Clinical trials: Dietary Fibre
Type 2 Diabetes, Cardiovascular Disease
Low Glycemic Index Diets vs. High Cereal Fibre Diets in Type 2 Diabetes
Large observational studies have shown cereal fiber to protect from diabetes and heart disease. Despite the success of acarbose, an α-glucosidase hydrolase inhibitor, which lowers the glycemic index of foods containing starch…
- Trial name
- NCT00438698
- Testing
- Low Glycemic Index diet, High Cereal Fibre Diets
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University of Toronto
Kidney Disease
Effects of High Dietary Fiber Supplementation in Diabetic Chronic Kidney Disease
Loss of kidney function results in accumulation in the blood of molecules that are either excreted or metabolized by the kidney. Collectively, these molecules are termed Uremic Retention Molecules (URMs) or toxins.
- Trial name
- NCT01838330
- Testing
- psyllium
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Utah
Dietary Modification, Healthy
Acute Glycemic and Insulinemic Response of FOSSENCE™
Short chain fructooligosaccharide (FOS) is known as a prebiotic fiber/nutrient and has been documented to demonstrate different health benefits including glucose control, gut health, mineral absorption, weight and immunity.
- Trial name
- NCT03755232
- Testing
- scFOS, Control
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TATA CHEMICALS LTD
Overweight, Obesity
Safety and Effectiveness Study of a Fiber Supplement for Weight Loss
Overweight and obesity are serious and growing problems within the United States. The usual approaches to weight loss-dieting, exercise, and behavioral interventions-rarely result in long-term weight loss.
- Trial name
- NCT00613600
- Testing
- Glucomannan, Inert microcrystalline cellulose
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rush University Medical Center
Autoimmune Diseases, Inflammatory Bowel Diseases
Chronic Inflammatory Disease, Lifestyle and Risk of Disease
Chronic inflammatory diseases (CID) - including inflammatory bowel diseases (Crohn's disease and ulcerative colitis), rheumatic conditions (rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis), inflammatory skin…
- Conditions
- Autoimmune Diseases, Inflammatory Bowel Diseases, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- PROCID-DCH (NCT03456206)
- Testing
- Intake of red and processed meat and fibres, Lifestyle factors independently or combined
- Where
- Denmark
- Volunteers
- 57,053 people
- Sponsor
- University of Southern Denmark
Appetite Suppression, Weight Loss
Effects of a Dietary Fibre Supplementation of a Low Calorie Diet on Appetite and Body Weight
This 18 week, randomized, double blind, placebo controlled trial will examine the effects of thick dietary fibre (PGX) supplementation of a low calorie diet (LCD) on appetite, weight loss, body composition, and compliance in…
- Trial name
- NCT01109199
- Testing
- PolyGlycopleX (PGX), Rice flour
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Canadian Center for Functional Medicine
Obesity, Childhood, Insulin Resistance
Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance
This is a 12-month, single center, three-arm parallel design, double-blind, randomized clinical trial, to compare the effects of supplemental dietary fiber and metformin (MET) alone and in combination over 12 months on glucose…
- Trial name
- NCT04578652
- Testing
- Metformin 850 mg oral tablet bid, Supplemental fiber mixture (35 g total) composed of 6g of Oligofructose + 12g of resistant maltodextrin + 12g of acacia gum + 5g of PGX.
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Alberta
Constipation, Neurologically Impaired
This Study Aims to Evaluate the Safety and Efficacy of Fiber Supplementation on Constipation in Neurologically Impaired Children Using Rectal Wall Thickness Measurement by Ultrasound.
The current increasing survival of children with central nervous system damage has created a major challenge for medical care. Gastrointestinal and nutritional problems in neurologically impaired children have been recognized as…
- Trial name
- NCT07740785
- Testing
- Psyllium Husk, Fiber
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Early-onset Colorectal Cancer, Late-onset Colorectal Cancer
Distinct Metastatic Phenotypes Between Early-onset and Late-onset Colorectal Cancer
The clinical and pathological features of early-onset colorectal cancer (EOCRC) differ from those of late-onset colorectal cancer (LOCRC).
