Clinical trials: Diffuse Parenchymal Lung Diseases
Wegener Granulomatosis, Microscopic Polyangiitis
PRO Development for ANCA Associated Vasculitis
A qualitative study using interviews with patients who have antineutrophil cytoplasm antibody (ANCA) associated vasculitis, to develop a patient reported outcome (PRO)measure
- Conditions
- Wegener Granulomatosis, Microscopic Polyangiitis, Churg-Strauss Syndrome
- Trial name
- NCT01729624
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Oxford
Lung Diseases, Interstitial
Post-marketing Surveillance on Long Term Use of Ofev Capsules in Systemic Scleroderma Associated Interstitial Lung Disease (SSc-ILD) in Japan
The primary objective is to confirm the incidence of adverse drug reactions (focus on gastrointestinal symptoms including diarrhoea and nausea) to Ofev Capsules seen in clinical trials with real world data generated in patients…
- Trial name
- NCT04325217
- Testing
- Nintedanib
- Where
- Japan
- Volunteers
- 586 people
- Sponsor
- Boehringer Ingelheim
Lung Diseases, Interstitial
Cryobiopsy Study to Assess Drug Distribution in Subjects With Suspected Interstitial Lung Disease
Interstitial lung disease (ILD) often affects distal lung, and the evaluation of drug distribution to the relevant lung compartments is essential for development of new treatment options.
- Trial name
- NCT03136120
- Testing
- Ipratropium Bromide, Flexible Bronchoscopy/Biopsy
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Kidney Transplant, Kidney Transplantation
Proteogenomic Biomarker Panels in a Serial Blood & Urine Monitoring Study of Kidney Transplant Recipients
There is a need to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had kidney transplant.
- Trial name
- PROGENI-KI (NCT01289717)
- Where
- 5 sites in United States
- Volunteers
- 307 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
ILD
Misdiagnosis Between Interstitial Lung Disease and Cardiac Patients
Aim of the study To determine the frequency misdiagnosis of cardiac congestion as interstitial lung disease based on initial High Resolution CT interpretation alone.
- Trial name
- NCT06198608
- Volunteers
- 80 people
- Sponsor
- Assiut University
Systemic Sclerosis (SSc), Scleroderma
Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)
The study is a Phase 2, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of tibulizumab over 24 weeks (Period 1) in adult participants with systemic sclerosis, followed by an open-label…
- Trial name
- NCT06843239
- Testing
- Tibulizumab
- Where
- 60 sites in United States, Argentina and 8 more
- Volunteers
- 80 people
- Sponsor
- Zura Bio Inc
Silicosis
Oxidative Stress Biomarkers to Monitor and Early Detect Health Impairment in Workers Exposed to Silica (Caesar Stone)
Silicosis is well-known occupational disease caused by free crystalline silica (silicon dioxide) and is marked by inflammation and pulmonary fibrosis.
- Trial name
- NCT01338064
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Idiopathic Pulmonary Fibrosis, Cough
Does CBT Improve the Perception/Impact of Cough and Breathlessness in IPF Patients
Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease of unknown cause for which there is no effective medical treatment.
- Conditions
- Idiopathic Pulmonary Fibrosis, Cough, Breathlessness
- Trial name
- NCT01738711
- Testing
- Cognitive behavioural therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Victoria Infirmary
Covid19, Interstitial Pneumonia
Comparison Between Positive and Negative COVID-19 Pneumonia
In the late 2019 a new Coronavirus was identified as the cause of a group of atypical interstitial pneumonia cases in Wuhan, a city in the Chinese province of Hubei.
- Trial name
- NCT04507893
- Testing
- Clinical, laboratory and imaging characteristics of pneumonia
- Where
- 3 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Palermo
Avian Hypersensitivity Pneumonitis
Research for Specific Proteins of Interest for the Serological Diagnosis of Bird Fancier's Lung
This study aims at identifying bird proteins useful for diagnostic tests to determine the cause of Bird Fancier's Lung (BFL).
