Clinical trials: Diastolic Dysfunction
Hypertension
Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension
Hypertensive patients are at increased risk of developing LV hypertrophy and myocardial fibrosis, which cause diastolic dysfunction.
- Trial name
- NCT02973035
- Testing
- Amlodipine, Valsartan
- Where
- 4 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Asan Medical Center
Diabetes Mellitus Type 2, Metabolic Syndrome
Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients
The most important cause of mortality amongst DM2 patients is cardiovascular disease. An early finding of cardiovascular disease in DM2 and obesity is diastolic dysfunction.
- Conditions
- Diabetes Mellitus Type 2, Metabolic Syndrome, Cardiovascular Disease, Diastolic Dysfunction
- Trial name
- MAGNA VICTORIA (NCT01761318)
- Testing
- Liraglutide
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Diastolic Dysfunction, Hypertension
To Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of the Heart to Fill and Empty, and the Ability of the Heart Muscle to Relax Adequately in People With High Blood Pressure.
Patients who have had high blood pressure for a long time may have diastolic dysfunction. Diastolic Dysfunction is when your heart has difficulty filling and emptying, and relaxing adequately.
- Trial name
- NCT00170924
- Testing
- Valsartan
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Novartis
Left Ventricular Diastolic Dysfunction
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.
The purpose of this research study is to evaluate the effects of cardiac hormone replacement with SQ (subcutaneous or under the skin) injection of BNP (brain natriuretic peptide, a hormone produced by the heart) on the pumping…
- Trial name
- NCT00405548
- Testing
- BNP (nesiritide)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Diastolic Dysfunction, Septic Shock
Reversibility of Diastolic Disfunction in Septic Shock
Objectives: To study the prognostic value of the evolution of diastolic function according to fluid balance in patients admitted to the ICU with a diagnosis of septic shock, in terms of mortality (ICU and hospital) and mortality…
- Trial name
- REPRISS (NCT03198611)
- Testing
- Echocardiography
- Where
- 5 sites in Spain
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Heart Disease, Atrial Fibrillation
Diastolic Dysfunction and Atrial Fibrillation in CABG Surgery
Left ventricular (LV) diastolic dysfunction is a common manifestation of heart disease that is responsible for significant morbidity and mortality.It is present when the ventricular filling is impaired as a result of delayed…
- Trial name
- NCT00188903
- Testing
- Diastolic measurements during TEE
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University Health Network, Toronto
Left Ventricular Function Diastolic Dysfunction, Fluid Responsiveness
Evaluation of the E/e' Ratio of the Mitral Annulus in Predicting Fluid Responsiveness.
Diastolic function may be evaluated by different measurements on transesophageal echocardiography (TEE). They include mitral inflow velocities obtained by pulsed-wave doppler (PW) : peak early diastolic velocity (E) and late…
- Trial name
- NCT02714244
- Testing
- Volume expansion
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Montreal Heart Institute
Left Ventricular Diastolic Dysfunction, Weaning Failure
Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation
Both premature and delayed extubation prolong the duration of mechanical ventilation and the intensive care unit (ICU) length of stay and increase morbidity and mortality.
- Conditions
- Left Ventricular Diastolic Dysfunction, Weaning Failure, Mechanical Ventilation Complication, Diaphragmatic Disorder
- Trial name
- NCT04703387
- Testing
- transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Heart Failure
The Role of Gut Microbiota in Heart Failure and Pre-Heart Failure With Preserved Ejection Fraction
Gut microbiota play an important role in normal cardiovascular function and pathophysiology of cardiovascular diseases. Patients with heart failure (HF) have substantial hemodynamic changes which lead to intestinal hypoperfusion…
- Trial name
- NCT02728154
- Testing
- Blood Sample, Stool Sample
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Diastolic Dysfunction and Cardiac Stiffness
Cardiac Elastography Measurement : an Intraoperative Cardiac Surgery Study
Since 20 years, the techniques of direct measurement of cardiac stiffness in the diagnosis of myocardial diseases do not exist. We propose a human study evaluating the direct measurement of cardiac ultrasound stiffness by…
- Trial name
- REA-FO (NCT02051920)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Critical Care, Weaning
Cardiorespiratory Changes in Patients Being Weaned Off Mechanical Ventilation
The objective of this study was to analyze changes in cardiac function using Doppler echocardiogram in critical patients during weaning from mechanical ventilation using two different weaning methods (pressure support and T-tube)…
- Trial name
- NCT00852891
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Coronary Heart Disease, Diastolic Dysfunction
Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart Disease
Based on accumulating evidence showing that impaired cardiac energetic metabolism plays important role in the mechanism of cardiac diastolic dysfunction,the study is designed to evaluate whether metabolic modulator treatment with…
- Trial name
- NCT03887013
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 226 people
- Sponsor
- China National Center for Cardiovascular Diseases
Diastolic Dysfunction
Diastolic Function in Myotonic Dystrophy Type 1
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders.
- Trial name
- NCT06029192
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Kidney Diseases, Diastolic Heart Failure
Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease
To explore the distribution of retinal vasculature parameters in patients with different subtypes of cardiovascular and ocular disease.
- Conditions
- Kidney Diseases, Diastolic Heart Failure, Small Vessel Disease, Glaucoma
- Trial name
- NCT06485128
- Testing
- Optical coherence tomography(-angiography) OCT(A), Fundus pictures, DVA 3.0
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cancer, Immune-related Adverse Event
Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors
The goal of this prospective, multicentre study is to investigate short- and long-term cardiovascular effects in cancer patients treated with immune checkpoint inhibitors (ICIs).
- Conditions
- Cancer, Immune-related Adverse Event, Cardiac Abnormalities, Variable, Immune Checkpoint Inhibitor-Related Myocarditis
- Trial name
- CAVACI (NCT05699915)
- Testing
- Cardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
- Where
- 4 sites in Belgium
- Volunteers
- 105 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Diastolic Heart Failure, Diastolic Dysfunction
Markers of Oxidative Stress Diastolic Dysfunction
This study is to look at the differences between people who have evidence of abnormal heart relaxation (diastolic dysfunction) on sound wave pictures of the heart (an echocardiogram) compared to those who do not.
- Trial name
- ODDS (NCT00846404)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Obesity, Heart Failure, Diastolic
Improving Metabolic Health in Patients With Diastolic Dysfunction
The purpose of this study is to determine whether 1 year of supervised exercise training in obese individuals at high risk for developing HF, incorporating high intensity interval training (HIIT) two to three times per week in…
- Conditions
- Obesity, Heart Failure, Diastolic, Metabolic Syndrome
- Trial name
- MTG (NCT03448185)
- Testing
- High intensity exercise, Omega-3 fish oil, Yoga
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Diastolic Function
Determination of Diastolic Dysfunction by Single Lead Electrocardiogram
It is a prospective, controlled, single-center, non-randomized, observational study. From September 2019 to December 2020, the study plans to prospectively include 400 patients aged 18 to 90 years.
- Trial name
- NCT04474639
- Testing
- echocardiographic examination
- Where
- Russia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Metabolic Syndrome X, Diastolic Dysfunction
Metformin in the Diastolic Dysfunction of Metabolic Syndrome
Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease with increasing prevalence worldwide and insulin resistance is central to its pathophysiology and multi-organ deleterious effects.
- Conditions
- Metabolic Syndrome X, Diastolic Dysfunction, Insulin Resistance
- Trial name
- MET-DIME (NCT02017561)
- Testing
- Lifestyle Counseling, Metformin
- Where
- Portugal
- Volunteers
- 54 people
- Sponsor
- Universidade do Porto