Clinical trials: Diffuse Parenchymal Lung Diseases
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis Registry China Study
By mean of registry of newly diagnosed Chinese IPF patients from more than 15 sites, this study aims to build IPF prospective cohort, set up normative clinical database and a biological specimen bank, and examine the clinical…
- Trial name
- PORTRAY (NCT03666234)
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Dai Huaping
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF) and the 3 Minutes Sit-to-stand Test
This study is designed to evaluate the reproductibility and the performance of the 3 minutes sit-to-stand test in patients with idiopathic pulmonary fibrosis.
- Trial name
- ST2-IPF (NCT03268915)
- Testing
- 3 minutes sit-to-stand test
- Where
- 2 sites in France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Grenoble
CTD-ILD
Phase III Clinical Trial of Telitacicept Injection in the Treatment of Patients With Connective Tissue Disease-related Interstitial Lung Disease
Interstitial lung disease (ILD) is a common pulmonary manifestation in chronic tissue diseases (CTD), significantly affecting patient's prognosis.
- Trial name
- NCT07495033
- Testing
- Telitacicept
- Where
- China
- Volunteers
- 260 people
- Sponsor
- RemeGen Co., Ltd.
Interstitial Lung Diseases (ILD), Airway Disease
Establishment of Diagnosis and Classification System for Lung Interstitial and Airway Diseases (LIAD)
This study focuses on both hospitalized and outpatient populations. Through a multicenter, retrospective study, it aims to comprehensively characterize:The comorbidity of interstitial lung diseases (ILD) and airway diseases;The…
- Trial name
- EDCS-LIAD (NCT06987266)
- Testing
- no intervention
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Xiangya Hospital of Central South University
Idiopathic Pulmonary Fibrosis
Conducting Airways in Lung Fibrosis (VACFI)
The purpose of this study is to determine whether extension of the conducting airways into the distal lung, or bronchiolization, occurs early in the course of Idiopathic Pulmonary Fibrosis, a disease wherein normal lung…
- Trial name
- VACFI (NCT01777373)
- Where
- France
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diffuse Parenchymal Lung Diseases
Fibered Confocal Fluorescence Microscopy Imaging in Patients With Diffuse Parenchymal Lung Diseases
Fibered confocal fluorescence microscopy (FCFM) (CellvizioR Lung, MaunaKea Technologies, France) could potentially provide diagnostic information on fibrosis and inflammation of the distal air spaces associated with diffuse…
- Trial name
- NCT01624753
- Testing
- confocal microscopy
- Where
- Singapore
- Volunteers
- 27 people
- Sponsor
- Singapore General Hospital
Chronic Obstructive Pulmonary Disease, Asthma
Study of the Tolerability and Pharmacokinetic of ZL-2102 With an Investigation of Food Effect in Healthy Male Subjects
The first-in-man study are designed as below to assess safety, tolerability, and preliminary pharmacokinetics of ZL-2102. Double-blind randomized, placebo-controlled ascending single oral doses (Part 1, ZL-2102-SAD); Open-label…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT02397005
- Testing
- ZL-2102
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zai Lab Pty. Ltd.
COPD Asthma, Pulmonary Fibrosis
Accuracy of Spircare Device as Compared to the Conventional Plethysmograph
The purpose of this study is to assess the accuracy of FRC and airway resistance calculate values of Spircare device as compared to the conventional body plethysmograph in healthy adults and patients with obstructive and…
- Trial name
- NCT03056066
- Testing
- Plethysmograph
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Spircare Ltd.
Idiopathic Pulmonary Fibrosis
A Trial of SHR - 1906 in Healthy Subjects
This study is a phase 1 single dose escalation study of SHR-1906 in healthy subjects. The purpose of the study is to evaluate the safety, tolerability and pharmacokinetics of SHR-1906 in healthy subjects.
- Trial name
- NCT04986540
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Interstitial Lung Disease
Diagnostic Yield of Transbronchial Cryobiopsy in Diagnosis of Interstitial Lung Diseases
Evaluation of diagnostic yield, feasibility and safety of transbronchial lung cryobiopsies done via bronchoscopy in the investigation of interstitial lung disease in comparison with videothoracoscopy-assisted surgical lung biopsy.
- Trial name
- NCT02235779
- Testing
- Transbronchial lung cryobiopsy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Sarcoidosis, Pulmonary
The Diagnostic and Prognostic Role of SAA in Intrathoracic Sarcoidosis
The goal of this observational study is to elucidate the role of serum amyloid A (SAA) in the diagnosis and follow-up of sarcoidosis, including its prognostic value.
