Clinical trials: Difference, Individual
Coronary Heart Disease
Multi-omics Study of Clinical Endpoints in CHD
This study aimed to explore underlying mechanisms of individual differences in drugs for coronary heart disease treatment and its association with adverse consequences.
- Trial name
- OmiDETCHD (NCT03797339)
- Testing
- risk factors of adverse cardiovascular events, multi-omics target discovery, validation
- Where
- 5 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Individuality
Effects of Hydrocortisone on Social Cognition and Memory
The effects of hydrocortisone on cognition will be investigated.
- Trial name
- CORT-COG (NCT02478021)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Depressive Disorder, Major
A Study to Test Different Doses of BI 1569912 in People With Depression
This study is open to adults between 18 and 65 years of age with a type of depression called major depressive disorder. The purpose of the study is to find out whether a medicine called BI 1569912 helps people with depression.
- Trial name
- NCT06558344
- Testing
- 5 mg BI 1569912, 10 mg BI 1569912, 20 mg of BI 1569912
- Where
- 41 sites in United States, Japan
- Volunteers
- 225 people
- Sponsor
- Boehringer Ingelheim
Healthy
A Study to Test How Much BI 3034701 Gets Into the Blood in Healthy People When Given in Two Different Ways
The aim of the trial is to investigate relative bioavailability of BI 3034701 treatment T vs. BI 3034701 treatment R.
- Trial name
- NCT07837648
- Testing
- BI3034701 formulation II, BI3034701 formulation C1
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Achilles Tendinopathy (AT), Musculoskeletal Diseases or Conditions
STICK2IT - Understanding Why People Do or Do Not Stick With Exercise Treatment for Achilles Tendinopathy
Achilles tendinopathy is a common condition that causes pain and stiffness in the tendon at the back of the ankle. It can make walking, exercise, work, and everyday activities difficult.
- Conditions
- Achilles Tendinopathy (AT), Musculoskeletal Diseases or Conditions, Adherence, Behaviour Change
- Trial name
- NCT07555184
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Dual Task Exercises in Elderly People
The Effect of Two Different Dual Task Balance Trainings in Older Adults
The aim of our study is to investigate the effect of integrated and consecutive dual-task exercise trainings in elderly people on the balance, fear of falling and gait performance.
- Trial name
- NCT03981692
- Testing
- Consecutive dual task, Integrated dual task
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Marmara University
Healthy
A Study to Test How Well Different Doses of BI 3034701 Are Tolerated by Healthy Men and People With Overweight or Obesity
This study is open to healthy people and people with overweight or obesity. It has 2 parts. Part A is open to healthy men between 18 and 55 years of age.
- Trial name
- NCT06352437
- Testing
- BI 3034701
- Where
- Germany
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Diabetes Mellitus, Skin and Connective Tissue Diseases
Treatment Effects of Two Pharmaceutical Skin Care Creams for Xerotic Feet Among Persons with Diabetes
Introduction Diabetic foot-ulcers leads to decreased quality of life, risk of major amputation, and resource demanding health-care.
- Trial name
- NCT06427889
- Testing
- Canoderm, Oviderm, Decubal
- Where
- Sweden
- Volunteers
- 98 people
- Sponsor
- Malmö University
Healthy
A Study in Healthy People to Test How 2 Different Formulations of BI 695501 Are Taken up by the Body When Given as an Injection
The main objective of this trial is to compare the pharmacokinetics (PK) of 40 mg BI 695501 100 mg/mL with 40 mg BI 695501 50 mg/mL following single subcutaneous administration.
- Trial name
- NCT05203289
- Testing
- BI 695501 - higher concentration, BI 695501 - lower concentration
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Multimorbidity
Personal Resources of Elderly People With Multimorbidity
PREFER II aims at developing psychological targeted theory- and evidence-based intervention components, which support older people with multiple illnesses in performing more physical activity.
- Trial name
- PREFER (NCT01577134)
- Testing
- Social-cognitive resource intervention, no intervention
- Where
- Germany
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- German Centre of Gerontology
Major Depressive Disorder
EXperimental Paradigm to Investigate Expectation Change in Depression 4
Research has shown that people with depressive symptoms maintain negative expectations even if they have positive experiences that contradict their expectations.
