Clinical trials: Difference, Individual
Hiv, Depression
Change My Story Task Shifted Mental Health Intervention
Psychological distress and depression are common among young people living with HIV (Y-PLWH) and negatively impact medication adherence and disease control.
- Conditions
- Hiv, Depression, Psychological Distress
- Trial name
- NCT06389565
- Testing
- Problem Solving Therapy, Change My Story
- Where
- Nigeria
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Pain, Individual Difference
Identifying Neuroimaging Biomarkers, Demographic, Personality and Sensory Factors for Predicting Extreme Pain Responses to Various Experimental Pain Stimulations in Healthy Subjects
The proneness to react to noxious stimuli varies widely between individuals and pain ratings of seemingly identical noxious stimuli may range from "no pain" to "excruciating pain" .
- Trial name
- NCT03436264
- Testing
- MRI
- Where
- Israel
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Healthy
A Study in Healthy People to Measure How Different Doses of Verducatib Affect the Heart
The main objective of this trial is to evaluate the effects of verducatib in the range of therapeutic to supra-therapeutic exposures on the QT/QTc-interval and other ECG parameters
- Trial name
- NCT07760246
- Testing
- Verducatib, Moxifloxacin
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Carcinoma, Pancreatic Ductal, Colorectal Neoplasms
A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.
The purpose of this study is to learn about the safety and effects of the study medicine when given alone or together with other anti-cancer therapies. Anti-cancer therapy is a type of treatment to stop the growth of cancer.
- Conditions
- Carcinoma, Pancreatic Ductal, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT06704724
- Testing
- PF-07985045, Gemcitabine, Nab-paclitaxel
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 30 people
- Sponsor
- Pfizer
Healthy Volunteers
Quality of Life and Behavioral Change of Retired Persons
Researchers have found that the first phase of aging, called "frailty", is insidious, silent and slowly progressive. It begins well before the first signs of aging and possibly before retirement age with physiological reserves…
- Trial name
- R-FORM' (NCT06432010)
- Testing
- Group nutrition and physical activity coaching, Group cognition coaching
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis
Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple Sclerosis
The goal of this clinical trial is to learn whether a structured lifestyle program can improve health and wellbeing in people living with multiple sclerosis (MS).
- Trial name
- HEAL-MS (NCT07589062)
- Testing
- Multi-Domain Lifestyle Intervention
- Where
- United Arab Emirates
- Volunteers
- 30 people
- Sponsor
- New York University Abu Dhabi
Type 2 Diabetes, Prediabetes
Sophia Step Study - a Behaviour Change Program on Physical Activity in Persons With Pre- and Type 2 Diabetes
The aim of the study is to investigate the effects of two levels of primary care physical activity interventions on metabolic control and cardiovascular risk factors, compared to usual care in patients with pre- and type 2…
- Trial name
- NCT02374788
- Testing
- Pedometer intervention, Group meetings, Individual consultations
- Where
- Sweden
- Volunteers
- 188 people
- Sponsor
- Sophiahemmet University
HIV Infection, Combined Antiretroviral Therapy
Impacts of Different ART Regimens on Lipid Metabolism in People Living With HIV
To compare the dynamic changes of lipid metabolism of people living HIV who treated with different antiretroviral therapy (ART) regimens such as Biktarvy EVG/c/TAF/FTC, DTG/FTC/TDF, TDF/3TC/EFV, etc.
- Trial name
- ART (NCT06019273)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Post-traumatic Stress Symptoms
Evaluating Symptom Variations and Observing Longitudinal Individual Change Effects in TF-CBT
The goal of this observational study is to learn about the level of change in post-traumatic stress symptoms in adolescents with traumatic experiences over the course of trauma-focused cognitive behavioral therapy for children…
- Trial name
- EVOLVE (NCT07402681)
- Testing
- Trauma-focused Cognitive Behavioral Therapy for Children and Adolescents
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University Children's Hospital, Zurich
Heart Failure
A Study of Ponsegromab in People With Heart Failure
The primary purpose of this clinical trial is to compare the effects of study medicine (Ponsegromab/PF-06946860) with a placebo (an injection that looks like the study medicine but does not contain the active medicine) to find…
- Trial name
- GARDEN TIMI 74 (NCT05492500)
- Testing
- Main cohort (Cohort A): Ponsegromab low dose, Main cohort (Cohort A): Ponsegromab medium dose, Main cohort (Cohort A): ponsegromab high dose
- Where
- 122 sites in United States, Australia and 9 more
- Volunteers
- 455 people
- Sponsor
- Pfizer
Sleep, Diabetes
Individual Differences in Diabetes Risk: Role of Slow WaveSleep
This study will examine the relationship between the amount of slow wave sleep (deep sleep) and the ability of the body to bring the blood sugar level to a normal range after receiving glucose.
- Trial name
- NCT00989378
- Testing
- baseline study
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Type 1 Diabetes Mellitus
Effects of Postprandial Exercise on Glycaemia and Metabolism in People with Type 1 Diabetes
A cornerstone in the management and treatment of people living with type 1 diabetes (T1D) is to engage in regular physical exercise for a variety of health and fitness reasons.
- Trial name
- PRANDEX-1 (NCT05179135)
- Testing
- Postprandial exercise of different modalities
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
Head and Neck Squamous Cell Carcinoma (HNSCC)
A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer
With an amendment of the protocol, this study is only open to adults with head and neck cancer. Previously also adults with liver cancer joined.
- Trial name
- NCT05249426
- Testing
- BI 765063, Ezabenlimab, BI 836880
- Where
- 25 sites in United States, France and 9 more
- Volunteers
- 48 people
- Sponsor
- Boehringer Ingelheim
Obesity, Overweight
Weight Regain After Consumption of Food Supplement and Interventional Diet Program
Effect of the dietary supplement (FAT-BINDER DAMM) on weight regain after 9 months of control weight program
- Conditions
- Obesity, Overweight, Weight Loss, Body Weight Changes
- Trial name
- fat-binder (NCT03554525)
- Testing
- Fat-binder damm
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Healthy Adult Participants
Alcohol Sensitivity Among Older Adults Who Consume Alcohol
This is a proof-of-concept study exploring individual differences in sensitivity to alcohol among older healthy current drinkers aged 65 to 80.
- Trial name
- NCT07636447
- Testing
- Alcohol (Oral)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fibromyalgia
Can Electroencephalography (EEG) Identify the Different Dimensions of Pain in Fibromyalgia?
Studies with quantitative electroencephalogram (qEEG) in people with fibromyalgia showed the existence of distinct patterns of brain electrical activity when compared to healthy individuals.
- Trial name
- NCT05962658
- Testing
- qEEG
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Experimental Pain in Healthy Human Subjects
Intra- and Inter-individual Differences of Pain
Pain is a highly subjective and variable phenomenon. Different persons perceive objectively identical nociceptive stimuli differently.
- Trial name
- NCT05616091
- Testing
- painful stimulation by using a laser device (DEKA Stimul 1340, Calenzano, Italy)
- Where
- Germany
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Hypertension, Overweight
Effects of Different Aerobic Exercise Programs With Nutritional Interventions in Hypertensive and Overweight People
Obesity and arterial hypertension (HTN) frequently coexist in the same patient. Moreover, the concept that obesity and HTN can be additive in terms of cardiovascular rist is widely accepted.
- Conditions
- Hypertension, Overweight, Sedentary
- Trial name
- EXERDIET-HTA (NCT02283047)
- Testing
- DIET, DIET & MODERATE CONTINUOUS TRAINING, DIET & HIGH VOLUME HIIT
- Where
- Spain
- Volunteers
- 176 people
- Sponsor
- University of the Basque Country (UPV/EHU)
Atrial Fibrillation
Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation
While there are several completed clinical trials that address treatment strategy in patients with symptomatic and recurrent AF, there are no randomized clinical trials that address treatment for first-detected AF.
- Trial name
- CHANGE-AFIB (NCT05130268)
- Testing
- Dronedarone
- Where
- 103 sites in United States
- Volunteers
- 339 people
- Sponsor
- American Heart Association
Overweight, Healthy
Precision Exercise Therapeutics (PET-pilot)
The aim of this randomized cross-over study is to collect information for the design of a precision exercise therapy cohort that will predict what modality of physical activity a physically inactive individual with overweight…
- Trial name
- NCT05718089
- Testing
- Continuous aerobic exercise, High intensity interval training, Resistance training
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet