Clinical trials: Diastolic Dysfunction
Diastolic Dysfunction, Obesity
The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction
Diabetes mellitus people have a higher incidence of cardiovascular disease, and the results of cardiovascular events are worse. Heart failure and diabetes both have a worse prognosis, with a 1.5-2 times increased risk of death.
- Trial name
- NCT05847244
- Testing
- Metformin
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Sara ElAdawy
Left Ventricular Diastolic Dysfunction
Characterization of Patients With Post-ischemic Left Ventricular Dysfunction
This is an observational, prospective, multicenter study (12 hospitals belonging to the Italian Cardiology Network) in patients with STEMI ST elevation myocardial infarction (STEMI) treated successfully with primary percutaneous…
- Trial name
- NCT04699565
- Testing
- Cardiac magnetic resonance
- Where
- 10 sites in Italy
- Volunteers
- 303 people
- Sponsor
- IRCCS San Raffaele
Diastolic Dysfunction
Diastolic Function in Myotonic Dystrophy Type 1
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders.
- Trial name
- NCT06029192
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Diabetes Mellitus, Type 2, Obesity, Abdominal
Ghrelin and Diastolic Heart Function
In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastolic function (LV-DF).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Abdominal, Diastolic Dysfunction
- Trial name
- NCT05988346
- Testing
- abdominal plastic intervention
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Diastolic Heart Failure, Left Ventricular Diastolic Dysfunction
2 New Measurements Used to Describe the Filling Phase of the Left Ventricle (LV).
As we live longer our population experiencing heart failure (HF) continues to grow consuming an increasing percent of healthcare dollars.
- Conditions
- Diastolic Heart Failure, Left Ventricular Diastolic Dysfunction, Left Ventricular Diastolic Collapse
- Trial name
- INDEX (NCT04154878)
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction
Sex Related Differences in Cardiac Function
The aim of the study is to investigate sex-specific differences in LV and RV function (systolic and diastolic) with regarding the development and progression of heart failure with preserved ejection fraction based on a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05796050
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Diastolic Dysfunction, Morbid Obesity
Diastolic Dysfunction in Morbidly Obese Patients Undergo Bariatric Surgery
Morbidly obese patients are at risk for diastolic cardiac dysfunction, which can lead to adverse event, such as, diastolic heart failure postoperatively.
- Trial name
- NCT04128735
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Mahidol University
Atrial Fibrillation, Diastolic Dysfunction
Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor
The goal of this study is to test the feasibility of guiding as-needed pharmacological rate control of atrial fibrillation (AF) by implantable cardiac monitors and to assess the impact of continuous beta-blocker therapy versus…
- Conditions
- Atrial Fibrillation, Diastolic Dysfunction, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT05745337
- Testing
- As needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont
Diastolic Dysfunction
Diastolic Function Assessment With Cardiac Magnetic Resonance Imaging
Cardiac magnetic resonance (CMR) imaging is excellent at assessing the contractility of the heart muscle. However, relatively little is known about CMR's ability to assess the relaxation (diastolic function) of the heart between…
- Trial name
- DIAMER (NCT05438030)
- Testing
- Cardiac MRI scan, Echocardiogram scan
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Imperial College London
Left Ventricular Diastolic Dysfunction, Weaning Failure
Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation
Both premature and delayed extubation prolong the duration of mechanical ventilation and the intensive care unit (ICU) length of stay and increase morbidity and mortality.
- Conditions
- Left Ventricular Diastolic Dysfunction, Weaning Failure, Mechanical Ventilation Complication, Diaphragmatic Disorder
- Trial name
- NCT04703387
- Testing
- transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Heart Failure With Preserved Ejection Fraction, Left Ventricular Diastolic Dysfunction
Invasive Left Heart Catheterization Registry
Retrospectively enrolled suspicious of heart failure with preserved ejection fraction (HFpEF) patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure.
- Trial name
- NCT04505449
- Testing
- Left heart catheterization
- Where
- South Korea
- Volunteers
- 404 people
- Sponsor
- Samsung Medical Center
Left Ventricular Diastolic Dysfunction
Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage
Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures.