- Trial name
- HYPERSENS (NCT03056404)
- Testing
- additional blood sample, respiratory functional exploration
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Interstitial Lung Diseases
Interstitial Lung Disease: A Study From Infancy to Elderly Including Relatives
The concerned patients are children and adults suffering from idiopathic interstitial pneumonias, other chronic fibrosing interstitial pneumonias with a progressive phenotype, and interstitial pneumonia associated with…
- Trial name
- RaDiCo-ILD 2 (NCT06036719)
- Where
- France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Idiopathic Pulmonary Fibrosis (IPF)
A Phase 2 Study to Evaluate the Safety and Tolerability of PBI-4050 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
This is a Phase 2, open-label, single-arm study of the safety and tolerability of PBI-4050 800 mg daily oral administration in 40 adult patients with IPF.
- Trial name
- NCT02538536
- Testing
- PBI4050
- Where
- 5 sites in Canada
- Volunteers
- 41 people
- Sponsor
- Liminal BioSciences Ltd.
Clinically Amyopathic Dermatomyisitis(CAMD)
Correlation Between the Change of Peripheral Lymphocyte Subsets and Clinically Amyopathic Dermatomyositis Combined With Rapidly Progressive Interstitial Lung Disease
Acute respiratory distress syndrome (ARDS) occurs in Clinically Amyopathic Dermatomyisitis(CADM) combined with Rapidly Progressive Interstitial Lung Disease(RPILD) within 1-3 months, which leads to death of patients and is…
- Trial name
- NCT04613219
- Testing
- Tofacitinib 5 MG [Xeljanz]
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jing Liang
Idiopathic Pulmonary Fibrosis (IPF)
The relatıonshıp Between Upper Extremity Exercise Test and Exercise Capacity ın patıents wıth Idiopathic Pulmonary Fibrosis
The primary aim of our study was to investigate the relationship between 6PBRT outcome measures and 6MWT, 1MSTST and UULEX outcome measures. The secondary aim is to investigate the predictors of 6PBRT test.
- Trial name
- NCT07119099
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Marmara University
Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging
Background: Injury or diseases of the heart and lung can sometimes cause scar tissue (fibrosis) to build up in those organs. Current imaging scans can see this scar tissue once it has formed, but researchers want to find a way to…
- Conditions
- Allogeneic Stem Cell Transplantation, Lung Allograft Transplantation, Interstitial Lung Disease, Acute Lung Injury
- Trial name
- NCT07613099
- Testing
- [18F]FAPI-74, 18F-FAPI-74 PET/CT Imaging
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Disease
Immunological Characterization of Bronchoalveolar Cells in Normals
To obtain the monocytes (white blood cells) from normal volunteers for the purpose of studying how proteins, fats, carbohydrates, as well as RNA and DNA for gene expression, relate to immunity.
- Trial name
- NCT00843414
- Where
- United States
- Volunteers
- 1,232 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Heart Failure, Pulmonary Disease, Chronic Obstructive
Advancing Symptom Alleviation With Palliative Treatment
Chronic heart failure (CHF), chronic obstructive pulmonary disease (COPD), and interstitial lung disease (i.e., pulmonary fibrosis) are common serious illnesses.
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Emphysema, Pulmonary Fibrosis, Interstitial Lung Disease
- Trial name
- ADAPT (NCT02713347)
- Testing
- ADAPT Intervention
- Where
- 2 sites in United States
- Volunteers
- 306 people
- Sponsor
- VA Office of Research and Development
OSA
Prevalence of OSA in Patients of ILD
To evaluate the clinical predictors of OSA in patients with ILD
- Trial name
- NCT06058052
- Volunteers
- 81 people
- Sponsor
- Assiut University
Pulmonary Hypertension Due to Lung Disease (Disorder)
A Phase 3 Study to Evaluate the Safety and Efficacy L606 in Participants With PH-ILD
The purpose of this study is to find out if L606 is safe and if it helps people with high blood pressure in the lungs (pulmonary hypertension) caused by interstitial lung disease (PH-ILD, WHO Group 3).
- Trial name
- Re-Spire (NCT07285655)
- Testing
- L606
- Where
- 44 sites in United States, Australia and 10 more
- Volunteers
- 344 people
- Sponsor
- Liquidia Technologies, Inc.
Scleroderma
MRI for Screening and Monitoring Scleroderma ILD
The purpose of this study is to test MRI methods for evaluating patients with Scleroderma-associated interstitial lung disease.
- Trial name
- NCT05204355
- Testing
- MRI, Hyperpolarized Xe129, HRCT
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
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