Clinical trials: Difference, Individual
Cystic Fibrosis (CF), CFTR-related Disorders
A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis
Sometimes it is very difficult to tell if someone has cystic fibrosis (CF), especially when they have rare CF genes. Without this certainty, they are unlikely to get the correct treatment so their health may be affected.
- Trial name
- ADVANCE-CFTR (NCT07402434)
- Testing
- Rectal Biopsy, Rectal biopsy taken opportunistically during endoscopy procedure for other reasons., Blood test for CFTR Genotyping
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Kidney Disease, Chronic
A Study to Test Whether Different Doses of BI 690517 Alone or in Combination With Empagliflozin Improve Kidney Function in People With Chronic Kidney Disease
This study is open to adults with chronic kidney disease. People with and without type 2 diabetes can take part in this study. The purpose of this study is to find out whether a medicine called BI 690517 improves kidney function…
- Trial name
- NCT05182840
- Testing
- BI 690517, Empagliflozin
- Where
- 203 sites in United States, Argentina and 27 more
- Volunteers
- 714 people
- Sponsor
- Boehringer Ingelheim
Elderly Person, Comfort
Effect of Care Provided Through Skin Care Protocol on Elderly Patients
The rate of elderly population is increasing in the world. It is reported that the proportion of the world population over the age of 60 will increase to 22% by 2050.
- Conditions
- Elderly Person, Comfort, Quality of Life, Skin Moisture
- Trial name
- NCT06462690
- Testing
- pre-mid-post test
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Duygu AKÇA
Individual Satisfaction, Pain Management
The Effect on Pain and Satisfaction of Two Different Non-Pharmacological Methods Used During Coronavirus (Covid-19) Vaccination
The aim of this study was to determine the effect on pain and satisfaction during the administration of Covid-19 vaccination of two different non-pharmacological methods: squeezing a stress ball and placing Buzzy® on the…
- Trial name
- NCT05514262
- Testing
- The stress ball, The Buzzy® device
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Uludag University
Gastrointestinal Cancer, Lung Cancer
A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
This is a study in adults from Asia with different types of advanced cancer (solid tumours). People can join the study if they have cancer of the stomach, large bowel and rectum, pancreas, liver, head and neck or non-small cell…
- Conditions
- Gastrointestinal Cancer, Lung Cancer, Pancreatic Cancer, Colorectal Cancer
- Trial name
- NCT06091930
- Testing
- BI 765049, Ezabenlimab
- Where
- 3 sites in Japan
- Volunteers
- 21 people
- Sponsor
- Boehringer Ingelheim
Solid Tumors, KRAS Mutation
A Study to Test Different Doses of BI 3011441 in Japanese People With Different Types of Advanced Cancer (NRAS/KRAS Mutation Positive)
This study is open to Japanese adults with different types of advanced cancer that are positive for NRAS/KRAS mutations. This is a study in people for whom previous treatment was not successful or no standard treatment exists.
- Trial name
- NCT04742556
- Testing
- BI 3011441
- Where
- 3 sites in Japan
- Volunteers
- 15 people
- Sponsor
- Boehringer Ingelheim
Health Behavior, Physical Activity
Days in Motion: A Planning Intervention Study With Couples to Enhance Daily Physical Activity
Regular physical activity is one prominent health-protective behaviour which might increase with the help of self-regulatory strategies such as action planning.
- Conditions
- Health Behavior, Physical Activity, Couples
- Trial name
- DiM (NCT01963494)
- Testing
- Dyadic planning intervention, Individual planning intervention, General motivational treatment
- Where
- Germany
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- Freie Universität Berlin
Type 2 Diabetes
Change of Lifestyle by Persons in Risk of Type 2 Diabetes
We know that changing lifestyle can prevent type 2 diabetes. The challenge is how to help people changing their lifestyle. We have people in 2 groups: half of them is meeting in grops of 10 persons (interventiongroup), the other…
- Trial name
- NCT00202748
- Testing
- Increase in activity to control weight, Increase in activity to control weight.
- Where
- Norway
- Volunteers
- 220 people
- Sponsor
- Sorlandet Hospital HF
Diabetes Mellitus
This Will Be an Observational, Exploratory Study Targeting a Population of Subjects with Diabetes from 4 Different Geographical Areas of Emilia- Romagna.
This will be an observational, exploratory study targeting a population of subjects with diabetes from 4 different geographical areas of Emilia- Romagna.
- Trial name
- REWINDER (NCT06639100)
- Where
- Italy
- Volunteers
- 63,500 people
- Sponsor
- AUSL Romagna Rimini
Malaria Infection
Humanitarian Evaluation of Spatial Emanators for Malaria Control
The overall aim of this study is to evaluate the feasibility, implementation, public health effectiveness, durability, acceptability and cost of delivering long-lasting spatial emanators at scale through United Nations High…
- Trial name
- NCT07886281
- Testing
- Guardian™ long-lasting spatial emanators
- Where
- South Sudan
- Volunteers
- 32,584 people, healthy volunteers welcome
- Sponsor
- The Mentor Initiative
Lupus Nephritis, Autoimmune Diseases
A Phase 1 Study of Prulacabtagene Leucel (Prula-cel, Formerly ADI-001) in Autoimmune Disease
ADI-202300103 is a phase 1 multicenter, open label, dose finding and dose expansion, safety/efficacy study in patients with autoimmune disease.
- Conditions
- Lupus Nephritis, Autoimmune Diseases, Systemic Sclerosis (SSc), Systemic Lupus Erythematosus (SLE)
- Trial name
- NCT06375993
- Testing
- ADI-001, Fludarabine, Cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Adicet Therapeutics
Healthy
Individual Differences in Placebo Analgesic Effects
This study examines the effects of placebo suggestions tailored to match or mismatch individual participants' motivational styles-an issue of person-situation 'fit' with important effects in public health settings, but which has…
- Trial name
- NCT04669093
- Testing
- Control cream
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Small Cell Lung Carcinoma, Neuroendocrine Neoplasms
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
This study is open to adults with small cell lung cancer and other neuroendocrine tumours. The study is in people with advanced cancer for whom previous treatment was not successful or no standard treatment exists.
- Conditions
- Small Cell Lung Carcinoma, Neuroendocrine Neoplasms, Extra-pulmonary Neuroendocrine Carcinoma
- Trial name
- NCT05882058
- Testing
- BI 764532, dose 1, BI 764532, dose 2, Ventana DLL3 RxDx assay
- Where
- 59 sites in United States, Belgium and 10 more
- Volunteers
- 204 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes
Educative Intervention to Improve Type 2 Diabetes Mellitus Control in Corrientes
Objective: To evaluate the effect of system interventions (data recording procedures and complete coverage of medications and supplies) with or without physician and/or patient education, upon the psychological, clinical…
- Trial name
- PRODIACOR (NCT01456806)
- Testing
- Education
- Where
- Argentina
- Volunteers
- 468 people
- Sponsor
- Centro de Endocrinologia Experimental y Aplicada
Physical Activity, Behavior Change
Individual and Environmental Mechanisms of PA Change
The focus of this study is to determine the mechanisms that underlie Physical Activity behavior change. We have 2 primary objectives.
- Trial name
- NCT00432133
- Testing
- Protection Motivation Theory-Based Intervention, Environmenta
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Stroke
The Effects of Inspiratory Pressures on Diaphragmatic Contraction in People After Stroke
This is a cross-sectional study to determine the optimal inspiratory muscle training (IMT) intensity for stroke survivors. Participants will breathe through a pressure threshold inspiratory loading device with varying loads in…
- Trial name
- NCT06267768
- Testing
- Various intensities of inspiratory muscle training
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Depressive Disorder, Major
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
This study is open to adults with depression (major depressive disorder) for whom standard treatment with antidepressants alone does not work sufficiently.
- Trial name
- NCT04521478
- Testing
- BI 1358894, Quetiapine
- Where
- 120 sites in United States, Argentina and 12 more
- Volunteers
- 389 people
- Sponsor
- Boehringer Ingelheim
Verticality Perception in Healthy Human Subjects, Individual Contribution of Different Sensory Systems
Verticality Perception - Multisensory Contribution
The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects.
- Trial name
- NCT02212704
- Testing
- Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk), 3D-video-head impulse testing, Vestibular-evoked myogenic potentials (VEMPs)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cerebral Palsy
Different Virtual Reality Devices in People With Cerebral Palsy
A computer program was developed with the same task, but with two possibilities of user interaction: a) interface with contact: in which the individual touches the computer screen to finish the task and b) interface without…
- Trial name
- NCT03352440
- Testing
- Cerebral Palsy - Kinect, Cerebral Palsy - Touchscreen, Control Group - Kinect
- Where
- Brazil
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 1358894 Affects the Way the Body Breaks Down Midazolam
The primary objective of the trial is to investigate the safety and tolerability of BI 1358894 in healthy male subjects following oral administration of multiple rising doses over 14 days.
- Trial name
- NCT03754959
- Testing
- BI 1358894, Midazolam
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim