Clinical trials: Dietary Fats
Dietary Fat Metabolism
Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ
Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors.
- Trial name
- NCT06313606
- Testing
- Dietary fat positive control, Dietary fat negative control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Healthy
Dietary Variety Versus Dietary Fat Effects in Energy Intake
The relative importance of dietary patterns vs. macronutrient composition in affecting energy intake and body weight remains uncertain.
- Trial name
- NCT00285571
- Testing
- Controlled Feeding Intervention
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ageing, Mitochondrial Function
The Effect of Fish Oils With Dairy or Plant Based Lipids on Mitochondrial and Physical, and Cognitive Function, in Elderly Humans
The aim of this study is to determine whether dairy or plant based fats combined with fish oils can alter skeletal muscle mitochondrial, physical, and cognitive function.
- Conditions
- Ageing, Mitochondrial Function, Physical Function, Cognitive Function
- Trial name
- NCT04194983
- Testing
- Fish oils and dairy fat, Fish oils and plant fat
- Where
- 2 sites in Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Cold Exposure
Energy Dense Fueling for Cold-Weather Operations
High daily energy expenditures without compensatory increases in energy intakes results in severe energy deficits during cold-weather military operations.
- Trial name
- NCT07489690
- Testing
- High Fat, High Carbohydrate
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Vitamin D Deficiency
A Pilot Study of the Effect of Dietary Fat Type and Amount on Vitamin D3 Absorption
This study will examine whether the amount and type of fat, mono-unsaturated fat (MUFA) vs. poly-unsaturated fat (PUFA), in a meal affects the absorption of vitamin D, which is taken after that meal.
- Trial name
- MUFA/PUFA (NCT01508845)
- Testing
- cholecalciferol
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Tufts University
Dietary Modification
Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake
The capacity to burn fat as fuel for exercise may have important implications for sporting performance, with dietary fat intake positively influencing this ability.
- Trial name
- NCT02568592
- Testing
- High Fat, Normal, Normal + Extra Fat
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Obesity, Metabolic Disease
Body Fat Distribution and Fat Metabolism
The primary purpose of the study is to examine the effect of body fat distribution on the physiological response to a dietary fat intervention.
- Trial name
- NCT00475774
- Testing
- Long-chain (C18:2) and medium chain fatty acid (C8 and C10).
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- TNO
Heart Failure With Reduced Ejection Fraction (HFrEF)
Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction
The OLEA-HF study aims to explore whether daily supplementation of extra-virgin olive oil (EVOO) for 12 weeks during participation in a cardiac rehabilitation program (standard of care) is feasible in patients with heart failure…
- Trial name
- OLEA-HF (NCT07644806)
- Testing
- Extra-virgin olive oil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Old Dominion University
Fat Consumption, Inflammatory Markers
Preoperative Dietary Fat Consumption and Baseline Inflammatory Markers
This single-center, prospective pilot study will examine dietary fat consumption and its relationship with inflammatory markers before surgery and the incidence of perioperative neurocognitive disorders in older surgical…
- Trial name
- D&D (NCT07442981)
- Testing
- Inflammatory markers test in blood prior to surgery, Inflammatory markers test in CSF (cerebrospinal fluid), MOCA test
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Ohio State University
Healthy
Diets With a Spectrum of Fat Intake for Preventing Obesity: A Randomized Controlled-feeding Trial
The aim of the current study is to evaluate the effects of diets with three levels of dietary fat on weight change and related cardiometabolic risk factors in a 6-month randomized controlled-feeding trial.
- Trial name
- NCT02355795
- Testing
- low-fat diet, moderate-fat diet, high-fat diet
- Where
- China
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Breast Cancer Lymphedemas
Bioelectrical Impedance Utilization and Dietary Intake Relation in the Breast Cancer Related Lymphedema
The purpose of this study was to investigate the clinical role of bioelectrical impedance analysis (BIA) and the relationship between the occurrence of breast cancer related lymphedema (BCRL) and dietary factors in breast cancer…
- Trial name
- NCT03391206
- Testing
- Inbody 720
- Where
- South Korea
- Volunteers
- 228 people
- Sponsor
- Severance Hospital
Insulin Resistance
The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans
In this research study, investigators will test the effects of an approved medication for diabetes,Liraglutide, to reduce insulin resistance that develops from eating a diet high in saturated fats.
- Trial name
- NCT02403284
- Testing
- Liraglutide, Sugar Pill
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Phoenix VA Health Care System
Obese, Insulin Resistance
Blood Lipopolysaccharide (LPS) Rifaximin Study
Metabolic syndrome is a condition involving elevated levels of fat in the blood, a tendency towards diabetes, hypertension, and too much fat around the abdomen (an increased waistline).
- Conditions
- Obese, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT02124512
- Testing
- Rifaximin SSD
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Philip Kern
Lipids, Lipid Metabolism
RISSCI-1 Blood Cholesterol Response Study
Raised blood cholesterol (also referred to as blood LDL-cholesterol) is a major risk factor for developing heart disease. Dietary saturated fat is recognised as the main dietary component responsible for raising blood…
- Conditions
- Lipids, Lipid Metabolism, Healthy
- Trial name
- RISSCI-1 (NCT03270527)
- Testing
- High SFA diet (Diet 1), Low SFA diet (Diet 2)
- Where
- 2 sites in United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Short Chain Fatty Acids Concentration in Stools, Gut Microbiota Diversity and Composition
Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults
This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity.
- Conditions
- Short Chain Fatty Acids Concentration in Stools, Gut Microbiota Diversity and Composition, Blood Lipid Profiles, Inflammation Biomarkers
- Trial name
- NCT07550023
- Testing
- Butter, Coconut oil, Extra Virgin Olive Oil
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Acute Pancreatitis
The Effect of Dietary Fat Content on the Recurrence of Pancreatitis
This trial aims to test the effects of two different diets on the recurrence of acute pancreatitis, and acute pancreatitis associated mortality.
- Trial name
- EFFORT (NCT04761523)
- Testing
- Dietary intervention: reduced fat diet, Dietary intervention: standard healthy diet
- Where
- Hungary
- Volunteers
- 384 people
- Sponsor
- University of Pecs
Headache
Effects of Changes in Dietary Intake and Headache's Attacks
Headache is a frequently disabling disorder, which occurs in about 30% of the adult population, particularly in overweight/obese women.
- Trial name
- NCT01917474
- Testing
- low lipid diet, normal lipid diet
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Federico II University
Metabolic Syndrome
Acute Effects of Dietary Fats and Carbohydrate in Subjects With Metabolic Syndrome
There is increasing evidence suggests that elevated levels of postprandial triacylglycerol (TAG)-rich lipoproteins may promote the development of cardiovascular diseases (CVD).
- Trial name
- NCT01571947
- Testing
- Acute Effects of Fats and Carbohydrate
- Where
- 2 sites in Malaysia
- Volunteers
- 30 people
- Sponsor
- Malaysia Palm Oil Board
Atherosclerosis, Cardiovascular Diseases
Dietary Fat, Plasma Lipids, and Other CHD Risk Factors
To assess the extent to which consumption of different sources of hydrogenated fat relative to unhydrogenated oil or butter alters plasma lipoprotein concentrations and measures of lipid metabolism.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart Diseases
- Trial name
- NCT00005532
- Sponsor
- Tufts University
Type 2 Diabetes Mellitus
Optimal Dietary Fat Pattern to Prevent Cardiovascular Disease Among Type 2 Diabetes
Cardiovascular complications are the leading cause of death among type 2 diabetic patients. Postprandial triglyceride-rich lipoproteins (ppTRLs) are atherogenic.
- Trial name
- NCT00467168
- Testing
- Diet
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University