Clinical trials: Diastolic Heart Failure
Heart Failure and Preserved Ejection Fraction, Heart Failure
Investigation on the Impact of Finerenone on Myocardial Remodeling in Patients With Diabetic Kidney Disease and Heart Failure
The goal of this clinical trial is to evaluate the impact of Finerenone on myocardial remodeling in patients with diabetic kidney disease (DKD) and heart failure with a left ventricular ejection fraction (LVEF) ≥ 40%.
- Conditions
- Heart Failure and Preserved Ejection Fraction, Heart Failure, Heart Failure and Mildly Reduced Ejection Fraction
- Trial name
- FINE-REMODEL (NCT07442448)
- Testing
- Finerenone
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Cathay General Hospital
Congestive Heart Failure
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
In congestive heart failure, cardiac output is low, blood pressure is high, and the body becomes congested with fluid. In normal people, when there is high blood pressure, the heart muscle cells secrete a hormone that excretes…
- Trial name
- PPG1 (NCT00387621)
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Horng Chen
Heart Failure, Heart Failure, Diastolic
Personalized Atrial Septostomy for Heart Failure
This study aims to investigate the safety and efficacy of personalized atrial septostomy (PAS) with combined use of radiofrequency-ablation and balloon-dilation (CURB) in heart failure with reduced ejection fraction (HFrEF) and…
- Trial name
- PAS (NCT04573166)
- Testing
- Personalized atrial septostomy with combined use of radiofrequency-ablation and balloon-dilation
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart Failure Preserved Ejection Fraction, Pacing
Mechanistic Insights From Temporary Pacing in HFpEF
Heart failure with preserved ejection fraction (HFpEF) is characterised by impaired diastolic function. A recent clinical trial has demonstrated multiple beneficial outcomes in HFpEF patients receiving personalised accelerated…
- Trial name
- NCT06467266
- Testing
- Acute Haemodynamic Study
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiovascular Diseases, Heart Failure
Yôga and Breathing Techniques Training in Patients With Heart Failure and Preserved Ejection Fraction
Current therapies for heart failure (HF) bring together strategies to improve quality of life and exercise tolerance, as well as to reduce morbidity and mortality.
- Conditions
- Cardiovascular Diseases, Heart Failure, Heart Failure, Diastolic
- Trial name
- NCT03028168
- Testing
- Yôga, Breathing technique, Control group
- Where
- 2 sites in Brazil
- Volunteers
- 32 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure With Preserved Ejection Fraction, Healthy
Understanding the Mechanisms of Diastolic Dysfunction
Heart failure is a clinical syndrome marked by breathlessness, even at low levels of exertion, general fatigue, and fluid retention and is estimated to affect 5.1 million people in the United States.
- Trial name
- NCT03340233
- Testing
- MRI (cardiac) off-label use gadolinium contrast (IND exempt), MRI (cardiac)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diastolic Dysfunction, Heart Failure
Assessment of Diastolic Function in High Risk Patients Undergoing Major Vascular Surgery
Patients scheduled for Thoracic Endovascular Aortic Repair (TEVAR) surgery will have transthoracic echocardiography evaluation of left ventricle diastolic function during the perioperative period.
- Conditions
- Diastolic Dysfunction, Heart Failure, Aneurysm Aortic
- Trial name
- NCT03534440
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Warsaw
Heart Failure With Normal Ejection Fraction
ImCardia for DHF to Treat Diastolic Heart Failure (DHF) Patient a Pilot Study
This study is designed to evaluate the ImCardia safety and to demonstrate system functionality in patients undergoing AV replacement with respect to 36 months follow up.
- Trial name
- ImCardia (NCT01347125)
- Testing
- ImCardia Device
- Volunteers
- 19 people
- Sponsor
- CorAssist Cadiovascular Ltd.
Heart Failure
Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients
Background Heart failure is the final consequence of various heart disease and is also the leading cause of mortality worldwide.
- Trial name
- ALEVENT (NCT01503671)
- Testing
- Atorvastatin
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- National Taiwan University Hospital
Diastolic Dysfunction, Symptomatic Heart Failure
Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure
This study will test the effects of valsartan versus placebo on exercise tolerance in patients with symptoms of heart failure
- Trial name
- NCT00171106
- Testing
- valsartan
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 150 people
- Sponsor
- Novartis
Heart Failure, HIV
Characterizing HIV-related Diastolic Dysfunction
This is a multicenter clinical trial of a cross section of HIV+ patients with and without diastolic dysfunction. Approximately 200 HAART-treated virally suppressed HIV+ subjects (100 HIV+/DD+ \& 100 HIV+/DD-) will be enrolled.
- Conditions
- Heart Failure, HIV, Diastolic Dysfunction
- Trial name
- HFN_HIV (NCT02860156)
- Where
- 12 sites in United States
- Volunteers
- 195 people
- Sponsor
- Duke University
Inflammatory Arthritis, Rheumatoid Arthritis
The Relationship Between Inflammatory ARTritis and CArdiac DIseAse
The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to…
- Conditions
- Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis
- Trial name
- ARTCADIA (NCT05647577)
- Where
- Denmark
- Volunteers
- 1,285 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Heart Failure
Comparative Effects of Nebivolol and Carvedilol on Diastolic Function in the Elderly Heart Failure Patients
Heart failure (HF) is a common and disabling condition in the elderly. Randomized clinical trials and meta-analyses have clearly demonstrated that long-term use of β blockers improves the outcomes of patients with HF.
- Trial name
- NCT02619526
- Testing
- Nebivolol, Carvedilol
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Dong-A University
Heart Failure
Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome
Tens of thousands of Veterans have heart failure with preserved ejection fraction (HFpEF), and suffer poor quality of life, frequent hospitalizations, and high death rates.
- Trial name
- NCT03170375
- Testing
- Performance of WHEELS-I in promoting DASH/SRD adoption
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Heart Failure Preserved Ejection Fraction
Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
The purpose of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart failure with preserved ejection fraction
- Conditions
- Heart Failure, Heart Failure Preserved Ejection Fraction, Cardiovascular Diseases, Heart Diseases
- Trial name
- Cycle-2-PEF (NCT06215586)
- Testing
- Tovinontrine (CRD-750)
- Where
- 84 sites in United States, Australia and 13 more
- Volunteers
- 303 people
- Sponsor
- Cardurion Pharmaceuticals, Inc.
Diastolic Heart Failure
Mathematical Modeling to Determine Basic Muscle Properties in the Failing Heart
According to the most recent information released by the American Heart Association, heart failure affects 5.8 million Americans and over 23 million people worldwide.
- Trial name
- NCT01778894
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Heart Failure, Diastolic
External Body Pressure in Heart Failure With Preserved Ejection Fraction
The primary objective of the study is to test the impact of positive and negative body pressure on exercise capacity, symptoms, blood volume distribution and central cardiac hemodynamics in patients with heart failure and…
- Trial name
- NCT05764564
- Testing
- Positive or negative pressure
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duke University
Diastolic Heart Failure NYHA Class III-IV, Diastolic Dysfunction Secondary to Aortic Stenosis
CORolla™ TAA for Heart Failure and Preserved Ejection Fraction and Diastolic Dysfunction
The study purpose is to evaluate the safety and feasibility of the CORolla™ TAA in two treatment groups, "CORolla™ Stand-alone group" and " AVR \& CORolla™ Add on group".
- Trial name
- NCT01956526
- Testing
- CORolla™ TAA device
- Where
- 2 sites in Italy
- Volunteers
- 12 people
- Sponsor
- CorAssist Cadiovascular Ltd.
Heart Failure Preserved Ejection Fraction, Pregnancy Complications
Middle-aged Women With Adverse Pregnancy Outcomes and Heart Failure With Preserved Ejection Fraction
Due to the steady increase in the burden of HFpEF, especially in women, it is an important task to search for new markers and early predictors associated with the development of this disease.
- Trial name
- MAPO-HF (NCT06338943)
- Testing
- Echocardiography, Questionnaire
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Heart Failure, Congestive, Heart Decompensation
Evaluation of the Effects of Carperitide in Patients With Congestive Heart Failure
The study will evaluate the safety and efficacy of intravenous infusion of carperitide using pressure measurements inside the heart and great vessels and measuring carperitide concentration in the blood.
- Conditions
- Heart Failure, Congestive, Heart Decompensation, Left Ventricular Failure, Myocardiopathies
- Trial name
- NCT00259038
- Testing
- Carperitide
- Where
- 34 sites in United States, Canada
- Volunteers
- 162 people
- Sponsor
- Daiichi Sankyo