Clinical trials: Diffuse Parenchymal Lung Diseases
Diffuse Parenchymal Lung Disease
The Clinical Value of Serum KL-6 Changes on Evaluating Disease Development in Different Diffuse Parenchymal Lung Disease
Diffuse Parenchymal Lung Disease(DPLD) is a chronic progressive fibrosis lung disease that with a highly variable clinical process.Krebs von den Lungen-6 (KL-6) is a high-molecular-weight glycoprotein, classified as human MUC1…
- Trial name
- NCT03101397
- Where
- China
- Volunteers
- 180 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Idiopathic Pulmonary Fibrosis
Safety, Pharmacodynamics, and Pharmacokinetics of Orally Administered BLD-2660 in Subjects With IPF
A Phase 2a, Double-Blind, Placebo-Controlled Study to Evaluate Pharmacodynamics, Pharmacokinetics, and Safety of BLD-2660 Administered Orally in Subjects with Idiopathic Pulmonary Fibrosis
- Trial name
- NCT04244825
- Testing
- BLD-2660
- Where
- United Kingdom
- Sponsor
- Blade Therapeutics
Pneumoconiosis, Healthy Lifestyle
Acceptance-based Healthy Lifestyles Program for Patients With Pneumoconiosis
Symptoms, such as cough and shortness of breath, are common among patients with pneumoconiosis. Depression and anxiety can be elicited by the symptoms, while avoidance of daily activities is believed to reduce trigger of…
- Trial name
- NCT06563674
- Testing
- Acceptance-based healthy lifestyles program (intervention group), Acceptance-based healthy lifestyles program (control group)
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Idiopathic Pulmonary Fibrosis
Current Status of Diagnosis, Treatment and Quality of Life for Patients with Idiopathic Pulmonary Fibrosis
The goal of this observational study is to explore current status of diagnosis, treatment and quality of life for patients with idiopathic pulmonary fibrosis.
- Trial name
- IPFLife (NCT06629623)
- Testing
- No intervention
- Where
- China
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Chu Hongling
Idiopathic Pulmonary Fibrosis, Progressive Pulmonary Fibrosis
A Study to Test Whether BI 1839100 Improves Cough in People With Idiopathic Pulmonary Fibrosis or Progressive Pulmonary Fibrosis
Adults 40 years of age and older with idiopathic pulmonary fibrosis (IPF) or 18 years and older with progressive pulmonary fibrosis (PPF) can participate in this study. Only people who have a chronic cough can take part.
- Trial name
- NCT06360094
- Testing
- BI 1839100
- Where
- 99 sites in United States, Australia and 22 more
- Volunteers
- 85 people
- Sponsor
- Boehringer Ingelheim
Interstitial Lung Disease
Nebulized Fentanyl in Patients With Mild to Moderate Interstitial Lung Disease and Chronic Dyspnea
Patients with interstitial lung disease (ILD) experience distressing activity-related respiratory discomfort which is challenging to manage therapeutically.
- Trial name
- NCT03018756
- Testing
- Fentanyl Citrate
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Dr. Denis O'Donnell
Pulmonary Sarcoidosis
Antibody Response to Influenza Vaccine in Patients With Sarcoidosis
The purpose of this study is to determine the efficacy of influenza vaccine (antibody response) in patients with sarcoidosis.
- Trial name
- IVS (NCT00828828)
- Testing
- Influenza Vaccine
- Where
- Iran
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Sarcoidosis, Pulmonary
Evaluation of the Efficacy and Safety of Compound Betamethasone in Pulmonary Sarcoidosis
The goal of this clinical trial is to learn whether a study drug called Compound Betamethasone (also known as Diprospan) works to treat pulmonary sarcoidosis in people with early-stage disease (stage I or II).
- Trial name
- NCT07668895
- Testing
- Prednisone, Compound betamethasone
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Peking Union Medical College Hospital
Restrictive Lung Diseases
Effects of Inspiratory Muscle Training and Positive Expiratory Pressure on Mechanically Ventilated Restrictive Lung Disease Patients
Restrictive lung diseases (RLD) represent a significant cause of morbidity, often necessitating intensive interventions such as mechanical ventilation due to diminished lung compliance (LC) and reduced total lung capacity (TLC).
- Trial name
- NCT07867730
- Testing
- Inspiratory muscle training, Conventional Chest Physical Therapy
- Where
- 3 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad
Idiopathic Pulmonary Fibrosis
Effect of Fostair® on Biomarkers of Platelet Adhesion in Idiopathic Pulmonary Fibrosis
The investigator has recently studied markers of platelet activation in idiopathic pulmonary fibrosis (IPF) and found that in IPF patients there is a significantly increased platelet reactivity when compared with controls which…
- Trial name
- NCT02048644
- Testing
- fostair
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Interstitial Lung Disease
Neuromuscular Electrical Stimulation in Patients With Interstitial Lung Disease
Decreased exercise capacity and quality of life, increased dyspnea and fatigue perception and hypoxemia during exercise is seen in patients with interstitial lung disease.
- Trial name
- NCT02497144
- Testing
- NMES Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Familial Pulmonary Fibrosis, Interstitial Lung Abnormalities
A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis
This study is open to people aged 40 years or older who have at least 1 family member with pulmonary fibrosis. Pulmonary fibrosis is a condition where lung tissue becomes scarred, making it harder to breathe.
- Conditions
- Familial Pulmonary Fibrosis, Interstitial Lung Abnormalities, Interstitial Lung Diseases
- Trial name
- NCT07201922
- Testing
- Nerandomilast
- Where
- 55 sites in United States, Argentina and 11 more
- Volunteers
- 80 people
- Sponsor
- Boehringer Ingelheim
Interstitial Lung Diseases
Home-based Pulmonary Rehabilitation in Interstitial Lung Disease
Pulmonary rehabilitation (PR) is a comprehensive, multidisciplinary intervention incorporating exercise training, education, and behavior change, shown to improve dyspnea, exercise capacity, and health-related quality of life…
- Trial name
- NCT07830602
- Testing
- Home-based pulmonary rehabilitation, Standard-of-care treatment
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Healthy Subjects, Rheumatoid Arthritis
Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis, Vasculitis or Pulmonary Sarcoidosis
This study evaluates safety, tolerability, biodistribution and performance of the [68Ga]Ga-DOTA-Siglec-9 following a single intravenous administration in patients with active rheumatoid arthritis, vasculitis or pulmonary…
- Conditions
- Healthy Subjects, Rheumatoid Arthritis, Vasculitis, Pulmonary Sarcoidosis
- Trial name
- SIGLEC (NCT03755245)
- Testing
- [68Ga]Ga-DOTA-Siglec-9
- Where
- Finland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Rheumatoid Arthritis
The Safety and Effects of Mesenchymal Stem Cell (MSCs) in the Treatment of Rheumatoid Arthritis
This study evaluates the safety and therapeutic effects of single-dose human umbilical cord blood mesenchymal stem cells (UC-MSCs) on the adult patients with moderate/severe Rheumatoid Arthritis accompany with anemia or/and…
- Trial name
- NCT03798028
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Xijing Hospital
Lung Disease, Chronic Obstructive, Lung Disease, Interstitial
Diagnosis of Cardio-Pulmonary Pathology Using Transthoracic Parametric Doppler (TPD)
This is a study that seeks to characterize data obtained from patients with a variety of lung diseases using ultrasound signals obtained from the lung tissue.
- Conditions
- Lung Disease, Chronic Obstructive, Lung Disease, Interstitial, Asthma, Sarcoidosis
- Trial name
- NCT01361139
- Where
- 2 sites in Israel
- Volunteers
- 500 people
- Sponsor
- Echosense Ltd.
Idiopathic Pulmonary Fibrosis, Cough
Treatment of Chronic Cough in Idiopathic Pulmonary Fibrosis With Thalidomide
Idiopathic Pulmonary Fibrosis (IPF) is a rapidly progressive lung disorder that is often associated with a chronic, intractable cough.
- Trial name
- NCT00600028
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Fibrosis, Pulmonary
HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis
This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic…
- Trial name
- HOGWARTS (NCT07373288)
- Testing
- Biopsy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Modena and Reggio Emilia
Langerhans Cell Histiocytosis (LCH), Juvenile Xanthogranuloma (JXG)
Mirdametinib in Histiocytic Disorders
The purpose of this study is to see if treatment with mirdametinib in patients with Langerhans cell histiocytosis (LCH) or other histiocytic disorders will be better than current treatments and with fewer side effects.
- Conditions
- Langerhans Cell Histiocytosis (LCH), Juvenile Xanthogranuloma (JXG), Rosai-Dorfman Disease (RDD), Histiocytic Disorders
- Trial name
- NCT06153173
- Testing
- Mirdametinib
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
SARS-CoV-2 Infection, Fibrosis Lung
Pilot Study to Assess Efficacy and Safety of Treamid in the Rehabilitation of Patients After COVID-19 Pneumonia
The innovative drug Treamid is planned for use in the rehabilitation of patients after COVID-19 pneumonia in a pilot, multicenter, randomized, double-blind, placebo-controlled Phase II clinical study to assess the efficacy and…
- Trial name
- NCT04527354
- Testing
- Treamid
- Where
- 8 sites in Russia
- Volunteers
- 60 people
- Sponsor
- PHARMENTERPRISES LLC
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