- Trial name
- EXPECD4 (NCT03780881)
- Testing
- Expectation confirmation, Expectation disconfirmation
- Where
- Germany
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Healthy, Controlled Feeding Trial
Gut Microbial Metabolites of Apple Polyphenols
The goal of this controlled feeding trial is to learn about the metabolism of polyphenols, a common class of compounds found in plant-based foods, by the gut microbiome.
- Trial name
- GutMMAP (NCT06107192)
- Testing
- Dietary intervention - apple catechin diet, Dietary intervention - low catechin diet
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Depression - Major Depressive Disorder, Anxiety
Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis
This parallel three-arm, single-blind (assessor-blinded), randomized controlled trial (RCT) aims to compare the effects of ACT, CBT, and treatment-as-usual (TAU) on the severity of depressive symptoms (primary outcome), the…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Marital Conflict
- Trial name
- NCT07808021
- Testing
- Acceptance and Commitment Therapy, Cognitive Behavioral Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Universiti Sains Malaysia
Opioid Sensitivity, Individual Difference
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans
Within-subject, double-blind, placebo-controlled examination of opioid abuse potential in healthy individuals as a function of A118G SNP on the OPRM1 gene.
- Conditions
- Opioid Sensitivity, Individual Difference, Abuse Opioids
- Trial name
- NCT02360371
- Testing
- Within-subject test of blinded study medication
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Apnea, Obstructive, Hypertension
Mechanisms for Individual Differences in Hypertension in Obstructive Sleep
Hypertension is a common consequence of obstructive sleep apnea (OSA). However, not all individuals with OSA have hypertension and there are major individual differences in blood pressure response to positive airway pressure…
- Trial name
- PISA-BP (NCT03176732)
- Testing
- Positive Airway Pressure
- Where
- 2 sites in United States, Iceland
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Surgery, Individuality
The Realtime Detection for Prediction of Opioid Analgesic
This study aimed to find a quick and timely way to predict the individual variation of efficacy of opioid analgesic during the operation and postoperative analgesia in Chinese patients undergoing elective surgeries.
- Trial name
- NCT01868152
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Huazhong University of Science and Technology
Diabetes Mellitus, Type 2
A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Lower Blood Sugar in People With Type 2 Diabetes
This study will look at how well a new medicine called NNC0519-0130 helps people with type 2 diabetes lower their blood sugar and body weight. The study will test up to 7 different doses of NNC0519-0130.
- Trial name
- NCT06326047
- Testing
- NNC0519-0130, Trizepatide
- Where
- 110 sites in United States, Australia and 5 more
- Volunteers
- 299 people
- Sponsor
- Novo Nordisk A/S
Obesity
A Research Study to Compare How Much of the Medicine NNC0519-0130 is in the Blood of People With Overweight or Obesity Who Receive 2 Preparations of the Medicine
This study will look into a new study medicine called NNC0519-0130 to improve the treatment option for people living with excess body weight or type 2 diabetes or both.
- Trial name
- NCT06642571
- Testing
- NNC0519-0130 B, NNC0519-0130 C
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Novo Nordisk A/S
Burning Mouth Syndrome
Effect of Treatments on Pain and Quality of Life in Individual With Burning Mouth Syndrome
Burning Mouth Syndrome (BMS) is characterized by a burning sensation on the tongue or other areas of the mouth, often bilateral but occasionally unilateral. It is more prevalent in postmenopausal women.
- Trial name
- NCT06040190
- Testing
- topical clonazepam rinse, oral alpha-lipoic acid capsule, topical phytotherapic capsaicin gel
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of Minas Gerais
Pulmonary Disease, Chronic Obstructive
Internet-based Rehabilitation Aftercare Focusing on Physical Activity Promotion in Persons With COPD
The aim of the study is to evaluate a 12-week internet-based rehabilitation aftercare program with an emphasis on physical activity promotion for persons with COPD.
- Trial name
- COPD-AReNa (NCT05006560)
- Testing
- Pulmonary Rehabilitation (usual care), Pulmonary Rehabilitation (usual care) + familiarization with components of the aftercare program, After care: Exercise and physical activity promotion
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Erlangen-Nürnberg