Clinical trials: Differential Diagnosis
Leukemia
Interventional Validation of an MDS-Specific Measure of Quality of Life: Assessing the Responsiveness of the Quality of Life in Myelodysplasia Scale (QUALMS-1) to Different Hypomethylating Agent Regimens for Low and Intermediate Risk Disease
The goal of this research study is to test a quality-of-life questionnaire called QUALMS-1 in patients with MDS. This is an investigational study. Up to 240 participants will be enrolled in this multicenter study.
- Trial name
- NCT02378701
- Testing
- QUALMS-1 Questionnaire, FACT-An Questionnaire
- Where
- 6 sites in United States
- Volunteers
- 102 people
- Sponsor
- M.D. Anderson Cancer Center
Analgesia, Dexamethasone
Low-dose Intravenous Dexamethasone at Different Times as Adjunvants for Brachial Plexus Blocks
Dexamethasone has been tested as an effective adjuvant to prolong the effect of local anesthetics for peripheral nerve blocks, both perineurally and intravenously.
- Conditions
- Analgesia, Dexamethasone, Brachial Plexus Block, Intravenous Drug Usage
- Trial name
- NCT04714112
- Testing
- dexamethasone
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Oesophageal Cancer, Gastric Cancer
Multicenter Validation Trial of [18F]AlF-FAPI-74 for PET Imaging of Cancer-associated Fibroblasts Through Fibroblast Activation Protein Inhibitors (FAPI) in Different Tumor Types
The aim of the project is to demonstrate superior detection ratio of [18F]AlF-FAPI-74 PET/CT compared to [18F]FDG PET/CT or conventional imaging in treatment-naïve, newly diagnosed patients with oesophagogastric adenocarcinoma…
- Conditions
- Oesophageal Cancer, Gastric Cancer, Pancreatic Ductal Adenocarcinoma, FAP
- Trial name
- FAPIDO (NCT06782412)
- Testing
- [18F]AlF-FAPI-74 PET/CT
- Where
- 3 sites in Belgium
- Volunteers
- 109 people
- Sponsor
- KU Leuven
Respiratory Function, Vocal Performance
Combined SOVT and Respiratory Exercises: Effects on MPT and Respiratory Function
This study aims to investigate the effects of combined SOVT and breathing exercises, administered twice weekly for six weeks to conservatory students, through a randomized controlled trial.
- Conditions
- Respiratory Function, Vocal Performance, Voice
- Trial name
- NCT07677501
- Testing
- combined soft and breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Obesity, Overfeeding
Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity
- Conditions
- Obesity, Overfeeding, Muscle Mass, Body Composition
- Trial name
- LIPOGAIN-2 (NCT02211612)
- Testing
- PUFA-group, SFA-group
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Osteopenia
A Comparison of Changes in Bone Density With the Same Bone-health Plan, But With Different Bone-health Supplements
A comparison of changes in bone density following the same bone-health plan, but with a different bone-health supplement.
- Trial name
- NCT01114685
- Testing
- AlgaeCal-1, AlgaeCal-2
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Integrative Health Technologies, Inc.
Heart Failure
LV Dysfunction Following Pacemaker Placement
Several studies have confirmed the link between chronic RV apical pacing and the development of heart failure and LV systolic dysfunction in some patients 1,2.
- Trial name
- NCT03850808
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Oregon Health and Science University
Respiratory Insufficiency
Effect of Physiotherapy Methods on Functional and Respiratory Outcomes in ICU Patients With Respiratory Failure
The aim of the biomedical study is to assess the changes in functional and qualitative indicators of critically ill patients with respiratory failure by applying different physiotherapy methods.
- Trial name
- NCT06912308
- Testing
- Active Physiotherapy, Passive Physiotherapy
- Where
- Lithuania
- Volunteers
- 150 people
- Sponsor
- Laura Rutkauskienė
Physical Activity
Investigations of the Effects and Associated Neural Mechanisms of Different Exercise in People With Metabolic Syndrome
Metabolic syndrome (MetS) is a risk for many chronic diseases of middle-aged and older adults. Hence, prevention and treatment of MetS is a crucial global health issue.
- Trial name
- NCT05672940
- Testing
- Aerobic plus resistance training, Stretching plus breathing training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Type 2
Safety and Efficacy of Empagliflozin (BI 10773) and Sitagliptin Versus Placebo Over 76 Weeks in Patients With Type 2 Diabetes
This study will investigate the efficacy and long term safety and tolerability of BI 10773 in type 2 diabetic patients.
- Trial name
- NCT01289990
- Testing
- BI 10773, Sitagliptin 100mg
- Where
- 243 sites in United States, Belgium and 17 more
- Volunteers
- 2,705 people
- Sponsor
- Boehringer Ingelheim
Neuropathic Pain, Nociplastic Pain
Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches
The primary objective of this study will be to demonstrate a change in pain sensitization parameters before and after the application of the high-concentration capsaicin patch.
- Trial name
- CAPSASENS (NCT07660510)
- Testing
- Quantitative Sensory Testing and questionnaires
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Acute Decompensated Heart Failure
A Comparison of Recombinant Human Brain Natriuretic Peptide and Dobutamine
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide (rhBNP) with dobutamine on acute decompensated heart failure patients with different blood BNP levels
- Trial name
- NCT01837849
- Volunteers
- 104 people
- Sponsor
- Nantong University
Transcranial Direct Current Stimulation
Exploit the Functional Higher Neural Connectivity and Electrophysiological Intervention of Freezing of Gait in PD and PSP During Different Ambulatory Complexities
In the current proposal, investigators will investigate three crucial issues of FOG. Firstly, investigators will identify the possible source(s) of FOG in PD and PSP patients during unconstrained walking using a 64-channel…
- Trial name
- NCT05092243
- Testing
- Transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Pneumonia
Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy
The purpose of this study is to investigate the incidence of ventilator associated pneumonia and late complications by comparing two different cannulas and two different percutaneous tracheostomy techniques.
- Trial name
- NCT00184925
- Testing
- Tracheostomy, cannula with subglottic drainage
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Hypertension, Microalbuminuria
Community-based Microalbuminuria Screening in Patients With Hypertension
This study evaluates the effectiveness of different anti-hypertensive drugs on patients with hypertension and microalbuminuria.
- Trial name
- CMSIH (NCT03596840)
- Volunteers
- 3,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes Mellitus, Type 2
A Clinical Trial Comparing The Efficacy And Safety Of 2 Different Initial Dose Prescriptions For Exubera.
The primary objective of this study is to assess whether a simple initial dose prescription of inhaled insulin (Exubera) achieves glycemic control (HbA1c) after 16 weeks that is non-inferior compared to the standard weight-based…
- Trial name
- NCT00437489
- Testing
- Inhaled Human Insulin (Exubera)
- Where
- 9 sites in Hong Kong, Pakistan and 2 more
- Volunteers
- 49 people
- Sponsor
- Pfizer
Dementia
The Effect of Different Virtual Reality Trainings on Gait, Balance and Posture of Individuals With Dementia
Dementia, a part of geriatric syndrome, is characterized by the deterioration of multiple cognitive domains such as memory, language, orientation, learning and personality as a result of damage to the central nervous system and…
- Trial name
- NCT04377191
- Testing
- exergame, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Yildirim Beyazıt University
Community-acquired Pneumonia, Acute Respiratory Distress Syndrome
Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia
Randomized Controlled Trial Comparing Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia. The control strategy will be based on ARDSNet approach.
- Trial name
- STAMINA (NCT04972318)
- Testing
- Positive end-expiratory pressure titration with driving pressure control, ARDSNet ventilatory strategy
- Where
- 6 sites in Brazil
- Volunteers
- 214 people
- Sponsor
- Hospital do Coracao
Type 2 Diabetes
The Interaction Between Protein Intake, Gut Microbiota and Type 2 Diabetes in Subjects With Different Ethnic Backgrounds
Context and justification: There is growing evidence that the gut microbiota is a key element in the pathophysiology of cardio-metabolic diseases (CMD) such as Type 2 Diabetes (T2D).
- Trial name
- MICRODIET (NCT03732690)
- Testing
- Diet HP, Diet LP
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Leptin Resistance
Effect of Increased Free Fatty Acids on Leptin Function
Obese people have elevated levels of the hormone leptin. Despite this, they seem to be resistant to the effects of this hormone, which usually regulates appetite and energy expenditure.
- Trial name
- NCT01520454
- Testing
- Saline, Intralipid, Water
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center