Clinical trials: Diet, Reducing
Seizure, Epilepsy
Efficacy of Low Glycemic Index Diet Versus Classic Ketogenic Diet in Pediatric Epilepsy Treatment
Epilepsy is a common disease among children. Today, treating epilepsy remains a major challenge, with many children affected by this condition. According to reports, 30% of children with epilepsy do not respond well to treatment.
- Conditions
- Seizure, Epilepsy, Drug Resistant Epilepsy
- Trial name
- NCT06703983
- Testing
- Low Glycemic index therapy, Classic Ketogenic Diet
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Mashhad University of Medical Sciences
Obesity
Effectiveness of the Optifast Program Compared With a Reduced-energy Food Based Diet Plan on Body Weight
Compare percent change in loss of body weight between the OPTIFAST program and a food-based energy-deficit program
- Trial name
- Opti-WIN (NCT02635698)
- Testing
- Optifast, Food-Based
- Where
- 9 sites in United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Blood Pressure
Diet, ExerCIse and carDiovascular hEalth (DECIDE) - Salt Reduction Strategies for the Elderly in Nursing Homes in China
The DECIDE - Salt in Elderly (Diet, ExerCIse and carDiovascular hEalth - Salt Reduction Strategies for the Elderly in Nursing Homes in China) is to evaluate the effects, safety and cost-effectiveness of salt substitution (SS) and…
- Trial name
- DECIDE-Salt (NCT03290716)
- Testing
- SS, SSSC
- Where
- China
- Volunteers
- 1,612 people
- Sponsor
- Peking University
Dietary Behavior, Free Sugar
This Trial Aims to Assess the Effects of Three Different Taste-based Dietary Recommendations for Reducing Free Sugar Intakes on Free Sugar Consumption in UK High Free Sugar Consumers
This randomised controlled trial aims to assess the effects of three different taste-based dietary recommendations for reducing free sugar intakes on free sugar consumption in UK high free sugar consumers.
- Conditions
- Dietary Behavior, Free Sugar, Sweet Taste
- Trial name
- NCT06925932
- Testing
- Dietary advice - Sweet taste, Dietary advice - Taste, Dietary advice - No taste
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Dietary Behaviour
Reducing Free Sugar Intakes: A Role for Sweet Taste
This randomised controlled trial aims to assess the effects of three different types of dietary advice for reducing free sugar intakes, on intakes of free sugar, in a sample of the UK population.
- Trial name
- NCT05684757
- Testing
- Dietary Advice
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Obesity and Type 2 Diabetes
Evaluate the Efficacy and Safety of NT-0796 in Participants With Obesity With or Without Type 2 Diabetes Mellitus
A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NT-0796 as an Adjunct to a Reduced Calorie Diet and Increased Physical Activity in Obese Participants With/Without Type 2…
- Trial name
- RESOLVE-1 (NCT07055516)
- Testing
- NT-0796
- Where
- 11 sites in United States
- Volunteers
- 176 people
- Sponsor
- Rezera (formerly NodThera Limited)
Depression, Major Depressive Disorder
Diet and Depression
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a…
- Conditions
- Depression, Major Depressive Disorder, Weight Gain, Obesity
- Trial name
- NCT06252701
- Testing
- Reduction of Ultra-processed foods
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Obesity
Factors Affecting Caloric Regulation in Human Feeding
This study will test the hypothesis that reducing the energy density of the diet by incorporating more water-rich foods will result in: 1) greater weight loss and weight maintenance; 2) greater diet satisfaction and satiety; and…
- Trial name
- NCT00108784
- Testing
- Reduced-energy-density diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NAFLD
Healthy Eating Through Reduction Of Excess Sugar
The purpose of the study is to determine the effect of dietary sugar reduction in obese children and examine whether there are differential effects based on genotype of a single amino acid substitution in the PNPLA3 gene that is…
- Trial name
- HEROES (NCT02948647)
- Testing
- Standard of care plus sugar-reduction education
- Where
- 2 sites in United States
- Volunteers
- 113 people
- Sponsor
- University of Southern California
Overweight and Obesity, Weight Loss Maintenance
Feasibility and Preliminary Efficacy of a Reverse Diet as a Novel Weight Loss Maintenance Strategy for Weight-Reduced Adults With Overweight/Obesity
The purpose of this project is to test, for the first time, a reverse diet in adults with current or prior overweight/obesity (Ow/Ob).
- Conditions
- Overweight and Obesity, Weight Loss Maintenance, Dietary Habits
- Trial name
- NCT03560635
- Testing
- Weight Loss Maintenance (Control vs. Reverse Diet)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Obesity
Testing the Effect of Multiple Weight Management Modalities for Chronic Disease Risk Reduction in a Clinical Setting
This project will test 3 methods of dietary changes in a weight loss clinic. Participants will be randomized to one of 3 arms: low-carbohydrate diet, intermittent energy restriction, or Hunger Training.
- Trial name
- LIHT (NCT03998878)
- Testing
- Low-Carbohydrate Diet, Intermittent Energy Restriction, Hunger Training
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Obesity
B195: Effect of Diet-Induced Energy Deficit and Body Fat Reduction on Inflammatory Markers in Obese Subjects
Aim: To dissociate the effects on plasma concentrations of the inflammatory marker c-reactive protein of a negative energy balance and a reduction in body fat stores.
- Trial name
- NCT00302926
- Testing
- energy restriction and maintenance
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Bariatric Surgery (Gastric Bypass)
Can Postprandial Reactive Hypoglycaemia be Reduced in Patients After Roux-en-Y Gastric Bypass With a Low Carbohydrate Diet?
Roux-en-Y gastric bypass (RYGB) accelerates nutrient delivery to the small intestine causing higher peak blood glucose concentration early after meal intake.
- Trial name
- NCT02665715
- Testing
- Low carbohydrate meals, Standard carbohydrate meals
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Amirsalar Samkani
Cognition, Obese Older Adults
Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults
The deleterious effects of obesity on cardiovascular disease (CVD) and metabolic risk factors (dyslipidemia, hypertension, and insulin resistance) are well-documented.
- Conditions
- Cognition, Obese Older Adults, Mediterranean Diet
- Trial name
- NCT03129048
- Testing
- MedDiet
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Constipation - Functional
Effect of Weight Reduction on Constipation
In total, 125 women aged between 20 and 40 years were recruited in this study. Participants were considered eligible when they met the inclusion criteria of being diagnosed with functional constipation, as defined by the Rome…
- Trial name
- constipation (NCT03106857)
- Testing
- Group A
- Where
- 2 sites in Egypt
- Volunteers
- 125 people
- Sponsor
- Ahlia University
Irritable Bowel Syndrome, Gluten Sensitivity
Reduced Content of Gluten Diet on Patients With Irritable Bowel Syndrome (Pro.Ali.Fun.)
This study aim to manufacture bread and pasta with an reduced content of gluten and to assess the impact of reducing the daily intake of gluten by 50% in irritable bowel syndrome (IBS) patients.
- Trial name
- PROALIFUN (NCT03638544)
- Testing
- Reduced gluten bread and Pasta compared o normal gluten bread and Pasta
- Volunteers
- 20 people
- Sponsor
- University of Bari
Irritable Bowel Syndrome, Obesity
Response of Irritable Bowel Syndrome to Abdominal Fat Reduction
The purpose of the study is to find out the response of Irritable Bowel Syndrome (IBS) to abdominal fat reduction in central obese patients using: application of High Intensity Focused Ultrasound (cavitation) on the abdominal…
- Conditions
- Irritable Bowel Syndrome, Obesity, Abdominal Obesity
- Trial name
- NCT05879692
- Testing
- focused ultrasound, Low Caloric Diet (LCD) and a low (FODMAPs) diet, aerobic exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Diet Modification, Lung Cancer
Reducing Insulin, Growth Hormones, and Tumors
The objective of this project is to compare the effect of two widely implemented cancer diets, differing drastically in macronutrient content, on biomarkers of inflammation, compared to a control diet.
- Trial name
- RIGHT (NCT03785808)
- Testing
- Special Diet Therapy (low-carb), Special Diet Therapy (low-fat), Special Diet Therapy (USDA control)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Fred Hutchinson Cancer Center
Pre-diabetes, Obesity
Sub-Study of the PREVIEW Study Australia
The aim of this study is to investigate possible enduring effects of a standard 2-month weight loss program on appetite regulation, bone homeostasis and muscle strength in younger and older adults, as well as the impact of…
- Trial name
- NCT02030249
- Testing
- Low calorie diet administered from 0 to 2 months, High Protein / Low Glycaemic Index, Moderate Protein / High Glycaemic Index
- Where
- 3 sites in Australia
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Primary Hypertension
Dietary Nitrate and the Oral Microbiome in Children With Primary Hypertension
Children and adolescents with primary hypertension (high blood pressure without an underlying secondary cause) are at increased risk of cardiovascular disease in adulthood.
- Trial name
- NCT07236125
- Testing
- No active intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yelda Kasımoğlu