Clinical trials: Diastolic Dysfunction
Diastolic Dysfunction
Clinical Observational Study Investigating the Role of Diastolic Dysfunction in Determining Abnormal Cardiorespiratory Exercise Testing Parameters in Patients Undergoing Major Surgery
REASON FOR STUDY Major non-cardiac surgery has a high degree of morbidity and mortality. Recently, suitable measurements of a patient's preoperative cardiorespiratory reserve, performed non-invasively by cardiopulmonary exercise…
- Trial name
- NCT00765349
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Peripartum Cardiomyopathy, Diastolic Dysfunction
Diastolic Dysfunction PPCM in Patients With Documented Left Ventricular Systolic Function Recovery
The purpose of this project is to evaluate parameters of diastolic dysfunction assessed by clinical echocardiogram in patients who have had recovery of systolic function.
- Trial name
- NCT04143997
- Testing
- A clinical Transthoracic echocardiogram
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy
Long Term Effects of Enalapril and Losartan on Genetic Heart Disease
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into circulation.
- Conditions
- Hypertrophic Cardiomyopathy, Left Ventricular Hypertrophy, Myocardial Ischemia
- Trial name
- NCT00001534
- Testing
- Losartan
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2, Diabetic Cardiomyopathies
Efficacy of Trimetazidine in Diabetic Patients
Subclinical diastolic dysfunction represents the early phase of diabetic cardiomyopathy and is a common complication among type 2 diabetic patients that increases mortality rate among those patients and can progress to heart…
- Trial name
- NCT05556005
- Testing
- Trimetazidine Dihydrochloride
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Hidradenitis, Hidradenitis Suppurativa
HIDRAdenitis Suppurativa and HEART Disease
In a prospective observational cohort study (n = 250) the investigators aim to assess the correlation between cardiac biomarkers, advanced echocardiography and HS severity and determine whether these are prognostic markers of…
- Conditions
- Hidradenitis, Hidradenitis Suppurativa, Hidradenitis Suppurativa, Familial, Left Ventricular Dysfunction
- Trial name
- NCT05989945
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Herlev and Gentofte Hospital
Diabetes Mellitus, Type 2
Teneligliptin on the Progressive Left Ventricular Diastolic Dysfunction With Type 2 Diabetes Mellitus Study
This is the clinical trial designed to assess the cardiac diastolic function of long term treatment with teneligliptin compared to that without teneligliptin in patients with type 2 diabetes mellitus by two arms; one includes…
- Trial name
- TOPLEVEL (NCT02449330)
- Testing
- Teneligliptin
- Where
- Japan
- Volunteers
- 936 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Type 1 Diabetes, Coronary Artery Calcifications
Relation of Visceral Fat and Associated Cytokines With Early Cardiovascular Complications in Type 1 Diabetes.
Objective: To investigate whether visceral adipose tissue (VAT) and its adipokines contribute to early signs of cardiovascular disease, meaning coronary artery calcifications (CAC) and diastolic dysfunction in type 1 diabetes…
- Conditions
- Type 1 Diabetes, Coronary Artery Calcifications, Diastolic Dysfunction
- Trial name
- VISCERA (NCT02689570)
- Testing
- observational
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Heart Failure With Preserved Ejection Fraction, Healthy
Understanding the Mechanisms of Diastolic Dysfunction
Heart failure is a clinical syndrome marked by breathlessness, even at low levels of exertion, general fatigue, and fluid retention and is estimated to affect 5.1 million people in the United States.
- Trial name
- NCT03340233
- Testing
- MRI (cardiac) off-label use gadolinium contrast (IND exempt), MRI (cardiac)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cushing's Syndrome Cardiomyopathy
Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrs
Pathophysiology of Cushing's Syndrome (CS) cardiomyopathy is yet unclear and a specific treatment have not been indicated. It was already demonstrated the positive impact of phosphodiesterase type 5A (PDE5A) inhibition in several…
- Trial name
- ERGO (NCT02611258)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Andrea M. Isidori
Diastolic Dysfunction
Pre-operative Focused Transthoracic Echocardiography for Prediction of Post-operative Cardiac Complications
The extent focused transthoracic echocardiography when done pre-operatively to patients admitted for elective surgery and suspected to be at risk of cardiac disease specially the geriatric population can affect perioperative…
- Trial name
- NCT04114474
- Testing
- TRANSTHORACIC ECHOCARDIOGRAPY
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- South Egypt Cancer Institute
Critical Illness, Diastolic Dysfunction
Diastolic dYsfunctioN AssessMent in critICally Ill Patients
The role of the left ventricular diastolic function (LVDD) in the weaning failure from mechanical ventilation in unclear. Specifically, is unclear whether the outcome of the weaning process could be affected by a pre-existing…
- Conditions
- Critical Illness, Diastolic Dysfunction, Diastolic Heart Failure, Weaning Failure
- Trial name
- DYNAMIC (NCT04584203)
- Testing
- Bedside Echocardiography, Spontaneuos breathing trial, Bedside Echocardiography_1
- Where
- 8 sites in Italy
- Volunteers
- 297 people
- Sponsor
- Humanitas Clinical and Research Center