Clinical trials: Diastolic Dysfunction
Mitral Regurgitation
Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease)
The investigators hypothesize that beta-1 receptor blockade (ß1-RB) attenuates extracellular matrix (ECM) degradation and progressive adverse Left Ventricular (LV) remodeling and failure in the volume overload of mitral…
- Trial name
- P1A1 (NCT01052428)
- Testing
- metoprolol succinate (Toprol XL)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Congestive Heart Failure
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
In congestive heart failure, cardiac output is low, blood pressure is high, and the body becomes congested with fluid. In normal people, when there is high blood pressure, the heart muscle cells secrete a hormone that excretes…
- Trial name
- PPG1 (NCT00387621)
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Horng Chen
Hypertension
Systolic Blood Pressure Intervention Trial
Elevated blood pressure (BP) is an important public health concern. It is highly prevalent, the prevalence may be increasing, and it is a risk factor for several adverse health outcomes, especially coronary heart disease, stroke…
- Trial name
- SPRINT (NCT01206062)
- Testing
- Intensive control of SBP, Standard control of SBP
- Where
- United States
- Volunteers
- 9,361 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 2 Diabetes, Coronary Heart Disease
Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM)
The purpose of this study is to examine the existence of heart abnormalities in patients with diabetes and the effect of pioglitazone in correcting these abnormalities.
- Trial name
- NCT01588470
- Testing
- pioglitazone
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Hypertension, High Blood Pressure
Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients
This project will evaluate the clinical and cost effectiveness of a novel, multidisciplinary approach to identify and treat pre-clinical cardiac dysfunction (PCCD) in asymptomatic hypertensive patients identified in a single…
- Conditions
- Hypertension, High Blood Pressure, Ventricular Hypertrophy, Diastolic Dysfunction
- Trial name
- NCT00689819
- Testing
- Exercise, Weight Loss, Low Sodium Diet
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Obesity, Heart Failure, Diastolic
Improving Metabolic Health in Patients With Diastolic Dysfunction
The purpose of this study is to determine whether 1 year of supervised exercise training in obese individuals at high risk for developing HF, incorporating high intensity interval training (HIIT) two to three times per week in…
- Conditions
- Obesity, Heart Failure, Diastolic, Metabolic Syndrome
- Trial name
- MTG (NCT03448185)
- Testing
- High intensity exercise, Omega-3 fish oil, Yoga
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Vascular Stiffness, Endothelial Dysfunction
Targeting Inflammation to Treat Cardiovascular Aging
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States with older age being a primary risk factor.
- Conditions
- Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- TIVA (NCT01775865)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Diastolic Dysfunction
Early Diagnosis of Diastolic Dysfunction and Reliability of DSE in Detecting Stress Diastolic Dysfunction
The heart becoming "stiff" due to increased fibrous tissue or decreased elasticity of the heart tissue is one of the earliest changes caused by heart failure.
- Trial name
- NCT00998205
- Testing
- Dobutamine stress echo (DSE), Atropine bolus
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia