Clinical trials: Diastolic Dysfunction, open to volunteers
Exercise-induced Myocardial Damage, Right Ventricular Diastolic Dysfunction
Effects of Exogenous Ketones on Acute Changes and Recovery of the Heart Muscle After Intense Exercise.
It is well known that scar tissue on the heart muscle can cause (life-threatening) arrhythmias. However, the exact cause of this scar tissue is not entirely clear.
- Trial name
- NCT06715748
- Testing
- Ketone Monoester (KE)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Diabetes
Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular Dysfunction
There is an epidemic of type 2 diabetes in younger adults. These patients are at very high lifetime risk of heart-related complications.
- Trial name
- Diastolic (NCT02590822)
- Testing
- Cambridge Weight Plan, Supervised Exercise Sessions
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Hypertension (HTN), Hyperhomocysteinemia
Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension
This prospective single-center observational study aims to evaluate the relationship between elevated plasma homocysteine levels and early echocardiographic abnormalities in patients with newly diagnosed essential hypertension.
- Conditions
- Hypertension (HTN), Hyperhomocysteinemia, Diastolic Dysfunction
- Trial name
- HHT-EDD (NCT07480265)
- Testing
- Homocysteine Measurement and Echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Necmettin Erbakan University
Covid19, Arterial Stiffness
Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)
The purpose of the study is to evaluate the presence of early vascular aging 6 months and 12 months after COVID-19 infection.
- Conditions
- Covid19, Arterial Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- CARTESIAN (NCT04558450)
- Testing
- carotid-femoral pulse-wave velocity
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HFpEF, LVDD
Triple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEF
Patients with advanced heart failure with preserved ejection fraction (HFpEF) will be randomly assigned in open-label multicenter study to receive triple combination therapy with [angiotensin receptor/neprilysin inhibitor [ARNI]…
- Conditions
- HFpEF, LVDD, Myocardial Fibrosis
- Trial name
- NCT06655480
- Testing
- [ARNI + SGLTi + AMR], [SGLTi + previously taken RAAS blocker]
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Mitral Insufficiency
Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity
The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend surgery in patient with mitral regurgitation (MR) based on 1) the severity of MR and 2) the presence or absence of symptoms.
- Trial name
- NCT06738615
- Testing
- Pressure volume loop evaluation, cardiovascular magnetic resonance imaging, Cardiopulmonary exercise testing (CPET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Atlantic Health System
Angina With No Obstructive Coronary Artery Disease, ANOCA
Coronary Sinus Reducer in Patients With Angina With no Obstructive Coronary Disease
Even half of patients with angina undergoing invasive coronary angiography presents without any significant epicardial stenosis.
- Conditions
- Angina With No Obstructive Coronary Artery Disease, ANOCA, Coronary Sinus Reducer
- Trial name
- REDUCE-ANOCA (NCT07010029)
- Testing
- Coronary Sinus Reducer
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Cardiomyopathies, Dilated Cardiomyopathy
Pediatric Cardiomyopathy Mutation Analysis
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder.
- Conditions
- Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT02432092
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Cirrhotic Cardiomyopathy, Empagliflozin
DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis
1. This proposed double-blind placebo controlled randomized controlled trial incorporates recent advances in management of heart failure and portal hypertension using the SGLT-2 inhibitor i.e. EMPAGLIFLOZIN.
- Conditions
- Cirrhotic Cardiomyopathy, Empagliflozin, Cardiometabolic Risk Factors, Cirrhosis
- Trial name
- DICE (NCT07322237)
- Testing
- Empagliflozin + Carvedilol, Carvedilol
- Where
- India
- Volunteers
- 400 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Heart Failure With Preserved Ejection Fraction (HFPEF), Renal Dysfunction
Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Heart failure (HF) in patients at risk is often overlooked, and when detected, there is a lack of early and effective preventive interventions.
- Conditions
- Heart Failure With Preserved Ejection Fraction (HFPEF), Renal Dysfunction, Stage B Heart Failure
- Trial name
- WE-CARE-HF-CMR (NCT07185100)
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- German Heart Institute
Obesity, Diastolic Dysfunction
Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function
The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity.
- Conditions
- Obesity, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- NCT07565610
- Volunteers
- 150 people
- Sponsor
- Itshak Amsalem
Lupus Nephritis, Diastolic Dysfunction
Diastolic Dysfunction and Inflammatory Biomarkers in Lupus Nephritis
This cross-sectional observational study aims to investigate the correlation between echocardiographic parameters of left ventricular diastolic dysfunction (E/A ratio, e', E/e' ratio, LAVI, and LVEF) and systemic inflammatory…
- Conditions
- Lupus Nephritis, Diastolic Dysfunction, Systemic Lupus Erythematosus, Heart Failure, Diastolic
- Trial name
- NCT07837544
- Volunteers
- 90 people
- Sponsor
- Assiut University
Cardiovascular Diseases, Cardiovascular Morbidity
Assessment and Digital-health Based Intervention on Subclinical Organ Damage and Cardiovascular Risk in Chinese
To comprehensively evaluate subclinical organ damage of Chinese adults and its association with future cardiovascular disease and events.
- Conditions
- Cardiovascular Diseases, Cardiovascular Morbidity, Subclinical Organ Damage, Digital Health
- Trial name
- NCT05435898
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Shanghai 10th People's Hospital
Bradycardia
Impact of Allometric Pacing Rate on Ventricular Diastolic Function and Cerebral Blood Flow in Hypertensive Patients With Sinus Node Dysfunction
The study is a prospective, randomized controlled study in hypertensive patients with a bradycardia indications for pacing therapy and a plan to receive dual-chamber pacemaker.
- Trial name
- NCT07589452
- Testing
- Personalized lower rate pacing, Standard lower rate pacing
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
PreDiabetes, Insulin Resistance
Disease Prevention in Clinical Practice Base on Patient Specific Physiology
It is well known that the Type 2 diabetes and vascular disease are preceded by over ten years by metabolic dysfunction and anatomic changes that can be quantified.
- Conditions
- PreDiabetes, Insulin Resistance, Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis
- Trial name
- STOPDISEASE (NCT03308773)
- Testing
- Lifestyle modification in routine care of patients
- Volunteers
- 5,000 people
- Sponsor
- Pacific Coast Family Medical Group
Diastolic Dysfunction
A Cross-sectional Study on the Impact of Shift Work on Diastolic Dysfunction in Healthcare Workers
The goal of this observational cross-sectional study is to assess the prevalence of left ventricular diastolic dysfunction and identify associated risk factors in health-care workers of various ages and both sexes.
- Trial name
- NCT07331233
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Sickle Cell Disease
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart…
- Trial name
- NCT05583721
- Testing
- [13N]NH3, Lexiscan, Positron emission tomography
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
HFpEF
Predictors of Poor Prognosis in HFpEF
Patients with HFpEF who have undergone meticulous clinical and instrumental evaluation (including diastolic exercise testing) between 2013 and 2020, will be followed up for at least 3 years.
- Trial name
- NCT06844032
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Diastolic Dysfunction
Effect of Swimming Exercise on Diastolic Dysfunction
The aim of the study was to determine the rehabilitative effects of 12-week variable intensity swimming exercises on the cardiovascular system in women with diastolic dysfunction.
- Trial name
- NCT06945913
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uşak University