atopic Dermatitis
- Trial name
- NCT07444008
- Testing
- BioAmicus Complete
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- NovoNatum Ltd
Diarrhea Chronic, UC - Ulcerative Colitis
ND-12 Combined With H-6 for Adult Chronic Inflammatory Diarrhea
This is a randomized controlled trial to explore the efficacy and safety of ND-12 combined with H-6 for patients with chronic inflammatory diarrhea
- Trial name
- NCT07767370
- Testing
- mesalazine, ND-12, ND-12/H-6
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Clostridium; Difficile, As Cause of Disease Classified Elsewhere, Clostridium Difficile Diarrhea
Advantages and Disadvantages of TOXCLEAN As Add on Treatment to SOC in Patients with Clostridium Difficile-associated Diarrhea
This is a single center, randomized, exploratory clinical investigation that will evaluate the safety and efficacy of Toxclean (ABResearch srl) as add on treatment to Standard therapy in 24 patients with recurrent CDAD.
- Trial name
- NCT06839209
- Testing
- Toxclean 1g
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- ABResearch S.r.l.
IBS (Irritable Bowel Syndrome), IBS-D (Diarrhea-predominant)
Efficacy of Rifaximin With NAC in IBS-D
The purpose of this study is to examine the effectiveness of using a combination of a drug, rifaximin and a dietary supplement, N-acetyl-L-cysteine (NAC), to treat patients with irritable bowel syndrome with diarrhea (IBS-D).
- Trial name
- NCT06727422
- Testing
- rifaximin 66mg + N-acetylcysteine 560mg three times daily, RNIB21 containing rifaximin 132mg + N-acetylcysteine 560mg three times daily
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Mark Pimentel, MD
Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea
Effect of Consuming a Nutraceutical Composition on Signs and Symptoms in Adult Patients With Irritable Bowel Syndrome
Irritable bowel syndrome is characterized by the presence of chronic, recurrent abdominal pain, alterations in bowel habits, and abdominal distension. The medical diagnosis is made using the Rome IV criteria.
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome With Constipation, Irritable Bowel Syndrome Mixed
- Trial name
- NCT07103772
- Testing
- Ananá
- Where
- Mexico
- Volunteers
- 94 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Bile Acid Diarrhea
The 8x5 Diet for Bile Acid Diarrhoea: A Feasibility Randomised Controlled Trial
Bile acid diarrhoea is a common cause of chronic watery diarrhoea. Treatment is life-long medication. However, about 50% of people have ongoing, bothersome diarrhoea.
- Trial name
- NCT06259396
- Testing
- The 8x5 Diet
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Manchester
Diarrhea Infantile
Phenotype and Multi-omics Analysis of Children With Congenital Diarrhea and Enteropathy in China
This study will establish a clinical cohort of children with congenital diarrhea and enteropathy (CODE), mine biomarkers of CODE through multi-omics technology and construct a clinical risk prediction model.
- Trial name
- NCT06356545
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Acute Infectious Diarrhoea in Children
Evaluating the LGG of on Acute Infectious Diarrhea in Children
Acute diarrhea due to infectious causes is a major source of morbidity in the pediatric population. Although it is generally self-limiting, acute diarrhea may lead to severe dehydration, hospitalization, and, rarely, death…
- Trial name
- PROBAGE 2 (NCT07342101)
- Testing
- LGG, Standart of care
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 480 people
- Sponsor
- Eskisehir Osmangazi University
Diarrhea-predominant Irritable Bowel Syndrome
Clinical Efficacy and Safety of Jingfang Granules in Treating Diarrhea-Predominant Irritable Bowel Syndrome With Cold-Dampness Disturbing Spleen Syndrome
This prospective, open-label, randomized controlled clinical trial aims to evaluate the clinical efficacy and safety of Jingfang Granules in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) with…
- Trial name
- NCT07688161
- Testing
- Trimebutine Maleate Tablets, Jingfang Granules
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Xiao Chai Hu Tang, Irinotecan-induced Diarrhea
XCHT for Irinotecan-Induced Gut Toxicities (Randomized Controlled Trial)
Randomized double-blind placebo-controlled trial (RCT) study, to determine the impact of XCHT on irinotecan-induced severe delayed-onset diarrhea (SDOD), and to determine the feasibility of using plasma raloxifene-4'-glucuronide…
- Trial name
- NCT06055179
- Testing
- Xiao Chai Hu Tang (XCHT), Irinotecan regimen, Raloxifene
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Diarrhea-predominant Irritable Bowel Syndrome, Irritable Bowel Syndrome of Diarrhea Type (IBS-D)
Evaluation of the Efficacy and Safety of Gelsectan in the Treatment of Diarrhea-predominant Irritable Bowel Syndrome
This clinical study aims to investigate the effectiveness and safety of Gelsectan, a treatment containing xyloglucan, in adults diagnosed with diarrhea-predominant irritable bowel syndrome (IBS-D) in Vietnam.
- Trial name
- GELIBS (NCT07000383)
- Testing
- Gelsectan, Antispasmodic Agent
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Allogeneic Hematopoietic Stem Cell Transplantation
Acupoint Application With Herbal Fumigation and Wash for Preventing Diarrhea-induced Perianal Infection in Allo-HSCT Patients
The goal of this clinical trial is to evaluate whether the combination of herbal fumigation and acupoint application can effectively prevent diarrhea in patients undergoing allogeneic hematopoietic stem cell transplantation…
- Trial name
- NCT06912347
- Testing
- Intervention Group, control group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Ruijin Hospital
Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation
Efficacy of Chatbot for Irritable Bowel Syndrome (IBS) Patients
The goal of this clinical trial is to evaluate the efficacy of an automated chatbot system in improving quality of life, reducing depression and anxiety, and decreasing visceral sensitivity in patients with Irritable Bowel…
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation, Irritable Bowel Syndrome - Diarrhoea, Irritable Bowel Syndrome - Mixed
- Trial name
- IrBiS (NCT06837064)
- Testing
- Chatbot supporting system
- Where
- Russia
- Volunteers
- 54 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
Irritable Bowel Syndrome
A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)
This study is designed to evaluate the efficacy and safety of camlipixant in adults with IBS-D and IBS-M. The study has two parts.
- Trial name
- BALANCE (NCT07519395)
- Testing
- Camlipixant
- Where
- 114 sites in United States
- Volunteers
- 420 people
- Sponsor
- GlaxoSmithKline
Dientamoeba Fragilis Infection
Paromomycin or Metronidazole for Symptomatic Dientamoeba Fragilis in Adults
Dientameba Fragilis (D.fragilis) is a protozoan found in the digestive tract - in the human colon. there are disagreements regarding the preferred treatment for these cases, with several regimens tested in mostly small…
- Trial name
- COMFORTER (NCT06907498)
- Testing
- Paromomycin
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Solid Organ Transplant Complications
Washed Microbiota Transplantation in Solid Organ Transplantation
Solid organ transplantation (SOT), an alternative therapy for end-stage diseases, offers increased longevity and better quantity of life.
- Trial name
- NCT06708676
- Testing
- Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Malnutrition, Child
Hens Hatching Hope
The study is a prospective community-cluster non-randomized trial that will evaluate the effectiveness of a program that will provide 30-day egg vouchers to mothers of 6 to 24 month-old children living in rural areas of Intibucá…
- Trial name
- NCT04721197
- Testing
- Egg vouchers, Standard of Care
- Where
- Honduras
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Diarrhea
Safety of Lactobacillus LB Postbiotic in Immunocompromised Paediatric Patients With Diarrhoeal Disease
This prospective, interventional, single-center, open-label, phase 1 clinical trial to assess the safety of the Postbiotic Lactobacillus LB in immunocompromised paediatric patients with diarrhoeal disease will be performed at…
- Trial name
- NCT07758933
- Testing
- Lactobacillus LB
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez