Clinical trials: Dietary Fiber, active
Prediabetes or Overweight
Whole Food Fibers for Support of Key Gut Bacteria for Human Health
The purpose of this supplementation study is to understand how whole food fibers may affect gut microbiota composition and overall health. The investigators will enroll up to 24 people in this study.
- Trial name
- NCT07840170
- Testing
- Whole food fiber mixture, inulin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Purdue University
Dietary Fibers, Intermediate Fasting
The Role of the Microbiome in the Response to Dietary Fibers Intake During Intermittent Fasting
Dietary fibers are generally not degraded by the endogenous digestive enzymes, but rather by the complex ensemble of microorganisms that reside in the human gut [1].
- Trial name
- NCT04633369
- Testing
- dietary fibers, Intermediate fasting
- Where
- Israel
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Weizmann Institute of Science
Dysbiosis, Cardiometabolic Health Indicators
Pulse Education and Children
This parallel-arm, randomized controlled trial will evaluate the effectiveness of a 6-week pulse-focused nutrition intervention in school-aged children (6-13 years).
- Conditions
- Dysbiosis, Cardiometabolic Health Indicators, Education on Feeding and Health Status, Gut Motility
- Trial name
- NCT07648446
- Testing
- Education Only, Education + Pulse Provision, Cooking Class
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Resistant Starch, Tapioca Starch
Evaluation of VEDAN RT-90 Resistant Cassava Starch for Glycemic Control and Prebiotic Fiber Development in a Human Trial
This study aims to investigate the effects of RT-90 resistant cassava starch on glycemic control using a human dietary trial and to evaluate its potential as a prebiotic fiber supplement.
- Conditions
- Resistant Starch, Tapioca Starch, Prebiotic Fiber, Blood Sugar
- Trial name
- NCT07282496
- Testing
- RT-90 resistant tapioca starch, control group, Commercially available resistant starch
- Where
- Taiwan
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Obesity & Overweight, Metabolic Syndrome
Kodo Millet Porridge and Its Effects on Gut Health and Metabolic Syndrome
Dietary fiber are components in foods that are not digested by human gastrointestinal enzymes (alpha amylase and alpha glucosidase) but are instead broken down and fermented by gut microbes.
- Conditions
- Obesity & Overweight, Metabolic Syndrome, Gut Dysbiosis, Insulin Resistance
- Trial name
- KMGMS (NCT07703371)
- Testing
- Kodo Millet Porridge Beverage
- Where
- India
- Volunteers
- 50 people
- Sponsor
- JSS MEDICAL COLLEGE, JSS ACADEMY OF HIGHER EDUCATION AND RESEARCH
Breast Neoplasm
Preventing Chemotherapy-induced Peripheral Neuropathy Using PRESIONA Exercise Program
The aim of this study is to determinate if therapeutic exercise with blood flow restriction (BFR) during neoadjuvant chemotherapy potentialy neurotoxic could prevent the onset of chemotherapy induced peripheral neuropathy (CIPN)…
- Trial name
- PRESIONA (NCT04652609)
- Testing
- PRESIONA
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad de Granada
Diabetic Peripheral Neuropathy
Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy
This is a prospective randomized control trial. Participants enrolled into the study will be randomized into one of three groups, two of which are treatment groups and the third is a control group.
- Trial name
- NCT06287736
- Testing
- Spinal Cord Stimulator Implantation (SCS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA)
A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization
Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays, and increased healthcare costs.
- Conditions
- Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococci, Carbapenem-Resistant Enterobacteriaceae
- Trial name
- MDRO-Fiber (NCT07792915)
- Testing
- Resistant Potato Starch, Maltodextrin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Mixed Fiber Supplementation for Healthy Adults
Assessing the Short-Term Effects of Multi-Fiber Supplementation on Gut Health
This is a randomized, parallel-group interventional study evaluating the short-term gastrointestinal effects of a standardized multi-fiber supplement in healthy adults.
- Trial name
- NCT07787026
- Testing
- Prebiotic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brown University
Digestive Health, Quality of Life
Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints
A positive impact of a fermented dairy protein with prebiotic fiber supplement on self-reported GI complaints and wellbeing has been suggested (Wardenaar et al. 2024).
- Trial name
- NCT06946017
- Testing
- Fermented dairy protein with prebiotic fiber supplement
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Solid Tumor Cancer, Immune-Related Adverse Events
Cancer Nutrition Study - A Study of Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors
The goal of this clinical trial is to learn whether changing the diet can help improve gut health and support recovery from immune-related side effects caused by immune checkpoint inhibitor (ICI) cancer treatment in adults with…
- Trial name
- CaNS (NCT07804225)
- Testing
- High-Fermented Food Diet, HI-MAIZE 260 Resistant Starch
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
IBS (Irritable Bowel Syndrome)
High-Resolution Measurements of Diet-Microbiome Interactions
The goal of this clinical trial is to characterize regional intestinal fermentation physiology and determine how the response to fermentable dietary fiber differs between healthy individuals and individuals with irritable bowel…
- Trial name
- NCT07856823
- Testing
- Inulin, Low-fiber control breakfast shake, Atmo Gas-Sensing Capsule
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Melanoma, Stage II
Explorative Study on Addition of High-fiber Dried Chicory Root in Patients With an Intermediate to High-risk Cutaneous Melanoma.
Exploring the effect of supplementation with daily addition of prebiotic dried chicory root (WholeFiberTM) for 6 weeks on fecal SCFA levels, gut microbial composition and immune cell composition in minimal stage II A melanoma…
- Trial name
- MELFIB (NCT07206017)
- Testing
- prebiotic dried chicory root (WholeFiber)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
HIV, Non-Alcoholic Fatty Liver Disease
The Gut, Liver And Metabolome in Human Immunodeficiency Virus and Non Alcoholic Fatty Liver Disease
Persons with human immunodeficiency virus (HIV) have higher risk of developing fatty liver disease (NAFLD) than HIV-negative persons but the reasons for this discrepancy are not known.
- Conditions
- HIV, Non-Alcoholic Fatty Liver Disease, Metabolic-Associated Steatotic Liver Disease
- Trial name
- GLAM HIV NAFLD (NCT06113003)
- Testing
- Prebiotic, Probiotic
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Vanderbilt University Medical Center
Sensory Neuropathy, Small Fiber Neuropathy
IVIG in Painful Sensory Neuropathy
The goal of this clinical trial is to assess effect of Intravenous immunoglobulins (antibodies) as compared to Placebo, on pain intensity in patients from 18-65 years with painful sensory neuropathy without a known cause.
- Trial name
- NCT06183008
- Testing
- Intravenous immunoglobulin
- Volunteers
- 20 people
- Sponsor
- Sorlandet Hospital HF
Rotator Cuff
Muscle Fiber Fragments for Improved Function of Rotator Cuff Musculature Following Rotator Cuff Repair
In this study, a chest muscle sample (biopsy) will be taken and the muscle fibers will be removed from the sample and made into smaller strands or fragments.
- Trial name
- NCT03752034
- Testing
- Muscle Fiber Fragments (MFFs)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Obesity
Dietary Fiber: Is it the Missing Link in Achieving Long Term Behavior Change?
The overall objective of this three-arm randomized controlled trial is to compare a dietary fiber-focused behavioral intervention to standard weight loss education for improving eating-related behavior and cognition, weight, and…
- Trial name
- NCT06227494
- Testing
- Fiber Intervention, Standard Weight Loss Education
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Cerebral Palsy (CP)
Spastic Myopathy in Adults With Cerebral Palsy
Cerebral palsy (CP) is indeed the result of a central neurological lesion, but it also involves a lesser-known muscular condition that we refer to as spastic myopathy.
- Trial name
- MYOSPAS-IMC (NCT07293988)
- Testing
- Guided Self-rehabilitation Contract, Conventional therapy group
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Neuroloco
Subjective Cognitive Decline
Gut-brain Health Effects of PREbiotics in Older Adults With Suspected COgnitive DEcline
As people around the world are living longer, the number of individuals with dementia, particularly Alzheimer's disease (AD), is expected to triple by 2050.
- Trial name
- PRECODE (NCT06433037)
- Testing
- Chicory inulin, Resistant dextrin, Seaweed polysaccharide
- Where
- Netherlands
- Volunteers
- 164 people
- Sponsor
- Wageningen University
Breast Reconstruction After Mastectomy, Neurotization
Longitudinal Evaluation of Direct Neurotization Technique in Breast Reconstruction With Fully Autologous Components
This clinical trial aims to evaluate whether direct neurotization using fully autologous components during autologous breast reconstruction improves postoperative breast sensation and sensory-related quality of life in women…
- Conditions
- Breast Reconstruction After Mastectomy, Neurotization, Mastectomy and Breast Reconstruction, Peripheral Nerve Regeneration
- Trial name
- NCT07308275
- Testing
- Autologous Breast Reconstruction With Direct Neurotization, Autologous Breast Reconstruction without Neurotization
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia