Clinical trials: Diffuse Parenchymal Lung Diseases
Lung Diseases, Interstitial
INCHANGE - Nintedanib for Changes in Cough and Dyspnea in Patients Suffering From Chronic Fibrosing Interstitial Lung Disease With a Progressive Phenotype in Everyday Clinical Practice: a Real-world Evaluation
The primary objective of this study is to investigate the correlation between changes from baseline to 52 weeks in Forced Vital Capacity (FVC) [% pred.] and changes from baseline to 52 weeks in dyspnea score [points] or cough…
- Trial name
- NCT05151640
- Testing
- Nintedanib
- Where
- 31 sites in Bulgaria, Czechia and 3 more
- Volunteers
- 158 people
- Sponsor
- Boehringer Ingelheim
Idiopathic Pulmonary Fibrosis
The Predictive Ability of 4MGS in IPF
This study investigates whether usual walking speed, measured by the 4 metre gait speed test (4MGS), and change in usual walking speed over 6 months predicts death and hospital admissions in patients with Idiopathic Pulmonary…
- Trial name
- IPFMORT (NCT02436278)
- Testing
- 4MGS
- Where
- United Kingdom
- Volunteers
- 132 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Interstitial Fibrosis/Tubular Atrophy of Transplanted Kidneys
Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM)
: GREFFE_ELASTO IRM will evaluate Magnetic Resonance Elastography (MRE) in renal transplant patients with suspected interstitial fibrosis/tubular atrophy lesions requiring biopsy graft sampling under ultrasound control.
- Trial name
- NCT03918161
- Testing
- MRE exam
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Bordeaux
Idiopathic Pulmonary Fibrosis
SC1011 Twice Daily vs Placebo in Patients Diagnosed With Idiopathic Pulmonary Fibrosis (IPF)
Evaluating Sufenidone (SC1011) in IPF patients for efficacy and safety. Includes screening, treatment, and follow-up, with FVC decline and health checks.
- Trial name
- NCT06125327
- Testing
- SC1011
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Guangzhou JOYO Pharma Co., Ltd
Idiopathic Pulmonary Fibrosis (IPF)
Confirmatory Clinical Study of HEC585 Tablets in Patients With IPF
A multicenter, parallel, randomized, placebo (double-blind) and pirfenidone (open-label) controlled Phase III clinical trial to evaluate the efficacy and safety of HEC585 in patients with idiopathic pulmonary fibrosis (IPF)
- Trial name
- NCT07082842
- Testing
- HEC585, Pirfenidone
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Interstitial Lung Disease
The Role of KL-6 in the Clinical Diagnosis of ILD
The purpose of the study is to evaluate the significance of KL-6 as a biomarker in the clinical diagnosis of interstitial lung disease (ILD) by detecting serum KL-6 levels among patients with ILD, and comparing them to the…
- Trial name
- NCT02197364
- Volunteers
- 1,190 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Systemic Sclerosis
Clinical Relevance of Thoracic Echography for the Early Diagnosis of Interstitial Lung Disease in Systemic Scleroderma - Pilot Study
Diffuse interstitial lung disease (PID) is the leading cause of death in systemic scleroderma (SSc). Major progress has recently been made in its therapeutic management. Early diagnosis is essential to optimize this management.
- Trial name
- PRECOSS (NCT04725786)
- Testing
- thoracic echography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Chronic Obstructive Pulmonary Disease, Asthma
Study of the Tolerability and Pharmacokinetic of ZL-2102 With an Investigation of Food Effect in Healthy Male Subjects
The first-in-man study are designed as below to assess safety, tolerability, and preliminary pharmacokinetics of ZL-2102. Double-blind randomized, placebo-controlled ascending single oral doses (Part 1, ZL-2102-SAD); Open-label…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT02397005
- Testing
- ZL-2102
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zai Lab Pty. Ltd.
Familial Pulmonary Fibrosis, Interstitial Lung Abnormalities
A Study to Test Whether Nerandomilast Can Help Slow Down Changes in the Lung in People With a Family History of Pulmonary Fibrosis
This study is open to people aged 40 years or older who have at least 1 family member with pulmonary fibrosis. Pulmonary fibrosis is a condition where lung tissue becomes scarred, making it harder to breathe.
- Conditions
- Familial Pulmonary Fibrosis, Interstitial Lung Abnormalities, Interstitial Lung Diseases
- Trial name
- NCT07201922
- Testing
- Nerandomilast
- Where
- 55 sites in United States, Argentina and 11 more
- Volunteers
- 80 people
- Sponsor
- Boehringer Ingelheim
Scleroderma, Interstitial Lung Disease
Safety & Suitability of Dabigatran to Inhibit Thrombin in Scleroderma
This study evaluates if dabigatran etexilate is safe for use in patients with Scleroderma and Interstitial Lung Disease. All patients will receive 75mg of dabigatran etexilate twice a day for 6 months.
- Trial name
- NCT02426229
- Testing
- dabigatran etexilate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medical University of South Carolina
Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
Acute Effect of Sildenafil on Exercise Tolerance and Functional Capacity in COPD, IPF and Post Pneumonectomy Patients
Pulmonary diseases are increasingly important causes of morbidity and mortality in the modern world. Sildenafil, an orally administered a phosphodiesterase type 5 (PDE-5) inhibitor, targets the nitric oxide (NO) pathway.
- Trial name
- NCT01382368
- Testing
- Sildenafil
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Idiopathic Pulmonary Fibrosis
LYT-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)
This study a randomized, double-blind, four arm study to evaluate the safety and efficacy of LYT-100 compared to pirfenidone or placebo in adults with Idiopathic Pulmonary Fibrosis.
- Trial name
- ELEVATE (NCT05321420)
- Testing
- Pirfenidone, Deupirfenidone
- Where
- 103 sites in United States, Argentina and 12 more
- Volunteers
- 240 people
- Sponsor
- PureTech
Interstitial Lung Disease
Evaluation of the Effectiveness, Safety, and Cost of a Smart Home-based Hospital System for Patients With Interstitial Lung Disease: Prospective Multicenter Randomized Controlled Trial
This study aims to analyze the effectiveness/safety/cost of the Smart Homespital system that provides a service that allows patients with interstitial lung disease to easily access and use biosignals generated using biosignal…
- Trial name
- NCT06601790
- Testing
- Immediate application of the Smart Homespital system, Delayed application of the Smart Homespital system after 3 months
- Where
- South Korea
- Volunteers
- 83 people
- Sponsor
- Yonsei University
Idiopathic Pulmonary Fibrosis
Cyclophosphamide for Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a major event of IPF with an annual incidence between 5 and 10% and is responsible for the death of one third of IPF patients.
- Trial name
- EXAFIP (NCT02460588)
- Testing
- Cyclophosphamide, Corticosteroid (prednisolone)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fibrosing Interstitial Lung Diseases, Idiopathic Pulmonary Fibrosis
Yoga in Patients With Fibrosing Interstitial Lung Diseases
Fibrosing interstitial lung diseases are characterized by loss of lung function, which leads to a decrease in quality of life and physical capacity.
- Trial name
- NCT03979703
- Testing
- 12 week yoga class
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Heidelberg University
Radiation Pneumonitis
Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients
This randomized clinical study aims to assess whether prophylactic treatment with inhaled steroids in patients with locally advanced or concomitantly treated non-small cell lung carcinoma who are candidates for combination…
- Trial name
- NCT03803787
- Testing
- Inhaled budesonide
- Where
- 2 sites in Mexico
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Pulmonary Fibrosis
Pulmonary Fibrosis and Telomerase Mutation Study
This study is an observational and retrospective study of patients with pulmonary fibrosis associated or not with telomerase mutation.
- Trial name
- NCT01501578
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires
Pulmonary Hypertension, Interstitial Lung Disease
Aerobic Exercise in Patients With Pulmonary Hypertension
This study will determine if a rehabilitation exercise program can help people with pulmonary hypertension (PH) increase their physical activity.
- Trial name
- NCT00678821
- Testing
- Aerobic exercise
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Interstitial Lung Disease (ILD)
VR-Assisted Exercise for Symptom Management and Rehabilitation in Interstitial Lung Disease
This project aims to create and improve a VR-based breathing exercise program for patients with interstitial lung diseases (ILDs).
- Trial name
- NCT07628725
- Testing
- Flyer, VR-based
- Volunteers
- 32 people
- Sponsor
- University of Manitoba
Pulmonary Hypertension, Interstitial Lung Disease
A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier)
A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Inhaled Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease
- Conditions
- Pulmonary Hypertension, Interstitial Lung Disease, Vascular Diseases, Cardiovascular Diseases
- Trial name
- NCT07816185
- Testing
- Mosliciguat, Dry Powder Inhaler
- Where
- 3 sites in United States
- Volunteers
- 376 people
- Sponsor
- Pulmovant, Inc.
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