Clinical trials: Diastolic Heart Failure
Bacterial Overgrowth Syndrome Small Bowel, Heart Failure with Preserved Ejection Fraction
Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
Single-center, double-blind, randomized, controlled intervention study of the effect of correction of bacterial overgrowth syndrome in the small intestine (SIBO) on cardiac function in patients with heart failure with preserved…
- Trial name
- SIBO-HFpEF (NCT06652087)
- Testing
- Rifaximin, Standard HFpEF treatment
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Diastolic Heart Failure
CMR Exercise Stress Testing in HFpEF
Patients of the University Hospital Göttingen with echocardiographic signs for diastolic heart failure and indication for right heart catheterisation will undergo additional diagnostic testing with CMR including exercise stress…
- Trial name
- HFpEF-Stress (NCT03260621)
- Testing
- stress CMR
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University of Göttingen
Valvular Heart Disease Patients, Aortic Stenosis
Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)
Heart valve disease and weakened heart muscle (left ventricular systolic dysfunction) are common in older adults and often go undetected until serious complications such as heart failure develop.
- Conditions
- Valvular Heart Disease Patients, Aortic Stenosis, Mitral Regurgitation, Left Ventricular Diastolic Dysfunction
- Trial name
- IMPROVE (NCT07756398)
- Testing
- Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.)
- Where
- 2 sites in United States
- Volunteers
- 1,088 people
- Sponsor
- University of Texas Southwestern Medical Center
Heart Failure With Preserved Ejection Fraction
Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction
The purpose of this study was to evaluate the effect of LCZ696 compared to valsartan in the reduction of cardiovascular death and heart failure(HF) hospitalizations in patients with HF with preserved ejection fraction.
- Trial name
- PARAGON-HF (NCT01920711)
- Testing
- LCZ696, Valsartan
- Where
- 715 sites in United States, Argentina and 41 more
- Volunteers
- 4,822 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Diastolic
Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction (HFPEF) accounts for 40-50% of all heart failure patients with a frequency of hospital admissions for acute decompensation and short and long term mortality similar to patients with…
- Trial name
- ROPA-DOP (NCT01901809)
- Testing
- Furosemide, Dopamine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction
Incretin Therapies in Obesity-related HFpEF
The central hypothesis to be tested is that patients with obesity and heart failure with preserved ejection fraction (HFpEF) prescribed tirzepatide will demonstrate reductions in measured plasma volume.
- Conditions
- Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Obesity
- Trial name
- NCT07554638
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Diastolic Dysfunction, Left Ventricular Hypertrophy
Effects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular Hypertrophy
This is a clinical, randomised, double-blinded study in which patients eligible for aortic valve replacement are enrolled. Patients receive infusion of either levosimendan or placebo 4 hours prior to surgery and until the end of…
- Trial name
- NCT01188369
- Testing
- levosimendan
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Acute Heart Failure
Gulf Acute Heart Failure Registry
The Gulf Heart Association (GHA) sponsored Gulf acute heart failure registry (Gulf CARE)is a multinational , multicentre, prospective, observational, hospital-based registry of patients with acute heart failure(AHF) with 3 month…
- Trial name
- GulfCARE (NCT01467973)
- Where
- Oman
- Volunteers
- 5,005 people
- Sponsor
- Gulf Heart Association
Heart Failure
Chronic Sildenafil Treatment in Heart Failure
In heart failure (HF), a defective nitric oxide (NO) signaling may be involved in left ventricular (LV) diastolic abnormalities and LV remodelling progression.
- Trial name
- NCT00975494
- Testing
- Sildenafil
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Heart Failure, Diastolic Heart Failure
Heart Failure and Postoperative Outcome in Surgery - a National Registry Study
The study is an exploratory study that aims to explore the incidence of heart failure in a national surgical cohort, and to compare postoperative mortality and morbidity in patients with and without heart failure.
- Conditions
- Heart Failure, Diastolic Heart Failure, Systolic Heart Failure
- Trial name
- NCT07634822
- Where
- 2 sites in Sweden
- Volunteers
- 2,200,000 people
- Sponsor
- Umeå University
Heart Failure With Preserved Ejection Fraction, Left Ventricular Diastolic Dysfunction
Invasive Left Heart Catheterization Registry
Retrospectively enrolled suspicious of heart failure with preserved ejection fraction (HFpEF) patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure.
- Trial name
- NCT04505449
- Testing
- Left heart catheterization
- Where
- South Korea
- Volunteers
- 404 people
- Sponsor
- Samsung Medical Center
Diastolic Heart Failure
Metoprolol XR in Heart Failure With Normal Ejection Fraction
In contrast to the treatment of HF with reduced EF, information to guide the pharmacological therapy of patients with HFNEF are lacking and there is no evidence based treatment for patients with HFNEF.
- Trial name
- HFNEF (NCT03882710)
- Testing
- Metoprolol XR
- Where
- India
- Volunteers
- 102 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Heart Failure, Heart Failure, Diastolic
A Study of LY3971297 in Participants With Heart Failure
The main purpose of this study is to assess how well LY3971297 is tolerated and what side effects may occur in participants with heart failure with preserved ejection fraction (HFpEF) and participants with heart failure with…
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure, Systolic
- Trial name
- NCT07547540
- Testing
- LY3971297
- Where
- 11 sites in United States, Japan and 2 more
- Volunteers
- 90 people
- Sponsor
- Eli Lilly and Company
HFpEF
Predictors of Poor Prognosis in HFpEF
Patients with HFpEF who have undergone meticulous clinical and instrumental evaluation (including diastolic exercise testing) between 2013 and 2020, will be followed up for at least 3 years.
- Trial name
- NCT06844032
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Diastolic Heart Failure
Pedometer-Based Walking Intervention in Patients With Chronic Heart Failure With Preserved Ejection Fraction
A multicenter randomized controlled trial, with follow-up at 6 and 12 months. Physically inactive participants with chronic heart failure with preserved or mid-range ejection fraction will be randomly assigned to intervention or…
- Trial name
- NCT03041376
- Testing
- Walking intervention
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Charles University, Czech Republic
Arthritis, Rheumatoid, Spondylitis, Ankylosing
Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker
The purpose of this study is to determine possible alterations in cardiac function in patients with Rheumatoid Arthritis and Ankylosing Spondylitis under anti-TNF therapy, without clinical heart disfunction at baseline, using…
- Trial name
- NCT01072058
- Testing
- TNF blockers (infliximab, adalimumab, etanercept)
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Diastolic Heart Failure, Heart Failure With Preserved Ejection Fraction
Purinergic Signaling and the Postmenopausal Heart
There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling.
- Trial name
- NCT06015776
- Testing
- Gender
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Beth Israel Deaconess Medical Center
Heart Failure With a Preserved Ejection Fraction, Heart Failure, Diastolic
Efficacy Study of Pacemakers to Treat Slow Heart Rate in Patients With Heart Failure
Determine the impact of restoring normal heart rate response during exercise and daily activity in patients with heart failure and a preserved ejection fraction (HFpEF) and chronotropic incompetence (CI).
- Conditions
- Heart Failure With a Preserved Ejection Fraction, Heart Failure, Diastolic, Chronotropic Incompetence
- Trial name
- RAPID-HF (NCT02145351)
- Testing
- Rate adaptive atrial pacing using a dual-chamber pacemaker, Pacemaker system will be implanted but set to Pacing Off.
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Heart Failure with Preserved Ejection Fraction
"HerzCheck" - Detection of Early Heart Failure Using Telemedicine in Structurally Weak Regions
This study is intended to provide a basis for decision-making for the improved medical care of patients with asymptomatic heart failure, especially in structurally weak regions.
- Trial name
- NCT05122793
- Testing
- Prevention offer
- Where
- Germany
- Volunteers
- 4,509 people
- Sponsor
- German Heart Institute
Heart Failure, Preserved Ejection Fraction
Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF
HFpEF has a high incidence and lacks effective therapy, and its onset is closely related to systemic inflammation and intestinal dysbacteriosis.SGLT-2i exerts its effects by diuresis, anti-inflammatory and improving energy…
- Trial name
- NCT07687212
- Testing
- Henggliflozin Combined with Probiotics, Henggliflozin
- Where
- China
- Volunteers
- 162 people
- Sponsor
- The First Affiliated Hospital of Air Force Medical University