- Trial name
- NCT06040021
- Testing
- standardized treatment
- Volunteers
- 15,244 people
- Sponsor
- Fudan University
Obesity & Overweight
Polydextrose Functional Gummies for Weight Management in Adults With Overweight or Obesity
Overweight and obesity are common conditions that increase the risk of metabolic and cardiovascular diseases. Polydextrose is a type of dietary fiber that may help increase feelings of fullness by influencing natural hormones…
- Trial name
- DEXTRO-PESO (NCT07758387)
- Testing
- Polydextrose Gummies
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Nutris We Care About You S.L.
Obesity, Type 2 Diabetes
A Very High Fiber Diet Versus a Low-carbohydrate Diet for Weight Loss
Using a 2x2 complete factorial design, approximately 140 obese men and women who may or may not have type 2 diabetes will be randomized to one of two conditions (70 in each condition): (a) a high fiber diet, or (b) a…
- Trial name
- NCT01051674
- Testing
- High fiber vs. low-carbohydrate diets
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- Loma Linda University
Healthy
Dietary Fiber, Microbiota and Cognitive Function in Healthy Adults
Dietary fiber is well-known for its many health benefits, including the support of gastrointestinal, metabolic, and mental health.
- Trial name
- FOCUS (NCT04951674)
- Testing
- High fiber diet, Control diet
- Where
- Ireland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University College Cork
Healthy Adult
Dietary Fibres on Gut Fermentation
The goal of this clinical trial is to learn if adding a rapidly fermenting fibre to a meal containing a slow fermenting fibre affects gut bacterial fermentation and digestive comfort in healthy adults aged 18 to 85 years.
- Trial name
- NCT07837297
- Testing
- SCF Alone, SCF and FOS (Single Dose), SCF and FOS (Split Dose)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bath
Sensitivity
Evaluation of Post-operative Sensitivity of Bulk Fill Resin Composite Versus the Nano Resin Composite.
Our study evaluated and compared the postoperative sensitivity of the placement technique (incremental and bulk fill) in class II posterior composite resin restorations bonded with two different adhesive strategies (self-etch and…
- Trial name
- EPSBN (NCT03792178)
- Testing
- Bulk fill composite, Nano resin composite
- Volunteers
- 60 people
- Sponsor
- Rasmia Mamdouh Ali Salem
Insulin Resistance
Effects of Hi-maize Resistant Starch on Insulin Sensitivity
The purpose of this study is to determine the effects of a dietary fiber, resistant starch, on insulin sensitivity. Low insulin sensitivity is a risk factor for some diseases including type 2 diabetes and heart disease.
- Trial name
- NCT01058135
- Testing
- Hi-maize starch (Low dose), Hi-maize starch (High-dose), Control (starch)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ingredion Incorporated
Obesity
High Fat Diet II on Weight Loss
To evaluate two different diets and their effects on weight loss and measurements of several risk factors for cardiovascular disease.
- Trial name
- HFD (NCT00525850)
- Testing
- high fat diet, low saturated fat diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christiana Care Health Services
Gout, Hyperuricemia
The Diet Gout Trial
Unhealthy diet has long been associated with high uric acid levels and gout. The DASH diet may lower uric acid levels. This study will examine the effects of the DASH diet on uric acid in adults with a history of gout.
- Trial name
- DIGO (NCT03569020)
- Testing
- Subsidy for food purchases and dietitian education
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postprandial Period
The Postprandial Effects of Chick-Pea Consumption on Glucose, Insulin, and Gut Hormone Responses (PEA-POD).
Pulses have a high fibre content, contribute to lowering fasting blood cholesterol levels and improving glycaemic control, and have shown also considerable promise in supporting the dietary management of cardiovascular disease…
- Trial name
- NCT03994276
- Testing
- Chickpea powder
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- King's College London