- Trial name
- SARCO (NCT05811962)
- Testing
- No intervention
- Where
- Slovenia
- Volunteers
- 135 people
- Sponsor
- University Medical Centre Ljubljana
Pulmonary Fibrosis, Interstitial Lung Disease
The Study of the Use of Nintedanib in Slowing Lung Disease in Patients With Fibrotic or Non-Fibrotic Interstitial Lung Disease Related to COVID-19
This is a collaborative study between Icahn School of Medicine at Mount Sinai, Boehringer Ingelheim Pharmaceuticals and up to 9 other clinical centers across the US to determine the effect of nintedanib on slowing the rate of…
- Conditions
- Pulmonary Fibrosis, Interstitial Lung Disease, Respiratory Disease
- Trial name
- ENDCOV-I (NCT04619680)
- Testing
- Nintedanib
- Where
- 7 sites in United States
- Volunteers
- 103 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
This is a research study of a drug called cobimetinib in children and adults diagnosed with Langerhans cell histiocytosis (LCH), and other histiocytic disorders that has returned or does not respond to treatment.
- Conditions
- Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma, Erdheim-Chester Disease, Rosai Dorfman Disease
- Trial name
- NACHO-COBI (NCT04079179)
- Testing
- Cobimetinib
- Where
- 12 sites in United States
- Volunteers
- 90 people
- Sponsor
- Carl Allen
Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis)
Breathlessness Perceptions Within Respiratory Diseases
Breathlessness is a complex symptom that results in poor quality of life, increased hospitalisations and increased mortality. Breathlessness is influenced by physiological, psychological and functional factors but these are…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Interstitial Lung Disease (ILD), Bronchiectasis
- Trial name
- BiRD (NCT07648082)
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry
The Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry started recruiting in 2014 with the objective of studying Idiopathic Pulmonary Fibrosis.
- Trial name
- IPF/ILD-PRO (NCT01915511)
- Where
- 47 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Duke University
Pulmonary Hypertension, Interstitial Lung Disease
Bosentan in Pulmonary Hypertension in Interstitial Lung Disease Treatment Study
Over time, patients with fibrosing or interstitial lung disease (ILD) can develop high lung blood pressures (pulmonary hypertension), and this is associated with poorer prognosis and survival.
- Conditions
- Pulmonary Hypertension, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Nonspecific Interstitial Pneumonia
- Trial name
- B-PHIT (NCT00637065)
- Testing
- Bosentan
- Where
- 3 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Lung Cancer, Small Cell Lung Cancer
A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China
The primary objective of this study is to assess the safety and effectiveness of Human Multigene Methylation Detection Kit (Fluorescent PCR Method) for help diagnose lung cancer by comparing with clinical standard method…
- Conditions
- Lung Cancer, Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Squamous Cell Carcinoma
- Trial name
- NCT05337163
- Testing
- Diagnostic Test: Sputum DNA methylation analysis, chest CT or pathological examination
- Where
- China
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Creative Biosciences (Guangzhou) Co., Ltd.
Interstitial Lung Disease
A Multicenter Prospective Study of Risk Factors in Progressive Pulmonary Fibrosis
The goal of this observational study is to learn about risk of progressive pulmonary fibrosis (PPF). The main questions it aims to answer are: Risk factors of PPF Prevalence of PPF Mortality of PPF Patients with interstitial lung…
- Trial name
- NCT05895409
- Where
- China
- Volunteers
- 610 people
- Sponsor
- Qianfoshan Hospital
Rheumatoid Arthritis, Interstitial Lung Disease Due to Systemic Disease (Disorder)
Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung Disease
Pulmonary abnormalities are present in up to 60% of patients with early rheumatoid arthritis (RA), and up to 10% of the patients will develop clinical interstitial lung disease (ILD).
- Conditions
- Rheumatoid Arthritis, Interstitial Lung Disease Due to Systemic Disease (Disorder), RA, ILD
- Trial name
- PULMORA (NCT04311567)
- Testing
- Tofacitinib, Methotrexate
- Where
- 3 sites in Sweden
- Volunteers
- 3 people
- Sponsor
- Vastra Gotaland Region
Pulmonary Disease, Oropharyngeal Disease
Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
This study will examine bacteria and toxins in the mouth, lung and digestive system that may be the cause of various diseases or symptoms. H.
- Conditions
- Pulmonary Disease, Oropharyngeal Disease, Lymphangioleiomyomatosis, Pulmonary Fibrosis
- Trial name
- NCT00366509
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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