- Trial name
- NCT04549298
- Testing
- No interventions
- Volunteers
- 88 people
- Sponsor
- Neuromed IRCCS
Pacemaker, Diastolic Dysfunction
Personalized Pacing: A New Paradigm for Patients With Diastolic Dysfunction or Heart Failure With Preserved Ejection Fraction
Recent exploratory studies suggest that pacemaker patients with diastolic dysfunction (DD) or heart failure with preserved ejection fraction (HFpEF) may benefit from a higher backup heart rate (HR) setting than the factory…
- Conditions
- Pacemaker, Diastolic Dysfunction, Diastolic Heart Failure
- Trial name
- myPACE (NCT04721314)
- Testing
- Adjustment of lower rate limit, Maintenance of lower rate limit
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- University of Vermont
Hypovolemia, Heart Failure
Prevalence of Hypovolemia and Heart Failure in Non-cardiac Surgery
Prevalence of biventricular function of the heart and preoperative level of venous return is not known in non-cardiac non-morbid obese population.
- Conditions
- Hypovolemia, Heart Failure, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT03349593
- Testing
- Echocardiography
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Umeå University
Critical Illness, Diastolic Dysfunction
Diastolic dYsfunctioN AssessMent in critICally Ill Patients
The role of the left ventricular diastolic function (LVDD) in the weaning failure from mechanical ventilation in unclear. Specifically, is unclear whether the outcome of the weaning process could be affected by a pre-existing…
- Conditions
- Critical Illness, Diastolic Dysfunction, Diastolic Heart Failure, Weaning Failure
- Trial name
- DYNAMIC (NCT04584203)
- Testing
- Bedside Echocardiography, Spontaneuos breathing trial, Bedside Echocardiography_1
- Where
- 8 sites in Italy
- Volunteers
- 297 people
- Sponsor
- Humanitas Clinical and Research Center
Cardiomyopathies, Chemotherapy Effect
Bisoprolol Administration to Prevent Anthracycline-induced Cardiotoxicity
Anthracyclines are one of the most well-known and effective drugs used to treat malignancies.The most important limiting factor in the use of this drug is its cardiac toxicity which includes cardiomyopathy and congestive heart…
- Conditions
- Cardiomyopathies, Chemotherapy Effect, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05175066
- Testing
- Bisoprolol
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Hemodynamic Instability, Anesthesia; Adverse Effect
Heart Failure and Hemodynamic Stability During Anesthesia Induction
The study aim is to investigate whether preoperative heart failure has impact on hemodynamic stability during anesthesia induction by target controlled infusion of anesthesia (TCI) in non-cardiac, non-morbidly obese surgery.
- Conditions
- Hemodynamic Instability, Anesthesia; Adverse Effect, Heart Failure, Diastolic Dysfunction
- Trial name
- NCT03576261
- Testing
- Preoperative colloid fluid bolus (Gelofusine), Preoperative transthoracic echocardiography
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Umeå University
End Stage Renal Disease (ESRD), Hemodialysis
Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dialysate temperature and the…
- Conditions
- End Stage Renal Disease (ESRD), Hemodialysis, Hemodiafiltration, Intradialytic Hypotension
- Trial name
- HOLLANT (NCT03249532)
- Testing
- standard hemodialysis, cool hemodialysis, low volume hemodiafiltration
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Covid19, Arterial Stiffness
Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)
The purpose of the study is to evaluate the presence of early vascular aging 6 months and 12 months after COVID-19 infection.
- Conditions
- Covid19, Arterial Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- CARTESIAN (NCT04558450)
- Testing
- carotid-femoral pulse-wave velocity
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease, Diastolic Dysfunction
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD
This is a prospective study to determine the relationships between pauci-inflammatory exacerbations and diastolic dysfunction, and their implications in hospitalized patients with acute exacerbations of COPD.
- Trial name
- NCT03110614
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Alabama at Birmingham