Clinical trials: Dietary Proteins
Medical Oncology, Integrative Oncology
A Pilot and Feasibility Study of a Dietary Intervention With Low-protein Meals in Cancer Patients Receiving Immunotherapies
The main idea of this study is that a low protein diet may alter the environment surrounding the tumor, enhancing the body's immune response leading to greater anticancer effects of treatment.
- Conditions
- Medical Oncology, Integrative Oncology, Medical Nutrition Therapy
- Trial name
- NCT05356182
- Testing
- Diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Acid Base Disorder
Effect of the Diet on Urinary Excretion of Alpha-ketoglutarate
The G coupled-protein receptors 99 (GPR99) was discovered in 2002 by Wittenberg et al. and is involved as a metabolic receptor. It has been shown that the natural ligand of GPR99 is an intermediate in the Krebs cycle…
- Trial name
- NCT01880281
- Testing
- Meat and vegetable diet
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Michel Burnier
Polycystic Kidney, Autosomal Dominant, ADPKD
Wishing to Decrease Aquaresis in ADPKD Patients Treated With a V2Ra; the Effect of Regulating Protein and Salt
This study evaluates the effect of regulating salt and protein intake on urinevolume in patients with ADPKD treated with a vasopressine V2 receptor antagonist (V2RA).
- Conditions
- Polycystic Kidney, Autosomal Dominant, ADPKD, Autosomal Dominant Polycystic Kidney
- Trial name
- WATER (NCT04310319)
- Testing
- Sodiumchloride, Protein
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Esther Meijer
Healthy
Effect of the Level of Dietary Protein on the Infant Hormonal Profile and Body Composition
A double blind, controlled, randomized, single site clinical trial of 2 parallel groups (Low protein formula =LoF and High protein formula =HiF) with a breastfeeding group (BF) as reference from birth to 1 year of age and a…
- Trial name
- NCT02282488
- Testing
- Low protein formula, High protein formula
- Where
- France
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Dietary Supplement
A Study to Evaluate the Effects of Pre-Meal Whey Protein Microgels Administration on Post-Prandial Glycemic Response.
This is a mechanistic, randomized, investigator-blinded, placebo-controlled, single-center, crossover study designed to evaluate the effects of premeal administration of whey protein microgels compared to placebo on postprandial…
- Trial name
- NCT04639726
- Testing
- Whey Protein Micro Gel, Water without Whey Protein.
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Cancer Cachexia, Omega 3
Effects of Dietary Supplementation With omega3-fatty Acids (Fish Oil) and Progressive Resistance Training on Skeletal Muscle Status in Gynaecological, Gastrointestinal and Urological Cancer Patients
Cancer cachexia is a common and prognostically relevant complication of advanced malignancies, characterized by systemic inflammation, increased catabolism, and reduced nutritional intake, leading to a progressive loss of…
- Conditions
- Cancer Cachexia, Omega 3, Resistance Training, Cancer
- Trial name
- SUPPORT (NCT07643558)
- Testing
- Omega 3 FA (Fish Oil), Training
- Where
- Germany
- Volunteers
- 288 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Geriatric Diseases
Increased Focus on Protein Intake Among Geriatric Patients
Up to approximately 38 (unknown drop-out rate) geriatric patients (at least 65 years old) are recruited from a Geriatric ward at Slagelse Sygehus.
- Trial name
- NCT03075189
- Testing
- Whey protein supplement
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Copenhagen
Diabetes Mellitus, Type 2, Overweight and Obesity
Effect of a Low-calorie and High-protein Diet Specially Rich in Animal Protein Compared to a Low-calorie and High-protein Diet Specially Rich in Plant Protein on Glucose Metabolism in Subjects With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
The aim of the study is to explore the effect of a low-calorie diet rich in protein (with a content of 35% of the total calories of the diet), mostly coming from animal sources (75% of total protein), compared to a hypocaloric…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, PreDiabetes
- Trial name
- NCT05456347
- Testing
- Low-calorie and high-protein diet with the majority of protein coming from animal sources., Low-calorie and high-protein diet with the majority of protein coming from plant sources.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
End-Stage Renal Disease, Malnutrition
A Plant Based High Protein Diet to Improve Nutritional Outcomes in Peritoneal Dialysis Patients
The study proposes that addition of high protein plant based diet will improve serum albumin as well serum phosphate for patients with End Stage Renal Disease (ESRD) on Dialysis.
- Trial name
- PBPD (NCT02360748)
- Testing
- Plant based high protein food items
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Ochsner Health System
Obesity, Metabolic Syndrome
Diet, Obesity and Genes (DiOGenes)
Study Title: Diogenes, A randomised controlled trial comparing the effect of reduced-fat diets varying in glycaemic index (high vs. low) and protein content (high vs.
