Clinical trials: Diffuse Parenchymal Lung Diseases
Healthy Subjects
A Study to Assess the Effect of AZD5055 on the Pharmacokinetics (PK) of Nintedanib in Healthy Participants.
The study is intended to quantify the effect of co-administration and staggered dosing of AZD5055 and nintedanib on exposures of nintedanib in healthy participants.
- Trial name
- NCT05644600
- Testing
- Nintedanib, AZD5055
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Lung Diseases, Interstitial, Hematopoietic Stem Cell Transplantation
MSC for Treatment of Interstitial Lung Disease After Allo-HSCT
Interstitial lung disease (ILD） is the late pulmonary complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT) leading to high morbidity and mortality.
- Conditions
- Lung Diseases, Interstitial, Hematopoietic Stem Cell Transplantation, Bronchiolitis Obliterans
- Trial name
- NCT02543073
- Testing
- MSCs, AZM, Glucocorticoid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Respiratory Failure, Hypoxemia
Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia
The aim of this multicenter crossover trial is to describe the effect of adding a therapeutic dose of exertional oxygen therapy, in terms of exercise performance, gas exchange, heart rate, symptoms perception and subjective…
- Conditions
- Chronic Respiratory Failure, Hypoxemia, Chronic Obstructive Pulmonary Disease (COPD), Interstitial Lung Disease
- Trial name
- NCT07451977
- Testing
- Usual Oxygen During 6-Minute Walk Test, Supplemental Oxygen During 6-Minute Walk Test
- Where
- 6 sites in Italy
- Volunteers
- 114 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Idiopathic Pulmonary Fibrosis
68Ga-BMV101 PET/CT in Patients With Idiopathic Pulmonary Fibrosis
Inflammation mediated by macrophage infiltration plays a vital role in a diverse range of physiological conditions. In particular, recent evidence suggests this type of macrophage response is important for the disease pathology…
- Trial name
- NCT02485886
- Testing
- 68Ga-BMV101
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking Union Medical College Hospital
Pulmonary Fibrosis
Study Evaluating the Safety and Efficacy of Etanercept in Patients With Idiopathic Pulmonary Fibrosis
The objective of the study is to evaluate the safety and efficacy of etanercept in comparison with placebo in a double-blind, parallel, randomized fashion in subjects with idiopathic pulmonary fibrosis (IPF) who failed previous…
- Trial name
- NCT00063869
- Testing
- Etanercept
- Volunteers
- 88 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Lung Neoplasms, Radiation Pneumonitis
Application of 4DCT-Based Pulmonary Ventilation Imaging in Lung Cancer Radiotherapy
This retrospective single-center study investigates whether four-dimensional CT (4DCT)-based lung ventilation imaging can guide functional lung avoidance radiotherapy (FLAR) for patients with primary lung cancer.
- Trial name
- FLAR-4DCT (NCT07312682)
- Where
- China
- Volunteers
- 202 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Idiopathic Pulmonary Fibrosis, IPF
The Coagulation Cascade in Idiopathic Pulmonary Fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) is incompletely understood but recurrent epithelial injury occurs which evokes the coagulation cascade.
- Conditions
- Idiopathic Pulmonary Fibrosis, IPF, Interstitial Lung Disease
- Trial name
- NCT02885961
- Testing
- Dabigatran, FDG PET scan
- Volunteers
- 12 people
- Sponsor
- University College, London
Pulmonary Fibrosis
Diaphragmatic Release vs Inspiratory Muscle Training in Pulmonary Fibrosis
This study evaluates the efficacy of adding manual Diaphragmatic Release Technique (DRT) versus Targeted Inspiratory Muscle Training (IMT) to standard medical therapy in patients with stable pulmonary fibrosis.
- Trial name
- DR-IMT-PF (NCT07810153)
- Testing
- Diaphragmatic Release Technique (DRT), Targeted Inspiratory Muscle Training (IMT)
- Volunteers
- 40 people
- Sponsor
- Pharos University in Alexandria
Idiopathic Pulmonary Fibrosis
Study To Investigate The Potential DDI Between HEC585 And Pirfenidone/Nintedanib In Healthy Subjects
A single-center, open-label study designed to assess the drug-drug interaction of HEC585 and pirfenidone in healthy male and female subjects.
- Trial name
- NCT07588646
- Testing
- HEC585, Nintedanib, Pirfenidone
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Pneumonia, Interstitial
Exploration of the Predictive Marker and Establishment of Predictive Models of Checkpoint Inhibitor Pneumonitis
This is a prospective, multicenter observational study to explore the predictive factors of checkpoint inhibitor pneumonitis (CIP) and to establish predictive models by combining imaging information for IRP.
- Trial name
- NCT04734067
- Testing
- Immune checkpoint inhibitors(ICIs) therapy
- Volunteers
- 440 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Progressive Pulmonary Fibrosis, Interstitial Lung Disease
PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis
This is a prospective, observational cohort study. Participants with non-idiopatic pulmonary fibrosis, interstitial lung disease (ILD) will be followed for 24 months to systematically collect clinical, imaging, and biospecimen…
- Trial name
- PRIME-PPF (NCT06855329)
- Where
- 24 sites in United States, Australia and 11 more
- Volunteers
- 500 people
- Sponsor
- University of Massachusetts, Worcester
Pulmonary Fibrosis, Interstitial Lung Disease
Retrospective Validation of AccuPulmo CT Portal for Detecting Pulmonary Fibrosis on Chest CT
This retrospective observational study evaluates the diagnostic performance of AccuPulmo CT Portal, an artificial intelligence-assisted medical imaging software, for detecting pulmonary fibrosis on pre-existing chest computed…
- Trial name
- ACCUPULMO-FIBR (NCT07761377)
- Testing
- AccuPulmo CT Portal
- Where
- Taiwan
- Volunteers
- 900 people
- Sponsor
- Taichung Veterans General Hospital
Inflammation, Vasculitis
Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis
This study will collect fluid and tissue samples from the bronchi (air passages to the lungs) of patients with Wegener's granulomatosis for laboratory examination.
- Conditions
- Inflammation, Vasculitis, Wegener's Granulomatosis
- Trial name
- NCT00001541
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
Inspiratory Flow Rate Capability in Pulmonary Fibrosis Patients
The goal of this observational study is to learn about the inspiratory flow rate capability in patients with pulmonary fibrosis (IPF or PPF) when using inhaler devices with different resistances.
- Trial name
- NCT07820254
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Langerhans Cell Histiocytosis (LCH), Juvenile Xanthogranuloma (JXG)
Mirdametinib in Histiocytic Disorders
The purpose of this study is to see if treatment with mirdametinib in patients with Langerhans cell histiocytosis (LCH) or other histiocytic disorders will be better than current treatments and with fewer side effects.
- Conditions
- Langerhans Cell Histiocytosis (LCH), Juvenile Xanthogranuloma (JXG), Rosai-Dorfman Disease (RDD), Histiocytic Disorders
- Trial name
- NCT06153173
- Testing
- Mirdametinib
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Idiopathic Pulmonary Fibrosis
A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of PMG1015
This is a Phase 1A, first in human, randomized, double-blinded, placebo-controlled, dose escalation study of PMG1015 in healthy adult volunteers.
- Trial name
- NCT05022771
- Testing
- PMG1015 Dose 1, PMG1015 Dose 2, PMG1015 Dose 3
- Where
- Australia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pulmongene Ltd.
Pulmonary Hypertension, Interstitial Lung Disease
Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE
This was a multicenter, randomized (1:1 inhaled treprostinil: placebo), double-blinded, placebo-controlled trial to evaluate the safety and efficacy of inhaled treprostinil in subjects with pre-capillary pulmonary hypertension…
- Conditions
- Pulmonary Hypertension, Interstitial Lung Disease, Combined Pulmonary Fibrosis and Emphysema
- Trial name
- NCT02630316
- Testing
- Inhaled Treprostinil
- Where
- 97 sites in United States, Puerto Rico
- Volunteers
- 326 people
- Sponsor
- United Therapeutics
Obstructive Sleep Apnea-hypopnea
The Study of Sleep Disordered Breathing in Patients With Interstitial Lung Diseases
This was a cross-sectional observational study to evaluate the prevalence and predictive factors of SDB in ILD and to analyze the relationship between polysomnography (PSG) findings, pulmonary function, disease severity…
- Trial name
- NCT06012526
- Testing
- Polysomnography
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Beni-Suef University
Idiopathic Pulmonary Fibrosis
Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis
The MUSIC OL study is an open-label extension study, in which all eligible patients having completed the double-blind AC-055B201/MUSIC study as scheduled receive macitentan 10 mg once daily.
- Trial name
- MUSIC OL (NCT01346930)
- Testing
- Macitentan
- Sponsor
- Actelion
Assessment of Serum Level of SCD25 in RA, SSc (with or Without ILD) and IPF and Its Correlation with Disease Activity
Assessment of Serum CD25 Level in Systemic Sclerosis Patients with or Without Interstitial Lung Disease (ILD)
Assessment of serum level of sCD25 in SSc (with or without ILD) and its correlation with disease activity. Evaluating the clinical correlation of serum soluble CD25 (sCD25) in systemic sclerosis (SSc) (with or without ILD).
- Trial name
- NCT06615128
- Testing
- blood sampling
- Volunteers
- 66 people
- Sponsor
- Assiut University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.