- Conditions
- Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- DIOGENES (NCT00390637)
- Testing
- High or low Glycemic Index and high or low Protein Diet
- Where
- Denmark
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Aging
The Influence of Regular Beef Consumption and Protein Density of the Diet on Training-induced Gains in Muscle Strength and Performance in Healthy Adults
Humans lose muscle and strength as they get older. Further, ageing is accompanied by loss in cognitive function. It is not quite clear why this happens; however, it is known that the loss of muscle and strength can increase risk…
- Trial name
- NCT03029975
- Testing
- Resistance Training Exercise, Beef Protein Consumption
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Diabetic Nephropathies
Effect of Low Protein Diet in Preventing the Progression of Diabetic Nephropathy
Diabetic nephropathy is the leading cause of chronic kidney disease all the world in spite of progress in new treatment for diabetes and anti hypertensive drugs.
- Trial name
- LPD (NCT00448526)
- Testing
- low protein diet
- Sponsor
- Kanazawa Medical University
Protein Deposition
Protein Source on Plasma Amino Acid Concentrations
This study will determine the effect of the same ounce-equivalents of fresh pork versus nuts, beans, and eggs on postprandial plasma essential amino acid availability in adults. Each participant will receive all four treatments.
- Trial name
- NCT03649568
- Testing
- Pork, Egg, Black beans
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Purdue University
Aging, Nutrition
Sustainable Insect-based Protein Supplement in the Elderly: a Pilot Study
This pilot randomized, double-blind, controlled trial evaluated the effects of a Tenebrio molitor-enriched protein biscuit combined with a structured physical activity program on cardiometabolic health in older adults.
- Conditions
- Aging, Nutrition, Sustainable Diets, Cardiometabolic Health
- Trial name
- SIPSE (NCT07456319)
- Testing
- INSECT - Protein suplement based on edible insect flour, Control
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitat Oberta de Catalunya
Cardiovascular Diseases, Sarcopenic Obesity
A High-PRotein Mediterranean Diet and Resistance Exercise for Cardiac Rehabilitation
Cardiovascular disease is responsible for a quarter of all deaths in the UK and risk seems to be higher in cardiac rehabilitation (CR) with lower body weight which may be due to sarcopenci obesity (SO) or low muscle mass with…
- Trial name
- PRiMER (NCT04272073)
- Testing
- High-Protein Mediterranean Diet, Resistance Exercise, Standard Dietary Advice
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Liverpool John Moores University
Multiple Myeloma, Smoldering, Multiple Myeloma
A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS)
The researchers are going this to look at how butyrate levels change in participants' stool after they are on a plant-based diet or dietary supplements (omega-3, curcumin or probiotics) for 2 weeks.
- Conditions
- Multiple Myeloma, Smoldering, Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance
- Trial name
- NCT06055894
- Testing
- Omega-3, Curcumin, Probiotic
- Where
- 7 sites in United States
- Volunteers
- 200 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acid-Base Balance Disorder, Metabolic Acidosis
Acid-Base Balance, Metabolism and Minerals
Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications.
- Trial name
- BASICA (NCT04229069)
- Testing
- alkaline salt mixture
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Healthy
Influence of Protein Hydrolysis on Dietary Protein Digestibility and Metabolism in Healthy Subjects
Hydrolysis of dietary protein may impact their gastrointestinal kinetics and further metabolism. The primary goal of this work was to measure the metabolic fate of intact or hydrolyzed protein using a protein of good nutritional…
- Trial name
- NCT00873951
- Testing
- Intestinal and metabolic exploration, 15N-labelled intact casein, 15N-labelled hydrolyzed casein
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
COPD
High Protein Diet and Physical Activity in COPD
COPD outpatients with severe and very severe (grade III-IV) disease at risk of malnutrition commencing rehabilitation (7-10-week physical activity program) were randomized to receive a high protein diet (≥ 25 energy percentage)…
- Trial name
- NCT04888182
- Testing
- intervention
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Jens Rikardt Andersen
Metabolic Syndrome X, Liver Diseases
Effects of Macronutrients on Hepatic Lipids, Plasma Triglycerides, and Insulin Sensitivity
The purpose of this study is to assess how the macronutrient composition of the diet effects lipid and glucose metabolism intrahepatic lipids insulin sensitivity in healthy lean subjects and in subjects with a high metabolic risk…
- Trial name
- MACRONUTR (NCT00523562)
- Testing
- diet intervention
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Lausanne